Details for: ASNS

Gene ID: 440

Symbol: ASNS

Ensembl ID: ENSG00000070669

Description: asparagine synthetase (glutamine-hydrolyzing)

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 2.6
    Marker Score: 2550
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.93
    Marker Score: 4081
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.37
    Marker Score: 1094
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.33
    Marker Score: 384.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.26
    Marker Score: 5117
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.25
    Marker Score: 12945
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.19
    Marker Score: 2076
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.02
    Marker Score: 415
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.01
    Marker Score: 295
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71776
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48000
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.92
    Marker Score: 583
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.92
    Marker Score: 1547
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5246
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2725
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5270
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.86
    Marker Score: 345
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.85
    Marker Score: 1371
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.83
    Marker Score: 12989
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.81
    Marker Score: 3768
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.81
    Marker Score: 183
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.81
    Marker Score: 1640
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1239
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 566
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 382
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.73
    Marker Score: 1477
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3037
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 285
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 649
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.68
    Marker Score: 286
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.68
    Marker Score: 228
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.67
    Marker Score: 753
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.65
    Marker Score: 996
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.64
    Marker Score: 775
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.62
    Marker Score: 774.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.62
    Marker Score: 371
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.62
    Marker Score: 1755
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.6
    Marker Score: 563
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.58
    Marker Score: 254
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.56
    Marker Score: 3348
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.55
    Marker Score: 177
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.54
    Marker Score: 262
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.53
    Marker Score: 599
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.52
    Marker Score: 1280
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.52
    Marker Score: 3335
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.51
    Marker Score: 232
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.5
    Marker Score: 2103
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5
    Marker Score: 320
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.49
    Marker Score: 438
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.49
    Marker Score: 2410
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.49
    Marker Score: 134
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.49
    Marker Score: 230
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.49
    Marker Score: 647
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.48
    Marker Score: 823
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.48
    Marker Score: 1009
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.48
    Marker Score: 319
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.47
    Marker Score: 431
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.46
    Marker Score: 128
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.46
    Marker Score: 401
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.46
    Marker Score: 652
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.46
    Marker Score: 192
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.43
    Marker Score: 1289
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.43
    Marker Score: 206
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.43
    Marker Score: 121
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.43
    Marker Score: 238
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.42
    Marker Score: 1622
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.42
    Marker Score: 132
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.42
    Marker Score: 444
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.41
    Marker Score: 144
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.41
    Marker Score: 285
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.41
    Marker Score: 101
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.41
    Marker Score: 107
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.4
    Marker Score: 380
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.4
    Marker Score: 1727
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4
    Marker Score: 13366
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.39
    Marker Score: 13623
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.39
    Marker Score: 556
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.38
    Marker Score: 90
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.38
    Marker Score: 2482
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.38
    Marker Score: 225
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.38
    Marker Score: 1031
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.38
    Marker Score: 3840
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.38
    Marker Score: 237
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.38
    Marker Score: 464
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.37
    Marker Score: 881
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.37
    Marker Score: 197
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.36
    Marker Score: 96
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.36
    Marker Score: 865
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.36
    Marker Score: 436
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.36
    Marker Score: 588
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.36
    Marker Score: 305
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.35
    Marker Score: 663
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.35
    Marker Score: 3023

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Other Information

**Key characteristics:** * The ASNS gene is located on chromosome 15q21.1. * It is a single gene with a length of approximately 11.7 kb. * It encodes a protein of 477 amino acids. * ASNS is a highly expressed gene in various cell types, with highest expression in pancreatic cells, particularly in the acinar cells of the pancreas. * It is also expressed in germ cells, neurons, and other cell types. **Pathways and functions:** * The ASNS gene is involved in multiple pathways and functions, including: * Asparagine biosynthetic process * Asparagine synthase (glutamine-hydrolyzing) activity * Aspartate and asparagine metabolism * Atf4 activates genes in response to endoplasmic reticulum (ER) stress * Cellular responses to stimuli * Cellular response to stress * Cellular response to glucose starvation * Cellular response to starvation * Glutamine metabolic process * Metabolism of amino acids and derivatives * Perk regulates gene expression * Protein binding * Response of eif2ak1 (hri) to heme deficiency * Response of eif2ak4 (gcn2) to amino acid deficiency * Unfolded protein response (upr) **Clinical significance:** * Mutations in the ASNS gene have been linked to several human diseases, including: * Diabetes * Cancer * Cardiovascular disease * Kidney disease * Obesity * ASNS inhibitors are being investigated as potential therapeutic agents for these diseases.

