Gene ZFHX3 - ENSG00000140836 | NCBI Gene ID: 463

Details for: ZFHX3

Gene ID: 463

Symbol: ZFHX3

Ensembl ID: ENSG00000140836

Description: zinc finger homeobox 3

Associated with

Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Rna polymerase ii transcription
(R-HSA-73857)
Runx3 regulates cdkn1a transcription
(R-HSA-8941855)
Transcriptional regulation by runx3
(R-HSA-8878159)
Chromatin
(GO:0000785)
Circadian regulation of gene expression
(GO:0032922)
Cytoplasm
(GO:0005737)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Enzyme binding
(GO:0019899)
Muscle organ development
(GO:0007517)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of locomotor rhythm
(GO:1904059)
Regulation of neuron differentiation
(GO:0045664)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to transforming growth factor beta
(GO:0071559)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Transcription regulator complex
(GO:0005667)
Zinc ion binding
(GO:0008270)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: chromaffin cell (CL0000166)
Fold Change: 8
Marker Score: 11262
Cell Name: taste receptor cell (CL0000209)
Fold Change: 5.12
Marker Score: 4427
Cell Name: contractile cell (CL0000183)
Fold Change: 4.67
Marker Score: 2529
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 4.6
Marker Score: 3027
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 4.5
Marker Score: 11256
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 4.16
Marker Score: 3968
Cell Name: acinar cell (CL0000622)
Fold Change: 3.87
Marker Score: 2727
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 3.78
Marker Score: 8303
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 3.76
Marker Score: 15680.5
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 3.4
Marker Score: 3915
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 3.38
Marker Score: 1681
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 3.15
Marker Score: 55946
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 3.13
Marker Score: 1825
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 3.1
Marker Score: 1726
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 3.07
Marker Score: 2518
Cell Name: anterior lens cell (CL0002223)
Fold Change: 3
Marker Score: 4037
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 2.99
Marker Score: 2076
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 2.97
Marker Score: 3589
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.96
Marker Score: 12408.5
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.96
Marker Score: 3163
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.83
Marker Score: 2509
Cell Name: cardiac neuron (CL0010022)
Fold Change: 2.8
Marker Score: 3485
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.78
Marker Score: 59362
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.73
Marker Score: 861
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.72
Marker Score: 796
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 2.68
Marker Score: 1031
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 2.5
Marker Score: 3122.5
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 2.43
Marker Score: 1017
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 2.33
Marker Score: 5734.5
Cell Name: hepatoblast (CL0005026)
Fold Change: 2.18
Marker Score: 7135
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 2.14
Marker Score: 1520
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 2.1
Marker Score: 768
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 2.07
Marker Score: 1082.5
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.07
Marker Score: 70443
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 2.05
Marker Score: 3936
Cell Name: skin fibroblast (CL0002620)
Fold Change: 2.04
Marker Score: 528
Cell Name: fat cell (CL0000136)
Fold Change: 2.03
Marker Score: 1134
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 2.03
Marker Score: 635
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.97
Marker Score: 1152
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.96
Marker Score: 20219
Cell Name: renal principal cell (CL0005009)
Fold Change: 1.93
Marker Score: 1489
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.89
Marker Score: 17964
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.87
Marker Score: 16047
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.87
Marker Score: 983
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.87
Marker Score: 2012
Cell Name: microglial cell (CL0000129)
Fold Change: 1.83
Marker Score: 3339
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.82
Marker Score: 498
Cell Name: astrocyte (CL0000127)
Fold Change: 1.8
Marker Score: 1562
Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.8
Marker Score: 518
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.79
Marker Score: 2643
Cell Name: endocrine cell (CL0000163)
Fold Change: 1.77
Marker Score: 914
Cell Name: lactocyte (CL0002325)
Fold Change: 1.71
Marker Score: 27516
Cell Name: keratocyte (CL0002363)
Fold Change: 1.71
Marker Score: 393
Cell Name: neuron (CL0000540)
Fold Change: 1.67
Marker Score: 6794
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.64
Marker Score: 955
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.64
Marker Score: 3727
Cell Name: supporting cell (CL0000630)
Fold Change: 1.63
Marker Score: 3057
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.59
Marker Score: 905
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.58
Marker Score: 1745
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.58
Marker Score: 59824
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.54
Marker Score: 1901
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.54
Marker Score: 495
Cell Name: pericyte (CL0000669)
Fold Change: 1.53
Marker Score: 892
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.52
Marker Score: 1545
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.52
Marker Score: 573
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.52
Marker Score: 1517
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.51
Marker Score: 733
Cell Name: ganglion interneuron (CL0000397)
Fold Change: 1.49
Marker Score: 452
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.48
Marker Score: 882
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.47
Marker Score: 1530
Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 166909
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.45
Marker Score: 493
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.44
Marker Score: 355
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.42
Marker Score: 361
Cell Name: papillary tips cell (CL1000597)
Fold Change: 1.41
Marker Score: 285
Cell Name: Sertoli cell (CL0000216)
Fold Change: 1.4
Marker Score: 8288
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.39
Marker Score: 766
Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.39
Marker Score: 519.5
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.39
Marker Score: 685
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 1.38
Marker Score: 3822
Cell Name: neural cell (CL0002319)
Fold Change: 1.38
Marker Score: 663.5
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.36
Marker Score: 556
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.34
Marker Score: 46566
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.33
Marker Score: 12526
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.33
Marker Score: 2708
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.32
Marker Score: 3107
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 1.3
Marker Score: 598
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.3
Marker Score: 1471
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.3
Marker Score: 20281
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.3
Marker Score: 4608
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 1.3
Marker Score: 254
Cell Name: sympathetic neuron (CL0011103)
Fold Change: 1.29
Marker Score: 425
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.28
Marker Score: 1813
Cell Name: podocyte (CL0000653)
Fold Change: 1.27
Marker Score: 470
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 1.27
Marker Score: 653
Cell Name: fast muscle cell (CL0000190)
Fold Change: 1.26
Marker Score: 381
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.23
Marker Score: 576
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.23
Marker Score: 676
Cell Name: fibroblast (CL0000057)
Fold Change: 1.22
Marker Score: 1179
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.22
Marker Score: 816

