Details for: ATF4

Gene ID: 468

Symbol: ATF4

Ensembl ID: ENSG00000128272

Description: activating transcription factor 4

Associated with

  • Atf4 activates genes in response to endoplasmic reticulum stress
    (R-HSA-380994)
  • Atf6 (atf6-alpha) activates chaperone genes
    (R-HSA-381183)
  • Atf6 (atf6-alpha) activates chaperones
    (R-HSA-381033)
  • Cellular responses to stimuli
    (R-HSA-8953897)
  • Cellular responses to stress
    (R-HSA-2262752)
  • Cellular response to chemical stress
    (R-HSA-9711123)
  • Cellular response to starvation
    (R-HSA-9711097)
  • Keap1-nfe2l2 pathway
    (R-HSA-9755511)
  • Nfe2l2 regulating anti-oxidant/detoxification enzymes
    (R-HSA-9818027)
  • Nfe2l2 regulating er-stress associated genes
    (R-HSA-9818035)
  • Nuclear events mediated by nfe2l2
    (R-HSA-9759194)
  • Perk regulates gene expression
    (R-HSA-381042)
  • Response of eif2ak1 (hri) to heme deficiency
    (R-HSA-9648895)
  • Response of eif2ak4 (gcn2) to amino acid deficiency
    (R-HSA-9633012)
  • Unfolded protein response (upr)
    (R-HSA-381119)
  • Bone mineralization
    (GO:0030282)
  • Camp response element binding protein binding
    (GO:0008140)
  • Cellular response to amino acid starvation
    (GO:0034198)
  • Cellular response to glucose starvation
    (GO:0042149)
  • Cellular response to hypoxia
    (GO:0071456)
  • Cellular response to leucine starvation
    (GO:1990253)
  • Cellular response to oxidative stress
    (GO:0034599)
  • Cellular response to uv
    (GO:0034644)
  • Chromatin
    (GO:0000785)
  • Circadian regulation of gene expression
    (GO:0032922)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Embryonic hemopoiesis
    (GO:0035162)
  • Endoplasmic reticulum unfolded protein response
    (GO:0030968)
  • Gamma-aminobutyric acid signaling pathway
    (GO:0007214)
  • General transcription initiation factor binding
    (GO:0140296)
  • Gluconeogenesis
    (GO:0006094)
  • Hri-mediated signaling
    (GO:0140468)
  • Identical protein binding
    (GO:0042802)
  • Integrated stress response signaling
    (GO:0140467)
  • Intracellular calcium ion homeostasis
    (GO:0006874)
  • Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
    (GO:0070059)
  • L-asparagine metabolic process
    (GO:0070982)
  • Lens fiber cell morphogenesis
    (GO:0070309)
  • Leucine zipper domain binding
    (GO:0043522)
  • Mrna transcription by rna polymerase ii
    (GO:0042789)
  • Negative regulation of cold-induced thermogenesis
    (GO:0120163)
  • Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
    (GO:1903377)
  • Negative regulation of potassium ion transport
    (GO:0043267)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of translational initiation in response to stress
    (GO:0032057)
  • Neuron differentiation
    (GO:0030182)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Perk-mediated unfolded protein response
    (GO:0036499)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of biomineral tissue development
    (GO:0070169)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Positive regulation of sodium-dependent phosphate transport
    (GO:2000120)
  • Positive regulation of transcription by rna polymerase i
    (GO:0045943)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of vascular associated smooth muscle cell apoptotic process
    (GO:1905461)
  • Positive regulation of vascular endothelial growth factor production
    (GO:0010575)
  • Promoter-specific chromatin binding
    (GO:1990841)
  • Protein binding
    (GO:0005515)
  • Protein heterodimerization activity
    (GO:0046982)
  • Protein kinase binding
    (GO:0019901)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of osteoblast differentiation
    (GO:0045667)
  • Regulation of synaptic plasticity
    (GO:0048167)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to endoplasmic reticulum stress
    (GO:0034976)
  • Response to manganese-induced endoplasmic reticulum stress
    (GO:1990737)
  • Response to nutrient levels
    (GO:0031667)
  • Response to toxic substance
    (GO:0009636)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 423.3495
    Cell Significance Index: -65.8500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 256.8961
    Cell Significance Index: -65.1600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 193.4955
    Cell Significance Index: -79.7100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 179.3549
    Cell Significance Index: -84.6800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 159.1609
    Cell Significance Index: -81.8700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 126.7991
    Cell Significance Index: -85.0900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 64.6495
    Cell Significance Index: -79.7100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 26.2444
    Cell Significance Index: -70.3100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 21.4544
    Cell Significance Index: -84.6600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 20.6449
    Cell Significance Index: -63.4100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 11.3771
    Cell Significance Index: 120.8800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.3681
    Cell Significance Index: -24.8800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 5.4248
    Cell Significance Index: 33.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.9300
