Details for: ATF4

Gene ID: 468

Symbol: ATF4

Ensembl ID: ENSG00000128272

Description: activating transcription factor 4

Associated with

  • Atf4 activates genes in response to endoplasmic reticulum stress
    (R-HSA-380994)
  • Atf6 (atf6-alpha) activates chaperone genes
    (R-HSA-381183)
  • Atf6 (atf6-alpha) activates chaperones
    (R-HSA-381033)
  • Cellular responses to stimuli
    (R-HSA-8953897)
  • Cellular responses to stress
    (R-HSA-2262752)
  • Cellular response to chemical stress
    (R-HSA-9711123)
  • Cellular response to starvation
    (R-HSA-9711097)
  • Keap1-nfe2l2 pathway
    (R-HSA-9755511)
  • Nfe2l2 regulating anti-oxidant/detoxification enzymes
    (R-HSA-9818027)
  • Nfe2l2 regulating er-stress associated genes
    (R-HSA-9818035)
  • Nuclear events mediated by nfe2l2
    (R-HSA-9759194)
  • Perk regulates gene expression
    (R-HSA-381042)
  • Response of eif2ak1 (hri) to heme deficiency
    (R-HSA-9648895)
  • Response of eif2ak4 (gcn2) to amino acid deficiency
    (R-HSA-9633012)
  • Unfolded protein response (upr)
    (R-HSA-381119)
  • Bone mineralization
    (GO:0030282)
  • Camp response element binding protein binding
    (GO:0008140)
  • Cellular response to amino acid starvation
    (GO:0034198)
  • Cellular response to glucose starvation
    (GO:0042149)
  • Cellular response to hypoxia
    (GO:0071456)
  • Cellular response to leucine starvation
    (GO:1990253)
  • Cellular response to oxidative stress
    (GO:0034599)
  • Cellular response to uv
    (GO:0034644)
  • Chromatin
    (GO:0000785)
  • Circadian regulation of gene expression
    (GO:0032922)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Embryonic hemopoiesis
    (GO:0035162)
  • Endoplasmic reticulum unfolded protein response
    (GO:0030968)
  • Gamma-aminobutyric acid signaling pathway
    (GO:0007214)
  • General transcription initiation factor binding
    (GO:0140296)
  • Gluconeogenesis
    (GO:0006094)
  • Hri-mediated signaling
    (GO:0140468)
  • Identical protein binding
    (GO:0042802)
  • Integrated stress response signaling
    (GO:0140467)
  • Intracellular calcium ion homeostasis
    (GO:0006874)
  • Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
    (GO:0070059)
  • L-asparagine metabolic process
    (GO:0070982)
  • Lens fiber cell morphogenesis
    (GO:0070309)
  • Leucine zipper domain binding
    (GO:0043522)
  • Mrna transcription by rna polymerase ii
    (GO:0042789)
  • Negative regulation of cold-induced thermogenesis
    (GO:0120163)
  • Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
    (GO:1903377)
  • Negative regulation of potassium ion transport
    (GO:0043267)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of translational initiation in response to stress
    (GO:0032057)
  • Neuron differentiation
    (GO:0030182)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Perk-mediated unfolded protein response
    (GO:0036499)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of biomineral tissue development
    (GO:0070169)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Positive regulation of sodium-dependent phosphate transport
    (GO:2000120)
  • Positive regulation of transcription by rna polymerase i
    (GO:0045943)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of vascular associated smooth muscle cell apoptotic process
    (GO:1905461)
  • Positive regulation of vascular endothelial growth factor production
    (GO:0010575)
  • Promoter-specific chromatin binding
    (GO:1990841)
  • Protein binding
    (GO:0005515)
  • Protein heterodimerization activity
    (GO:0046982)
  • Protein kinase binding
    (GO:0019901)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of osteoblast differentiation
    (GO:0045667)
  • Regulation of synaptic plasticity
    (GO:0048167)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to endoplasmic reticulum stress
    (GO:0034976)
  • Response to manganese-induced endoplasmic reticulum stress
    (GO:1990737)
  • Response to nutrient levels
    (GO:0031667)
  • Response to toxic substance
    (GO:0009636)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.03
    Marker Score: 2375
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.95
    Marker Score: 100295
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.89
    Marker Score: 3083
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.85
    Marker Score: 8140
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.79
    Marker Score: 13720
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.73
    Marker Score: 17405
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.71
    Marker Score: 2308
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.69
    Marker Score: 7423
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.66
    Marker Score: 6506.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.59
    Marker Score: 5898
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 2.54
    Marker Score: 701
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.49
    Marker Score: 9589
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.45
    Marker Score: 5571
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.45
    Marker Score: 4609
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.45
    Marker Score: 3939
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.44
    Marker Score: 15910
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.42
    Marker Score: 83828
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.39
    Marker Score: 1886
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.39
    Marker Score: 1002
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.36
    Marker Score: 3995
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.33
    Marker Score: 4731
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.32
    Marker Score: 1352
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 2.29
    Marker Score: 603
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.27
    Marker Score: 770
