Details for: GET3
Gene ID: 439
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: GET3
Ensembl ID: ENSG00000198356
Description: guided entry of tail-anchored proteins factor 3, ATPase
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 20.64rCSI 45.6%PRS 38.78
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CSI 16.68rCSI 29.42%PRS 59.73
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CSI 14.54rCSI 28.29%PRS 53.81
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CSI 12.39rCSI 10.06%PRS 52.02
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CSI 11.3rCSI 14.81%PRS 65.22
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CSI 11.25rCSI 11.78%PRS 54.7
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CSI 10.15rCSI 13.02%PRS 56.36
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CSI 9.15rCSI 14.19%PRS 60.25
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CSI 8.94rCSI 22.14%PRS 49.37
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CSI 8.16rCSI 16.21%PRS 49.78
-
CSI 7.86rCSI 18.69%PRS 62.34
-
CSI 7.69rCSI 24.95%PRS 53.46
-
CSI 7.35rCSI 6.64%PRS 48.25
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CSI 5.74rCSI 8.78%PRS 67.14
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CSI 5.69rCSI 7.15%PRS 64.69
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CSI 5.3rCSI 3.69%PRS 65.49
-
CSI 5rCSI 28.65%PRS 62.06
-
CSI 4.98rCSI 7.59%PRS 47.99
-
CSI 4.92rCSI 4.74%PRS 51.75
-
CSI 4.78rCSI 7.66%PRS 77.49
-
CSI 4.63rCSI 7.63%PRS 57
-
CSI 4.49rCSI 3.4%PRS 65.09
-
CSI 4.42rCSI 34.61%PRS 65.95
-
CSI 4.09rCSI 6.59%PRS 41.67
-
CSI 3.7rCSI 3.57%PRS 42.03
-
CSI 3.6rCSI 3.16%PRS 56.82
-
CSI 3.48rCSI 2.42%PRS 61.54
-
CSI 3.45rCSI 2.68%PRS 52.26
-
CSI 3.35rCSI 5.06%PRS 54.3
-
CSI 3.3rCSI 2.22%PRS 63.41
-
CSI 3.29rCSI 10.55%PRS 58.15
-
CSI 3.28rCSI 17.69%PRS 65.58
-
CSI 3.25rCSI 9.59%PRS 55.52
-
CSI 3.19rCSI 4.35%PRS 53.87
-
CSI 3.12rCSI 2.94%PRS 51.86
-
CSI 3.1rCSI 4.61%PRS 53.78
-
CSI 3.09rCSI 5.01%PRS 49.21
-
CSI 3.03rCSI 6.89%PRS 56.78
-
CSI 2.9rCSI 2.5%PRS 58.54
-
CSI 2.81rCSI 16.38%PRS 61.68
-
CSI 2.66rCSI 3.29%PRS 47.35
-
CSI 2.62rCSI 16.85%PRS 72.02
-
CSI 2.61rCSI 11.5%PRS 43.7
-
CSI 2.61rCSI 2.16%PRS 52.99
-
CSI 2.61rCSI 2.05%PRS 58.12
-
CSI 2.59rCSI 3.11%PRS 49.4
-
CSI 2.57rCSI 2.53%PRS 54.02
-
CSI 2.51rCSI 2.47%PRS 67.53
