Details for: ATF4

Gene ID: 468

Symbol: ATF4

Ensembl ID: ENSG00000128272

Description: activating transcription factor 4

Associated with

  • Atf4 activates genes in response to endoplasmic reticulum stress
    (R-HSA-380994)
  • Atf6 (atf6-alpha) activates chaperone genes
    (R-HSA-381183)
  • Atf6 (atf6-alpha) activates chaperones
    (R-HSA-381033)
  • Cellular responses to stimuli
    (R-HSA-8953897)
  • Cellular responses to stress
    (R-HSA-2262752)
  • Cellular response to chemical stress
    (R-HSA-9711123)
  • Cellular response to starvation
    (R-HSA-9711097)
  • Keap1-nfe2l2 pathway
    (R-HSA-9755511)
  • Nfe2l2 regulating anti-oxidant/detoxification enzymes
    (R-HSA-9818027)
  • Nfe2l2 regulating er-stress associated genes
    (R-HSA-9818035)
  • Nuclear events mediated by nfe2l2
    (R-HSA-9759194)
  • Perk regulates gene expression
    (R-HSA-381042)
  • Response of eif2ak1 (hri) to heme deficiency
    (R-HSA-9648895)
  • Response of eif2ak4 (gcn2) to amino acid deficiency
    (R-HSA-9633012)
  • Unfolded protein response (upr)
    (R-HSA-381119)
  • Bone mineralization
    (GO:0030282)
  • Camp response element binding protein binding
    (GO:0008140)
  • Cellular response to amino acid starvation
    (GO:0034198)
  • Cellular response to glucose starvation
    (GO:0042149)
  • Cellular response to hypoxia
    (GO:0071456)
  • Cellular response to leucine starvation
    (GO:1990253)
  • Cellular response to oxidative stress
    (GO:0034599)
  • Cellular response to uv
    (GO:0034644)
  • Chromatin
    (GO:0000785)
  • Circadian regulation of gene expression
    (GO:0032922)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Embryonic hemopoiesis
    (GO:0035162)
  • Endoplasmic reticulum unfolded protein response
    (GO:0030968)
  • Gamma-aminobutyric acid signaling pathway
    (GO:0007214)
  • General transcription initiation factor binding
    (GO:0140296)
  • Gluconeogenesis
    (GO:0006094)
  • Hri-mediated signaling
    (GO:0140468)
  • Identical protein binding
    (GO:0042802)
  • Integrated stress response signaling
    (GO:0140467)
  • Intracellular calcium ion homeostasis
    (GO:0006874)
  • Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
    (GO:0070059)
  • L-asparagine metabolic process
    (GO:0070982)
  • Lens fiber cell morphogenesis
    (GO:0070309)
  • Leucine zipper domain binding
    (GO:0043522)
  • Mrna transcription by rna polymerase ii
    (GO:0042789)
  • Negative regulation of cold-induced thermogenesis
    (GO:0120163)
  • Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
    (GO:1903377)
  • Negative regulation of potassium ion transport
    (GO:0043267)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of translational initiation in response to stress
    (GO:0032057)
  • Neuron differentiation
    (GO:0030182)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Perk-mediated unfolded protein response
    (GO:0036499)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of biomineral tissue development
    (GO:0070169)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Positive regulation of sodium-dependent phosphate transport
    (GO:2000120)
  • Positive regulation of transcription by rna polymerase i
    (GO:0045943)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of vascular associated smooth muscle cell apoptotic process
    (GO:1905461)
  • Positive regulation of vascular endothelial growth factor production
    (GO:0010575)
  • Promoter-specific chromatin binding
    (GO:1990841)
  • Protein binding
    (GO:0005515)
  • Protein heterodimerization activity
    (GO:0046982)
  • Protein kinase binding
    (GO:0019901)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of osteoblast differentiation
    (GO:0045667)
  • Regulation of synaptic plasticity
    (GO:0048167)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to endoplasmic reticulum stress
    (GO:0034976)
  • Response to manganese-induced endoplasmic reticulum stress
    (GO:1990737)
  • Response to nutrient levels
    (GO:0031667)
  • Response to toxic substance
    (GO:0009636)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Other Information

Genular Protein ID: 1683237712

Symbol: ATF4_HUMAN

Name: N/A

UniProtKB Accession Codes:

P18848 Q96AQ3 Q9UH31

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 26 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 ELM 1 EMBL 14 EPD 1 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 80 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 7 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1847461

Title: Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I.