    Cell Significance Index: 134.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.2455
    Cell Significance Index: 199.5400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 4.2402
    Cell Significance Index: 74.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.1869
    Cell Significance Index: 148.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.9725
    Cell Significance Index: 384.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.6129
    Cell Significance Index: 194.7400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.3830
    Cell Significance Index: 68.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.2698
    Cell Significance Index: 290.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.2276
    Cell Significance Index: 305.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.2217
    Cell Significance Index: 59.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.2014
    Cell Significance Index: 142.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.9429
    Cell Significance Index: 1061.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.9203
    Cell Significance Index: 40.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.9123
    Cell Significance Index: 235.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.8758
    Cell Significance Index: 338.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.8582
    Cell Significance Index: 202.1200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.6875
    Cell Significance Index: 25.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6594
    Cell Significance Index: 75.2200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.6380
    Cell Significance Index: 56.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.5810
    Cell Significance Index: 698.9900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 1.5298
    Cell Significance Index: 174.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.5118
    Cell Significance Index: 106.9200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4461
    Cell Significance Index: 41.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3913
    Cell Significance Index: 37.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.3713
    Cell Significance Index: 234.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3365
    Cell Significance Index: 37.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1332
    Cell Significance Index: 1023.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0337
    Cell Significance Index: 121.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9970
    Cell Significance Index: 51.7900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.9314
    Cell Significance Index: 24.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8477
    Cell Significance Index: 53.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7766
    Cell Significance Index: 154.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7103
    Cell Significance Index: 37.3000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.7068
    Cell Significance Index: 8.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6034
    Cell Significance Index: 98.1300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5013
    Cell Significance Index: 5.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3776
    Cell Significance Index: 75.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3210
    Cell Significance Index: 61.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2997
    Cell Significance Index: 226.8600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2188
    Cell Significance Index: 2.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1379
    Cell Significance Index: 49.4700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1036
    Cell Significance Index: 71.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0574
    Cell Significance Index: 0.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0437
    Cell Significance Index: 4.3200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0124
    Cell Significance Index: 0.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0130
    Cell Significance Index: -8.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0230
    Cell Significance Index: -43.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0254
    Cell Significance Index: -18.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0427
    Cell Significance Index: -78.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0539
    Cell Significance Index: -82.9600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0547
    Cell Significance Index: -40.0900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0553
    Cell Significance Index: -3.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0618
    Cell Significance Index: -6.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0619
    Cell Significance Index: -84.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0896
    Cell Significance Index: -56.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1046
    Cell Significance Index: -58.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1386
    Cell Significance Index: -62.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1680
    Cell Significance Index: -35.3900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1803
    Cell Significance Index: -1.3000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1835
    Cell Significance Index: -5.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1869