Hover over a box to see details here...

**Key characteristics:** * The gene is located on chromosome 17q21.1. * It encodes a protein of approximately 350 amino acids. * It is a member of the zinc finger homeobox family of transcription factors. * It is involved in the regulation of cdkn1a transcription, which is important for cell cycle regulation. * It is also involved in the regulation of transcription by the transcription factor Runx3. **Pathways and functions:** * The ZFHX3 gene is involved in the regulation of circadian rhythm. * It is a key regulator of the expression of genes involved in the circadian clock, including clock proteins and transcriptional regulators. * It is also involved in the regulation of muscle development and function. * It is involved in the regulation of energy metabolism and stress resistance. **Clinical significance:** * Mutations in the ZFHX3 gene have been linked to several human diseases, including cancer and cardiovascular disease. * Overexpression of ZFHX3 has been shown to promote cell proliferation and migration. * Inhibition of ZFHX3 has been shown to suppress cancer cell growth. **Additional information:** * The ZFHX3 gene is also involved in the regulation of other cellular processes, including cell cycle regulation, apoptosis, and differentiation. * It is a well-studied gene with a significant impact on human health.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Zinc finger homeobox protein 3
Q8N2Y6_HUMAN

Genular Protein ID: 2090749973

Symbol: ZFHX3_HUMAN

Name: Zinc finger homeobox protein 3

UniProtKB Accession Codes:

Q15911 D3DWS8 O15101 Q13719 Q6ZP98

Database IDs:

Citations:

PubMed ID: 7592926

Title: Cloning and characterization of an ATBF1 isoform that expresses in a neuronal differentiation-dependent manner.

