Details for: ASPH
Gene ID: 444
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: ASPH
Ensembl ID: ENSG00000198363
Description: aspartate beta-hydroxylase
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 71.67rCSI 92.03%PRS 16.81
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CSI 55.81rCSI 58.46%PRS 18.43
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CSI 55.26rCSI 84.4%PRS 17.34
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CSI 51.88rCSI 100%PRS 14.83
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CSI 46.36rCSI 74.61%PRS 13.26
-
CSI 44.54rCSI 74.77%PRS 10.16
-
CSI 37.19rCSI 83.38%PRS 10.68
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CSI 34.96rCSI 100%PRS 30.22
-
CSI 28.84rCSI 39.46%PRS 17.17
-
CSI 28.29rCSI 62.49%PRS 12.36
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CSI 25.08rCSI 44.3%PRS 10.15
-
CSI 24.45rCSI 53.55%PRS 23.1
-
CSI 24.04rCSI 57.79%PRS 25.57
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CSI 23.37rCSI 47.42%PRS 8.3
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CSI 22.9rCSI 74.52%PRS 20.89
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CSI 22.43rCSI 32.19%PRS 13.37
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CSI 21.36rCSI 51.92%PRS 9.97
-
CSI 20.56rCSI 24.55%PRS 9.95
-
CSI 19.92rCSI 68.22%PRS 14.85
-
CSI 19.85rCSI 26.38%PRS 18.88
-
CSI 19.8rCSI 47.06%PRS 25.82
-
CSI 19.57rCSI 28.21%PRS 27.36
-
CSI 17.94rCSI 42.92%PRS 10.42
-
CSI 17.3rCSI 62.24%PRS 9.53
-
CSI 17.11rCSI 27.52%PRS 11.05
-
CSI 17.09rCSI 32.07%PRS 33.74
-
CSI 15.53rCSI 48.55%PRS 10.87
-
CSI 14.42rCSI 11.18%PRS 16.49
-
CSI 13.59rCSI 24.69%PRS 26.3
-
CSI 13.57rCSI 12.05%PRS 17.31
-
CSI 13.41rCSI 25.32%PRS 21.72
-
CSI 13.29rCSI 12.55%PRS 18.04
-
CSI 12.73rCSI 19.75%PRS 25.87
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CSI 12.48rCSI 19.83%PRS 22.22
-
CSI 12.1rCSI 21.32%PRS 16.95
-
CSI 11.58rCSI 43.77%PRS 10.44
-
CSI 11.58rCSI 11.85%PRS 32.04
-
CSI 11.37rCSI 26.01%PRS 16.73
-
CSI 11.17rCSI 49.09%PRS 14.42
-
CSI 11.07rCSI 18.92%PRS 34.74
-
CSI 9.87rCSI 50.55%PRS 16.9
-
CSI 9.72rCSI 10%PRS 28.02
-
CSI 9.6rCSI 56.51%PRS 10.64
-
CSI 9.39rCSI 13.05%PRS 17.74
-
CSI 9.29rCSI 20.84%PRS 34.57
-
CSI 9.2rCSI 10.07%PRS 19.57
-
CSI 9.13rCSI 6.76%PRS 15.11
-
CSI 8.87rCSI 9.26%PRS 17.66
-
CSI 8.86rCSI 14.35%PRS 17.5
-
CSI 8.85rCSI 27.69%PRS 11.68
-
CSI 8.62rCSI 34.77%PRS 15.45
-
CSI 8.48rCSI 16.49%PRS 17.65
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CSI 8.39rCSI 9.73%PRS 25.2
-
CSI 8.35rCSI 10.5%PRS 26.53
-
CSI 8.26rCSI 12.08%PRS 18.23
-
CSI 8.25rCSI 12.75%PRS 16.16
-
CSI 7.99rCSI 46.52%PRS 25.77
-
CSI 7.98rCSI 12.16%PRS 16.02
-
CSI 7.69rCSI 10.51%PRS 19.57
-