Genular Protein ID: 3619525398

Symbol: ASNS_HUMAN

Name: Asparagine synthetase [glutamine-hydrolyzing]

UniProtKB Accession Codes:

P08243 A4D1I8 B4DXZ1 B7ZAA9 D6W5R3 E9PCI3 E9PCX6 P08184 Q15666 Q549T9 Q96HD0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EC 2 EMBL 27 EPD 1 Ensembl 7 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 4 RefSeq 6 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2886907

Title: Isolation of human cDNAs for asparagine synthetase and expression in Jensen rat sarcoma cells.

PubMed ID: 2886907

DOI: 10.1128/mcb.7.7.2435-2443.1987

PubMed ID: 2565875

Title: Molecular structure of the human asparagine synthetase gene.

PubMed ID: 2565875

DOI: 10.1016/0888-7543(89)90329-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3470743

Title: Molecular cloning of a gene that is necessary for G1 progression in mammalian cells.

PubMed ID: 3470743

DOI: 10.1073/pnas.84.6.1565

PubMed ID: 2569668

Title: Organization and expression of the cell cycle gene, ts11, that encodes asparagine synthetase.

PubMed ID: 2569668

DOI: 10.1128/mcb.9.6.2350-2359.1989

PubMed ID: 2564390

Title: Expression of human asparagine synthetase in Escherichia coli.

PubMed ID: 2564390

DOI: 10.1016/s0021-9258(18)83573-6

PubMed ID: 2573597

Title: The N-terminal cysteine of human asparagine synthetase is essential for glutamine-dependent activity.

PubMed ID: 2573597

DOI: 10.1016/s0021-9258(19)47138-x

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24139043

Title: Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy.

PubMed ID: 24139043

DOI: 10.1016/j.neuron.2013.08.013

Sequence Information:

  • Length: 561
  • Mass: 64370
  • Checksum: 3E9B75E21D799FBE
  • Sequence:
    • MCGIWALFGS DDCLSVQCLS AMKIAHRGPD AFRFENVNGY TNCCFGFHRL AVVDPLFGMQ 
PIRVKKYPYL WLCYNGEIYN HKKMQQHFEF EYQTKVDGEI ILHLYDKGGI EQTICMLDGV 
FAFVLLDTAN KKVFLGRDTY GVRPLFKAMT EDGFLAVCSE AKGLVTLKHS ATPFLKVEPF 
LPGHYEVLDL KPNGKVASVE MVKYHHCRDV PLHALYDNVE KLFPGFEIET VKNNLRILFN 
NAVKKRLMTD RRIGCLLSGG LDSSLVAATL LKQLKEAQVQ YPLQTFAIGM EDSPDLLAAR 
KVADHIGSEH YEVLFNSEEG IQALDEVIFS LETYDITTVR ASVGMYLISK YIRKNTDSVV 
IFSGEGSDEL TQGYIYFHKA PSPEKAEEES ERLLRELYLF DVLRADRTTA AHGLELRVPF 
LDHRFSSYYL SLPPEMRIPK NGIEKHLLRE TFEDSNLIPK EILWRPKEAF SDGITSVKNS 
WFKILQEYVE HQVDDAMMAN AAQKFPFNTP KTKEGYYYRQ VFERHYPGRA DWLSHYWMPK 
WINATDPSAR TLTHYKSAVK A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.