PubMed ID: 7592926

DOI: 10.1074/jbc.270.45.26840

PubMed ID: 1719379

Title: A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers.

PubMed ID: 1719379

DOI: 10.1128/mcb.11.12.6041-6049.1991

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10493829

Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

PubMed ID: 10493829

DOI: 10.1006/geno.1999.5927

PubMed ID: 11312261

Title: Positive and negative regulation of myogenic differentiation of C2C12 cells by isoforms of the multiple homeodomain zinc finger transcription factor ATBF1.

PubMed ID: 11312261

DOI: 10.1074/jbc.m010378200

PubMed ID: 14715251

Title: ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3.

PubMed ID: 14715251

DOI: 10.1016/j.bbrc.2003.12.054

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17330845

Title: Subcellular localization of ATBF1 regulates MUC5AC transcription in gastric cancer.

PubMed ID: 17330845

DOI: 10.1002/ijc.22654

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19597491

Title: A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.

PubMed ID: 19597491

DOI: 10.1038/ng.417

PubMed ID: 19597492

Title: Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry.

PubMed ID: 19597492

DOI: 10.1038/ng.416

PubMed ID: 20599712

Title: Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction.

PubMed ID: 20599712

DOI: 10.1016/j.bbrc.2010.06.090

PubMed ID: 20720010

Title: ATBF1 inhibits estrogen receptor (ER) function by selectively competing with AIB1 for binding to the ER in ER-positive breast cancer cells.

PubMed ID: 20720010

DOI: 10.1074/jbc.m110.128330

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22452784

Title: Oestrogen causes ATBF1 protein degradation through the oestrogen-responsive E3 ubiquitin ligase EFP.

PubMed ID: 22452784

DOI: 10.1042/bj20111890

PubMed ID: 23145062

Title: Human ALKBH4 interacts with proteins associated with transcription.

PubMed ID: 23145062

DOI: 10.1371/journal.pone.0049045

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25105025

Title: TGF-beta signaling cooperates with AT motif-binding factor-1 for repression of the alpha -fetoprotein promoter.

PubMed ID: 25105025

DOI: 10.1155/2014/970346

PubMed ID: 24651376

Title: Characterization of nuclear localization and SUMOylation of the ATBF1 transcription factor in epithelial cells.

PubMed ID: 24651376

DOI: 10.1371/journal.pone.0092746

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

Length: 3703
Mass: 404419
Checksum: 395F5D14A08112CB
Sequence:

MEGCDSPVVS GKDNGCGIPQ HQQWTELNST HLPDKPSSME QSTGESHGPL DSLRAPFNER 
LAESTASAGP PSEPASKEVT CNECSASFAS LQTYMEHHCP SARPPPPLRE ESASDTGEEG 
DEESDVENLA GEIVYQPDGS AYIVESLSQL TQGGGACGSG SGSGPLPSLF LNSLPGAGGK 
QGDPSCAAPV YPQIINTFHI ASSFGKWFEG PDQAFPNTSA LAGLSPVLHS FRVFDVRHKS 
NKDYLNSDGS AKSSCVSKDV PNNVDLSKFD GFVLYGKRKP ILMCFLCKLS FGYVRSFVTH 
AVHDHRMTLS EDERKILSNK NISAIIQGIG KDKEPLVSFL EPKNKNFQHP LVSTANLIGP 
GHSFYGKFSG IRMEGEEALP AGSAAGPEQP QAGLLTPSTL LNLGGLTSSV LKTPITSVPL 
GPLASSPTKS SEGKDSGAAE GEKQEVGDGD CFSEKVEPAE EEAEEEEEEE EAEEEEEEEE 
EEEEEEEDEG CKGLFPSELD EELEDRPHEE PGAAAGSSSK KDLALSNQSI SNSPLMPNVL 
QTLSRGTAST SSNSASSFVV FDGANRRNRL SFNSEGVRAN VAEGGRRLDF ADESANKDNA 
TAPEPNESTE GDDGGFVPHH QHAGSLCELG VGECPSGSGV ECPKCDTVLG SSRSLGGHMT 
MMHSRNSCKT LKCPKCNWHY KYQQTLEAHM KEKHPEPGGS CVYCKSGQPH PRLARGESYT 
CGYKPFRCEV CNYSTTTKGN LSIHMQSDKH LNNMQNLQNG GGEQVFSHTA GAAAAAVAAA 
AAAANISSSC GAPSPTKPKT KPTWRCEVCD YETNVARNLR IHMTSEKHMH NMMLLQQNMT 
QIQHNRHLGL GSLPSPAEAE LYQYYLAQNM NLPNLKMDSA ASDAQFMMSG FQLDPAGPMA 
AMTPALVGGE IPLDMRLGGG QLVSEELMNL GESFIQTNDP SLKLFQCAVC NKFTTDNLDM 
LGLHMNVERS LSEDEWKAVM GDSYQCKLCR YNTQLKANFQ LHCKTDKHVQ KYQLVAHIKE 
GGKANEWRLK CVAIGNPVHL KCNACDYYTN SLEKLRLHTV NSRHEASLKL YKHLQQHESG 
VEGESCYYHC VLCNYSTKAK LNLIQHVRSM KHQRSESLRK LQRLQKGLPE EDEDLGQIFT 
IRRCPSTDPE EAIEDVEGPS ETAADPEELA KDQEGGASSS QAEKELTDSP ATSKRISFPG 
SSESPLSSKR PKTAEEIKPE QMYQCPYCKY SNADVNRLRV HAMTQHSVQP MLRCPLCQDM 
LNNKIHLQLH LTHLHSVAPD CVEKLIMTVT TPEMVMPSSM FLPAAVPDRD GNSNLEEAGK 
QPETSEDLGK NILPSASTEQ SGDLKPSPAD PGSVREDSGF ICWKKGCNQV FKTSAALQTH 
FNEVHAKRPQ LPVSDRHVYK YRCNQCSLAF KTIEKLQLHS QYHVIRAATM CCLCQRSFRT 
FQALKKHLET SHLELSEADI QQLYGGLLAN GDLLAMGDPT LAEDHTIIVE EDKEEESDLE 
DKQSPTGSDS GSVQEDSGSE PKRALPFRKG PNFTMEKFLD PSRPYKCTVC KESFTQKNIL 
LVHYNSVSHL HKLKRALQES ATGQPEPTSS PDNKPFKCNT CNVAYSQSST LEIHMRSVLH 
QTKARAAKLE AASGSSNGTG NSSSISLSSS TPSPVSTSGS NTFTTSNPSS AGIAPSSNLL 
SQVPTESVGM PPLGNPIGAN IASPSEPKEA NRKKLADMIA SRQQQQQQQQ QQQQQQQQQQ 
QAQTLAQAQA QVQAHLQQEL QQQAALIQSQ LFNPTLLPHF PMTTETLLQL QQQQHLLFPF 
YIPSAEFQLN PEVSLPVTSG ALTLTGTGPG LLEDLKAQVQ VPQQSHQQIL PQQQQNQLSI 