    Cell Significance Index: -14.3400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1986
    Cell Significance Index: -1.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2471
    Cell Significance Index: -71.0900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3820
    Cell Significance Index: -3.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4345
    Cell Significance Index: -49.7800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4379
    Cell Significance Index: -5.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4472
    Cell Significance Index: -65.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4729
    Cell Significance Index: -11.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4935
    Cell Significance Index: -15.8100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5140
    Cell Significance Index: -13.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5156
    Cell Significance Index: -60.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5710
    Cell Significance Index: -7.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7146
    Cell Significance Index: -40.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7971
    Cell Significance Index: -83.0000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8779
    Cell Significance Index: -69.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8836
    Cell Significance Index: -23.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8893
    Cell Significance Index: -54.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9990
    Cell Significance Index: -67.1800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.0165
    Cell Significance Index: -23.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1230
    Cell Significance Index: -68.8500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.2537
    Cell Significance Index: -30.5900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -1.4164
    Cell Significance Index: -6.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.4824
    Cell Significance Index: -32.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.4825
    Cell Significance Index: -74.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.5312
    Cell Significance Index: -32.6100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.5482
    Cell Significance Index: -10.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.5943
    Cell Significance Index: -46.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ATF4 is a transcription factor that belongs to the CREB (cAMP response element-binding) family, which regulates gene expression in response to various stimuli. ATF4 is uniquely activated by ER stress, whereas other members of the CREB family are activated by different signals, such as cAMP or histone modifications. ATF4 is characterized by its ability to bind to specific DNA sequences, known as ATF4 binding elements (ATFEs), which are found in the promoter regions of target genes. ATF4 also forms heterodimers with other transcription factors, such as ATF6 and NF-κB, to regulate gene expression. **Pathways and Functions** ATF4 is involved in several cellular pathways, including: 1. **Unfolded Protein Response (UPR)**: ATF4 is a key regulator of the UPR, which is activated in response to ER stress. The UPR aims to restore ER homeostasis by increasing the expression of chaperone genes, reducing the production of misfolded proteins, and promoting the degradation of unfolded proteins. 2. **Cellular Stress Response**: ATF4 is activated in response to various forms of cellular stress, including ER stress, amino acid starvation, and oxidative stress. ATF4 regulates the expression of genes involved in stress response, such as heat shock proteins and antioxidant enzymes. 3. **Cell Differentiation**: ATF4 is involved in the regulation of cell differentiation, particularly in the development of skeletal muscle and neurons. ATF4 regulates the expression of genes involved in muscle differentiation, such as myosin heavy chain and actin. 4. **Apoptosis**: ATF4 can regulate apoptosis, or programmed cell death, in response to ER stress. ATF4 can promote or inhibit apoptosis, depending on the context and the presence of other transcription factors. **Clinical Significance** ATF4 has been implicated in various diseases and disorders, including: 1. **Cancer**: ATF4 has been shown to promote cancer cell survival and resistance to chemotherapy. ATF4 can regulate the expression of genes involved in cell survival and apoptosis, such as anti-apoptotic proteins and pro-apoptotic proteins. 2. **Neurodegenerative Diseases**: ATF4 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. ATF4 can regulate the expression of genes involved in neuronal survival and death, such as tau and amyloid precursor protein. 3. **Metabolic Disorders**: ATF4 has been shown to regulate glucose and lipid metabolism, and is implicated in metabolic disorders, such as diabetes and obesity. 4. **Infectious Diseases**: ATF4 has been implicated in the regulation of immune responses to infections, such as viral infections and bacterial infections. In summary, ATF4 is a critical transcription factor involved in various cellular processes, including stress response, cell differentiation, and survival. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of ATF4 in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 1683237712

