Details for: ASMT

Gene ID: 438

Symbol: ASMT

Ensembl ID: ENSG00000196433

Description: acetylserotonin O-methyltransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3062
    Cell Significance Index: 6.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2871
    Cell Significance Index: 4.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1750
    Cell Significance Index: 4.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1657
    Cell Significance Index: 4.2600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1258
    Cell Significance Index: 1.7700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1013
    Cell Significance Index: 1.4500
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.0727
    Cell Significance Index: 0.4500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0671
    Cell Significance Index: 0.9900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0586
    Cell Significance Index: 0.4000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0384
    Cell Significance Index: 0.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0246
    Cell Significance Index: 4.9300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0221
    Cell Significance Index: 15.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0167
    Cell Significance Index: 3.3100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0158
    Cell Significance Index: 0.2300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.0154
    Cell Significance Index: 0.1400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0135
    Cell Significance Index: 0.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0130
    Cell Significance Index: 2.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0105
    Cell Significance Index: 1.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0097
    Cell Significance Index: 3.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0062
    Cell Significance Index: 0.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0057
    Cell Significance Index: 0.1600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0044
    Cell Significance Index: 0.2200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0042
    Cell Significance Index: 0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0034
    Cell Significance Index: 6.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0023
    Cell Significance Index: 3.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0021
    Cell Significance Index: 3.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0014
    Cell Significance Index: 1.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0005
    Cell Significance Index: -0.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0009
    Cell Significance Index: -0.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0013
    Cell Significance Index: -0.6100
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0016
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0025
    Cell Significance Index: -1.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0027
    Cell Significance Index: -2.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0029
    Cell Significance Index: -0.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0029
    Cell Significance Index: -2.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0029
    Cell Significance Index: -1.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0034
    Cell Significance Index: -1.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0048
    Cell Significance Index: -0.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0055
    Cell Significance Index: -0.1800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0071
    Cell Significance Index: -0.1500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0080
    Cell Significance Index: -0.3300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0082
    Cell Significance Index: -0.9700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0085
    Cell Significance Index: -0.1700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0088
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0092
    Cell Significance Index: -1.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0108
    Cell Significance Index: -0.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0113
    Cell Significance Index: -1.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0118
    Cell Significance Index: -1.6200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0128
    Cell Significance Index: -0.3200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0128
    Cell Significance Index: -0.2200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0140
    Cell Significance Index: -0.1800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0147
    Cell Significance Index: -0.2900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0148
    Cell Significance Index: -0.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0159
    Cell Significance Index: -2.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0159
    Cell Significance Index: -1.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0167
    Cell Significance Index: -0.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0173
    Cell Significance Index: -1.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0191
    Cell Significance Index: -1.9600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0206
    Cell Significance Index: -0.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0221
    Cell Significance Index: -1.0300
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0224
    Cell Significance Index: -0.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0226
    Cell Significance Index: -1.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0259
    Cell Significance Index: -0.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0272
    Cell Significance Index: -2.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0293
    Cell Significance Index: -1.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0307
    Cell Significance Index: -1.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0331
    Cell Significance Index: -0.9000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0336
    Cell Significance Index: -0.5100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0338
    Cell Significance Index: -0.8500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0356
    Cell Significance Index: -0.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0359
    Cell Significance Index: -1.6900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0378
    Cell Significance Index: -0.7700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0388
    Cell Significance Index: -0.8100
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0391
    Cell Significance Index: -0.5900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0405
    Cell Significance Index: -0.5900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0415
    Cell Significance Index: -0.5600
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0433
    Cell Significance Index: -0.5100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0463
    Cell Significance Index: -1.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0487
    Cell Significance Index: -1.7100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0489
    Cell Significance Index: -1.8000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0497
    Cell Significance Index: -1.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0502
    Cell Significance Index: -1.4500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0507
    Cell Significance Index: -0.5500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0537
    Cell Significance Index: -1.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0562
    Cell Significance Index: -1.5000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0570
    Cell Significance Index: -0.6500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0580
    Cell Significance Index: -0.5500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0582
    Cell Significance Index: -1.1600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0585
    Cell Significance Index: -0.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0586
    Cell Significance Index: -1.7200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0589
    Cell Significance Index: -0.7000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0594
    Cell Significance Index: -1.7500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0598
    Cell Significance Index: -1.6000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0598
    Cell Significance Index: -0.9600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0601
    Cell Significance Index: -1.0400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0610
    Cell Significance Index: -0.7700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0613
    Cell Significance Index: -1.3100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0615
    Cell Significance Index: -0.6700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0639
    Cell Significance Index: -0.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Specificity:** ASMT is highly specific for its substrate, acetylserotonin, and exhibits a high degree of affinity for this substrate. 2. **Catalytic activity:** ASMT catalyzes the transfer of a methyl group from S-adenosylmethionine (SAMe) to acetylserotonin, resulting in the formation of N-acetylserotonin. 3. **Expression patterns:** ASMT is expressed in enterocytes, goblet cells, granulocytes, monocytes, and other cell types in the gastrointestinal tract, as well as in neurons and immune cells. 4. **Tissue specificity:** ASMT is highly expressed in the small intestine and colon, where it plays a critical role in lipid and amino acid metabolism. **Pathways and Functions:** 1. **Melatonin biosynthesis:** ASMT is the final enzyme in the melatonin biosynthesis pathway, converting acetylserotonin to N-acetylserotonin, which is then converted to melatonin. 2. **Lipid metabolism:** ASMT has been implicated in lipid metabolism, particularly in the context of fatty acid synthesis and degradation. 3. **Amino acid metabolism:** ASMT has been shown to be involved in the metabolism of amino acids, including the regulation of protein synthesis and degradation. 4. **Protein homodimerization:** ASMT has been shown to form homodimers, which may play a role in regulating its activity and interactions with other proteins. 5. **Indolalkylamine biosynthesis:** ASMT is also involved in the biosynthesis of indolalkylamines, such as serotonin, which are important neurotransmitters. **Clinical Significance:** 1. **Melatonin dysregulation:** Alterations in ASMT activity or expression have been implicated in various diseases, including insomnia, depression, and cancer. 2. **Gastrointestinal disorders:** ASMT expression and activity have been linked to gastrointestinal disorders, such as inflammatory bowel disease and irritable bowel syndrome. 3. **Neurological disorders:** ASMT has been implicated in neurological disorders, including Parkinson's disease and Alzheimer's disease. 4. **Cancer:** ASMT has been shown to play a role in cancer development and progression, particularly in the context of melatonin biosynthesis and indolalkylamine metabolism. In conclusion, ASMT is a critical enzyme involved in various cellular processes, including melatonin biosynthesis, lipid metabolism, amino acid metabolism, and protein homodimerization. Its expression and activity have significant implications for human health, and further research is needed to fully elucidate its role in disease and development.