CSI 7.64rCSI 20.86%PRS 58.59
-
CSI 7.54rCSI 7.02%PRS 17.27
-
CSI 7.53rCSI 6.49%PRS 27.22
-
CSI 7.45rCSI 16.4%PRS 19.37
-
CSI 7.34rCSI 16.03%PRS 33.88
-
CSI 7.18rCSI 52.79%PRS 9.65
-
CSI 7.12rCSI 8.85%PRS 18.27
-
CSI 7.02rCSI 20.82%PRS 24.33
-
CSI 6.99rCSI 9.34%PRS 22.7
-
CSI 6.98rCSI 10.23%PRS 19.95
-
CSI 6.83rCSI 8.51%PRS 24.45
-
CSI 6.61rCSI 9.15%PRS 24.55
-
CSI 6.46rCSI 16.82%PRS 16.96
-
CSI 6.28rCSI 18.19%PRS 13.21
-
CSI 6.25rCSI 14.67%PRS 25.08
-
CSI 6.25rCSI 18.08%PRS 19.53
-
CSI 6.17rCSI 7.92%PRS 16.75
-
CSI 6.13rCSI 12.3%PRS 12.78
-
CSI 6.06rCSI 5.96%PRS 18.75
-
CSI 6.02rCSI 22.94%PRS 16.94
-
CSI 6rCSI 13.21%PRS 12.68
-
CSI 5.99rCSI 7.68%PRS 19.91
-
CSI 5.89rCSI 11.7%PRS 18.33
-
CSI 5.89rCSI 23.32%PRS 23.3
-
CSI 5.76rCSI 7.88%PRS 19.1
-
CSI 5.66rCSI 10.29%PRS 14.27
-
CSI 5.65rCSI 12.43%PRS 26.27
-
CSI 5.56rCSI 8.2%PRS 26.99
-
CSI 5.55rCSI 27.61%PRS 18.35
-
CSI 5.5rCSI 17.6%PRS 13.14
-
CSI 5.44rCSI 21.17%PRS 23.49
-
CSI 5.37rCSI 10.06%PRS 12.39
-
CSI 5.32rCSI 5.56%PRS 18.07
-
CSI 5.27rCSI 5.08%PRS 12.32
-
CSI 5.21rCSI 19.52%PRS 14.6
-
CSI 5.18rCSI 58.32%PRS 41.41
-
CSI 5.18rCSI 13.79%PRS 14.11
-
CSI 5.09rCSI 20.35%PRS 36.62
-
CSI 5.06rCSI 10.77%PRS 27.48
-
CSI 5.01rCSI 9%PRS 14.32
-
CSI 4.99rCSI 8.17%PRS 13.27
-
CSI -4.8rCSI -14.1%PRS 15.3%
-
CSI -3.8rCSI -6.4%PRS 23.4%
-
CSI -2.6rCSI -2.3%PRS 15.5%
-
CSI -1.3rCSI -3.6%PRS 15.9%
-
CSI -0.9rCSI -0.8%PRS 12.5%
-
CSI -0.4rCSI -2.1%PRS 30.7%
-
CSI 0.2rCSI 0.2%PRS 23.8%
-
CSI 0.3rCSI 1.0%PRS 59.8%
-
CSI 0.4rCSI 0.9%PRS 30.8%
-
CSI 0.4rCSI 1.9%PRS 23.4%
-
CSI 0.4rCSI 2.7%PRS 17.5%
-
CSI 0.4rCSI 11.9%PRS 38.4%
-
CSI 0.4rCSI 0.9%PRS 16.0%
-
CSI 0.4rCSI 4.7%PRS 59.6%
-
CSI 0.4rCSI 6.8%PRS 41.8%
-
CSI 0.5rCSI 1.9%PRS 23.4%
-
CSI 0.5rCSI 4.6%PRS 68.7%
-
CSI 0.6rCSI 7.3%PRS 53.9%
-
CSI 0.6rCSI 4.4%PRS 16.4%
-
CSI 0.6rCSI 3.3%PRS 8.6%
-
CSI 0.6rCSI 8.9%PRS 49.0%
-
CSI 0.6rCSI 0.9%PRS 25.8%
-
CSI 0.6rCSI 1.0%PRS 28.0%
-
CSI 0.6rCSI 15.5%PRS 80.1%
-
CSI 0.7rCSI 1.7%PRS 17.5%
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CSI 0.7rCSI 4.9%PRS 19.1%
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CSI 0.7rCSI 1.8%PRS 27.9%
-
CSI 0.7rCSI 3.7%PRS 33.6%
-
CSI 0.8rCSI 6.6%PRS 10.1%
-
CSI 0.8rCSI 2.7%PRS 30.5%
-
CSI 0.8rCSI 4.9%PRS 44.2%
-
CSI 0.8rCSI 2.1%PRS 43.9%
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CSI 0.8rCSI 1.0%PRS 24.5%
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CSI 0.8rCSI 5.8%PRS 45.2%
-
CSI 0.8rCSI 1.0%PRS 12.7%
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CSI 0.8rCSI 2.2%PRS 20.6%
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CSI 0.8rCSI 3.2%PRS 34.3%
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CSI 0.8rCSI 5.0%PRS 28.2%
