Details for: ATF3

Gene ID: 467

Symbol: ATF3

Ensembl ID: ENSG00000162772

Description: activating transcription factor 3

Associated with

  • Atf4 activates genes in response to endoplasmic reticulum stress
    (R-HSA-380994)
  • Cellular responses to stimuli
    (R-HSA-8953897)
  • Cellular responses to stress
    (R-HSA-2262752)
  • Cellular response to starvation
    (R-HSA-9711097)
  • Perk regulates gene expression
    (R-HSA-381042)
  • Response of eif2ak1 (hri) to heme deficiency
    (R-HSA-9648895)
  • Response of eif2ak4 (gcn2) to amino acid deficiency
    (R-HSA-9633012)
  • Unfolded protein response (upr)
    (R-HSA-381119)
  • Cellular response to amino acid starvation
    (GO:0034198)
  • Chop-atf3 complex
    (GO:1990622)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Endoplasmic reticulum unfolded protein response
    (GO:0030968)
  • Gluconeogenesis
    (GO:0006094)
  • Identical protein binding
    (GO:0042802)
  • Negative regulation of erk1 and erk2 cascade
    (GO:0070373)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleolus
    (GO:0005730)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of trail-activated apoptotic signaling pathway
    (GO:1903984)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein heterodimerization activity
    (GO:0046982)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to endoplasmic reticulum stress
    (GO:0034976)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulator complex
    (GO:0090575)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Skeletal muscle cell differentiation
    (GO:0035914)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.94
    Marker Score: 5127
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.12
    Marker Score: 2444
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.12
    Marker Score: 106157
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.86
    Marker Score: 6509
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.51
    Marker Score: 2684
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.49
    Marker Score: 9604
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.44
    Marker Score: 15594
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.4
    Marker Score: 3534
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.37
    Marker Score: 3892.5
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.35
    Marker Score: 5327
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.23
    Marker Score: 3774
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.23
    Marker Score: 2136
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.22
    Marker Score: 9576
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.18
    Marker Score: 1018
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.18
    Marker Score: 8058
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.12
    Marker Score: 1129.5
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.08
    Marker Score: 788
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.06
    Marker Score: 1400
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2
    Marker Score: 1732
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2
    Marker Score: 497
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2
    Marker Score: 1411.5
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.96
    Marker Score: 3686
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.95
    Marker Score: 1945
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.93
    Marker Score: 2210
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.89
    Marker Score: 652
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.83
    Marker Score: 1921.5
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.81
    Marker Score: 9524
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.81
    Marker Score: 675
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.8
    Marker Score: 8654
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.79
    Marker Score: 731
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.78
    Marker Score: 2466
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.77
    Marker Score: 913
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.77
    Marker Score: 8694.5
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.77
    Marker Score: 2129
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.73
    Marker Score: 616
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.72
    Marker Score: 1081
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.72
    Marker Score: 19410
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.72
    Marker Score: 5408
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.71
    Marker Score: 716
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.71
    Marker Score: 335
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.68
    Marker Score: 2595
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.64
    Marker Score: 1397
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.64
    Marker Score: 1078
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 1.59
    Marker Score: 898
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.58
    Marker Score: 1951
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.57
    Marker Score: 775
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.57
    Marker Score: 6164
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.57
    Marker Score: 3127
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.55
    Marker Score: 4058
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.54
    Marker Score: 3983
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.52
    Marker Score: 1898
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.52
    Marker Score: 1271
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.5
    Marker Score: 430
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.49
    Marker Score: 9076
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.48
    Marker Score: 1030
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.47
    Marker Score: 1269
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.47
    Marker Score: 1894
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.46
    Marker Score: 2128
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.46
    Marker Score: 855
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.46
    Marker Score: 2317
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166535
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.45
    Marker Score: 1437
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.45
    Marker Score: 3433
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.44
    Marker Score: 409
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.44
    Marker Score: 416
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.43
    Marker Score: 786
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 1.41
    Marker Score: 384
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.4
    Marker Score: 322
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.4
    Marker Score: 724.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4
    Marker Score: 48428
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.39
    Marker Score: 12236
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.39
    Marker Score: 1184
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.36
    Marker Score: 34907
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.36
    Marker Score: 431
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.35
    Marker Score: 391
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.33
    Marker Score: 486
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.33
    Marker Score: 1285
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.33
    Marker Score: 2704.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.31
    Marker Score: 11400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.31
    Marker Score: 3201
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.31
    Marker Score: 761
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.3
    Marker Score: 597
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.27
    Marker Score: 324
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.27
    Marker Score: 71054
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.27
    Marker Score: 1836
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.27
    Marker Score: 306
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.27
    Marker Score: 1952
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.27
    Marker Score: 313
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 1.25
    Marker Score: 331.5
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.25
    Marker Score: 376
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.25
    Marker Score: 593
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.24
    Marker Score: 710
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.24
    Marker Score: 1443
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.22
    Marker Score: 414
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.22
    Marker Score: 2381
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.21
    Marker Score: 3085
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.21
    Marker Score: 2147
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.19
    Marker Score: 7759
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.19
    Marker Score: 510.5
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.19
    Marker Score: 4078