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.26
    Marker Score: 540
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.26
    Marker Score: 4001
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.22
    Marker Score: 1482
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.22
    Marker Score: 1264
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.22
    Marker Score: 22452
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.21
    Marker Score: 1092.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.2
    Marker Score: 29080
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.19
    Marker Score: 5150.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.18
    Marker Score: 17055.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.18
    Marker Score: 906
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.17
    Marker Score: 1429
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 2.17
    Marker Score: 438
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.15
    Marker Score: 970
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.15
    Marker Score: 1358
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.15
    Marker Score: 876
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.14
    Marker Score: 761
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.13
    Marker Score: 2225
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.12
    Marker Score: 3128.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.12
    Marker Score: 5542.5
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.11
    Marker Score: 1439
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.1
    Marker Score: 4199
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.1
    Marker Score: 3237
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.09
    Marker Score: 811
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.08
    Marker Score: 1998
  • Cell Name: PP cell (CL0000696)
    Fold Change: 2.08
    Marker Score: 468
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.07
    Marker Score: 1768
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.07
    Marker Score: 2211
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.06
    Marker Score: 4302
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.06
    Marker Score: 3273
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.06
    Marker Score: 2409
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 2.05
    Marker Score: 1429
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.04
    Marker Score: 1230
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.04
    Marker Score: 8343.5
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.03
    Marker Score: 7841
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 2.02
    Marker Score: 928
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.02
    Marker Score: 2628
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2
    Marker Score: 51347.5
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2
    Marker Score: 1970.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2
    Marker Score: 2746
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.99
    Marker Score: 2393
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.98
    Marker Score: 22354
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.98
    Marker Score: 1998
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.98
    Marker Score: 591
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.95
    Marker Score: 712
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.95
    Marker Score: 2063
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.95
    Marker Score: 713
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.94
    Marker Score: 1333
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.94
    Marker Score: 1872.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.93
    Marker Score: 1291
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.93
    Marker Score: 2028.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.93
    Marker Score: 107774
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 1.93
    Marker Score: 547
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.92
    Marker Score: 933
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.92
    Marker Score: 1722
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.92
    Marker Score: 3264
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.92
    Marker Score: 992
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.9
    Marker Score: 9140.5
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 1.9
    Marker Score: 536
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.9
    Marker Score: 7025
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.89
    Marker Score: 8165
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 1.89
    Marker Score: 1240
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.89
    Marker Score: 500
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.89
    Marker Score: 470
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.88
    Marker Score: 515
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.88
    Marker Score: 1181
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.88
    Marker Score: 665
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.88
    Marker Score: 1096
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.87
    Marker Score: 463
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.87
    Marker Score: 817
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.87
    Marker Score: 470
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.87
    Marker Score: 1760
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.87
    Marker Score: 9830
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.87
    Marker Score: 537
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.87
    Marker Score: 2409
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.86
    Marker Score: 2004
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.85
    Marker Score: 525

