Details for: ACLY

Gene ID: 47

Symbol: ACLY

Ensembl ID: ENSG00000131473

Description: ATP citrate lyase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 180.7834
    Cell Significance Index: -28.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 113.1904
    Cell Significance Index: -28.7100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 71.3374
    Cell Significance Index: -33.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 65.6235
    Cell Significance Index: -26.6600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 61.1798
    Cell Significance Index: -31.4700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.0809
    Cell Significance Index: -26.8100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.2645
    Cell Significance Index: -31.1500
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 17.6393
    Cell Significance Index: 283.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.9375
    Cell Significance Index: -29.3000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.0891
    Cell Significance Index: -31.9200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.0439
    Cell Significance Index: -21.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.5607
    Cell Significance Index: -12.1700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3610
    Cell Significance Index: 148.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0267
    Cell Significance Index: 203.7500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6466
    Cell Significance Index: 33.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6436
    Cell Significance Index: 351.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5027
    Cell Significance Index: 14.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4655
    Cell Significance Index: 93.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4342
    Cell Significance Index: 30.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4314
    Cell Significance Index: 77.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3869
    Cell Significance Index: 18.0400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3561
    Cell Significance Index: 57.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3542
    Cell Significance Index: 67.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3492
    Cell Significance Index: 34.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3357
    Cell Significance Index: 41.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3169
    Cell Significance Index: 113.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2930
    Cell Significance Index: 264.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2239
    Cell Significance Index: 154.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2172
    Cell Significance Index: 10.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2051
    Cell Significance Index: 13.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1907
    Cell Significance Index: 22.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1896
    Cell Significance Index: 10.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1830
    Cell Significance Index: 25.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1785
    Cell Significance Index: 78.9400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1736
    Cell Significance Index: 7.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1385
    Cell Significance Index: 3.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1270
    Cell Significance Index: 9.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1241
    Cell Significance Index: 21.1900
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.1240
    Cell Significance Index: 0.5400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1151
    Cell Significance Index: 8.1400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0928
    Cell Significance Index: 0.8500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0739
    Cell Significance Index: 8.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0513
    Cell Significance Index: 6.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0404
    Cell Significance Index: 2.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0362
    Cell Significance Index: 0.7700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0274
    Cell Significance Index: 0.6000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0072
    Cell Significance Index: 0.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0066
    Cell Significance Index: 5.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0018
    Cell Significance Index: -3.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0028
    Cell Significance Index: -4.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0029
    Cell Significance Index: -5.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0100
    Cell Significance Index: -7.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0100
    Cell Significance Index: -13.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0101
    Cell Significance Index: -0.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0180
    Cell Significance Index: -11.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0182
    Cell Significance Index: -2.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0222
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0233
    Cell Significance Index: -14.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0291
    Cell Significance Index: -21.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0365
    Cell Significance Index: -20.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0407
    Cell Significance Index: -18.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0451
    Cell Significance Index: -4.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0673
    Cell Significance Index: -14.1900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0715
    Cell Significance Index: -1.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0840
    Cell Significance Index: -12.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1058
    Cell Significance Index: -12.1200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1113
    Cell Significance Index: -1.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1123
    Cell Significance Index: -32.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1342
    Cell Significance Index: -8.2500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1526
    Cell Significance Index: -2.6200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1673
    Cell Significance Index: -2.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1738
    Cell Significance Index: -10.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1752
    Cell Significance Index: -13.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1759
    Cell Significance Index: -20.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1804
    Cell Significance Index: -12.1300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2398
    Cell Significance Index: -5.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2470
    Cell Significance Index: -12.9700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2587
    Cell Significance Index: -6.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2798
    Cell Significance Index: -8.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3029
    Cell Significance Index: -31.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3120
    Cell Significance Index: -8.3500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.3353
    Cell Significance Index: -3.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3457
    Cell Significance Index: -27.3800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3542
    Cell Significance Index: -12.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3647
    Cell Significance Index: -16.1300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3727
    Cell Significance Index: -8.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3913
    Cell Significance Index: -23.9900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3982
    Cell Significance Index: -7.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4291
    Cell Significance Index: -16.2500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4324
    Cell Significance Index: -8.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4827
    Cell Significance Index: -13.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5139
    Cell Significance Index: -13.2100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5158
    Cell Significance Index: -14.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5578
    Cell Significance Index: -7.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6171
    Cell Significance Index: -17.6900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6422
    Cell Significance Index: -3.8800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.6561
    Cell Significance Index: -5.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6954
    Cell Significance Index: -24.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7074
    Cell Significance Index: -22.5300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7214
    Cell Significance Index: -15.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** ACLY catalyzes the conversion of citrate to acetyl-CoA, a crucial step in the citric acid cycle and fatty acid biosynthesis. 2. **Subcellular Localization:** ACLY is primarily found in the cytosol, where it regulates metabolic processes. 3. **Cellular Expression:** ACLY is expressed in various cell types, including adipocytes, trophoblasts, epithelial cells, and hematopoietic progenitor cells. 4. **Regulatory Mechanisms:** ACLY's expression is modulated by various factors, including coenzyme A, citrate, and transcription factors like ChREBP. **Pathways and Functions:** 1. **Acetyl-CoA Biosynthetic Process:** ACLY is essential for the production of acetyl-CoA, a key intermediate in energy metabolism, fatty acid biosynthesis, and the citric acid cycle. 2. **Fatty Acid Metabolism:** ACLY regulates the synthesis and degradation of fatty acids, influencing lipid homeostasis and energy storage. 3. **Regulation of Metabolic Gene Expression:** ACLY interacts with transcription factors, such as ChREBP, to modulate the expression of metabolic genes involved in energy metabolism and lipid biosynthesis. 4. **Immune Response:** ACLY is involved in the regulation of immune cell function, including neutrophil degranulation and the production of azurophilic granules. **Clinical Significance:** 1. **Metabolic Disorders:** Alterations in ACLY expression have been linked to metabolic disorders, such as obesity, type 2 diabetes, and fatty liver disease. 2. **Cancer:** ACLY's involvement in fatty acid biosynthesis and energy metabolism suggests its potential role in cancer progression and treatment resistance. 3. **Neurological Disorders:** ACLY's expression in neurons and glial cells may contribute to the pathophysiology of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Infectious Diseases:** ACLY's role in immune cell function and the regulation of metabolic pathways may influence the outcome of infectious diseases, such as sepsis and tuberculosis. In conclusion, ACLY is a multifunctional enzyme that plays a crucial role in various cellular processes, including energy metabolism, lipid biosynthesis, and immune response. Further research into ACLY's regulation, expression, and clinical significance will provide valuable insights into its potential as a therapeutic target for metabolic and immune disorders.