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Other Information

**Key characteristics:** - ATF3 is a highly conserved transcription factor with a well-documented role in mammalian cells. - It is a key regulator of cellular stress response and adaptation. - It is involved in the regulation of numerous genes involved in stress response, cell cycle control, proliferation, differentiation, metabolism, and apoptosis. - It is a key regulator of cell growth, differentiation, and apoptosis. **Pathways and functions:** - ATF3 is a key regulator of the unfolded protein response (upr). - It is activated by unfolded or misfolded proteins, leading to the expression of stress response genes. - It is also involved in the regulation of cell cycle control, proliferation, differentiation, and apoptosis. - It is involved in the regulation of lipid metabolism, inflammation, and cell growth. - It is also involved in the regulation of the immune response, including the activation of immune cells and the regulation of inflammation. **Clinical significance:** - Mutations in ATF3 have been linked to various human diseases, including cancer, cardiovascular disease, and metabolic disorders. - Targeting ATF3 has emerged as a potential therapeutic strategy for these diseases. - Inhibition of ATF3 has been shown to mitigate cellular stress, inflammation, and cancer growth. **Additional notes:** - ATF3 is a member of the ATF family of transcription factors, which are characterized by their ability to bind to DNA and regulate gene expression. - It is a highly versatile transcription factor that can be regulated by various environmental cues, including stress, growth factors, and hormones. - It is a key regulator of cellular homeostasis and a potential therapeutic target for various diseases.

Genular Protein ID: 2353326803

Symbol: ATF3_HUMAN

Name: Activating transcription factor 3

UniProtKB Accession Codes:

P18847 Q5VTZ2 Q6ICQ9 Q7Z566 Q8WYM6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChiTaRS 1 ComplexPortal 18 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 18 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 3 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 3 RefSeq 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7515060

Title: ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms.

PubMed ID: 7515060

DOI: 10.1016/s0021-9258(17)40754-x

PubMed ID: 12034827

Title: An alternatively spliced isoform of transcriptional repressor ATF3 and its induction by stress stimuli.

PubMed ID: 12034827

DOI: 10.1093/nar/30.11.2398

PubMed ID: 12881527

Title: Amino acid deprivation and endoplasmic reticulum stress induce expression of multiple activating transcription factor-3 mRNA species that, when overexpressed in HepG2 cells, modulate transcription by the human asparagine synthetase promoter.

PubMed ID: 12881527

DOI: 10.1074/jbc.m304574200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2516827

Title: Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.

PubMed ID: 2516827

DOI: 10.1101/gad.3.12b.2083

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 25865756

Title: The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60.

PubMed ID: 25865756

DOI: 10.1038/ncomms7752

PubMed ID: 29463886

Title: A set of regulatory genes co-expressed in embryonic human brain is implicated in disrupted speech development.

PubMed ID: 29463886

DOI: 10.1038/s41380-018-0020-x

Sequence Information:

  • Length: 181
  • Mass: 20576
  • Checksum: EC5D8F065EEE2D9C
  • Sequence:
    • MMLQHPGQVS ASEVSASAIV PCLSPPGSLV FEDFANLTPF VKEELRFAIQ NKHLCHRMSS 
ALESVTVSDR PLGVSITKAE VAPEEDERKK RRRERNKIAA AKCRNKKKEK TECLQKESEK 
LESVNAELKA QIEELKNEKQ HLIYMLNLHR PTCIVRAQNG RTPEDERNLF IQQIKEGTLQ 
S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.