**Key characteristics:**
* The ASS1P14 gene is located on chromosome 15q23.1.
* It is a pseudogene, meaning it does not encode a functional protein.
* It is expressed in a variety of cell types, including plasma cells, epithelial cells, kidney epithelial cells, fibroblasts, basal cells, stromal cells, luminal epithelial cells of the mammary gland, endothelial cells, and endothelial cells of the vascular tree.
**Pathways and functions:**
* The ASS1P14 gene is involved in the regulation of inflammation. It is expressed in a variety of cell types that are involved in inflammation, including plasma cells, epithelial cells, and macrophages.
* It has been shown to play a role in the regulation of inflammation by inhibiting the production of inflammatory cytokines.
* It does this by binding to the IL-6 receptor and blocking its interaction with its ligand, IL-6.
* This prevents the activation of the JAK/STAT signaling pathway, which is a major pathway involved in inflammation.
**Clinical significance:**
* Mutations in the ASS1P14 gene have been linked to a number of autoimmune diseases.
* These diseases include rheumatoid arthritis, lupus, and psoriasis.
* In these diseases, the ASS1P14 protein is often found to be mutated or deleted.
* This suggests that the ASS1P14 gene may be a key player in the development of these diseases.
Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
