Details for: GET3

Gene ID: 439

Symbol: GET3

Ensembl ID: ENSG00000198356

Description: guided entry of tail-anchored proteins factor 3, ATPase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.81
    Marker Score: 2511
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.67
    Marker Score: 1787
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.19
    Marker Score: 1542
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.02
    Marker Score: 4256
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.88
    Marker Score: 8123
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.71
    Marker Score: 6720.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.69
    Marker Score: 6526.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.68
    Marker Score: 924
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.67
    Marker Score: 14430
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.62
    Marker Score: 2608
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.59
    Marker Score: 3322
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.58
    Marker Score: 4310
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.58
    Marker Score: 6450.5
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.54
    Marker Score: 9371
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.51
    Marker Score: 1010
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.51
    Marker Score: 1592
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.5
    Marker Score: 2155
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.46
    Marker Score: 428
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.43
    Marker Score: 9140
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.41
    Marker Score: 5013
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.41
    Marker Score: 5219.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.4
    Marker Score: 1452
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.39
    Marker Score: 1745.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.39
    Marker Score: 2043
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.38
    Marker Score: 341
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.38
    Marker Score: 15526
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.38
    Marker Score: 35279
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.38
    Marker Score: 1545
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.38
    Marker Score: 2339
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.37
    Marker Score: 2793
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.37
    Marker Score: 2677.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.37
    Marker Score: 15916
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.37
    Marker Score: 6561
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.37
    Marker Score: 862
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.37
    Marker Score: 703
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.36
    Marker Score: 2257
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.35
    Marker Score: 13623.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.35
    Marker Score: 10507
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.34
    Marker Score: 2202.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.34
    Marker Score: 1446
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.34
    Marker Score: 46254
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.33
    Marker Score: 644
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.33
    Marker Score: 664
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.3
    Marker Score: 2959
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.29
    Marker Score: 3576
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.29
    Marker Score: 1094
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.28
    Marker Score: 1779
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.28
    Marker Score: 1389
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.28
    Marker Score: 300
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.28
    Marker Score: 3221
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.27
    Marker Score: 722
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.27
    Marker Score: 17057
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.27
    Marker Score: 708
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.27
    Marker Score: 11021
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.27
    Marker Score: 1274
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.25
    Marker Score: 912
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.25
    Marker Score: 732
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.25
    Marker Score: 1113
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.24
    Marker Score: 357
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.24
    Marker Score: 12546
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.22
    Marker Score: 578
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.21
    Marker Score: 3290
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.2
    Marker Score: 1219
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.2
    Marker Score: 638
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.2
    Marker Score: 660
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.2
    Marker Score: 3548
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.2
    Marker Score: 11842
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.19
    Marker Score: 423
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.19
    Marker Score: 2227
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.18
    Marker Score: 807
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.18
    Marker Score: 441
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.18
    Marker Score: 1239
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.18
    Marker Score: 988
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.18
    Marker Score: 66015
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.17
    Marker Score: 3069
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.17
    Marker Score: 466
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.16
    Marker Score: 2060.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.16
    Marker Score: 7527
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.16
    Marker Score: 4805
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.15
    Marker Score: 1084
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.15
    Marker Score: 39177
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.15
    Marker Score: 1770
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.15
    Marker Score: 859
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.14
    Marker Score: 8502.5
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.14
    Marker Score: 2698.5
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.13
    Marker Score: 1364
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.12
    Marker Score: 742
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.11
    Marker Score: 1051
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.11
    Marker Score: 1048
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.11
    Marker Score: 1574
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.11
    Marker Score: 1179
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.11
    Marker Score: 582
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.09
    Marker Score: 6483
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.09
    Marker Score: 7102.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.09
    Marker Score: 1164
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.08
    Marker Score: 494
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.08
    Marker Score: 1885
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.08
    Marker Score: 470
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.07
    Marker Score: 2041.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.07
    Marker Score: 1295

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Other Information

**Key characteristics:** * The GET3 gene is a large protein (40 kDa) that is expressed in multiple isoforms. * The full-length protein is composed of a transmembrane domain and a cytoplasmic domain. * The transmembrane domain is responsible for the protein's interaction with the ER membrane. * The cytoplasmic domain is responsible for the protein's activity. **Pathways and functions:** * The GET3 gene is involved in the process of guided entry of tail-anchored proteins into the ER membrane. * Tail-anchored proteins are proteins that are tethered to the ER membrane by a transmembrane domain. * Once the GET3 protein is bound to the ER membrane, it inserts its cytoplasmic domain into the membrane. * The protein then undergoes a series of conformational changes that allow it to interact with other proteins in the ER. **Clinical significance:** * Mutations in the GET3 gene have been linked to a number of human diseases, including cancer and cardiovascular disease. * One way that GET3 mutations can lead to disease is through their effect on the function of other proteins that are involved in the process of guided entry of tail-anchored proteins into the ER membrane. * Understanding the role of GET3 in cancer and cardiovascular disease could lead to the development of new therapies for these diseases.

