IKKbeta | FBgn0024222 | NCBI 44432

Details for: IKKbeta

Gene ID: 44432

Symbol: IKKbeta

Ensembl ID: FBgn0024222

Description: I-kappaB kinase beta

Associated with

Antibacterial humoral response
(GO:0019731)
Atp binding
(GO:0005524)
Cellular response to hypoxia
(GO:0071456)
Cgas/sting signaling pathway
(GO:0140896)
Cytoplasm
(GO:0005737)
Defense response to virus
(GO:0051607)
Ikappab kinase activity
(GO:0008384)
Ikappab kinase complex
(GO:0008385)
Peptidoglycan recognition protein signaling pathway
(GO:0061057)
Peptidyl-serine phosphorylation
(GO:0018105)
Positive regulation of antibacterial peptide biosynthetic process
(GO:0006963)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of defense response to virus by host
(GO:0002230)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein catabolic process
(GO:0030163)
Protein kinase activity
(GO:0004672)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of innate immune response
(GO:0045088)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)

Other Information

Proteins

IKKB_DROME

Genular Protein ID: 4159383480

Symbol: IKKB_DROME

Name: N/A

UniProtKB Accession Codes:

Q9VEZ5 Q9GYV6 Q9NJI1 Q9U698 Q9U7F5

Database IDs:

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 10636911

Title: Lipopolysaccharide-activated kinase, an essential component for the induction of the antimicrobial peptide genes in Drosophila melanogaster cells.

PubMed ID: 10636911

DOI: 10.1074/jbc.275.3.2071

PubMed ID: 11018014

Title: A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity.

PubMed ID: 11018014

DOI: 10.1101/gad.817800

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 11156609

Title: The antibacterial arm of the Drosophila innate immune response requires an IkappaB kinase.

PubMed ID: 11156609

DOI: 10.1101/gad.856901

PubMed ID: 18327897

Title: Phosphoproteome analysis of Drosophila melanogaster embryos.

PubMed ID: 18327897

DOI: 10.1021/pr700696a

PubMed ID: 30119996

Title: The kinase IKKbeta regulates a STING- and NF-kappaB-dependent antiviral response pathway in Drosophila.

PubMed ID: 30119996

DOI: 10.1016/j.immuni.2018.07.013

Sequence Information:

Length: 751
Mass: 86373
Checksum: 0BD2452BED2F8E78
Sequence:

MITVVFCFSD CHGGIQILGR MSSVNKIKLN ENNKMHSFGN WERCRNLGEG GFGLVIHWRN 
RTTGREIATK HIKEMGALSA DQQVKLSERW NKELNWSRQF KNFPHIVAGV DIEDPDFLEY 
LNGMFSAKLP VIVLEYCNGG DVRKRLQSPE NANGLTEFEV RQILGALRKA LHFLHSQCGI 
CHRDLKPDNI VIQRGVDGKK IYKLTDFGLA RGTPDQTMVQ SVVGTRHYYA PEVVENGFYN 
STVDLWSFGV IAYELVTGEL PFIPHQTLKN IILNLIKKPA KCIAITEDPE DNTRFVNQFE 
LPQTHHLSRP WAAQFTKWLA SPLNSNYKER GQLAANNVPV VFADLDKILN MNVLTIFAVN 
NCERLEYAVS AEMTMKDLIA LIVLDTGMDE KELYFVLPTS HPHKTITPKS TPLQLYVEEW 
SDTSKDSRKW TKRSNPPVML YIFQVKKECD YKIPEPILSI LSRKFIANKF KTKERWLQKR 
VVLDMLYVLT KEQARYEMLV SGINERALSL EDEMMENSFI DSIDKQRIII SFAYDQLTSL 
LKEAQAKIPS RQLISSAQWE KLNRNYNFII QSAKSIRSFL EACLREAKDM VKTTNQLRKE 
VCEKDLFDCA RFYKKYLCNG AIISPSELNN DAEEFAKSRF KLYNEGEARH LPKSIDHMHY 
LYFKTKESIP VLLQQFCDIK KEIFQINLQM LMSASSTPPP KLELSAAMDR LAISSGSPSS 
DPFDSLRTIN AIEEAERINN ILVNEMKIDH Y

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: IKKbeta

Associated with

Other Information

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

Lipopolysaccharide-activated kinase, an essential component for the induction of the antimicrobial peptide genes in Drosophila melanogaster cells. PubMed ID: 10636911

A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity. PubMed ID: 11018014

A Drosophila full-length cDNA resource. PubMed ID: 12537569

The antibacterial arm of the Drosophila innate immune response requires an IkappaB kinase. PubMed ID: 11156609

Phosphoproteome analysis of Drosophila melanogaster embryos. PubMed ID: 18327897

The kinase IKKbeta regulates a STING- and NF-kappaB-dependent antiviral response pathway in Drosophila. PubMed ID: 30119996