Details for: ASS1P4

Gene ID: 449

Symbol: ASS1P4

Ensembl ID: ENSG00000213487

Description: argininosuccinate synthetase 1 pseudogene 4

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0372
    Cell Significance Index: -0.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** ASS1P4 is a non-functional pseudogene, meaning it lacks the coding potential to produce a protein. Despite this, it is significantly expressed in various cell types, indicating its regulatory role. 2. **Cell type specificity:** ASS1P4 is predominantly expressed in epithelial, plasma, and endothelial cells, as well as in cells of the vascular tree and mammary gland. 3. **Tissue specificity:** The expression patterns of ASS1P4 are tissue-specific, with higher levels detected in epithelial and endothelial cells, which are key components of the immune system. 4. **Evolutionary conservation:** ASS1P4 is conserved across species, suggesting its importance in maintaining cellular homeostasis and immune function. **Pathways and Functions:** The exact mechanisms by which ASS1P4 regulates immune responses are not fully understood. However, its expression in endothelial and epithelial cells suggests a role in: 1. **Angiogenesis:** ASS1P4 may influence the formation of new blood vessels, a critical process in tissue repair and inflammation. 2. **Inflammation:** The pseudogene's expression in epithelial cells may modulate the inflammatory response, potentially by regulating the production of pro-inflammatory cytokines. 3. **Cell signaling:** ASS1P4 may interact with other signaling pathways, such as the PI3K/AKT pathway, to regulate cellular responses to immune stimuli. **Clinical Significance:** While ASS1P4 is a pseudogene, its expression patterns and potential regulatory functions have significant implications for our understanding of immune-related diseases: 1. **Inflammation and tissue repair:** Dysregulation of ASS1P4 expression may contribute to chronic inflammation and tissue damage in conditions such as arthritis, asthma, and cardiovascular disease. 2. **Cancer:** The pseudogene's expression in epithelial cells may influence tumor development and progression, particularly in the context of angiogenesis and inflammation. 3. **Immunotherapy:** ASS1P4's role in regulating immune responses may provide new targets for immunotherapeutic interventions, such as checkpoint inhibitors and adoptive T-cell therapy. In conclusion, the argininosuccinate synthetase 1 pseudogene 4 (ASS1P4) gene is a fascinating component of the human genome, with significant implications for our understanding of immune cell regulation and disease. Further research is needed to elucidate the mechanisms by which ASS1P4 regulates immune responses and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.