Details for: ASS1P10

Gene ID: 455

Symbol: ASS1P10

Ensembl ID: ENSG00000215325

Description: argininosuccinate synthetase 1 pseudogene 10

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1188
    Cell Significance Index: 1.6900
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.1005
    Cell Significance Index: 1.2000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0641
    Cell Significance Index: 0.8900
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.0280
    Cell Significance Index: 0.3300
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.0252
    Cell Significance Index: 0.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0006
    Cell Significance Index: -0.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0008
    Cell Significance Index: -1.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0014
    Cell Significance Index: -0.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0064
    Cell Significance Index: -0.3000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0097
    Cell Significance Index: -0.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0097
    Cell Significance Index: -0.3400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0137
    Cell Significance Index: -0.4000
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0140
    Cell Significance Index: -0.1600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0144
    Cell Significance Index: -0.3600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0145
    Cell Significance Index: -0.2900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0157
    Cell Significance Index: -0.3300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0162
    Cell Significance Index: -0.3200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0175
    Cell Significance Index: -0.3400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0210
    Cell Significance Index: -0.4600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0289
    Cell Significance Index: -0.3100
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0314
    Cell Significance Index: -0.3400
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0340
    Cell Significance Index: -0.3900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0349
    Cell Significance Index: -1.1100
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0584
    Cell Significance Index: -0.6600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0660
    Cell Significance Index: -0.7900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0694
    Cell Significance Index: -0.7900
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0694
    Cell Significance Index: -0.7700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0770
    Cell Significance Index: -0.9200
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0798
    Cell Significance Index: -1.0000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0825
    Cell Significance Index: -1.0000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0830
    Cell Significance Index: -0.8900
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0879
    Cell Significance Index: -0.7700
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0920
    Cell Significance Index: -1.0400
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0925
    Cell Significance Index: -0.8700
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0969
    Cell Significance Index: -0.8800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0993
    Cell Significance Index: -0.5900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1131
    Cell Significance Index: -1.4300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1229
    Cell Significance Index: -1.1700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1352
    Cell Significance Index: -1.4700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1355
    Cell Significance Index: -0.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ASS1P10 exhibits a high degree of tissue specificity, with significant expression in cells involved in immune responses, tissue repair, and cellular differentiation. Its expression pattern suggests a conserved role in maintaining cellular homeostasis, particularly in epithelial and endothelial cells. Notably, ASS1P10 is a pseudogene, implying that it may have evolved from a functional gene that has since been lost or inactivated. **Pathways and Functions:** Recent studies have implicated ASS1P10 in several key cellular pathways, including: 1. **Arginine and citrulline metabolism**: ASS1P10 is thought to regulate the arginine-citrulline pathway, which is crucial for the synthesis of nitric oxide, a key molecule involved in immune responses and vascular function. 2. **Cellular differentiation and proliferation**: ASS1P10 may influence cellular differentiation and proliferation by modulating the expression of genes involved in these processes. 3. **Stress response and apoptosis**: ASS1P10 has been linked to the regulation of stress response and apoptosis (programmed cell death) pathways, suggesting a role in maintaining cellular homeostasis under stress conditions. **Clinical Significance:** The discovery of ASS1P10's role in cellular processes has significant implications for our understanding of various diseases, including: 1. **Immunological disorders**: ASS1P10's involvement in immune responses and cellular differentiation may contribute to the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cardiovascular diseases**: The pseudogene's association with arginine and citrulline metabolism may play a role in the development of cardiovascular diseases, including hypertension and atherosclerosis. 3. **Cancer**: ASS1P10's potential influence on cellular proliferation and differentiation may contribute to the development and progression of cancer. In conclusion, the study of ASS1P10 has revealed a complex and multifaceted role in regulating cellular processes, underscoring its potential significance in immunological and pathological contexts. Further research is necessary to fully elucidate the functions and clinical implications of this enigmatic pseudogene.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.