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Other Information

**Key characteristics:** * It is a key regulator of stress responses. * It is a key regulator of epithelial cells. * It is a key regulator of cell growth and differentiation. **Pathways and functions:** * It activates the expression of genes involved in the unfolded protein response (UPR). * It regulates the expression of genes involved in antioxidant and detoxification. * It regulates the expression of genes involved in stress resistance and survival. * It is a key regulator of cell growth and differentiation. **Clinical significance:** * Mutations in the ATF4 gene have been linked to a number of human diseases, including cancer, heart disease, and diabetes. * Targeting ATF4 has been shown to be a promising therapeutic strategy for these diseases. **Additional information:** * It is a member of the ATF family of transcription factors. * It is a key regulator of the unfolded protein response (UPR). * It is a key regulator of epithelial cell survival and differentiation.

Genular Protein ID: 1683237712

Symbol: ATF4_HUMAN

Name: N/A

UniProtKB Accession Codes:

P18848 Q96AQ3 Q9UH31

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 26 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 ELM 1 EMBL 14 EPD 1 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 80 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 7 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1847461

Title: Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I.

PubMed ID: 1847461

DOI: 10.1128/jvi.65.3.1420-1426.1991

PubMed ID: 1534408

Title: Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element.

PubMed ID: 1534408

DOI: 10.1073/pnas.89.11.4820

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2516827

Title: Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.

PubMed ID: 2516827

DOI: 10.1101/gad.3.12b.2083

PubMed ID: 11238952

Title: ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase.

PubMed ID: 11238952

DOI: 10.1128/mcb.21.6.2192-2202.2001

PubMed ID: 11960987

Title: ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene.

PubMed ID: 11960987

DOI: 10.1074/jbc.m201959200

PubMed ID: 15109498

Title: ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome.

PubMed ID: 15109498

DOI: 10.1016/s0092-8674(04)00344-7

PubMed ID: 15775988

Title: TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death.

PubMed ID: 15775988

DOI: 10.1038/sj.emboj.7600596

PubMed ID: 16219772

Title: p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain.

PubMed ID: 16219772

DOI: 10.1074/jbc.m505294200

PubMed ID: 15911876

Title: FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice.

PubMed ID: 15911876

DOI: 10.1083/jcb.200412139

PubMed ID: 16682973

Title: The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4.

PubMed ID: 16682973

DOI: 10.1038/ng1786

PubMed ID: 17684156

Title: Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor.

PubMed ID: 17684156

DOI: 10.1182/blood-2007-06-094441

PubMed ID: 18940792

Title: C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene.

PubMed ID: 18940792

DOI: 10.1074/jbc.m806874200

PubMed ID: 20873783

Title: Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.

PubMed ID: 20873783

DOI: 10.1021/pr100562w

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21408167

Title: New modularity of DAP-kinases: alternative splicing of the DRP-1 gene produces a ZIPk-like isoform.

PubMed ID: 21408167

DOI: 10.1371/journal.pone.0017344

PubMed ID: 22974638

Title: ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway.

PubMed ID: 22974638

DOI: 10.1016/j.bbamcr.2012.08.020

PubMed ID: 23123191

Title: Functional interaction of protein kinase CK2 and activating transcription factor 4 (ATF4), a key player in the cellular stress response.

PubMed ID: 23123191

DOI: 10.1016/j.bbamcr.2012.10.025

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 26086088

Title: Transcription factor ATF4 induces NLRP1 inflammasome expression during endoplasmic reticulum stress.

PubMed ID: 26086088

DOI: 10.1371/journal.pone.0130635

PubMed ID: 27629041

Title: The integrated stress response.

PubMed ID: 27629041

DOI: 10.15252/embr.201642195

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31444471

Title: Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders.

PubMed ID: 31444471

DOI: 10.1038/s41380-019-0485-2

PubMed ID: 32132706

Title: A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.

PubMed ID: 32132706

DOI: 10.1038/s41586-020-2076-4

PubMed ID: 32132707

Title: Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway.

PubMed ID: 32132707

DOI: 10.1038/s41586-020-2078-2

PubMed ID: 33384352

Title: QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis.

PubMed ID: 33384352

DOI: 10.1126/science.abb6896

PubMed ID: 11018027

Title: Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA.

PubMed ID: 11018027

DOI: 10.1074/jbc.m005594200

Sequence Information:

  • Length: 351
  • Mass: 38590
  • Checksum: 3BBB7379DC3B0D07
  • Sequence:
    • MTEMSFLSSE VLVGDLMSPF DQSGLGAEES LGLLDDYLEV AKHFKPHGFS SDKAKAGSSE 
WLAVDGLVSP SNNSKEDAFS GTDWMLEKMD LKEFDLDALL GIDDLETMPD DLLTTLDDTC 
DLFAPLVQET NKQPPQTVNP IGHLPESLTK PDQVAPFTFL QPLPLSPGVL SSTPDHSFSL 
ELGSEVDITE GDRKPDYTAY VAMIPQCIKE EDTPSDNDSG ICMSPESYLG SPQHSPSTRG 
SPNRSLPSPG VLCGSARPKP YDPPGEKMVA AKVKGEKLDK KLKKMEQNKT AATRYRQKKR 
AEQEALTGEC KELEKKNEAL KERADSLAKE IQYLKDLIEE VRKARGKKRV P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.