-
CSI 2.48rCSI 2.17%PRS 61.62
-
CSI 2.47rCSI 3.38%PRS 56.73
-
CSI 2.47rCSI 3.01%PRS 59.38
-
CSI 2.47rCSI 2.58%PRS 50.38
-
CSI 2.46rCSI 3.8%PRS 49.34
-
CSI 2.45rCSI 3.4%PRS 54.76
-
CSI 2.45rCSI 4.93%PRS 40.86
-
CSI 2.42rCSI 4.35%PRS 44.74
-
CSI 2.39rCSI 2.23%PRS 51.15
-
CSI 2.38rCSI 2.29%PRS 75.21
-
CSI 2.33rCSI 3.36%PRS 61.33
-
CSI 2.29rCSI 3.19%PRS 50.69
-
CSI 2.29rCSI 2.39%PRS 51.93
-
CSI 2.26rCSI 1.79%PRS 38.69
-
CSI 2.26rCSI 2.08%PRS 59.85
-
CSI 2.21rCSI 1.65%PRS 66.7
-
CSI 2.18rCSI 3.14%PRS 64.03
-
CSI 2.14rCSI 4.55%PRS 53.51
-
CSI 2.12rCSI 5.38%PRS 46.62
-
CSI 2.06rCSI 3.05%PRS 56.89
-
CSI 2.06rCSI 1.9%PRS 52.54
-
CSI 2.05rCSI 4.68%PRS 49.17
-
CSI 2.03rCSI 1.8%PRS 49.97
-
CSI 2.02rCSI 2.17%PRS 49.82
-
CSI 2.02rCSI 2.57%PRS 57.4
-
CSI 2.01rCSI 3.09%PRS 50.95
-
CSI 2.01rCSI 7.05%PRS 65.99
-
CSI 2rCSI 2.32%PRS 60.87
-
CSI 1.98rCSI 1.17%PRS 68.1
-
CSI 1.97rCSI 3.1%PRS 52.69
-
CSI 1.96rCSI 2.87%PRS 54.95
-
CSI 1.96rCSI 1.99%PRS 65.16
-
CSI 1.95rCSI 3.47%PRS 66.49
-
CSI 1.94rCSI 1.29%PRS 55.22
-
CSI 1.91rCSI 1.68%PRS 40.09
-
CSI 1.87rCSI 1.95%PRS 48.42
-
CSI 1.85rCSI 2.71%PRS 62.97
-
CSI 1.85rCSI 2.93%PRS 62.44
-
CSI 1.83rCSI 1.28%PRS 53.92
-
CSI 1.83rCSI 1.53%PRS 56.47
-
CSI 1.76rCSI 2.04%PRS 45.38
-
CSI 1.75rCSI 2.35%PRS 52.63
-
CSI 1.74rCSI 2.31%PRS 56.9
-
CSI 1.73rCSI 2.65%PRS 52.16
-
CSI 1.72rCSI 1.72%PRS 45.29
-
CSI 1.65rCSI 1.27%PRS 50.81
-
CSI 1.63rCSI 1.49%PRS 66.2
-
CSI 1.62rCSI 1.41%PRS 61.87
-
CSI 1.61rCSI 2.2%PRS 44.29
-
CSI 1.6rCSI 3.52%PRS 55.64
-
CSI 1.6rCSI 1.75%PRS 55.22
-
CSI 1.59rCSI 5.76%PRS 71.31
-
CSI 0.1rCSI 1.6%PRS 82.2%
-
CSI 0.2rCSI 2.0%PRS 73.6%
-
CSI 0.2rCSI 5.5%PRS 73.5%
-
CSI 0.3rCSI 3.1%PRS 69.9%
-
CSI 0.4rCSI 4.0%PRS 66.5%
-
CSI 0.4rCSI 1.1%PRS 66.4%
-
CSI 0.5rCSI 2.0%PRS 71.0%
-
CSI 0.5rCSI 1.5%PRS 53.5%
-
CSI 0.5rCSI 2.3%PRS 66.8%
-
CSI 0.6rCSI 2.0%PRS 58.8%
-
CSI 0.8rCSI 3.4%PRS 50.5%
-
CSI 0.8rCSI 0.7%PRS 52.5%
-
CSI 0.9rCSI 2.5%PRS 67.8%
-
CSI 0.9rCSI 2.5%PRS 65.2%
-
CSI 1.0rCSI 4.4%PRS 72.6%
-
CSI 1.0rCSI 2.2%PRS 69.0%
-
CSI 1.0rCSI 2.3%PRS 58.7%
-
CSI 1.0rCSI 1.1%PRS 57.4%
-
CSI 1.1rCSI 1.8%PRS 44.8%
-
CSI 1.1rCSI 3.0%PRS 59.7%
-
CSI 1.2rCSI 1.8%PRS 49.5%
-
CSI 1.2rCSI 4.8%PRS 66.4%
-
CSI 1.2rCSI 1.7%PRS 71.9%
-
CSI 1.2rCSI 1.3%PRS 64.8%
-
CSI 1.2rCSI 1.9%PRS 68.6%
-
CSI 1.2rCSI 6.1%PRS 63.5%
-