PubMed ID: 1847461

DOI: 10.1128/jvi.65.3.1420-1426.1991

PubMed ID: 1534408

Title: Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element.

PubMed ID: 1534408

DOI: 10.1073/pnas.89.11.4820

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2516827

Title: Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.

PubMed ID: 2516827

DOI: 10.1101/gad.3.12b.2083

PubMed ID: 11238952

Title: ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase.

PubMed ID: 11238952

DOI: 10.1128/mcb.21.6.2192-2202.2001

PubMed ID: 11960987

Title: ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene.

PubMed ID: 11960987

DOI: 10.1074/jbc.m201959200

PubMed ID: 15109498

Title: ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome.

PubMed ID: 15109498

DOI: 10.1016/s0092-8674(04)00344-7

PubMed ID: 15775988

Title: TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death.

PubMed ID: 15775988

DOI: 10.1038/sj.emboj.7600596

PubMed ID: 16219772

Title: p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain.

PubMed ID: 16219772

DOI: 10.1074/jbc.m505294200

PubMed ID: 15911876

Title: FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice.

PubMed ID: 15911876

DOI: 10.1083/jcb.200412139

PubMed ID: 16682973

Title: The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4.

PubMed ID: 16682973

DOI: 10.1038/ng1786

PubMed ID: 17684156

Title: Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor.

PubMed ID: 17684156

DOI: 10.1182/blood-2007-06-094441

PubMed ID: 18940792

Title: C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene.

PubMed ID: 18940792

DOI: 10.1074/jbc.m806874200

PubMed ID: 20873783

Title: Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.

PubMed ID: 20873783

DOI: 10.1021/pr100562w

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21408167

Title: New modularity of DAP-kinases: alternative splicing of the DRP-1 gene produces a ZIPk-like isoform.

PubMed ID: 21408167

DOI: 10.1371/journal.pone.0017344

PubMed ID: 22974638

Title: ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway.

PubMed ID: 22974638

DOI: 10.1016/j.bbamcr.2012.08.020

PubMed ID: 23123191

Title: Functional interaction of protein kinase CK2 and activating transcription factor 4 (ATF4), a key player in the cellular stress response.

PubMed ID: 23123191

DOI: 10.1016/j.bbamcr.2012.10.025

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 26086088

Title: Transcription factor ATF4 induces NLRP1 inflammasome expression during endoplasmic reticulum stress.

PubMed ID: 26086088

DOI: 10.1371/journal.pone.0130635

PubMed ID: 27629041

Title: The integrated stress response.

PubMed ID: 27629041

DOI: 10.15252/embr.201642195

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31444471

Title: Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders.

PubMed ID: 31444471

DOI: 10.1038/s41380-019-0485-2

PubMed ID: 32132706

Title: A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.

PubMed ID: 32132706

DOI: 10.1038/s41586-020-2076-4

PubMed ID: 32132707

Title: Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway.

PubMed ID: 32132707

DOI: 10.1038/s41586-020-2078-2

PubMed ID: 33384352

Title: QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis.

PubMed ID: 33384352

DOI: 10.1126/science.abb6896

PubMed ID: 11018027

Title: Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA.

PubMed ID: 11018027

DOI: 10.1074/jbc.m005594200

Sequence Information:

  • Length: 351
  • Mass: 38590
  • Checksum: 3BBB7379DC3B0D07
  • Sequence:
    • MTEMSFLSSE VLVGDLMSPF DQSGLGAEES LGLLDDYLEV AKHFKPHGFS SDKAKAGSSE 
WLAVDGLVSP SNNSKEDAFS GTDWMLEKMD LKEFDLDALL GIDDLETMPD DLLTTLDDTC 
DLFAPLVQET NKQPPQTVNP IGHLPESLTK PDQVAPFTFL QPLPLSPGVL SSTPDHSFSL 
ELGSEVDITE GDRKPDYTAY VAMIPQCIKE EDTPSDNDSG ICMSPESYLG SPQHSPSTRG 
SPNRSLPSPG VLCGSARPKP YDPPGEKMVA AKVKGEKLDK KLKKMEQNKT AATRYRQKKR 
AEQEALTGEC KELEKKNEAL KERADSLAKE IQYLKDLIEE VRKARGKKRV P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.