Details for: imd

Gene ID: 44339

Symbol: imd

Ensembl ID: FBgn0013983

Description: immune deficiency

Associated with

  • Antibacterial humoral response
    (GO:0019731)
  • Death domain binding
    (GO:0070513)
  • Defense response to gram-negative bacterium
    (GO:0050829)
  • Humoral immune response
    (GO:0006959)
  • Immune response
    (GO:0006955)
  • Intracellular signal transduction
    (GO:0035556)
  • Nervous system development
    (GO:0007399)
  • Peptidoglycan recognition protein signaling pathway
    (GO:0061057)
  • Positive regulation of antibacterial peptide biosynthetic process
    (GO:0006963)
  • Positive regulation of antibacterial peptide production
    (GO:0002803)
  • Positive regulation of biosynthetic process of antibacterial peptides active against gram-negative bacteria
    (GO:0006964)
  • Positive regulation of defense response to virus by host
    (GO:0002230)
  • Positive regulation of innate immune response
    (GO:0045089)
  • Protein binding
    (GO:0005515)
  • Response to bacterium
    (GO:0009617)
  • Signal transduction
    (GO:0007165)

Other Information

Genular Protein ID: 2930669212

Symbol: IMD_DROME

Name: N/A

UniProtKB Accession Codes:

Q7K4Z4 Q9NHG0

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 ELM 1 EMBL 6 EnsemblMetazoa 2 FlyBase 2 GO 16 Gene3D 1 GenomeRNAi 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhylomeDB 1 Proteomes 2 Reactome 4 RefSeq 2 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 7568155

Title: A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense.

PubMed ID: 7568155

DOI: 10.1073/pnas.92.21.9465

PubMed ID: 8808632

Title: The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults.

PubMed ID: 8808632

DOI: 10.1016/s0092-8674(00)80172-5

PubMed ID: 11269502

Title: The Drosophila caspase Dredd is required to resist Gram-negative bacterial infection.

PubMed ID: 11269502

DOI: 10.1093/embo-reports/kvd073

PubMed ID: 11703941

Title: Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis.

PubMed ID: 11703941

DOI: 10.1016/s1534-5807(01)00059-4

PubMed ID: 11266367

Title: The imd gene is required for local Cecropin expression in Drosophila barrier epithelia.

PubMed ID: 11266367

DOI: 10.1093/embo-reports/kve048

PubMed ID: 12433364

Title: The Drosophila immune defense against Gram-negative infection requires the death protein dFADD.

PubMed ID: 12433364

DOI: 10.1016/s1074-7613(02)00454-5

PubMed ID: 19837371

Title: The Drosophila ubiquitin-specific protease dUSP36/Scny targets IMD to prevent constitutive immune signaling.

PubMed ID: 19837371

DOI: 10.1016/j.chom.2009.09.007

PubMed ID: 19763182

Title: A novel system for the launch of alphavirus RNA synthesis reveals a role for the Imd pathway in arthropod antiviral response.

PubMed ID: 19763182

DOI: 10.1371/journal.ppat.1000582

PubMed ID: 20122400

Title: Caspase-mediated cleavage, IAP binding, and ubiquitination: linking three mechanisms crucial for Drosophila NF-kappaB signaling.

PubMed ID: 20122400

DOI: 10.1016/j.molcel.2009.12.036

PubMed ID: 23919485

Title: fat facets induces polyubiquitination of Imd and inhibits the innate immune response in Drosophila.

PubMed ID: 23919485

DOI: 10.1111/gtc.12085

PubMed ID: 25027767

Title: Identifying USPs regulating immune signals in Drosophila: USP2 deubiquitinates Imd and promotes its degradation by interacting with the proteasome.

PubMed ID: 25027767

DOI: 10.1186/s12964-014-0041-2

Sequence Information:

  • Length: 273
  • Mass: 29899
  • Checksum: 7247CA4B46F5545B
  • Sequence:
    • MSKLRNLLPT IFGGKEAQNP TPVEGRLEKD AAPVDDNEPD NNNSGALALP STAGTPTASS 
DLTESVLREL SDPNYNSMDV VHSANIPGTL SNVQTNNTMN VHSAQQQVVM NFSNANNLHF 
GSVYNFNQNL SACSSRKGST STAEESVASP DGKPRASATR KTVSIVAMMQ SQEEPDVRLL 
DVVSTHLGEG WKQVMRDLGM SEGQIDQAII DHQMHGNIRE VIYQLLLQWI RSSADGVATV 
GRLTTLLWES QHRDCVQRMK LVWKALEKRK TNS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.