Details for: ASS1P5

Gene ID: 450

Symbol: ASS1P5

Ensembl ID: ENSG00000227881

Description: argininosuccinate synthetase 1 pseudogene 5

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.2560
    Cell Significance Index: 2.7000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0368
    Cell Significance Index: 0.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0226
    Cell Significance Index: 1.1700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0031
    Cell Significance Index: 0.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0027
    Cell Significance Index: -0.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0028
    Cell Significance Index: -5.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0039
    Cell Significance Index: -0.7800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0354
    Cell Significance Index: -0.5200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0365
    Cell Significance Index: -0.7400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0373
    Cell Significance Index: -0.7400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0381
    Cell Significance Index: -0.7600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0397
    Cell Significance Index: -0.8400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0404
    Cell Significance Index: -0.8000
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0553
    Cell Significance Index: -0.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0576
    Cell Significance Index: -2.6900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0777
    Cell Significance Index: -0.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1278
    Cell Significance Index: -4.4900
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1300
    Cell Significance Index: -1.5100
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.1316
    Cell Significance Index: -1.2600
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1662
    Cell Significance Index: -2.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1682
    Cell Significance Index: -2.3000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1690
    Cell Significance Index: -1.9200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1790
    Cell Significance Index: -2.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1859
    Cell Significance Index: -5.0600
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1881
    Cell Significance Index: -1.8200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1915
    Cell Significance Index: -2.6300
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1940
    Cell Significance Index: -1.7600
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.2009
    Cell Significance Index: -2.7300
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.2067
    Cell Significance Index: -1.7100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2102
    Cell Significance Index: -2.5000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2243
    Cell Significance Index: -2.6900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2271
    Cell Significance Index: -1.3500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.2444
    Cell Significance Index: -3.3800
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.2478
    Cell Significance Index: -2.6900
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.2558
    Cell Significance Index: -2.8100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2678
    Cell Significance Index: -2.7400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2726
    Cell Significance Index: -3.8800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.2729
    Cell Significance Index: -3.5600
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.2998
    Cell Significance Index: -3.1600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.3110
    Cell Significance Index: -2.9200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.3206
    Cell Significance Index: -3.3500
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.3308
    Cell Significance Index: -3.2600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.3445
    Cell Significance Index: -4.1000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3732
    Cell Significance Index: -4.7100
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.3817
    Cell Significance Index: -3.6200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3851
    Cell Significance Index: -4.2000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.4034
    Cell Significance Index: -3.5500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4337
    Cell Significance Index: -5.1700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.4376
    Cell Significance Index: -5.3100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.4488
    Cell Significance Index: -4.8900
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.4494
    Cell Significance Index: -4.7100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.4509
    Cell Significance Index: -5.1600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.4813
    Cell Significance Index: -5.1600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.5182
    Cell Significance Index: -5.2900
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.5339
    Cell Significance Index: -4.9600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5454
    Cell Significance Index: -5.1700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.5495
    Cell Significance Index: -3.5800
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.6811
    Cell Significance Index: -4.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ASS1P5 is a pseudogene, a non-functional copy of a gene that has evolved to be non-coding. Despite its pseudogenic status, ASS1P5 exhibits significant expression in multiple cell types, including corneal epithelial cells, adventitial cells, pericytes, capillary endothelial cells, endothelial cells, epithelial cells, fibroblasts, mesenchymal stem cells, type II pneumocytes, and keratinocytes. This widespread expression suggests that ASS1P5 may play a role in regulating cellular processes, albeit indirectly. **Pathways and Functions:** The pathways through which ASS1P5 influences cellular processes are not yet fully understood. However, its expression in various cell types implies that ASS1P5 may be involved in regulating cell growth, differentiation, and survival. One potential pathway involves the regulation of arginine metabolism, as ASS1P5 is a pseudogene of argininosuccinate synthetase 1 (ASS1), an enzyme involved in the urea cycle. The urea cycle is critical for the removal of ammonia, a toxic byproduct of protein catabolism, and its dysregulation has been implicated in various diseases, including neurodegenerative disorders and cancer. Furthermore, ASS1P5 may interact with other signaling pathways, such as the PI3K/AKT pathway, which regulates cell survival and proliferation. The expression of ASS1P5 in mesenchymal stem cells and fibroblasts suggests that it may play a role in regulating the differentiation and function of these cells, which are critical in tissue repair and regeneration. **Clinical Significance:** While the clinical significance of ASS1P5 is still unclear, its expression in various cell types and potential involvement in regulating cellular processes make it an intriguing candidate for further study. For example, dysregulation of ASS1P5 may contribute to the development of diseases characterized by impaired cell growth and differentiation, such as cancer. Moreover, ASS1P5's expression in corneal epithelial cells and endothelial cells suggests that it may play a role in maintaining corneal health and function. The development of ASS1P5-targeted therapies could potentially be used to treat corneal disorders, such as corneal ulcers and dry eye syndrome. In conclusion, the study of ASS1P5 offers a fascinating glimpse into the complex world of pseudogenes and their potential immunological significance. Further research is necessary to fully understand the pathways and functions of ASS1P5 and its clinical implications, but the current evidence suggests that this enigmatic gene is worthy of further investigation. **Recommendations for Future Research:** 1. Investigate the molecular mechanisms by which ASS1P5 regulates cellular processes, including its potential interaction with other signaling pathways. 2. Examine the clinical significance of ASS1P5 in various diseases, including cancer, neurodegenerative disorders, and corneal disorders. 3. Utilize ASS1P5 as a model to study the role of pseudogenes in regulating cellular processes and their potential implications for human disease. By exploring the complexities of ASS1P5, we may uncover new insights into the intricate mechanisms that govern cellular function and disease, ultimately shedding light on the dark recesses of the human genome.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.