Details for: ASMT

Gene ID: 438

Symbol: ASMT

Ensembl ID: ENSG00000196433

Description: acetylserotonin O-methyltransferase

Associated with

Other Information

Genular Protein ID: 2640420139

Symbol: ASMT_HUMAN

Name: Acetylserotonin O-methyltransferase

UniProtKB Accession Codes:

P46597 B2RC33 Q16598 Q5JQ72 Q5JQ73

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 10 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 29 Ensembl 6 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 3 Rhea 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 7989373

Title: Structural analysis of the human hydroxyindole-O-methyltransferase gene. Presence of two distinct promoters.

PubMed ID: 7989373

DOI: 10.1016/s0021-9258(18)31790-3

PubMed ID: 8397829

Title: Human hydroxyindole-O-methyltransferase: presence of LINE-1 fragment in a cDNA clone and pineal mRNA.

PubMed ID: 8397829

DOI: 10.1089/dna.1993.12.715

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8574683

Title: Human hydroxyindole-O-methyltransferase in pineal gland, retina and Y79 retinoblastoma cells.

PubMed ID: 8574683

DOI: 10.1016/0006-8993(95)00651-6

PubMed ID: 8842389

Title: Hydroxyindole-O-methyltransferase in Y-79 cells: regulation by serum.

PubMed ID: 8842389

DOI: 10.1016/0006-8993(96)00359-9

PubMed ID: 8752109

Title: Retinoic acid increases hydroxyindole-O-methyltransferase activity and mRNA in human Y-79 retinoblastoma cells.

PubMed ID: 8752109

DOI: 10.1046/j.1471-4159.1996.67031032.x

PubMed ID: 22775292

Title: Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway.

PubMed ID: 22775292

DOI: 10.1111/j.1600-079x.2012.01020.x

PubMed ID: 17957233

Title: Is ASMT a susceptibility gene for autism spectrum disorders? A replication study in European populations.

PubMed ID: 17957233

DOI: 10.1038/sj.mp.4002069

PubMed ID: 17505466

Title: Abnormal melatonin synthesis in autism spectrum disorders.

PubMed ID: 17505466

DOI: 10.1038/sj.mp.4002016

PubMed ID: 21251267

Title: Mutation screening of ASMT, the last enzyme of the melatonin pathway, in a large sample of patients with intellectual disability.

PubMed ID: 21251267

DOI: 10.1186/1471-2350-12-17

PubMed ID: 21615493

Title: Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders.

PubMed ID: 21615493

DOI: 10.1111/j.1600-079x.2011.00902.x

PubMed ID: 22694957

Title: Genetic and functional abnormalities of the melatonin biosynthesis pathway in patients with bipolar disorder.

PubMed ID: 22694957

DOI: 10.1093/hmg/dds227

PubMed ID: 23349736

Title: Sequencing ASMT identifies rare mutations in Chinese Han patients with autism.

PubMed ID: 23349736

DOI: 10.1371/journal.pone.0053727

Sequence Information:

  • Length: 345
  • Mass: 38453
  • Checksum: 187A375E1E2940B7
  • Sequence:
    • MGSSEDQAYR LLNDYANGFM VSQVLFAACE LGVFDLLAEA PGPLDVAAVA AGVRASAHGT 
ELLLDICVSL KLLKVETRGG KAFYRNTELS SDYLTTVSPT SQCSMLKYMG RTSYRCWGHL 
ADAVREGRNQ YLETFGVPAE ELFTAIYRSE GERLQFMQAL QEVWSVNGRS VLTAFDLSVF 
PLMCDLGGGA GALAKECMSL YPGCKITVFD IPEVVWTAKQ HFSFQEEEQI DFQEGDFFKD 
PLPEADLYIL ARVLHDWADG KCSHLLERIY HTCKPGGGIL VIESLLDEDR RGPLLTQLYS 
LNMLVQTEGQ ERTPTHYHML LSSAGFRDFQ FKKTGAIYDA ILARK

Genular Protein ID: 2331626421

Symbol: X5D784_HUMAN

Name: N/A

UniProtKB Accession Codes:

X5D784

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 ExpressionAtlas 1 GO 3 Gene3D 2 GenomeRNAi 1 HOGENOM 1 InterPro 6 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PROSITE 1 Pfam 4 RefSeq 1 Rhea 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

Sequence Information:

  • Length: 298
  • Mass: 33192
  • Checksum: AAFC60D1F8D70E5A
  • Sequence:
    • MGSSEDQAYR LLNDYANGFM VSQVLFAACE LGVFDLLAEA PGPLDVAAVA AGVRASAHGT 
ELLLDICVSL KLLKVETRGG KAFYRNTELS SDYLTTVSPT SQCSMLKYMG RTSYRCWGHL 
ADAVREGRNQ YLETFGVPAE ELFTAIYRSE GERLQFMQAL QEVWSVNGRS VLTAFDLSVF 
PLMCDLGGDF FKDPLPEADL YILARVLHDW ADGKCSHLLE RIYHTCKPGG GILVIESLLD 
EDRRGPLLTQ LYSLNMLVQT EGQERTPTHY HMLLSSAGFR DFQFKKTGAI YDAILARK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.