Details for: GET3

Gene ID: 439

Symbol: GET3

Ensembl ID: ENSG00000198356

Description: guided entry of tail-anchored proteins factor 3, ATPase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 157.6712
    Cell Significance Index: -24.5300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 109.9970
    Cell Significance Index: -27.9000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 84.2340
    Cell Significance Index: -34.7000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 79.5801
    Cell Significance Index: -32.3300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 74.8958
    Cell Significance Index: -35.3600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 68.9950
    Cell Significance Index: -35.4900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 34.2186
    Cell Significance Index: -32.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.7812
    Cell Significance Index: -33.0200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.0268
    Cell Significance Index: -35.6200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.2469
    Cell Significance Index: -25.3300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.8609
    Cell Significance Index: -8.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.3202
    Cell Significance Index: 270.3900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.2146
    Cell Significance Index: 1999.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4734
    Cell Significance Index: 239.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.2947
    Cell Significance Index: 96.4900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2885
    Cell Significance Index: 11.8700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.2846
    Cell Significance Index: 10.7900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.2550
    Cell Significance Index: 10.0200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1379
    Cell Significance Index: 33.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.0650
    Cell Significance Index: 28.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0602
    Cell Significance Index: 49.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.0475
    Cell Significance Index: 55.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8889
    Cell Significance Index: 57.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8847
    Cell Significance Index: 45.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8713
    Cell Significance Index: 119.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8621
    Cell Significance Index: 470.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7969
    Cell Significance Index: 97.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7905
    Cell Significance Index: 142.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7383
    Cell Significance Index: 46.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7382
    Cell Significance Index: 87.0600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7343
    Cell Significance Index: 15.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6856
    Cell Significance Index: 47.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6831
    Cell Significance Index: 41.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6722
    Cell Significance Index: 86.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6391
    Cell Significance Index: 8.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6291
    Cell Significance Index: 278.1400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5761
    Cell Significance Index: 20.0200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5657
    Cell Significance Index: 6.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5018
    Cell Significance Index: 49.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4980
    Cell Significance Index: 35.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4978
    Cell Significance Index: 63.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4622
    Cell Significance Index: 12.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4441
    Cell Significance Index: 84.5200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4252
    Cell Significance Index: 4.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3841
    Cell Significance Index: 17.4100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3070
    Cell Significance Index: 4.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2804
    Cell Significance Index: 13.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2391
    Cell Significance Index: 5.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2158
    Cell Significance Index: 6.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1681
    Cell Significance Index: 33.7300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1661
    Cell Significance Index: 3.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1489
    Cell Significance Index: 4.2900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1285
    Cell Significance Index: 2.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1151
    Cell Significance Index: 22.8500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.1119
    Cell Significance Index: 1.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0809
    Cell Significance Index: 4.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0710
    Cell Significance Index: 25.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0659
    Cell Significance Index: 49.8500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0493
    Cell Significance Index: 1.3200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0405
    Cell Significance Index: 2.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0339
    Cell Significance Index: 1.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0275
    Cell Significance Index: 0.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0184
    Cell Significance Index: 0.4900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0022
    Cell Significance Index: 1.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0121
    Cell Significance Index: -1.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0130
    Cell Significance Index: -24.4500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0159
    Cell Significance Index: -0.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0264
    Cell Significance Index: -48.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0288
    Cell Significance Index: -4.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0321
    Cell Significance Index: -49.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0330
    Cell Significance Index: -24.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0364
    Cell Significance Index: -49.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0366
    Cell Significance Index: -23.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0408
    Cell Significance Index: -4.6700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0418
    Cell Significance Index: -28.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0537
    Cell Significance Index: -1.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0552
    Cell Significance Index: -31.1300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0552
    Cell Significance Index: -1.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0722
    Cell Significance Index: -32.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0794
    Cell Significance Index: -49.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1026
    Cell Significance Index: -29.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1127
    Cell Significance Index: -2.4000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1304
    Cell Significance Index: -1.6700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1578
    Cell Significance Index: -6.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1841
    Cell Significance Index: -26.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1917
    Cell Significance Index: -40.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2962
    Cell Significance Index: -23.4600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2972
    Cell Significance Index: -7.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3416
    Cell Significance Index: -35.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3681
    Cell Significance Index: -22.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3996
    Cell Significance Index: -26.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4008
    Cell Significance Index: -30.7600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4342
    Cell Significance Index: -12.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4536
    Cell Significance Index: -25.4600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4852
    Cell Significance Index: -15.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4945
    Cell Significance Index: -30.3200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.5126
    Cell Significance Index: -7.1900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.5943
    Cell Significance Index: -8.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6145
    Cell Significance Index: -10.5300
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.6910
    Cell Significance Index: -5.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GET3 is a member of the GET complex, a multi-subunit protein complex that mediates the insertion of TAPs into the ER membrane. The GET complex consists of three subunits: GET3, GET4, and GET5. GET3 is the ATPase subunit responsible for hydrolyzing ATP to drive the insertion process. The protein has a transmembrane domain recognition complex (Transmembrane Domain Recognition Complex) and exhibits metal ion binding properties. GET3 is also involved in the regulation of protein localization, cytoplasmic and nucleoplasmic localization, and protein binding. **Pathways and Functions:** GET3 is involved in several cellular pathways, including: 1. **Arsenite transmembrane transporter activity**: GET3 mediates the transport of arsenite across the ER membrane, regulating arsenic levels within the cell. 2. **Arsenite transport**: GET3 is involved in the transport of arsenite from the cytoplasm to the ER, facilitating arsenic detoxification. 3. **Atp binding and hydrolysis activity**: GET3 hydrolyzes ATP to drive the insertion process, regulating the activity of the GET complex. 4. **Cytoplasmic and nucleoplasmic localization**: GET3 regulates the localization of proteins within the cytoplasm and nucleoplasm, influencing various cellular processes. 5. **Protein binding**: GET3 interacts with various proteins, regulating their localization and activity. **Clinical Significance:** GET3 has been implicated in various diseases, including: 1. **Cancer**: GET3 overexpression has been observed in several types of cancer, including breast, lung, and colon cancer, suggesting its potential as a diagnostic marker. 2. **Neurodegenerative diseases**: GET3 has been linked to neurodegenerative diseases such as Alzheimer's and Parkinson's, where it may contribute to protein misfolding and aggregation. 3. **Infectious diseases**: GET3 has been implicated in the regulation of immune responses, suggesting its potential as a therapeutic target for infectious diseases. In conclusion, GET3 is a multifunctional gene that plays a critical role in regulating protein localization, insertion, and function. Its involvement in various cellular pathways and diseases highlights its importance as a potential therapeutic target and diagnostic marker. Further research is needed to fully elucidate the functions of GET3 and its implications in human disease.