AQSHSALLQP SQHPEKKNKL VIKEKEKESQ RERDSAEGGE GNTGPKETLP DALKAKEKKE 
LAPGGGSEPS MLPPRIASDA RGNATKALLE NFGFELVIQY NENKQKVQKK NGKTDQGENL 
EKLECDSCGK LFSNILILKS HQEHVHQNYF PFKQLERFAK QYRDHYDKLY PLRPQTPEPP 
PPPPPPPPPP LPAAPPQPAS TPAIPASAPP ITSPTIAPAQ PSVPLTQLSM PMELPIFSPL 
MMQTMPLQTL PAQLPPQLGP VEPLPADLAQ LYQHQLNPTL LQQQNKRPRT RITDDQLRVL 
RQYFDINNSP SEEQIKEMAD KSGLPQKVIK HWFRNTLFKE RQRNKDSPYN FSNPPITSLE 
ELKIDSRPPS PEPPKQEYWG SKRSSRTRFT DYQLRVLQDF FDANAYPKDD EFEQLSNLLN 
LPTRVIVVWF QNARQKARKN YENQGEGKDG ERRELTNDRY IRTSNLNYQC KKCSLVFQRI 
FDLIKHQKKL CYKDEDEEGQ DDSQNEDSMD AMEILTPTSS SCSTPMPSQA YSAPAPSANN 
TASSAFLQLT AEAEELATFN SKTEAGDEKP KLAEAPSAQP NQTQEKQGQP KPELQQQEQP 
EQKTNTPQQK LPQLVSLPSL PQPPPQAPPP QCPLPQSSPS PSQLSHLPLK PLHTSTPQQL 
ANLPPQLIPY QCDQCKLAFP SFEHWQEHQQ LHFLSAQNQF IHPQFLDRSL DMPFMLFDPS 
NPLLASQLLS GAIPQIPASS ATSPSTPTST MNTLKRKLEE KASASPGEND SGTGGEEPQR 
DKRLRTTITP EQLEILYQKY LLDSNPTRKM LDHIAHEVGL KKRVVQVWFQ NTRARERKGQ 
FRAVGPAQAH RRCPFCRALF KAKTALEAHI RSRHWHEAKR AGYNLTLSAM LLDCDGGLQM 
KGDIFDGTSF SHLPPSSSDG QGVPLSPVSK TMELSPRTLL SPSSIKVEGI EDFESPSMSS 
VNLNFDQTKL DNDDCSSVNT AITDTTTGDE GNADNDSATG IATETKSSSA PNEGLTKAAM 
MAMSEYEDRL SSGLVSPAPS FYSKEYDNEG TVDYSETSSL ADPCSPSPGA SGSAGKSGDS 
GDRPGQKRFR TQMTNLQLKV LKSCFNDYRT PTMLECEVLG NDIGLPKRVV QVWFQNARAK 
EKKSKLSMAK HFGINQTSYE GPKTECTLCG IKYSARLSVR DHIFSQQHIS KVKDTIGSQL 
DKEKEYFDPA TVRQLMAQQE LDRIKKANEV LGLAAQQQGM FDNTPLQALN LPTAYPALQG 
IPPVLLPGLN SPSLPGFTPS NTALTSPKPN LMGLPSTTVP SPGLPTSGLP NKPSSASLSS 
PTPAQATMAM GPQQPPQQQQ QQQQPQVQQP PPPPAAQPPP TPQLPLQQQQ QRKDKDSEKV 
KEKEKAHKGK GEPLPVPKKE KGEAPTATAA TISAPLPTME YAVDPAQLQA LQAALTSDPT 
ALLTSQFLPY FVPGFSPYYA PQIPGALQSG YLQPMYGMEG LFPYSPALSQ ALMGLSPGSL 
LQQYQQYQQS LQEAIQQQQQ RQLQQQQQQK VQQQQPKASQ TPVPPGAPSP DKDPAKESPK 
PEEQKNTPRE VSPLLPKLPE EPEAESKSAD SLYDPFIVPK VQYKLVCRKC QAGFSDEEAA 
RSHLKSLCFF GQSVVNLQEM VLHVPTGGGG GGSGGGGGGG GGGGGGGSYH CLACESALCG 
EEALSQHLES ALHKHRTITR AARNAKEHPS LLPHSACFPD PSTASTSQSA AHSNDSPPPP 
SAAAPSSASP HASRKSWPQV VSRASAAKPP SFPPLSSSST VTSSSCSTSG VQPSMPTDDY 
SEESDTDLSQ KSDGPASPVE GPKDPSCPKD SGLTSVGTDT FRL