Genular Protein ID: 3076587774

Symbol: GET3_HUMAN

Name: Transmembrane domain recognition complex 40 kDa ATPase subunit

UniProtKB Accession Codes:

O43681 A6NHP8 A8K740 Q53FC6 Q92849

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 CarbonylDB 1 ChEBI 5 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 8 EPD 1 Ensembl 2 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HAMAP-Rule 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8884272

Title: Isolation of the ATP-binding human homolog of the arsA component of the bacterial arsenite transporter.

PubMed ID: 8884272

DOI: 10.1006/geno.1996.0494

PubMed ID: 9712828

Title: Biochemical characterization of the human arsenite-stimulated ATPase (hASNA-I).

PubMed ID: 9712828

DOI: 10.1074/jbc.273.35.22173

PubMed ID: 9736449

Title: Dual cytoplasmic and nuclear distribution of the novel arsenite-stimulated human ATPase (hASNA-I).

PubMed ID: 9736449

DOI: 10.1002/(sici)1097-4644(19981001)71:1<1::aid-jcb1>3.3.co;2-r

PubMed ID: 9774623

Title: Immunohistochemical analysis of the distribution of the human ATPase (hASNA-I) in normal tissues and its overexpression in breast adenomas and carcinomas.

PubMed ID: 9774623

DOI: 10.1177/002215549804601104

PubMed ID: 17382883

Title: Identification of a targeting factor for posttranslational membrane protein insertion into the ER.

PubMed ID: 17382883

DOI: 10.1016/j.cell.2007.01.036

PubMed ID: 18477612

Title: Distinct targeting pathways for the membrane insertion of tail-anchored (TA) proteins.

PubMed ID: 18477612

DOI: 10.1242/jcs.020321

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21444755

Title: WRB is the receptor for TRC40/Asna1-mediated insertion of tail-anchored proteins into the ER membrane.

PubMed ID: 21444755

DOI: 10.1242/jcs.084277

PubMed ID: 23041287

Title: Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells.

PubMed ID: 23041287

DOI: 10.1016/j.molcel.2012.08.028

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24392163

Title: WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane.

PubMed ID: 24392163

DOI: 10.1371/journal.pone.0085033

PubMed ID: 25535373

Title: Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.

PubMed ID: 25535373

DOI: 10.1073/pnas.1402745112

PubMed ID: 31461301

Title: Biallelic variants in ASNA1, encoding a cytosolic targeting factor of tail-anchored proteins, cause rapidly progressive pediatric cardiomyopathy.

PubMed ID: 31461301

DOI: 10.1161/circgen.119.002507

PubMed ID: 32910895

Title: Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex.

PubMed ID: 32910895

DOI: 10.1016/j.molcel.2020.08.012

Sequence Information:

  • Length: 348
  • Mass: 38793
  • Checksum: DA52C4ACC35C7A36
  • Sequence:
    • MAAGVAGWGV EAEEFEDAPD VEPLEPTLSN IIEQRSLKWI FVGGKGGVGK TTCSCSLAVQ 
LSKGRESVLI ISTDPAHNIS DAFDQKFSKV PTKVKGYDNL FAMEIDPSLG VAELPDEFFE 
EDNMLSMGKK MMQEAMSAFP GIDEAMSYAE VMRLVKGMNF SVVVFDTAPT GHTLRLLNFP 
TIVERGLGRL MQIKNQISPF ISQMCNMLGL GDMNADQLAS KLEETLPVIR SVSEQFKDPE 
QTTFICVCIA EFLSLYETER LIQELAKCKI DTHNIIVNQL VFPDPEKPCK MCEARHKIQA 
KYLDQMEDLY EDFHIVKLPL LPHEVRGADK VNTFSALLLE PYKPPSAQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.