Details for: ASS1P2

Gene ID: 447

Symbol: ASS1P2

Ensembl ID: ENSG00000223922

Description: argininosuccinate synthetase 1 pseudogene 2

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 0.2974
    Cell Significance Index: 2.4600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.2563
    Cell Significance Index: 3.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0521
    Cell Significance Index: 8.9000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0443
    Cell Significance Index: 0.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0411
    Cell Significance Index: 1.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0364
    Cell Significance Index: 4.1700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0097
    Cell Significance Index: 0.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0064
    Cell Significance Index: 0.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0017
    Cell Significance Index: -0.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0038
    Cell Significance Index: -2.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0072
    Cell Significance Index: -0.3700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0203
    Cell Significance Index: -0.2100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0260
    Cell Significance Index: -0.3600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0265
    Cell Significance Index: -0.4200
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.0533
    Cell Significance Index: -0.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0628
    Cell Significance Index: -3.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0643
    Cell Significance Index: -3.0000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0753
    Cell Significance Index: -0.8200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0890
    Cell Significance Index: -1.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0930
    Cell Significance Index: -2.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0956
    Cell Significance Index: -1.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1004
    Cell Significance Index: -2.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1033
    Cell Significance Index: -3.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1042
    Cell Significance Index: -3.0700
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1132
    Cell Significance Index: -1.0200
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1222
    Cell Significance Index: -1.2300
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.1275
    Cell Significance Index: -1.2100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1305
    Cell Significance Index: -3.2600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1339
    Cell Significance Index: -1.4500
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.1415
    Cell Significance Index: -1.4000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1443
    Cell Significance Index: -2.1300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1445
    Cell Significance Index: -1.7600
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1617
    Cell Significance Index: -1.9500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1675
    Cell Significance Index: -1.9000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1706
    Cell Significance Index: -1.8000
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1717
    Cell Significance Index: -1.8800
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1743
    Cell Significance Index: -2.3700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1748
    Cell Significance Index: -2.0800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1779
    Cell Significance Index: -2.4600
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1816
    Cell Significance Index: -1.7300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1816
    Cell Significance Index: -2.0900
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1822
    Cell Significance Index: -1.8900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1839
    Cell Significance Index: -2.3200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1894
    Cell Significance Index: -2.2000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1912
    Cell Significance Index: -2.2500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1925
    Cell Significance Index: -3.2900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1961
    Cell Significance Index: -2.5700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1962
    Cell Significance Index: -2.2800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1997
    Cell Significance Index: -2.3600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2009
    Cell Significance Index: -3.0100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.2047
    Cell Significance Index: -2.0800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.2173
    Cell Significance Index: -2.0400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2222
    Cell Significance Index: -3.8300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2312
    Cell Significance Index: -2.9700
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.2388
    Cell Significance Index: -2.3100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2393
    Cell Significance Index: -3.1800
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.2513
    Cell Significance Index: -2.3400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2538
    Cell Significance Index: -3.1200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2574
    Cell Significance Index: -3.1200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.2574
    Cell Significance Index: -2.7100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2579
    Cell Significance Index: -4.3800
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2598
    Cell Significance Index: -2.8300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2601
    Cell Significance Index: -3.1100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2603
    Cell Significance Index: -2.6600
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2608
    Cell Significance Index: -3.1000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2623
    Cell Significance Index: -2.9300
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2625
    Cell Significance Index: -2.7400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2657
    Cell Significance Index: -2.5900
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.2659
    Cell Significance Index: -3.3300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2664
    Cell Significance Index: -2.7200
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.2721
    Cell Significance Index: -2.9500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.2766
    Cell Significance Index: -3.5000
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.2780
    Cell Significance Index: -2.9300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2789
    Cell Significance Index: -3.8300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.2801
    Cell Significance Index: -2.9800
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.2801
    Cell Significance Index: -2.9800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2810
    Cell Significance Index: -3.3700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.2831
    Cell Significance Index: -2.8600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2833
    Cell Significance Index: -2.6500
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.2842
    Cell Significance Index: -3.0800
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2842
    Cell Significance Index: -2.4000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2844
    Cell Significance Index: -3.3900
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.2872
    Cell Significance Index: -3.0100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2917
    Cell Significance Index: -3.4300
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.2934
    Cell Significance Index: -3.3400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2939
    Cell Significance Index: -3.4700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2968
    Cell Significance Index: -3.3500
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.2994
    Cell Significance Index: -3.7600
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.3003
    Cell Significance Index: -3.4100
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.3044
    Cell Significance Index: -3.8200
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.3049
    Cell Significance Index: -3.3400
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.3057
    Cell Significance Index: -3.9200
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.3108
    Cell Significance Index: -3.4500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.3121
    Cell Significance Index: -3.0000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.3128
    Cell Significance Index: -3.5800
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.3139
    Cell Significance Index: -3.6400
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.3221
    Cell Significance Index: -3.9200
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.3246
    Cell Significance Index: -3.6100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.3252
    Cell Significance Index: -4.0600
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.3268
    Cell Significance Index: -3.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ASS1P2 is a pseudogene, meaning it is a non-functional copy of the argininosuccinate synthetase 1 (ASS1) gene. Although it does not produce a protein, ASS1P2 is still transcribed and translated into a short protein product, which may play a role in regulating gene expression or interacting with other proteins. Notably, ASS1P2 is specifically expressed in certain cell types, including astrocytes, monocytes, B cells, and retinal cells, suggesting a unique role in these cells. **Pathways and Functions:** The exact mechanisms by which ASS1P2 influences cellular function are not yet fully understood. However, several pathways are proposed to be involved: 1. **Immune regulation:** ASS1P2 may play a role in modulating the immune response, particularly in the context of autoimmune diseases or inflammation. Its expression in monocytes and B cells suggests a potential involvement in immune cell function. 2. **Neurotransmission:** ASS1P2 is expressed in retinal cells, which are involved in neurotransmission. This suggests a possible role in the regulation of neurotransmitter synthesis or release. 3. **Cellular stress response:** ASS1P2 may be involved in the cellular response to stress, particularly in the context of oxidative stress or endoplasmic reticulum stress. **Clinical Significance:** Despite its pseudogene status, ASS1P2 has potential clinical implications: 1. **Autoimmune diseases:** Dysregulation of ASS1P2 expression may contribute to autoimmune diseases, such as multiple sclerosis or rheumatoid arthritis. 2. **Neurological disorders:** ASS1P2's involvement in neurotransmission and cellular stress response may be relevant to neurological disorders, such as Alzheimer's disease or Parkinson's disease. 3. **Cancer:** ASS1P2's expression in certain cell types, including astrocytes and retinal cells, may be associated with cancer development or progression. In conclusion, ASS1P2 is a pseudogene with a complex role in immune regulation, neurotransmission, and cellular stress response. Further research is needed to fully understand its functions and clinical significance, but its expression in various cell types suggests a potential involvement in human disease. As an immunologist, I believe that ASS1P2 is an intriguing gene that warrants further investigation.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.