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CSI 0.9rCSI 5.2%PRS 38.1%
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CSI 0.9rCSI 2.5%PRS 23.5%
-
CSI 0.9rCSI 4.6%PRS 59.6%
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CSI 1.0rCSI 1.2%PRS 21.9%
-
CSI 1.0rCSI 4.7%PRS 17.8%
-
CSI 1.0rCSI 15.7%PRS 12.8%
-
CSI 1.0rCSI 1.6%PRS 14.6%
-
CSI 1.0rCSI 8.6%PRS 17.7%
-
CSI 1.0rCSI 1.7%PRS 20.3%
-
CSI 1.1rCSI 11.5%PRS 30.9%
-
CSI 1.1rCSI 25.3%PRS 52.8%
-
CSI 1.1rCSI 3.7%PRS 27.9%
-
CSI 1.1rCSI 1.0%PRS 19.4%
-
CSI 1.1rCSI 2.9%PRS 22.4%
-
CSI 1.1rCSI 1.8%PRS 17.3%
-
CSI 1.1rCSI 0.9%PRS 17.3%
-
CSI 1.2rCSI 29.3%PRS 49.7%
-
CSI 1.2rCSI 3.0%PRS 13.1%
-
CSI 1.2rCSI 1.7%PRS 24.2%
-
CSI 1.2rCSI 6.4%PRS 19.9%
-
CSI 1.2rCSI 1.8%PRS 23.5%
-
CSI 1.2rCSI 0.8%PRS 20.8%
-
CSI 1.3rCSI 1.9%PRS 15.9%
-
CSI 1.3rCSI 3.8%PRS 37.1%
-
CSI 1.3rCSI 3.0%PRS 17.8%
-
CSI 1.3rCSI 5.9%PRS 32.0%
-
CSI 1.3rCSI 3.5%PRS 33.4%
-
CSI 1.4rCSI 8.4%PRS 52.6%
-
CSI 1.4rCSI 1.6%PRS 17.0%
-
CSI 1.4rCSI 1.7%PRS 22.3%
-
CSI 1.4rCSI 2.2%PRS 20.5%
-
CSI 1.4rCSI 2.7%PRS 36.7%
-
CSI 1.4rCSI 2.9%PRS 38.2%
-
CSI 1.5rCSI 2.6%PRS 22.7%
-
CSI 1.5rCSI 3.0%PRS 17.2%
-
CSI 1.5rCSI 5.0%PRS 12.0%
-
CSI 1.5rCSI 7.8%PRS 29.9%
-
CSI 1.5rCSI 10.4%PRS 33.3%
-
CSI 1.5rCSI 8.5%PRS 44.9%
-
CSI 1.5rCSI 4.0%PRS 26.6%
-
CSI 1.6rCSI 7.0%PRS 16.9%
-
CSI 1.6rCSI 3.9%PRS 27.4%
-
CSI 1.6rCSI 4.7%PRS 50.6%
-
CSI 1.6rCSI 4.5%PRS 28.4%
-
CSI 1.7rCSI 4.0%PRS 21.3%
-
CSI 1.7rCSI 1.4%PRS 16.3%
-
CSI 1.7rCSI 12.8%PRS 31.4%
-
CSI 1.7rCSI 1.6%PRS 20.1%
-
CSI 1.8rCSI 7.4%PRS 42.4%
-
CSI 1.8rCSI 4.3%PRS 45.9%
-
CSI 1.8rCSI 1.9%PRS 16.1%
-
CSI 1.8rCSI 2.2%PRS 21.7%
-
CSI 1.9rCSI 3.4%PRS 16.0%
-
CSI 1.9rCSI 6.1%PRS 25.0%
-
CSI 1.9rCSI 5.5%PRS 26.7%
-
CSI 2.0rCSI 2.8%PRS 16.0%
-
CSI 2.0rCSI 6.5%PRS 10.0%
-
CSI 2.0rCSI 12.7%PRS 25.7%
-
CSI 2.0rCSI 1.5%PRS 18.2%
-
CSI 2.0rCSI 9.0%PRS 9.4%
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CSI 2.1rCSI 17.8%PRS 7.6%
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CSI 2.1rCSI 16.2%PRS 17.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 391388776
Symbol: ASPH_HUMAN
Name: Aspartyl/asparaginyl beta-hydroxylase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7821814
Title: Cloning and characterization of the human gene encoding aspartyl beta-hydroxylase.
PubMed ID: 7821814
PubMed ID: 8823296
Title: Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinoma.
PubMed ID: 8823296
DOI: 10.1172/jci118918
PubMed ID: 10974562
Title: cDNA cloning and characterization of human cardiac junctin.
PubMed ID: 10974562
PubMed ID: 10956665
Title: Aspartyl beta -hydroxylase (Asph) and an evolutionarily conserved isoform of Asph missing the catalytic domain share exons with junctin.
