Details for: ATF1

Gene ID: 466

Symbol: ATF1

Ensembl ID: ENSG00000123268

Description: activating transcription factor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.36
    Marker Score: 50126
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.35
    Marker Score: 12834.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.34
    Marker Score: 82703.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.33
    Marker Score: 11398.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.28
    Marker Score: 5218
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.24
    Marker Score: 47198
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.23
    Marker Score: 4747
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.23
    Marker Score: 18334
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.22
    Marker Score: 24202.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.2
    Marker Score: 11320.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.18
    Marker Score: 1822
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.18
    Marker Score: 9028
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.12
    Marker Score: 4675
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.11
    Marker Score: 754
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.1
    Marker Score: 1917
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.08
    Marker Score: 11202.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.07
    Marker Score: 1126
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.05
    Marker Score: 4370
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.04
    Marker Score: 16246
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.03
    Marker Score: 601
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71643
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1
    Marker Score: 2186
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1
    Marker Score: 291
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47866
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.99
    Marker Score: 2475
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.99
    Marker Score: 344
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30382
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.98
    Marker Score: 1127
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.97
    Marker Score: 1070
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.96
    Marker Score: 1038
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.96
    Marker Score: 20488
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.95
    Marker Score: 555
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.95
    Marker Score: 954
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.95
    Marker Score: 1220
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2388
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.91
    Marker Score: 308
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.9
    Marker Score: 284
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2685
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.89
    Marker Score: 2432
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5035
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.88
    Marker Score: 1830
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.87
    Marker Score: 931
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.86
    Marker Score: 794
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.86
    Marker Score: 1394
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.86
    Marker Score: 1649
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.85
    Marker Score: 533
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.85
    Marker Score: 903
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.85
    Marker Score: 256
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.83
    Marker Score: 2256
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.83
    Marker Score: 3572
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.83
    Marker Score: 619
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.82
    Marker Score: 196
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 325
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.81
    Marker Score: 1378
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.81
    Marker Score: 3180
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.81
    Marker Score: 27473
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8
    Marker Score: 1963
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.8
    Marker Score: 9324
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.78
    Marker Score: 700
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.78
    Marker Score: 318
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.78
    Marker Score: 497.5
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.78
    Marker Score: 170
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.77
    Marker Score: 5031
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 590
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.77
    Marker Score: 13660
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.77
    Marker Score: 321
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.77
    Marker Score: 511
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.76
    Marker Score: 16996.5
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.76
    Marker Score: 371
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.76
    Marker Score: 1730
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.76
    Marker Score: 815
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.75
    Marker Score: 1778
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.75
    Marker Score: 881
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.75
    Marker Score: 7564.5
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.75
    Marker Score: 304
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.75
    Marker Score: 172
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.75
    Marker Score: 2653
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.75
    Marker Score: 158.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.74
    Marker Score: 272
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.73
    Marker Score: 366
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.73
    Marker Score: 776
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.73
    Marker Score: 355
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.73
    Marker Score: 199
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.72
    Marker Score: 770
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 372
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.72
    Marker Score: 517
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.71
    Marker Score: 775
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.71
    Marker Score: 1772
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.71
    Marker Score: 327
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.71
    Marker Score: 175
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.71
    Marker Score: 583
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2975
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.71
    Marker Score: 1003.5
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.71
    Marker Score: 1389
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.71
    Marker Score: 241
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.71
    Marker Score: 710.5

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * The ATF1 gene is located on chromosome 15q21.1. * It is a protein of approximately 130 kDa. * It is a member of the ATF family of transcription factors. * It is expressed in a variety of cell types, including immune cells, neurons, and endothelial cells. **Pathways and functions:** * ATF1 is a key regulator of the immune system. It is involved in the development and maintenance of immune tolerance, and it is also involved in the regulation of inflammation and cell growth. * In immune tolerance, ATF1 helps to regulate the development and function of immune cells. It does this by controlling the expression of immune checkpoint molecules and by regulating the production of inflammatory cytokines. * In inflammation, ATF1 is involved in the recruitment of immune cells to sites of injury. It also promotes the differentiation of dendritic cells into regulatory T cells. * In cell growth, ATF1 is involved in the regulation of cell proliferation, differentiation, and apoptosis. **Clinical significance:** * Mutations in the ATF1 gene have been linked to a number of autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. * In these diseases, ATF1 is often overexpressed, which leads to the activation of immune cells and the development of inflammation and tissue damage. * Therefore, ATF1 is a promising target for the treatment of autoimmune diseases.

Genular Protein ID: 3635521474

Symbol: ATF1_HUMAN

Name: Cyclic AMP-dependent transcription factor ATF-1

UniProtKB Accession Codes:

P18846 B4DRF9 P25168 Q9H4A8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 5 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 5 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 6 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2196176

Title: Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain.

PubMed ID: 2196176

DOI: 10.1002/j.1460-2075.1990.tb07434.x

PubMed ID: 1655749

Title: The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A.

PubMed ID: 1655749

DOI: 10.1016/s0021-9258(18)55078-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2516827

Title: Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.

PubMed ID: 2516827

DOI: 10.1101/gad.3.12b.2083

PubMed ID: 11063792

Title: Genetic characterization of angiomatoid fibrous histiocytoma identifies fusion of the FUS and ATF-1 genes induced by a chromosomal translocation involving bands 12q13 and 16p11.

PubMed ID: 11063792

DOI: 10.1016/s0165-4608(00)00237-5

PubMed ID: 8621702

Title: Regulation of activating transcription factor-1 and the cAMP response element-binding protein by Ca2+/calmodulin-dependent protein kinases type I, II, and IV.

PubMed ID: 8621702

DOI: 10.1074/jbc.271.6.3066

PubMed ID: 15884099

Title: Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma.

PubMed ID: 15884099

DOI: 10.1002/gcc.20201

PubMed ID: 18794154

Title: Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation.

PubMed ID: 18794154

DOI: 10.1158/0008-5472.can-08-1137

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20980392

Title: Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress.

PubMed ID: 20980392

DOI: 10.1242/jcs.073627

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29983246

Title: The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress.

PubMed ID: 29983246

DOI: 10.1016/j.cmet.2018.06.008

Sequence Information:

  • Length: 271
  • Mass: 29233
  • Checksum: BAFECBFFB244FCED
  • Sequence:
    • MEDSHKSTTS ETAPQPGSAV QGAHISHIAQ QVSSLSESEE SQDSSDSIGS SQKAHGILAR 
RPSYRKILKD LSSEDTRGRK GDGENSGVSA AVTSMSVPTP IYQTSSGQYI AIAPNGALQL 
ASPGTDGVQG LQTLTMTNSG STQQGTTILQ YAQTSDGQQI LVPSNQVVVQ TASGDMQTYQ 
IRTTPSATSL PQTVVMTSPV TLTSQTTKTD DPQLKREIRL MKNREAAREC RRKKKEYVKC 
LENRVAVLEN QNKTLIEELK TLKDLYSNKS V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.