Details for: ATF3

Gene ID: 467

Symbol: ATF3

Ensembl ID: ENSG00000162772

Description: activating transcription factor 3

Associated with

  • Atf4 activates genes in response to endoplasmic reticulum stress
    (R-HSA-380994)
  • Cellular responses to stimuli
    (R-HSA-8953897)
  • Cellular responses to stress
    (R-HSA-2262752)
  • Cellular response to starvation
    (R-HSA-9711097)
  • Perk regulates gene expression
    (R-HSA-381042)
  • Response of eif2ak1 (hri) to heme deficiency
    (R-HSA-9648895)
  • Response of eif2ak4 (gcn2) to amino acid deficiency
    (R-HSA-9633012)
  • Unfolded protein response (upr)
    (R-HSA-381119)
  • Cellular response to amino acid starvation
    (GO:0034198)
  • Chop-atf3 complex
    (GO:1990622)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Endoplasmic reticulum unfolded protein response
    (GO:0030968)
  • Gluconeogenesis
    (GO:0006094)
  • Identical protein binding
    (GO:0042802)
  • Negative regulation of erk1 and erk2 cascade
    (GO:0070373)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleolus
    (GO:0005730)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of trail-activated apoptotic signaling pathway
    (GO:1903984)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein heterodimerization activity
    (GO:0046982)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to endoplasmic reticulum stress
    (GO:0034976)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulator complex
    (GO:0090575)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Skeletal muscle cell differentiation
    (GO:0035914)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Other Information

Genular Protein ID: 2353326803

Symbol: ATF3_HUMAN

Name: Activating transcription factor 3

UniProtKB Accession Codes:

P18847 Q5VTZ2 Q6ICQ9 Q7Z566 Q8WYM6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChiTaRS 1 ComplexPortal 18 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 18 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 3 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 3 RefSeq 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7515060

Title: ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms.

PubMed ID: 7515060

DOI: 10.1016/s0021-9258(17)40754-x

PubMed ID: 12034827

Title: An alternatively spliced isoform of transcriptional repressor ATF3 and its induction by stress stimuli.

PubMed ID: 12034827

DOI: 10.1093/nar/30.11.2398

PubMed ID: 12881527

Title: Amino acid deprivation and endoplasmic reticulum stress induce expression of multiple activating transcription factor-3 mRNA species that, when overexpressed in HepG2 cells, modulate transcription by the human asparagine synthetase promoter.

PubMed ID: 12881527

DOI: 10.1074/jbc.m304574200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2516827

Title: Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.

PubMed ID: 2516827

DOI: 10.1101/gad.3.12b.2083

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 25865756

Title: The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60.

PubMed ID: 25865756

DOI: 10.1038/ncomms7752

PubMed ID: 29463886

Title: A set of regulatory genes co-expressed in embryonic human brain is implicated in disrupted speech development.

PubMed ID: 29463886

DOI: 10.1038/s41380-018-0020-x

Sequence Information:

  • Length: 181
  • Mass: 20576
  • Checksum: EC5D8F065EEE2D9C
  • Sequence:
    • MMLQHPGQVS ASEVSASAIV PCLSPPGSLV FEDFANLTPF VKEELRFAIQ NKHLCHRMSS 
ALESVTVSDR PLGVSITKAE VAPEEDERKK RRRERNKIAA AKCRNKKKEK TECLQKESEK 
LESVNAELKA QIEELKNEKQ HLIYMLNLHR PTCIVRAQNG RTPEDERNLF IQQIKEGTLQ 
S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.