Details for: ATF1

Gene ID: 466

Symbol: ATF1

Ensembl ID: ENSG00000123268

Description: activating transcription factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 173.7115
    Cell Significance Index: -27.0200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 115.5954
    Cell Significance Index: -29.3200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 85.4963
    Cell Significance Index: -35.2200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 72.0152
    Cell Significance Index: -34.0000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 62.7740
    Cell Significance Index: -32.2900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 50.7286
    Cell Significance Index: -34.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.1404
    Cell Significance Index: -32.2300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.9333
    Cell Significance Index: -26.6100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.4423
    Cell Significance Index: -25.9300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.4262
    Cell Significance Index: -33.2500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.7167
    Cell Significance Index: -14.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.0372
    Cell Significance Index: 140.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4124
    Cell Significance Index: 19.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3883
    Cell Significance Index: 37.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1772
    Cell Significance Index: 236.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1374
    Cell Significance Index: 30.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1092
    Cell Significance Index: 66.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1080
    Cell Significance Index: 219.8800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0890
    Cell Significance Index: 207.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0290
    Cell Significance Index: 111.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7234
    Cell Significance Index: 117.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7233
    Cell Significance Index: 653.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6908
    Cell Significance Index: 247.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6263
    Cell Significance Index: 48.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5023
    Cell Significance Index: 13.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4967
    Cell Significance Index: 343.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4812
    Cell Significance Index: 21.8100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.4721
    Cell Significance Index: 11.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4218
    Cell Significance Index: 23.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4197
    Cell Significance Index: 11.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3974
    Cell Significance Index: 48.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3616
    Cell Significance Index: 65.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3250
    Cell Significance Index: 9.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3199
    Cell Significance Index: 141.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3176
    Cell Significance Index: 40.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3164
    Cell Significance Index: 43.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2756
    Cell Significance Index: 150.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2317
    Cell Significance Index: 10.8900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2150
    Cell Significance Index: 25.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1581
    Cell Significance Index: 7.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1426
    Cell Significance Index: 3.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1377
    Cell Significance Index: 3.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1080
    Cell Significance Index: 203.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0849
    Cell Significance Index: 5.7100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0763
    Cell Significance Index: 1.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0710
    Cell Significance Index: 45.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0529
    Cell Significance Index: 6.8400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0527
    Cell Significance Index: 5.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0430
    Cell Significance Index: 2.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0398
    Cell Significance Index: 18.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0254
    Cell Significance Index: 34.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0236
    Cell Significance Index: 36.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0163
    Cell Significance Index: 30.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0130
    Cell Significance Index: 0.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0034
    Cell Significance Index: 0.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0077
    Cell Significance Index: -0.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0170
    Cell Significance Index: -0.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0191
    Cell Significance Index: -1.3500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0198
    Cell Significance Index: -0.3400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0199
    Cell Significance Index: -1.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0209
    Cell Significance Index: -15.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0229
    Cell Significance Index: -16.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0284
    Cell Significance Index: -1.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0400
    Cell Significance Index: -29.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0493
    Cell Significance Index: -5.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0519
    Cell Significance Index: -29.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0553
    Cell Significance Index: -1.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0568
    Cell Significance Index: -0.9500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0582
    Cell Significance Index: -1.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0590
    Cell Significance Index: -10.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0609
    Cell Significance Index: -38.0600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0630
    Cell Significance Index: -1.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0640
    Cell Significance Index: -4.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0998
    Cell Significance Index: -28.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1056
    Cell Significance Index: -15.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1079
    Cell Significance Index: -12.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1242
    Cell Significance Index: -3.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1485
    Cell Significance Index: -6.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1741
    Cell Significance Index: -36.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2099
    Cell Significance Index: -24.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2231
    Cell Significance Index: -8.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2613
    Cell Significance Index: -27.2100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2828
    Cell Significance Index: -7.0700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3262
    Cell Significance Index: -2.6600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3320
    Cell Significance Index: -9.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3583
    Cell Significance Index: -28.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3583
    Cell Significance Index: -7.6300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.3726
    Cell Significance Index: -2.3200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3792
    Cell Significance Index: -3.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3983
    Cell Significance Index: -20.9100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4050
    Cell Significance Index: -20.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4056
    Cell Significance Index: -8.4900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4436
    Cell Significance Index: -12.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4546
    Cell Significance Index: -27.8700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4804
    Cell Significance Index: -10.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4882
    Cell Significance Index: -13.0600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5056
    Cell Significance Index: -12.1300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.5092
    Cell Significance Index: -3.4500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5109
    Cell Significance Index: -6.0900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5199
    Cell Significance Index: -7.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ATF1 is a member of the ATF/CREB family of transcription factors, which are known for their ability to regulate gene expression in response to a wide range of stimuli. ATF1 is characterized by its ability to bind to specific DNA sequences, known as cAMP response elements (CRE), and to interact with other transcription factors to modulate gene expression. ATF1 is also known for its ability to phosphorylate and activate downstream targets, including CREB, which is a key regulator of gene expression in response to various stimuli. **Pathways and Functions:** ATF1 plays a critical role in the regulation of gene expression in response to various stimuli, including cytokines, growth factors, and stress signals. Some of the key pathways and functions of ATF1 include: 1. **Cytokine Signaling:** ATF1 is involved in the regulation of cytokine signaling pathways, including the NF-κB and MAPK signaling pathways, which are critical for the regulation of immune response. 2. **Neuronal Development:** ATF1 is also involved in the regulation of neuronal development and function, including the regulation of gene expression in response to neurotrophic factors. 3. **Cell Survival:** ATF1 plays a critical role in the regulation of cell survival, including the regulation of apoptosis and autophagy in response to various stimuli. 4. **Stress Response:** ATF1 is also involved in the regulation of the stress response, including the regulation of gene expression in response to oxidative stress and other forms of cellular stress. **Clinical Significance:** ATF1 has been implicated in various diseases, including: 1. **Autoimmune Diseases:** ATF1 has been implicated in the regulation of autoimmune diseases, including rheumatoid arthritis and lupus, where dysregulation of ATF1 has been shown to contribute to disease pathogenesis. 2. **Cancer:** ATF1 has been implicated in the regulation of cancer, including the regulation of gene expression in response to various stimuli, including cytokines and growth factors. 3. **Neurological Disorders:** ATF1 has been implicated in the regulation of neurological disorders, including Alzheimer's disease and Parkinson's disease, where dysregulation of ATF1 has been shown to contribute to disease pathogenesis. In conclusion, ATF1 is a multifaceted transcription factor that plays a critical role in the regulation of gene expression in response to various stimuli, including cytokines, growth factors, and stress signals. Its dysregulation has been implicated in various diseases, including autoimmune diseases, cancer, and neurological disorders, highlighting the importance of ATF1 in maintaining normal cellular function and preventing disease.

