Details for: ASMT
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.3062
Cell Significance Index: 6.7100 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.2871
Cell Significance Index: 4.9200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.1750
Cell Significance Index: 4.6900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.1657
Cell Significance Index: 4.2600 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.1258
Cell Significance Index: 1.7700 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.1013
Cell Significance Index: 1.4500 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.0727
Cell Significance Index: 0.4500 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.0671
Cell Significance Index: 0.9900 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.0586
Cell Significance Index: 0.4000 - Cell Name: thymocyte (CL0000893)
Fold Change: 0.0384
Cell Significance Index: 0.4900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0246
Cell Significance Index: 4.9300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0221
Cell Significance Index: 15.2600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0167
Cell Significance Index: 3.3100 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.0158
Cell Significance Index: 0.2300 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.0154
Cell Significance Index: 0.1400 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.0135
Cell Significance Index: 0.2000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0130
Cell Significance Index: 2.3400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0105
Cell Significance Index: 1.5300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0097
Cell Significance Index: 3.4900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.0062
Cell Significance Index: 0.0900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0057
Cell Significance Index: 0.1600 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0044
Cell Significance Index: 0.2200 - Cell Name: proerythroblast (CL0000547)
Fold Change: 0.0042
Cell Significance Index: 0.0600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0034
Cell Significance Index: 6.4200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0023
Cell Significance Index: 3.5800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0021
Cell Significance Index: 3.8400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0014
Cell Significance Index: 1.9300 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.0003
Cell Significance Index: 0.0100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.0005
Cell Significance Index: -0.0500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0009
Cell Significance Index: -0.5800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0013
Cell Significance Index: -0.6100 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: -0.0016
Cell Significance Index: -0.0200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0025
Cell Significance Index: -1.8500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0027
Cell Significance Index: -2.0100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0029
Cell Significance Index: -0.8400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0029
Cell Significance Index: -2.2200 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0029
Cell Significance Index: -1.6000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0034
Cell Significance Index: -1.9100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0048
Cell Significance Index: -0.5900 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0055
Cell Significance Index: -0.1800 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0071
Cell Significance Index: -0.1500 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0080
Cell Significance Index: -0.3300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0082
Cell Significance Index: -0.9700 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0085
Cell Significance Index: -0.1700 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0088
Cell Significance Index: -0.1900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0092
Cell Significance Index: -1.9300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0108
Cell Significance Index: -0.8300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0113
Cell Significance Index: -1.9300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0118
Cell Significance Index: -1.6200 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0128
Cell Significance Index: -0.3200 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0128
Cell Significance Index: -0.2200 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.0140
Cell Significance Index: -0.1800 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0147
Cell Significance Index: -0.2900 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0148
Cell Significance Index: -0.5200 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0159
Cell Significance Index: -2.0600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0159
Cell Significance Index: -1.6600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0167
Cell Significance Index: -0.7400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0173
Cell Significance Index: -1.9900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0191
Cell Significance Index: -1.9600 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.0206
Cell Significance Index: -0.2500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0221
Cell Significance Index: -1.0300 - Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: -0.0224
Cell Significance Index: -0.3600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0226
Cell Significance Index: -1.2700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0259
Cell Significance Index: -0.9800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0272
Cell Significance Index: -2.0300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0293
Cell Significance Index: -1.5400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0307
Cell Significance Index: -1.6000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0331
Cell Significance Index: -0.9000 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.0336
Cell Significance Index: -0.5100 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0338
Cell Significance Index: -0.8500 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.0356
Cell Significance Index: -0.7000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0359
Cell Significance Index: -1.6900 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.0378
Cell Significance Index: -0.7700 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.0388
Cell Significance Index: -0.8100 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: -0.0391
Cell Significance Index: -0.5900 - Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.0405
Cell Significance Index: -0.5900 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: -0.0415
Cell Significance Index: -0.5600 - Cell Name: ependymal cell (CL0000065)
Fold Change: -0.0433
Cell Significance Index: -0.5100 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.0463
Cell Significance Index: -1.1300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0487
Cell Significance Index: -1.7100 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0489
Cell Significance Index: -1.8000 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0497
Cell Significance Index: -1.0400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0502
Cell Significance Index: -1.4500 - Cell Name: pro-B cell (CL0000826)
Fold Change: -0.0507
Cell Significance Index: -0.5500 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0537
Cell Significance Index: -1.3400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0562
Cell Significance Index: -1.5000 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0570
Cell Significance Index: -0.6500 - Cell Name: neuron (CL0000540)
Fold Change: -0.0580
Cell Significance Index: -0.5500 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.0582
Cell Significance Index: -1.1600 - Cell Name: medium spiny neuron (CL1001474)
Fold Change: -0.0585
Cell Significance Index: -0.7900 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0586
Cell Significance Index: -1.7200 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.0589
Cell Significance Index: -0.7000 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0594
Cell Significance Index: -1.7500 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0598
Cell Significance Index: -1.6000 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.0598
Cell Significance Index: -0.9600 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.0601
Cell Significance Index: -1.0400 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.0610
Cell Significance Index: -0.7700 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.0613
Cell Significance Index: -1.3100 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0615
Cell Significance Index: -0.6700 - Cell Name: fast muscle cell (CL0000190)
Fold Change: -0.0639
Cell Significance Index: -0.8400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2640420139
Symbol: ASMT_HUMAN
Name: Acetylserotonin O-methyltransferase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7989373
Title: Structural analysis of the human hydroxyindole-O-methyltransferase gene. Presence of two distinct promoters.