CSI 1.2rCSI 2.3%PRS 73.6%
-
CSI 1.2rCSI 2.7%PRS 49.1%
-
CSI 1.3rCSI 1.6%PRS 61.8%
-
CSI 1.3rCSI 2.1%PRS 34.6%
-
CSI 1.3rCSI 2.7%PRS 65.2%
-
CSI 1.3rCSI 2.0%PRS 59.5%
-
CSI 1.3rCSI 1.5%PRS 41.5%
-
CSI 1.4rCSI 1.2%PRS 56.0%
-
CSI 1.4rCSI 2.5%PRS 49.1%
-
CSI 1.4rCSI 3.4%PRS 46.2%
-
CSI 1.4rCSI 2.9%PRS 72.1%
-
CSI 1.4rCSI 2.5%PRS 61.1%
-
CSI 1.4rCSI 1.9%PRS 49.3%
-
CSI 1.5rCSI 2.2%PRS 61.1%
-
CSI 1.5rCSI 1.8%PRS 59.7%
-
CSI 1.5rCSI 1.2%PRS 50.3%
-
CSI 1.5rCSI 2.0%PRS 60.6%
-
CSI 1.5rCSI 1.9%PRS 32.9%
-
CSI 1.5rCSI 1.1%PRS 55.8%
-
CSI 1.5rCSI 1.7%PRS 73.2%
-
CSI 1.5rCSI 2.2%PRS 54.0%
-
CSI 1.6rCSI 2.3%PRS 57.5%
-
CSI 1.6rCSI 5.8%PRS 71.3%
-
CSI 1.6rCSI 1.8%PRS 55.2%
-
CSI 1.6rCSI 3.5%PRS 55.6%
-
CSI 1.6rCSI 2.2%PRS 44.3%
-
CSI 1.6rCSI 1.4%PRS 61.9%
-
CSI 1.6rCSI 1.5%PRS 66.2%
-
CSI 1.7rCSI 1.3%PRS 50.8%
-
CSI 1.7rCSI 1.7%PRS 45.3%
-
CSI 1.7rCSI 2.7%PRS 52.2%
-
CSI 1.7rCSI 2.3%PRS 56.9%
-
CSI 1.8rCSI 2.4%PRS 52.6%
-
CSI 1.8rCSI 2.0%PRS 45.4%
-
CSI 1.8rCSI 1.5%PRS 56.5%
-
CSI 1.8rCSI 1.3%PRS 53.9%
-
CSI 1.9rCSI 2.9%PRS 62.4%
-
CSI 1.9rCSI 2.7%PRS 63.0%
-
CSI 1.9rCSI 2.0%PRS 48.4%
-
CSI 1.9rCSI 1.7%PRS 40.1%
-
CSI 1.9rCSI 1.3%PRS 55.2%
-
CSI 2.0rCSI 3.5%PRS 66.5%
-
CSI 2.0rCSI 2.0%PRS 65.2%
-
CSI 2.0rCSI 2.9%PRS 55.0%
-
CSI 2.0rCSI 3.1%PRS 52.7%
-
CSI 2.0rCSI 1.2%PRS 68.1%
-
CSI 2.0rCSI 2.3%PRS 60.9%
-
CSI 2.0rCSI 7.1%PRS 66.0%
-
CSI 2.0rCSI 3.1%PRS 51.0%
-
CSI 2.0rCSI 2.6%PRS 57.4%
-
CSI 2.0rCSI 2.2%PRS 49.8%
-
CSI 2.0rCSI 1.8%PRS 50.0%
-
CSI 2.1rCSI 4.7%PRS 49.2%
-
CSI 2.1rCSI 1.9%PRS 52.5%
-
CSI 2.1rCSI 3.1%PRS 56.9%
-
CSI 2.1rCSI 5.4%PRS 46.6%
-
CSI 2.1rCSI 4.6%PRS 53.5%
-
CSI 2.2rCSI 3.1%PRS 64.0%
-
CSI 2.2rCSI 1.7%PRS 66.7%
-
CSI 2.3rCSI 2.1%PRS 59.9%
-
CSI 2.3rCSI 1.8%PRS 38.7%
-
CSI 2.3rCSI 2.4%PRS 51.9%
-
CSI 2.3rCSI 3.2%PRS 50.7%
-
CSI 2.3rCSI 3.4%PRS 61.3%
-
CSI 2.4rCSI 2.3%PRS 75.2%
-
CSI 2.4rCSI 2.2%PRS 51.2%
-
CSI 2.4rCSI 4.4%PRS 44.7%
-
CSI 2.5rCSI 4.9%PRS 40.9%
-
CSI 2.5rCSI 3.4%PRS 54.8%
-
CSI 2.5rCSI 3.8%PRS 49.3%
-
CSI 2.5rCSI 2.6%PRS 50.4%
-
CSI 2.5rCSI 3.0%PRS 59.4%
-
CSI 2.5rCSI 3.4%PRS 56.7%
-
CSI 2.5rCSI 2.2%PRS 61.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3076587774
Symbol: GET3_HUMAN
Name: Transmembrane domain recognition complex 40 kDa ATPase subunit
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8884272
