Details for: ASS1P14

Gene ID: 459

Symbol: ASS1P14

Ensembl ID: ENSG00000257316

Description: argininosuccinate synthetase 1 pseudogene 14

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.0015
    Cell Significance Index: 0.0100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0025
    Cell Significance Index: -0.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ASS1P14 is a pseudogene, meaning that it lacks a functional open reading frame (ORF) and does not produce a protein. However, its expression is widespread, suggesting that it may be involved in regulatory or non-coding functions. The pseudogene is located on chromosome 14q32.1 and is closely related to the functional argininosuccinate synthetase 1 (ASS1) gene. Notably, ASS1P14 is not detectable in all cell types, with a significant absence in hematopoietic cells, which may indicate its pseudogenic nature. **Pathways and Functions:** The functional pathways and mechanisms underlying ASS1P14's expression and potential functions are not well understood. However, several possibilities can be hypothesized based on the gene's location and expression profile: 1. **Regulation of arginine metabolism:** ASS1P14's proximity to the functional ASS1 gene suggests that it may regulate or modulate arginine metabolism, which is crucial for various cellular processes, including protein synthesis, nitric oxide production, and immune response. 2. **Non-coding RNA functions:** Pseudogenes like ASS1P14 can act as non-coding RNAs, influencing gene expression through various mechanisms, such as microRNA binding sites, enhancer regions, or chromatin remodeling. 3. **Epigenetic regulation:** ASS1P14's expression in stem cells and endothelial cells may indicate its involvement in epigenetic regulation, influencing cellular differentiation, proliferation, or survival. **Clinical Significance:** The clinical significance of ASS1P14 remains unclear, but its widespread expression in human tissues suggests that it may be involved in various diseases or conditions. Potential associations include: 1. **Cancer:** ASS1P14's expression in epithelial cells and endothelial cells may indicate its involvement in tumor development or progression. 2. **Immunological disorders:** The pseudogene's expression in plasma cells and endothelial cells may suggest its role in immune system dysregulation or vascular inflammation. 3. **Stem cell biology:** ASS1P14's expression in mesenchymal stem cells may indicate its involvement in stem cell differentiation, proliferation, or maintenance. In conclusion, ASS1P14 is a pseudogene with a complex expression profile, suggesting that it may have non-coding functions or regulate arginine metabolism. Further research is needed to elucidate the mechanisms underlying ASS1P14's expression and potential clinical significance.

Database document:

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