Genular Protein ID: 2640420139

Symbol: ASMT_HUMAN

Name: Acetylserotonin O-methyltransferase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7989373

Title: Structural analysis of the human hydroxyindole-O-methyltransferase gene. Presence of two distinct promoters.

PubMed ID: 7989373

DOI: 10.1016/s0021-9258(18)31790-3

PubMed ID: 8397829

Title: Human hydroxyindole-O-methyltransferase: presence of LINE-1 fragment in a cDNA clone and pineal mRNA.

PubMed ID: 8397829

DOI: 10.1089/dna.1993.12.715

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8574683

Title: Human hydroxyindole-O-methyltransferase in pineal gland, retina and Y79 retinoblastoma cells.

PubMed ID: 8574683

DOI: 10.1016/0006-8993(95)00651-6

PubMed ID: 8842389

Title: Hydroxyindole-O-methyltransferase in Y-79 cells: regulation by serum.

PubMed ID: 8842389

DOI: 10.1016/0006-8993(96)00359-9

PubMed ID: 8752109

Title: Retinoic acid increases hydroxyindole-O-methyltransferase activity and mRNA in human Y-79 retinoblastoma cells.

PubMed ID: 8752109

DOI: 10.1046/j.1471-4159.1996.67031032.x

PubMed ID: 22775292

Title: Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway.

PubMed ID: 22775292

DOI: 10.1111/j.1600-079x.2012.01020.x

PubMed ID: 17957233

Title: Is ASMT a susceptibility gene for autism spectrum disorders? A replication study in European populations.

PubMed ID: 17957233

DOI: 10.1038/sj.mp.4002069

PubMed ID: 17505466

Title: Abnormal melatonin synthesis in autism spectrum disorders.

PubMed ID: 17505466

DOI: 10.1038/sj.mp.4002016

PubMed ID: 21251267

Title: Mutation screening of ASMT, the last enzyme of the melatonin pathway, in a large sample of patients with intellectual disability.

PubMed ID: 21251267

DOI: 10.1186/1471-2350-12-17

PubMed ID: 21615493

Title: Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders.

PubMed ID: 21615493

DOI: 10.1111/j.1600-079x.2011.00902.x

PubMed ID: 22694957

Title: Genetic and functional abnormalities of the melatonin biosynthesis pathway in patients with bipolar disorder.

PubMed ID: 22694957

DOI: 10.1093/hmg/dds227

PubMed ID: 23349736

Title: Sequencing ASMT identifies rare mutations in Chinese Han patients with autism.

PubMed ID: 23349736

DOI: 10.1371/journal.pone.0053727

Sequence Information:

  • Length: 345
  • Mass: 38453
  • Checksum: 187A375E1E2940B7
  • Sequence:
  • MGSSEDQAYR LLNDYANGFM VSQVLFAACE LGVFDLLAEA PGPLDVAAVA AGVRASAHGT 
    ELLLDICVSL KLLKVETRGG KAFYRNTELS SDYLTTVSPT SQCSMLKYMG RTSYRCWGHL 
    ADAVREGRNQ YLETFGVPAE ELFTAIYRSE GERLQFMQAL QEVWSVNGRS VLTAFDLSVF 
    PLMCDLGGGA GALAKECMSL YPGCKITVFD IPEVVWTAKQ HFSFQEEEQI DFQEGDFFKD 
    PLPEADLYIL ARVLHDWADG KCSHLLERIY HTCKPGGGIL VIESLLDEDR RGPLLTQLYS 
    LNMLVQTEGQ ERTPTHYHML LSSAGFRDFQ FKKTGAIYDA ILARK

Genular Protein ID: 2331626421

Symbol: X5D784_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

Sequence Information:

  • Length: 298
  • Mass: 33192
  • Checksum: AAFC60D1F8D70E5A
  • Sequence:
  • MGSSEDQAYR LLNDYANGFM VSQVLFAACE LGVFDLLAEA PGPLDVAAVA AGVRASAHGT 
    ELLLDICVSL KLLKVETRGG KAFYRNTELS SDYLTTVSPT SQCSMLKYMG RTSYRCWGHL 
    ADAVREGRNQ YLETFGVPAE ELFTAIYRSE GERLQFMQAL QEVWSVNGRS VLTAFDLSVF 
    PLMCDLGGDF FKDPLPEADL YILARVLHDW ADGKCSHLLE RIYHTCKPGG GILVIESLLD 
    EDRRGPLLTQ LYSLNMLVQT EGQERTPTHY HMLLSSAGFR DFQFKKTGAI YDAILARK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.