PubMed ID: 7989373
PubMed ID: 8397829
Title: Human hydroxyindole-O-methyltransferase: presence of LINE-1 fragment in a cDNA clone and pineal mRNA.
PubMed ID: 8397829
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15772651
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8574683
Title: Human hydroxyindole-O-methyltransferase in pineal gland, retina and Y79 retinoblastoma cells.
PubMed ID: 8574683
PubMed ID: 8842389
Title: Hydroxyindole-O-methyltransferase in Y-79 cells: regulation by serum.
PubMed ID: 8842389
PubMed ID: 8752109
Title: Retinoic acid increases hydroxyindole-O-methyltransferase activity and mRNA in human Y-79 retinoblastoma cells.
PubMed ID: 8752109
PubMed ID: 22775292
Title: Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway.
PubMed ID: 22775292
PubMed ID: 17957233
Title: Is ASMT a susceptibility gene for autism spectrum disorders? A replication study in European populations.
PubMed ID: 17957233
PubMed ID: 17505466
Title: Abnormal melatonin synthesis in autism spectrum disorders.
PubMed ID: 17505466
PubMed ID: 21251267
Title: Mutation screening of ASMT, the last enzyme of the melatonin pathway, in a large sample of patients with intellectual disability.
PubMed ID: 21251267
PubMed ID: 21615493
Title: Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders.
PubMed ID: 21615493
PubMed ID: 22694957
Title: Genetic and functional abnormalities of the melatonin biosynthesis pathway in patients with bipolar disorder.
PubMed ID: 22694957
DOI: 10.1093/hmg/dds227
PubMed ID: 23349736
Title: Sequencing ASMT identifies rare mutations in Chinese Han patients with autism.
PubMed ID: 23349736
Sequence Information:
- Length: 345
- Mass: 38453
- Checksum: 187A375E1E2940B7
- Sequence:
MGSSEDQAYR LLNDYANGFM VSQVLFAACE LGVFDLLAEA PGPLDVAAVA AGVRASAHGT ELLLDICVSL KLLKVETRGG KAFYRNTELS SDYLTTVSPT SQCSMLKYMG RTSYRCWGHL ADAVREGRNQ YLETFGVPAE ELFTAIYRSE GERLQFMQAL QEVWSVNGRS VLTAFDLSVF PLMCDLGGGA GALAKECMSL YPGCKITVFD IPEVVWTAKQ HFSFQEEEQI DFQEGDFFKD PLPEADLYIL ARVLHDWADG KCSHLLERIY HTCKPGGGIL VIESLLDEDR RGPLLTQLYS LNMLVQTEGQ ERTPTHYHML LSSAGFRDFQ FKKTGAIYDA ILARK
Genular Protein ID: 2331626421
Symbol: X5D784_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 24722188
Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
PubMed ID: 24722188
Sequence Information:
- Length: 298
- Mass: 33192
- Checksum: AAFC60D1F8D70E5A
- Sequence:
MGSSEDQAYR LLNDYANGFM VSQVLFAACE LGVFDLLAEA PGPLDVAAVA AGVRASAHGT ELLLDICVSL KLLKVETRGG KAFYRNTELS SDYLTTVSPT SQCSMLKYMG RTSYRCWGHL ADAVREGRNQ YLETFGVPAE ELFTAIYRSE GERLQFMQAL QEVWSVNGRS VLTAFDLSVF PLMCDLGGDF FKDPLPEADL YILARVLHDW ADGKCSHLLE RIYHTCKPGG GILVIESLLD EDRRGPLLTQ LYSLNMLVQT EGQERTPTHY HMLLSSAGFR DFQFKKTGAI YDAILARK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.