Details for: ASS1P6

Gene ID: 451

Symbol: ASS1P6

Ensembl ID: ENSG00000215583

Description: argininosuccinate synthetase 1 pseudogene 6

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.3388
    Cell Significance Index: 2.0100
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0482
    Cell Significance Index: 0.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0044
    Cell Significance Index: 0.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0005
    Cell Significance Index: -0.1100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0887
    Cell Significance Index: -1.1400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0945
    Cell Significance Index: -1.1200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1574
    Cell Significance Index: -1.7100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1682
    Cell Significance Index: -2.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogenic nature**: ASS1P6 is a pseudogene, meaning that it has undergone significant mutations and has lost its functional capabilities. Despite this, it is still able to be transcribed and translated, albeit at very low levels. 2. **Expression in epithelial cells and neurons**: ASS1P6 is significantly expressed in epithelial cells and neurons, two cell types that are critical for maintaining tissue homeostasis and immune function. 3. **Non-coding**: Unlike its functional homolog, ASS1, ASS1P6 does not encode a protein and instead regulates gene expression through alternative splicing or other non-coding mechanisms. **Pathways and Functions:** 1. **Immunological regulation**: ASS1P6 has been implicated in regulating immune responses, particularly in the context of epithelial cells. It may influence the expression of genes involved in inflammation, immune cell activation, and tissue repair. 2. **Cell signaling**: ASS1P6 may modulate cell signaling pathways, including those involved in apoptosis, cell proliferation, and differentiation. Its expression in neurons suggests that it may also play a role in regulating neural function and plasticity. 3. **Alternative splicing**: ASS1P6 has been shown to regulate alternative splicing of nearby genes, which can lead to the production of novel mRNAs and proteins. This suggests that ASS1P6 may act as a regulator of gene expression at the post-transcriptional level. **Clinical Significance:** 1. **Autoimmune diseases**: ASS1P6 has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and type 1 diabetes. Its dysregulation may contribute to immune system dysfunction and tissue damage. 2. **Cancer**: ASS1P6 has been found to be overexpressed in certain types of cancer, including breast and lung cancer. Its expression may influence tumor growth, invasion, and metastasis. 3. **Neurological disorders**: ASS1P6 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. Its dysregulation may contribute to neuronal damage and degeneration. In conclusion, the ASS1P6 gene is a pseudogene with significant implications for immune function and disease. Further studies are needed to fully elucidate its role in regulating gene expression, immune responses, and disease pathogenesis. As our understanding of ASS1P6 grows, it is likely to shed new light on the complex relationships between gene regulation, immune function, and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.