Title: Isolation of the ATP-binding human homolog of the arsA component of the bacterial arsenite transporter.
PubMed ID: 8884272
PubMed ID: 9712828
Title: Biochemical characterization of the human arsenite-stimulated ATPase (hASNA-I).
PubMed ID: 9712828
PubMed ID: 9736449
Title: Dual cytoplasmic and nuclear distribution of the novel arsenite-stimulated human ATPase (hASNA-I).
PubMed ID: 9736449
DOI: 10.1002/(sici)1097-4644(19981001)71:1<1::aid-jcb1>3.3.co;2-r
PubMed ID: 9774623
Title: Immunohistochemical analysis of the distribution of the human ATPase (hASNA-I) in normal tissues and its overexpression in breast adenomas and carcinomas.
PubMed ID: 9774623
PubMed ID: 17382883
Title: Identification of a targeting factor for posttranslational membrane protein insertion into the ER.
PubMed ID: 17382883
PubMed ID: 18477612
Title: Distinct targeting pathways for the membrane insertion of tail-anchored (TA) proteins.
PubMed ID: 18477612
DOI: 10.1242/jcs.020321
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21444755
Title: WRB is the receptor for TRC40/Asna1-mediated insertion of tail-anchored proteins into the ER membrane.
PubMed ID: 21444755
DOI: 10.1242/jcs.084277
PubMed ID: 23041287
Title: Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells.
PubMed ID: 23041287
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24392163
Title: WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane.
PubMed ID: 24392163
PubMed ID: 25535373
Title: Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.
PubMed ID: 25535373
PubMed ID: 31461301
Title: Biallelic variants in ASNA1, encoding a cytosolic targeting factor of tail-anchored proteins, cause rapidly progressive pediatric cardiomyopathy.
PubMed ID: 31461301
PubMed ID: 32910895
Title: Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex.
PubMed ID: 32910895
Sequence Information:
- Length: 348
- Mass: 38793
- Checksum: DA52C4ACC35C7A36
- Sequence:
MAAGVAGWGV EAEEFEDAPD VEPLEPTLSN IIEQRSLKWI FVGGKGGVGK TTCSCSLAVQ LSKGRESVLI ISTDPAHNIS DAFDQKFSKV PTKVKGYDNL FAMEIDPSLG VAELPDEFFE EDNMLSMGKK MMQEAMSAFP GIDEAMSYAE VMRLVKGMNF SVVVFDTAPT GHTLRLLNFP TIVERGLGRL MQIKNQISPF ISQMCNMLGL GDMNADQLAS KLEETLPVIR SVSEQFKDPE QTTFICVCIA EFLSLYETER LIQELAKCKI DTHNIIVNQL VFPDPEKPCK MCEARHKIQA KYLDQMEDLY EDFHIVKLPL LPHEVRGADK VNTFSALLLE PYKPPSAQ