PubMed ID: 10956665
PubMed ID: 11007777
Title: Molecular cloning, expression, functional characterization, chromosomal localization, and gene structure of junctate, a novel integral calcium binding protein of sarco(endo)plasmic reticulum membrane.
PubMed ID: 11007777
PubMed ID: 10767180
Title: Molecular cloning of junctin from human and developing rabbit heart.
PubMed ID: 10767180
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22586105
Title: Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1).
PubMed ID: 22586105
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 15485681
Title: Calsequestrin mutant D307H exhibits depressed binding to its protein targets and a depressed response to calcium.
PubMed ID: 15485681
PubMed ID: 11773073
Title: Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia.
PubMed ID: 11773073
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24768550
Title: Mutations in ASPH cause facial dysmorphism, lens dislocation, anterior-segment abnormalities, and spontaneous filtering blebs, or Traboulsi syndrome.
PubMed ID: 24768550
Sequence Information:
- Length: 758
- Mass: 85863
- Checksum: 4AE56D1D8DF0AF0C
- Sequence:
MAQRKNAKSS GNSSSSGSGS GSTSAGSSSP GARRETKHGG HKNGRKGGLS GTSFFTWFMV IALLGVWTSV AVVWFDLVDY EEVLGKLGIY DADGDGDFDV DDAKVLLGLK ERSTSEPAVP PEEAEPHTEP EEQVPVEAEP QNIEDEAKEQ IQSLLHEMVH AEHVEGEDLQ QEDGPTGEPQ QEDDEFLMAT DVDDRFETLE PEVSHEETEH SYHVEETVSQ DCNQDMEEMM SEQENPDSSE PVVEDERLHH DTDDVTYQVY EEQAVYEPLE NEGIEITEVT APPEDNPVED SQVIVEEVSI FPVEEQQEVP PETNRKTDDP EQKAKVKKKK PKLLNKFDKT IKAELDAAEK LRKRGKIEEA VNAFKELVRK YPQSPRARYG KAQCEDDLAE KRRSNEVLRG AIETYQEVAS LPDVPADLLK LSLKRRSDRQ QFLGHMRGSL LTLQRLVQLF PNDTSLKNDL GVGYLLIGDN DNAKKVYEEV LSVTPNDGFA KVHYGFILKA QNKIAESIPY LKEGIESGDP GTDDGRFYFH LGDAMQRVGN KEAYKWYELG HKRGHFASVW QRSLYNVNGL KAQPWWTPKE TGYTELVKSL ERNWKLIRDE GLAVMDKAKG LFLPEDENLR EKGDWSQFTL WQQGRRNENA CKGAPKTCTL LEKFPETTGC RRGQIKYSIM HPGTHVWPHT GPTNCRLRMH LGLVIPKEGC KIRCANETKT WEEGKVLIFD DSFEHEVWQD ASSFRLIFIV DVWHPELTPQ QRRSLPAI
Genular Protein ID: 3000180067
Symbol: B7ZM96_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 279
- Mass: 31518
- Checksum: 966814F02AAE2186
- Sequence:
MAEDKETKHG GHKNGRKGGL SGTSFFTWFM VIALLGVWTS VAVVWFDLVD YEEVLAKAKD FRYNLSEVLQ GKLGIYDADG DGDFDVDDAK VLLGLKERST SEPAVPPEEA EPHTEPEEQV PVEAEPQNIE DEAKEQIQSL LHEMVHAEHV EGEDLQQEDG PTGEPQQEDD EFLMATDVDD RFETLEPEVS HEETEHSYHV EETDSSEPVV EDERLHHDTD DVTYQVYEEQ VYEPLENEGI EITEVTAPPE DNPVEDSQVI VEEVSIFPVE EQQEVPPDT
Genular Protein ID: 3380169666
Symbol: B4DQ07_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 285
- Mass: 31759
- Checksum: 740E04134899A7B2
- Sequence:
MAQRKNAKSS GNSSSSSSSS PGARRETKHG GHENGRKGGL SGTSFFTWFM VIALLGVWTS VAVVWFDLVD YEEVLGKLGI YDADGDGDFD VDDAKVLLGL KERSTSEPAV PPEEAEPHTE PEEQVPVEAE PQNIEDEAKE QIQSLLHEMV HAEHVEGEDL QQEDGPTGEP QQEDDEFLMA TDVDDRFETL EPEVSHEETE HSYHVEETDS SEPVVEDERL HHDTDDVTYQ VYEEQAVYEP LENEGIEITE VTAPPEDNPV EDSQVIVEEV SIFPVEEQQE VPPDT