ASNS | ENSG00000070669 | NCBI 440

Details for: ASNS

Gene ID: 440

Symbol: ASNS

Ensembl ID: ENSG00000070669

Description: asparagine synthetase (glutamine-hydrolyzing)

Associated with

Aspartate and asparagine metabolism
(R-HSA-8963693)
Atf4 activates genes in response to endoplasmic reticulum stress
(R-HSA-380994)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Perk regulates gene expression
(R-HSA-381042)
Response of eif2ak1 (hri) to heme deficiency
(R-HSA-9648895)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Unfolded protein response (upr)
(R-HSA-381119)
Asparagine biosynthetic process
(GO:0006529)
Asparagine synthase (glutamine-hydrolyzing) activity
(GO:0004066)
Atp binding
(GO:0005524)
Cellular response to glucose starvation
(GO:0042149)
Cytosol
(GO:0005829)
Glutamine metabolic process
(GO:0006541)
L-asparagine biosynthetic process
(GO:0070981)
Negative regulation of apoptotic process
(GO:0043066)
Positive regulation of mitotic cell cycle
(GO:0045931)
Protein binding
(GO:0005515)

Other Information

Proteins

Asparagine synthetase [glutamine-hydrolyzing]

Genular Protein ID: 3619525398

Symbol: ASNS_HUMAN

Name: Asparagine synthetase [glutamine-hydrolyzing]

UniProtKB Accession Codes:

P08243 A4D1I8 B4DXZ1 B7ZAA9 D6W5R3 E9PCI3 E9PCX6 P08184 Q15666 Q549T9 Q96HD0

Database IDs:

Citations:

PubMed ID: 2886907

Title: Isolation of human cDNAs for asparagine synthetase and expression in Jensen rat sarcoma cells.

PubMed ID: 2886907

DOI: 10.1128/mcb.7.7.2435-2443.1987

PubMed ID: 2565875

Title: Molecular structure of the human asparagine synthetase gene.

PubMed ID: 2565875

DOI: 10.1016/0888-7543(89)90329-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3470743

Title: Molecular cloning of a gene that is necessary for G1 progression in mammalian cells.

PubMed ID: 3470743

DOI: 10.1073/pnas.84.6.1565

PubMed ID: 2569668

Title: Organization and expression of the cell cycle gene, ts11, that encodes asparagine synthetase.

PubMed ID: 2569668

DOI: 10.1128/mcb.9.6.2350-2359.1989

PubMed ID: 2564390

Title: Expression of human asparagine synthetase in Escherichia coli.

PubMed ID: 2564390

DOI: 10.1016/s0021-9258(18)83573-6

PubMed ID: 2573597

Title: The N-terminal cysteine of human asparagine synthetase is essential for glutamine-dependent activity.

PubMed ID: 2573597

DOI: 10.1016/s0021-9258(19)47138-x

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24139043

Title: Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy.

PubMed ID: 24139043

DOI: 10.1016/j.neuron.2013.08.013

Sequence Information:

Length: 561
Mass: 64370
Checksum: 3E9B75E21D799FBE
Sequence:

MCGIWALFGS DDCLSVQCLS AMKIAHRGPD AFRFENVNGY TNCCFGFHRL AVVDPLFGMQ 
PIRVKKYPYL WLCYNGEIYN HKKMQQHFEF EYQTKVDGEI ILHLYDKGGI EQTICMLDGV 
FAFVLLDTAN KKVFLGRDTY GVRPLFKAMT EDGFLAVCSE AKGLVTLKHS ATPFLKVEPF 
LPGHYEVLDL KPNGKVASVE MVKYHHCRDV PLHALYDNVE KLFPGFEIET VKNNLRILFN 
NAVKKRLMTD RRIGCLLSGG LDSSLVAATL LKQLKEAQVQ YPLQTFAIGM EDSPDLLAAR 
KVADHIGSEH YEVLFNSEEG IQALDEVIFS LETYDITTVR ASVGMYLISK YIRKNTDSVV 
IFSGEGSDEL TQGYIYFHKA PSPEKAEEES ERLLRELYLF DVLRADRTTA AHGLELRVPF 
LDHRFSSYYL SLPPEMRIPK NGIEKHLLRE TFEDSNLIPK EILWRPKEAF SDGITSVKNS 
WFKILQEYVE HQVDDAMMAN AAQKFPFNTP KTKEGYYYRQ VFERHYPGRA DWLSHYWMPK 
WINATDPSAR TLTHYKSAVK A

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ASNS

Associated with

Other Information

Isolation of human cDNAs for asparagine synthetase and expression in Jensen rat sarcoma cells. PubMed ID: 2886907

Molecular structure of the human asparagine synthetase gene. PubMed ID: 2565875

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 7: DNA sequence and biology. PubMed ID: 12690205

The DNA sequence of human chromosome 7. PubMed ID: 12853948

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular cloning of a gene that is necessary for G1 progression in mammalian cells. PubMed ID: 3470743

Organization and expression of the cell cycle gene, ts11, that encodes asparagine synthetase. PubMed ID: 2569668

Expression of human asparagine synthetase in Escherichia coli. PubMed ID: 2564390

The N-terminal cysteine of human asparagine synthetase is essential for glutamine-dependent activity. PubMed ID: 2573597

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy. PubMed ID: 24139043