Genular Protein ID: 3076587774

Symbol: GET3_HUMAN

Name: Transmembrane domain recognition complex 40 kDa ATPase subunit

UniProtKB Accession Codes:

O43681 A6NHP8 A8K740 Q53FC6 Q92849

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 CarbonylDB 1 ChEBI 5 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 8 EMDB 2 Ensembl 2 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8884272

Title: Isolation of the ATP-binding human homolog of the arsA component of the bacterial arsenite transporter.

PubMed ID: 8884272

DOI: 10.1006/geno.1996.0494

PubMed ID: 9712828

Title: Biochemical characterization of the human arsenite-stimulated ATPase (hASNA-I).

PubMed ID: 9712828

DOI: 10.1074/jbc.273.35.22173

PubMed ID: 9736449

Title: Dual cytoplasmic and nuclear distribution of the novel arsenite-stimulated human ATPase (hASNA-I).

PubMed ID: 9736449

DOI: 10.1002/(sici)1097-4644(19981001)71:1<1::aid-jcb1>3.3.co;2-r

PubMed ID: 9774623

Title: Immunohistochemical analysis of the distribution of the human ATPase (hASNA-I) in normal tissues and its overexpression in breast adenomas and carcinomas.

PubMed ID: 9774623

DOI: 10.1177/002215549804601104

PubMed ID: 17382883

Title: Identification of a targeting factor for posttranslational membrane protein insertion into the ER.

PubMed ID: 17382883

DOI: 10.1016/j.cell.2007.01.036

PubMed ID: 18477612

Title: Distinct targeting pathways for the membrane insertion of tail-anchored (TA) proteins.

PubMed ID: 18477612

DOI: 10.1242/jcs.020321

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21444755

Title: WRB is the receptor for TRC40/Asna1-mediated insertion of tail-anchored proteins into the ER membrane.

PubMed ID: 21444755

DOI: 10.1242/jcs.084277

PubMed ID: 23041287

Title: Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells.

PubMed ID: 23041287

DOI: 10.1016/j.molcel.2012.08.028

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24392163

Title: WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane.

PubMed ID: 24392163

DOI: 10.1371/journal.pone.0085033

PubMed ID: 25535373

Title: Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.

PubMed ID: 25535373

DOI: 10.1073/pnas.1402745112

PubMed ID: 31461301

Title: Biallelic variants in ASNA1, encoding a cytosolic targeting factor of tail-anchored proteins, cause rapidly progressive pediatric cardiomyopathy.

PubMed ID: 31461301

DOI: 10.1161/circgen.119.002507

PubMed ID: 32910895

Title: Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex.

PubMed ID: 32910895

DOI: 10.1016/j.molcel.2020.08.012

Sequence Information:

  • Length: 348
  • Mass: 38793
  • Checksum: DA52C4ACC35C7A36
  • Sequence:
    • MAAGVAGWGV EAEEFEDAPD VEPLEPTLSN IIEQRSLKWI FVGGKGGVGK TTCSCSLAVQ 
LSKGRESVLI ISTDPAHNIS DAFDQKFSKV PTKVKGYDNL FAMEIDPSLG VAELPDEFFE 
EDNMLSMGKK MMQEAMSAFP GIDEAMSYAE VMRLVKGMNF SVVVFDTAPT GHTLRLLNFP 
TIVERGLGRL MQIKNQISPF ISQMCNMLGL GDMNADQLAS KLEETLPVIR SVSEQFKDPE 
QTTFICVCIA EFLSLYETER LIQELAKCKI DTHNIIVNQL VFPDPEKPCK MCEARHKIQA 
KYLDQMEDLY EDFHIVKLPL LPHEVRGADK VNTFSALLLE PYKPPSAQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.