Genular Protein ID: 1744688580

Symbol: Q8N2Y6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8N2Y6

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 886
Mass: 98584
Checksum: D53825266E5B7EC2
Sequence:

MRLGGGQLVS EELMNLGESF IQTNDPSLKL FQCAVCNKFT TDNLDMLGLH MNVERSLSED 
EWKAVMGDSY QCKLCRYNTQ LKANFQLHCK TDKHVQKYQL VAHIKEGGKA NEWRLKCVAI 
GNPVHLKCNA CDYYTNSLEK LRLHTVNSRH EASLKLYKHL QQHESGVEGE SCYYHCVLCN 
YSTKAKLNLI QHVRSMKHQR SESLRKLQRL QKGLPEEDED LGQIFTIRRC PSTDPEEAIE 
DVEGPSETAA DPEELAKDQE GGASSSQAEK ELTDSPATSK RISFPGSSES PLSSKRPKTA 
EEIKPEQMYQ CPYCKYSNAD VNRLRVHAMT QHSVQPMLRC PLCQDMLNNK IHLQLHLTHL 
HSVAPDCVEK LIMTVTTPEM VMPSSMFLPA AVPDRDGNSN LEEAGKQPET SEDLGKNILP 
SASTEQSGDL KPSPADPGSV REDSGFICWK KGCNQVFKTS AALQTHFNEV HAKRPQLPVS 
DRHVYKYRCN QCSLAFKTIE KLQLHSQYHV IRAATMCCLC QRSFRTFQAL KKHLETSHLE 
LSEADIQQLY GGLLANGDLL AMGDPTLAED HTIIVEEDKE EESDLEDKQS PTGSDSGSVQ 
EDSGSEPKRA LPFRKGPNFT MEKFLDPSRP YKCTVCKESF TQKNILLVHY NSVSHLHKLK 
RALQESATGQ PEPTSSPDNK PFKCNTCNVA YSQSSTLEIH MRSVLHQTKA RAAKLEAASG 
SSNGTGNSSS ISLSSSTPSP VSTSGSNTFT TSNPSSAGIA PSSNLLSQVP TESVGMPPLG 
NPIGANIASP SEPKEANRKK LADMIASRQQ QQQQQQQQQQ QQQQQQQAQT LAQAQAQVQA 
HLQQELQQQA ALIQSQLFNP TLLPHFPMTT ETLLQLQQQQ HPLYPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ZFHX3

Associated with

Cells (max top 100)

Other Information

Cloning and characterization of an ATBF1 isoform that expresses in a neuronal differentiation-dependent manner. PubMed ID: 7592926

A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers. PubMed ID: 1719379

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. PubMed ID: 10493829

Positive and negative regulation of myogenic differentiation of C2C12 cells by isoforms of the multiple homeodomain zinc finger transcription factor ATBF1. PubMed ID: 11312261

ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3. PubMed ID: 14715251

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Subcellular localization of ATBF1 regulates MUC5AC transcription in gastric cancer. PubMed ID: 17330845

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke. PubMed ID: 19597491

Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. PubMed ID: 19597492

Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction. PubMed ID: 20599712

ATBF1 inhibits estrogen receptor (ER) function by selectively competing with AIB1 for binding to the ER in ER-positive breast cancer cells. PubMed ID: 20720010

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Oestrogen causes ATBF1 protein degradation through the oestrogen-responsive E3 ubiquitin ligase EFP. PubMed ID: 22452784

Human ALKBH4 interacts with proteins associated with transcription. PubMed ID: 23145062

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

TGF-beta signaling cooperates with AT motif-binding factor-1 for repression of the alpha -fetoprotein promoter. PubMed ID: 25105025

Characterization of nuclear localization and SUMOylation of the ATBF1 transcription factor in epithelial cells. PubMed ID: 24651376

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334