Genular Protein ID: 632920189

Symbol: ACLY_HUMAN

Name: ATP-citrate synthase

UniProtKB Accession Codes:

P53396 B4DIM0 B4E3P0 Q13037 Q9BRL0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 1 CTD 1 CarbonylDB 1 ChEBI 24 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 7 EMDB 18 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 35 PDBsum 35 PIR 1 PIRSF 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 6 Rhea 2 SABIO-RK 1 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1371749

Title: Cloning and expression of a human ATP-citrate lyase cDNA.

PubMed ID: 1371749

DOI: 10.1111/j.1432-1033.1992.tb16659.x

PubMed ID: 9116495

Title: Variant cDNA sequences of human ATP:citrate lyase: cloning, expression, and purification from baculovirus-infected insect cells.

PubMed ID: 9116495

DOI: 10.1006/prep.1996.0668

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10653665

Title: Phosphorylation of recombinant human ATP:citrate lyase by cAMP-dependent protein kinase abolishes homotropic allosteric regulation of the enzyme by citrate and increases the enzyme activity. Allosteric activation of ATP:citrate lyase by phosphorylated sugars.

PubMed ID: 10653665

DOI: 10.1021/bi992159y

PubMed ID: 16139798

Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

PubMed ID: 16139798

DOI: 10.1016/j.bbrc.2005.08.132

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19286649

Title: A novel direct homogeneous assay for ATP citrate lyase.

PubMed ID: 19286649

DOI: 10.1194/jlr.d900008-jlr200

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23932781

Title: Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth.

PubMed ID: 23932781

DOI: 10.1016/j.molcel.2013.07.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27664236

Title: Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression.

PubMed ID: 27664236

DOI: 10.1101/gad.283283.116

PubMed ID: 29779826

Title: The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.

PubMed ID: 29779826

DOI: 10.1016/j.cmet.2018.04.015

PubMed ID: 34491895

Title: ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation.

PubMed ID: 34491895

DOI: 10.7554/elife.62394

PubMed ID: 20558738

Title: Identification of the citrate-binding site of human ATP-citrate lyase using X-ray crystallography.

PubMed ID: 20558738

DOI: 10.1074/jbc.m109.078667

PubMed ID: 22102020

Title: ADP-Mg2+ bound to the ATP-grasp domain of ATP-citrate lyase.

PubMed ID: 22102020

DOI: 10.1107/s1744309111028363

Sequence Information:

  • Length: 1101
  • Mass: 120839
  • Checksum: 12BB4416A30DC30C
  • Sequence:
    • MSAKAISEQT GKELLYKFIC TTSAIQNRFK YARVTPDTDW ARLLQDHPWL LSQNLVVKPD 
QLIKRRGKLG LVGVNLTLDG VKSWLKPRLG QEATVGKATG FLKNFLIEPF VPHSQAEEFY 
VCIYATREGD YVLFHHEGGV DVGDVDAKAQ KLLVGVDEKL NPEDIKKHLL VHAPEDKKEI 
LASFISGLFN FYEDLYFTYL EINPLVVTKD GVYVLDLAAK VDATADYICK VKWGDIEFPP 
PFGREAYPEE AYIADLDAKS GASLKLTLLN PKGRIWTMVA GGGASVVYSD TICDLGGVNE 
LANYGEYSGA PSEQQTYDYA KTILSLMTRE KHPDGKILII GGSIANFTNV AATFKGIVRA 
IRDYQGPLKE HEVTIFVRRG GPNYQEGLRV MGEVGKTTGI PIHVFGTETH MTAIVGMALG 
HRPIPNQPPT AAHTANFLLN ASGSTSTPAP SRTASFSESR ADEVAPAKKA KPAMPQDSVP 
SPRSLQGKST TLFSRHTKAI VWGMQTRAVQ GMLDFDYVCS RDEPSVAAMV YPFTGDHKQK 
FYWGHKEILI PVFKNMADAM RKHPEVDVLI NFASLRSAYD STMETMNYAQ IRTIAIIAEG 
IPEALTRKLI KKADQKGVTI IGPATVGGIK PGCFKIGNTG GMLDNILASK LYRPGSVAYV 
SRSGGMSNEL NNIISRTTDG VYEGVAIGGD RYPGSTFMDH VLRYQDTPGV KMIVVLGEIG 
GTEEYKICRG IKEGRLTKPI VCWCIGTCAT MFSSEVQFGH AGACANQASE TAVAKNQALK 
EAGVFVPRSF DELGEIIQSV YEDLVANGVI VPAQEVPPPT VPMDYSWARE LGLIRKPASF 
MTSICDERGQ ELIYAGMPIT EVFKEEMGIG GVLGLLWFQK RLPKYSCQFI EMCLMVTADH 
GPAVSGAHNT IICARAGKDL VSSLTSGLLT IGDRFGGALD AAAKMFSKAF DSGIIPMEFV 
NKMKKEGKLI MGIGHRVKSI NNPDMRVQIL KDYVRQHFPA TPLLDYALEV EKITTSKKPN 
LILNVDGLIG VAFVDMLRNC GSFTREEADE YIDIGALNGI FVLGRSMGFI GHYLDQKRLK 
QGLYRHPWDD ISYVLPEHMS M

Genular Protein ID: 267288009

Symbol: Q4LE36_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4LE36

Database IDs:

ARBA 15 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 7 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 6 Gene3D 4 IntAct 1 InterPro 12 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PROSITE 3 Pfam 4 RefSeq 2 Rhea 2 SAM 1 SMART 2 SUPFAM 4

Sequence Information:

  • Length: 1137
  • Mass: 124557
  • Checksum: E634EE8F9AEDB882
  • Sequence:
    • LPAAGVLRIL RGSSGLWKKR RARTSAETGR AGLSAAMSAK AISEQTGKEL LYKFICTTSA 
IQNRFKYARV TPDTDWARLL QDHPWLLSQN LVVKPDQLIK RRGKLGLVGV NLTLDGVKSW 
LKPRLGQEAT VGKATGFLKN FLIEPFVPHS QAEEFYVCIY ATREGDYVLF HHEGGVDVGD 
VDAKAQKLLV GVDEKLNPED IKKHLLVHAP EDKKEILASF ISGLFNFYED LYFTYLEINP 
LVVTKDGVYV LDLAAKVDAT ADYICKVKWG DIEFPPPFGR EAYPEEAYIA DLDAKSGASL 
KLTLLNPKGR IWTMVAGGGA SVVYSDTICD LGGVNELANY GEYSGAPSEQ QTYDYAKTIL 
SLMTREKHPD GKILIIGGSI ANFTNVAATF KGIVRAIRDY QGPLKEHEVT IFVRRGGPNY 
QEGLRVMGEV GKTTGIPIHV FGTETHMTAI VGMALGHRPI PNQPPTAAHT ANFLLNASGS 
TSTPAPSRTA SFSESRADEV APAKKAKPAM PQDSVPSPRS LQGKSTTLFS RHTKAIVWGM 
QTRAVQGMLD FDYVCSRDEP SVAAMVYPFT GDHKQKFYWG HKEILIPVFK NMADAMRKHP 
EVDVLINFAS LRSAYDSTME TMNYAQIRTI AIIAEGIPEA LTRKLIKKAD QKGVTIIGPA 
TVGGIKPGCF KIGNTGGMLD NILASKLYRP GSVAYVSRSG GMSNELNNII SRTTDGVYEG 
VAIGGDRYPG STFMDHVLRY QDTPGVKMIV VLGEIGGTEE YKICRGIKEG RLTKPIVCWC 
IGTCATMFSS EVQFGHAGAC ANQASETAVA KNQALKEAGV FVPRSFDELG EIIQSVYEDL 
VANGVIVPAQ EVPPPTVPMD YSWARELGLI RKPASFMTSI CDERGQELIY AGMPITEVFK 
EEMGIGGVLG LLWFQKRLPK YSCQFIEMCL MVTADHGPAV SGAHNTIICA RAGKDLVSSL 
TSGLLTIGDR FGGALDAAAK MFSKAFDSGI IPMEFVNKMK KEGKLIMGIG HRVKSINNPD 
MRVQILKDYV RQHFPATPLL DYALEVEKIT TSKKPNLILN VDGLIGVAFV DMLRNCGSFT 
REEADEYIDI GALNGIFVLG RSMGFIGHYL DQKRLKQGLY RHPWDDISYV LPEHMSM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.