Symbol: ATF4_HUMAN

Name: N/A

UniProtKB Accession Codes:

P18848 Q96AQ3 Q9UH31

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 26 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 ELM 1 EMBL 14 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 78 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 7 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1847461

Title: Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I.

PubMed ID: 1847461

DOI: 10.1128/jvi.65.3.1420-1426.1991

PubMed ID: 1534408

Title: Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element.

PubMed ID: 1534408

DOI: 10.1073/pnas.89.11.4820

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2516827

Title: Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.

PubMed ID: 2516827

DOI: 10.1101/gad.3.12b.2083

PubMed ID: 11238952

Title: ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase.

PubMed ID: 11238952

DOI: 10.1128/mcb.21.6.2192-2202.2001

PubMed ID: 11960987

Title: ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene.

PubMed ID: 11960987

DOI: 10.1074/jbc.m201959200

PubMed ID: 15109498

Title: ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome.

PubMed ID: 15109498

DOI: 10.1016/s0092-8674(04)00344-7

PubMed ID: 15775988

Title: TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death.

PubMed ID: 15775988

DOI: 10.1038/sj.emboj.7600596

PubMed ID: 16219772

Title: p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain.

PubMed ID: 16219772

DOI: 10.1074/jbc.m505294200

PubMed ID: 15911876

Title: FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice.

PubMed ID: 15911876

DOI: 10.1083/jcb.200412139

PubMed ID: 16682973

Title: The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4.

PubMed ID: 16682973

DOI: 10.1038/ng1786

PubMed ID: 17684156

Title: Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor.

PubMed ID: 17684156

DOI: 10.1182/blood-2007-06-094441

PubMed ID: 18940792

Title: C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene.

PubMed ID: 18940792

DOI: 10.1074/jbc.m806874200

PubMed ID: 20873783

Title: Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.

PubMed ID: 20873783

DOI: 10.1021/pr100562w

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21408167

Title: New modularity of DAP-kinases: alternative splicing of the DRP-1 gene produces a ZIPk-like isoform.

PubMed ID: 21408167

DOI: 10.1371/journal.pone.0017344

PubMed ID: 22974638

Title: ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway.

PubMed ID: 22974638

DOI: 10.1016/j.bbamcr.2012.08.020

PubMed ID: 23123191

Title: Functional interaction of protein kinase CK2 and activating transcription factor 4 (ATF4), a key player in the cellular stress response.

PubMed ID: 23123191

DOI: 10.1016/j.bbamcr.2012.10.025

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 26086088

Title: Transcription factor ATF4 induces NLRP1 inflammasome expression during endoplasmic reticulum stress.

PubMed ID: 26086088

DOI: 10.1371/journal.pone.0130635

PubMed ID: 27629041

Title: The integrated stress response.

PubMed ID: 27629041

DOI: 10.15252/embr.201642195

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31444471

Title: Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders.

PubMed ID: 31444471

DOI: 10.1038/s41380-019-0485-2

PubMed ID: 32132706

Title: A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.

PubMed ID: 32132706

DOI: 10.1038/s41586-020-2076-4

PubMed ID: 32132707

Title: Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway.

PubMed ID: 32132707

DOI: 10.1038/s41586-020-2078-2

PubMed ID: 33384352

Title: QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis.

PubMed ID: 33384352

DOI: 10.1126/science.abb6896

PubMed ID: 11018027

Title: Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA.

PubMed ID: 11018027

DOI: 10.1074/jbc.m005594200

Sequence Information:

  • Length: 351
  • Mass: 38590
  • Checksum: 3BBB7379DC3B0D07
  • Sequence:
    • MTEMSFLSSE VLVGDLMSPF DQSGLGAEES LGLLDDYLEV AKHFKPHGFS SDKAKAGSSE 
WLAVDGLVSP SNNSKEDAFS GTDWMLEKMD LKEFDLDALL GIDDLETMPD DLLTTLDDTC 
DLFAPLVQET NKQPPQTVNP IGHLPESLTK PDQVAPFTFL QPLPLSPGVL SSTPDHSFSL 
ELGSEVDITE GDRKPDYTAY VAMIPQCIKE EDTPSDNDSG ICMSPESYLG SPQHSPSTRG 
SPNRSLPSPG VLCGSARPKP YDPPGEKMVA AKVKGEKLDK KLKKMEQNKT AATRYRQKKR 
AEQEALTGEC KELEKKNEAL KERADSLAKE IQYLKDLIEE VRKARGKKRV P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.