Details for: ASMT

Gene ID: 438

Symbol: ASMT

Ensembl ID: ENSG00000196433

Description: acetylserotonin O-methyltransferase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1174
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 873
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 858
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 1.23
    Marker Score: 3597
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 488
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7690
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4820
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 504
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 799
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71833
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48058
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.97
    Marker Score: 437
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5334
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.69
    Marker Score: 658
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.59
    Marker Score: 388
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 233
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.55
    Marker Score: 4682
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 476
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.38
    Marker Score: 1116
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.38
    Marker Score: 218
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.28
    Marker Score: 184.5
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.26
    Marker Score: 155
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.25
    Marker Score: 514
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.24
    Marker Score: 212
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.24
    Marker Score: 678.5
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.21
    Marker Score: 62
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.17
    Marker Score: 101
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.17
    Marker Score: 696
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.16
    Marker Score: 93
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.16
    Marker Score: 2141
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.16
    Marker Score: 254
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.15
    Marker Score: 62
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.13
    Marker Score: 91
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.12
    Marker Score: 1261
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.12
    Marker Score: 38
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.11
    Marker Score: 639
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.1
    Marker Score: 119
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.09
    Marker Score: 152
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.09
    Marker Score: 34
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.09
    Marker Score: 102
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.09
    Marker Score: 194
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.09
    Marker Score: 132
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.08
    Marker Score: 41
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.08
    Marker Score: 338
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.08
    Marker Score: 281
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.08
    Marker Score: 46
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.08
    Marker Score: 37
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.08
    Marker Score: 44
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.08
    Marker Score: 88
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.07
    Marker Score: 70
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.07
    Marker Score: 68
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.07
    Marker Score: 71
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.07
    Marker Score: 210
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.07
    Marker Score: 169
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.07
    Marker Score: 49
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.07
    Marker Score: 43
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.06
    Marker Score: 117
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.06
    Marker Score: 41
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.06
    Marker Score: 145
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.06
    Marker Score: 79
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.06
    Marker Score: 40
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.06
    Marker Score: 53
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.06
    Marker Score: 501
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.06
    Marker Score: 52
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.06
    Marker Score: 543
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.06
    Marker Score: 18

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Other Information

**Key characteristics:** * ASMT is a protein with a molecular weight of approximately 150 kDa. * It is found in a variety of tissues, including the enterocyte of the epithelium of large intestine, colon goblet cell, granulocyte monocyte progenitor cell, intestinal crypt stem cell of small intestine, ON-bipolar cell, transit amplifying cell of small intestine, goblet cell, enterocyte of epithelium of small intestine, transit amplifying cell of colon, and early T lineage precursor. * ASMT is a highly conserved protein, with a similar sequence found in organisms from yeast to humans. * It is an enzyme that is involved in the regulation of serotonin and melatonin levels in the body. **Pathways and functions:** * ASMT is involved in the biosynthesis of serotonin and melatonin. * Serotonin is a neurotransmitter that is involved in a variety of physiological processes, including mood, appetite, and sleep. * Melatonin is a hormone that is involved in the regulation of the circadian clock. * ASMT activity is regulated by a number of factors, including the levels of serotonin and melatonin in the body. * Inhibition of ASMT activity can lead to a decrease in serotonin and melatonin levels, which can have a number of negative effects on the body. **Clinical significance:** * Mutations in the ASMT gene have been linked to a number of human diseases, including autism, schizophrenia, and depression. * ASMT inhibitors are being investigated as a potential treatment for these disorders. * ASMT is a promising target for the treatment of depression and other psychiatric disorders.

Genular Protein ID: 2640420139

Symbol: ASMT_HUMAN

Name: Acetylserotonin O-methyltransferase

UniProtKB Accession Codes:

P46597 B2RC33 Q16598 Q5JQ72 Q5JQ73

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 10 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 29 Ensembl 6 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 3 Rhea 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 7989373

Title: Structural analysis of the human hydroxyindole-O-methyltransferase gene. Presence of two distinct promoters.

PubMed ID: 7989373

DOI: 10.1016/s0021-9258(18)31790-3

PubMed ID: 8397829

Title: Human hydroxyindole-O-methyltransferase: presence of LINE-1 fragment in a cDNA clone and pineal mRNA.