Genular Protein ID: 3635521474

Symbol: ATF1_HUMAN

Name: Cyclic AMP-dependent transcription factor ATF-1

UniProtKB Accession Codes:

P18846 B4DRF9 P25168 Q9H4A8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 5 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2196176

Title: Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain.

PubMed ID: 2196176

DOI: 10.1002/j.1460-2075.1990.tb07434.x

PubMed ID: 1655749

Title: The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A.

PubMed ID: 1655749

DOI: 10.1016/s0021-9258(18)55078-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2516827

Title: Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.

PubMed ID: 2516827

DOI: 10.1101/gad.3.12b.2083

PubMed ID: 11063792

Title: Genetic characterization of angiomatoid fibrous histiocytoma identifies fusion of the FUS and ATF-1 genes induced by a chromosomal translocation involving bands 12q13 and 16p11.

PubMed ID: 11063792

DOI: 10.1016/s0165-4608(00)00237-5

PubMed ID: 8621702

Title: Regulation of activating transcription factor-1 and the cAMP response element-binding protein by Ca2+/calmodulin-dependent protein kinases type I, II, and IV.

PubMed ID: 8621702

DOI: 10.1074/jbc.271.6.3066

PubMed ID: 15884099

Title: Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma.

PubMed ID: 15884099

DOI: 10.1002/gcc.20201

PubMed ID: 18794154

Title: Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation.

PubMed ID: 18794154

DOI: 10.1158/0008-5472.can-08-1137

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20980392

Title: Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress.

PubMed ID: 20980392

DOI: 10.1242/jcs.073627

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29983246

Title: The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress.

PubMed ID: 29983246

DOI: 10.1016/j.cmet.2018.06.008

Sequence Information:

  • Length: 271
  • Mass: 29233
  • Checksum: BAFECBFFB244FCED
  • Sequence:
    • MEDSHKSTTS ETAPQPGSAV QGAHISHIAQ QVSSLSESEE SQDSSDSIGS SQKAHGILAR 
RPSYRKILKD LSSEDTRGRK GDGENSGVSA AVTSMSVPTP IYQTSSGQYI AIAPNGALQL 
ASPGTDGVQG LQTLTMTNSG STQQGTTILQ YAQTSDGQQI LVPSNQVVVQ TASGDMQTYQ 
IRTTPSATSL PQTVVMTSPV TLTSQTTKTD DPQLKREIRL MKNREAAREC RRKKKEYVKC 
LENRVAVLEN QNKTLIEELK TLKDLYSNKS V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.