PubMed ID: 8397829

DOI: 10.1089/dna.1993.12.715

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8574683

Title: Human hydroxyindole-O-methyltransferase in pineal gland, retina and Y79 retinoblastoma cells.

PubMed ID: 8574683

DOI: 10.1016/0006-8993(95)00651-6

PubMed ID: 8842389

Title: Hydroxyindole-O-methyltransferase in Y-79 cells: regulation by serum.

PubMed ID: 8842389

DOI: 10.1016/0006-8993(96)00359-9

PubMed ID: 8752109

Title: Retinoic acid increases hydroxyindole-O-methyltransferase activity and mRNA in human Y-79 retinoblastoma cells.

PubMed ID: 8752109

DOI: 10.1046/j.1471-4159.1996.67031032.x

PubMed ID: 22775292

Title: Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway.

PubMed ID: 22775292

DOI: 10.1111/j.1600-079x.2012.01020.x

PubMed ID: 17957233

Title: Is ASMT a susceptibility gene for autism spectrum disorders? A replication study in European populations.

PubMed ID: 17957233

DOI: 10.1038/sj.mp.4002069

PubMed ID: 17505466

Title: Abnormal melatonin synthesis in autism spectrum disorders.

PubMed ID: 17505466

DOI: 10.1038/sj.mp.4002016

PubMed ID: 21251267

Title: Mutation screening of ASMT, the last enzyme of the melatonin pathway, in a large sample of patients with intellectual disability.

PubMed ID: 21251267

DOI: 10.1186/1471-2350-12-17

PubMed ID: 21615493

Title: Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders.

PubMed ID: 21615493

DOI: 10.1111/j.1600-079x.2011.00902.x

PubMed ID: 22694957

Title: Genetic and functional abnormalities of the melatonin biosynthesis pathway in patients with bipolar disorder.

PubMed ID: 22694957

DOI: 10.1093/hmg/dds227

PubMed ID: 23349736

Title: Sequencing ASMT identifies rare mutations in Chinese Han patients with autism.

PubMed ID: 23349736

DOI: 10.1371/journal.pone.0053727

Sequence Information:

  • Length: 345
  • Mass: 38453
  • Checksum: 187A375E1E2940B7
  • Sequence:
    • MGSSEDQAYR LLNDYANGFM VSQVLFAACE LGVFDLLAEA PGPLDVAAVA AGVRASAHGT 
ELLLDICVSL KLLKVETRGG KAFYRNTELS SDYLTTVSPT SQCSMLKYMG RTSYRCWGHL 
ADAVREGRNQ YLETFGVPAE ELFTAIYRSE GERLQFMQAL QEVWSVNGRS VLTAFDLSVF 
PLMCDLGGGA GALAKECMSL YPGCKITVFD IPEVVWTAKQ HFSFQEEEQI DFQEGDFFKD 
PLPEADLYIL ARVLHDWADG KCSHLLERIY HTCKPGGGIL VIESLLDEDR RGPLLTQLYS 
LNMLVQTEGQ ERTPTHYHML LSSAGFRDFQ FKKTGAIYDA ILARK

Genular Protein ID: 2331626421

Symbol: X5D784_HUMAN

Name: N/A

UniProtKB Accession Codes:

X5D784

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 ExpressionAtlas 1 GO 3 Gene3D 2 GenomeRNAi 1 HOGENOM 1 InterPro 6 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PROSITE 1 Pfam 4 RefSeq 1 Rhea 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

Sequence Information:

  • Length: 298
  • Mass: 33192
  • Checksum: AAFC60D1F8D70E5A
  • Sequence:
    • MGSSEDQAYR LLNDYANGFM VSQVLFAACE LGVFDLLAEA PGPLDVAAVA AGVRASAHGT 
ELLLDICVSL KLLKVETRGG KAFYRNTELS SDYLTTVSPT SQCSMLKYMG RTSYRCWGHL 
ADAVREGRNQ YLETFGVPAE ELFTAIYRSE GERLQFMQAL QEVWSVNGRS VLTAFDLSVF 
PLMCDLGGDF FKDPLPEADL YILARVLHDW ADGKCSHLLE RIYHTCKPGG GILVIESLLD 
EDRRGPLLTQ LYSLNMLVQT EGQERTPTHY HMLLSSAGFR DFQFKKTGAI YDAILARK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.