Details for: ACLY

Gene ID: 47

Symbol: ACLY

Ensembl ID: ENSG00000131473

Description: ATP citrate lyase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 3.54
    Marker Score: 1718
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.23
    Marker Score: 1994
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.75
    Marker Score: 704
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.5
    Marker Score: 3535
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.48
    Marker Score: 1593
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.47
    Marker Score: 537
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167726
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.23
    Marker Score: 457
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.18
    Marker Score: 686
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.18
    Marker Score: 797
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.17
    Marker Score: 4150
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.15
    Marker Score: 395
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.14
    Marker Score: 1421
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.12
    Marker Score: 1160
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.07
    Marker Score: 37155
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.03
    Marker Score: 1159
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.03
    Marker Score: 4274
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1
    Marker Score: 15640
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.98
    Marker Score: 2414
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30385
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.96
    Marker Score: 513
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2388
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.94
    Marker Score: 1510
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.92
    Marker Score: 322
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 472
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.91
    Marker Score: 1314
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.91
    Marker Score: 205
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2723
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 428
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.9
    Marker Score: 865
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.9
    Marker Score: 282
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5102
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.88
    Marker Score: 218
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.88
    Marker Score: 588
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.88
    Marker Score: 825
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.88
    Marker Score: 804
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.87
    Marker Score: 279
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.87
    Marker Score: 7595
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.85
    Marker Score: 905
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.84
    Marker Score: 435
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.84
    Marker Score: 1048
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.83
    Marker Score: 415
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.83
    Marker Score: 3591
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.83
    Marker Score: 587
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.83
    Marker Score: 5405
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.83
    Marker Score: 1274
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.82
    Marker Score: 551.5
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.82
    Marker Score: 1863
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.82
    Marker Score: 462
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.81
    Marker Score: 797
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.81
    Marker Score: 494
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.81
    Marker Score: 982
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.81
    Marker Score: 1319
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.81
    Marker Score: 9419
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.81
    Marker Score: 445.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.81
    Marker Score: 812
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.81
    Marker Score: 549
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.81
    Marker Score: 9069
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.8
    Marker Score: 270
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.8
    Marker Score: 1624
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.8
    Marker Score: 6937
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.79
    Marker Score: 196
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.79
    Marker Score: 375
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.79
    Marker Score: 575
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.79
    Marker Score: 3786
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.78
    Marker Score: 4707
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 313
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.78
    Marker Score: 659
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.77
    Marker Score: 431
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.77
    Marker Score: 334
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.77
    Marker Score: 4902
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.77
    Marker Score: 209
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.76
    Marker Score: 519
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.75
    Marker Score: 4576
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.75
    Marker Score: 19279
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 575
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.75
    Marker Score: 342
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.74
    Marker Score: 415
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.74
    Marker Score: 470
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.74
    Marker Score: 302
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.74
    Marker Score: 414
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.74
    Marker Score: 213
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.74
    Marker Score: 45403
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.74
    Marker Score: 267
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.73
    Marker Score: 548
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.73
    Marker Score: 2810
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.73
    Marker Score: 2971
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.72
    Marker Score: 6792
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.72
    Marker Score: 455.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.72
    Marker Score: 40154
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.72
    Marker Score: 772
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.71
    Marker Score: 945
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.71
    Marker Score: 1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.71
    Marker Score: 169
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.71
    Marker Score: 638
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.71
    Marker Score: 747
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2958.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.7
    Marker Score: 1402

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Other Information

**Key characteristics:** * Gene name: ACLY * Ensembl ID: ENSG00000131473 * Protein: ACLY_HUMAN (ATP-citrate synthase) * Protein length: 531 amino acids * Subcellular location: Mitochondria * Expression: Significantly expressed in epicardial adipocyte, extravillous trophoblast, type A enteroendocrine cell, kidney proximal straight tubule epithelial cell, Leydig cell, subcutaneous fat cell, mural cell, P/D1 enteroendocrine cell, luminal cell of prostate epithelium, proerythroblast **Pathways and functions:** * **Acetyl-CoA biosynthetic process:** ACLY is involved in the citric acid cycle, a central metabolic pathway responsible for the metabolism of acetyl-CoA derived from the breakdown of carbohydrates, fats, and proteins. * **Atp binding:** ACLY can bind to ATP, regulating its activity through allosteric interactions. * **Atp citrate synthase activity:** ACLY is a key enzyme in the citric acid cycle, catalyzing the hydrolysis of ATP to ADP and citrate. * **Chrebp activates metabolic gene expression:** Through phosphorylation by Chrebp, ACLY is activated, leading to the expression of genes involved in the citric acid cycle. * **Citrate metabolic process:** ACLY is involved in the citric acid cycle, where it catalyzes the transfer of a hydrogen ion from citrate to oxaloacetate, generating a proton gradient used to generate ATP through oxidative phosphorylation. * **Fatty acid metabolism:** ACLY is involved in fatty acid metabolism, including the synthesis of ketone bodies from acetyl-CoA derived from fatty acids. * **Fatty acyl-CoA biosynthesis:** ACLY is involved in the biosynthesis of fatty acyl-CoA, a precursor for the synthesis of ketone bodies and other lipids. * **Immune system:** ACLY is expressed in immune cells, where it plays a role in innate immune responses and the regulation of inflammation. * **Innate immune system:** ACLY is involved in the regulation of inflammation and immune responses. * **Integration of energy metabolism:** ACLY is involved in the integration of energy metabolism, ensuring that the citric acid cycle is activated during periods of energy stress. * **Metabolism:** ACLY is involved in various metabolic processes, including the metabolism of lipids, protein, and carbohydrates. * **Metal ion binding:** ACLY can bind to metal ions, such as calcium and magnesium, which are involved in various cellular processes. * **Neutrophil degranulation:** ACLY is expressed in neutrophils, where it plays a role in the degranulation of these immune cells. * **Oxaloacetate metabolic process:** ACLY is involved in the oxaloacetate metabolic process, a central metabolic pathway in the mitochondria. **Clinical significance:** * Mutations in the ACLY gene have been linked to various human diseases, including obesity, diabetes, and metabolic syndrome. * Studies have shown that targeting ACLY with small molecule inhibitors can improve insulin sensitivity, reduce inflammation, and promote metabolism.

Genular Protein ID: 632920189

Symbol: ACLY_HUMAN

Name: ATP-citrate synthase

UniProtKB Accession Codes:

P53396 B4DIM0 B4E3P0 Q13037 Q9BRL0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 1 CTD 1 CarbonylDB 1 ChEBI 24 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 7 EMDB 18 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 4 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 48 PDBsum 35 PIR 1 PIRSF 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 6 Rhea 2 SABIO-RK 1 SAM 1 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1371749

Title: Cloning and expression of a human ATP-citrate lyase cDNA.

PubMed ID: 1371749

DOI: 10.1111/j.1432-1033.1992.tb16659.x

PubMed ID: 9116495

Title: Variant cDNA sequences of human ATP:citrate lyase: cloning, expression, and purification from baculovirus-infected insect cells.

PubMed ID: 9116495

DOI: 10.1006/prep.1996.0668

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10653665

Title: Phosphorylation of recombinant human ATP:citrate lyase by cAMP-dependent protein kinase abolishes homotropic allosteric regulation of the enzyme by citrate and increases the enzyme activity. Allosteric activation of ATP:citrate lyase by phosphorylated sugars.

PubMed ID: 10653665

DOI: 10.1021/bi992159y

PubMed ID: 16139798

Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

PubMed ID: 16139798

DOI: 10.1016/j.bbrc.2005.08.132

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19286649

Title: A novel direct homogeneous assay for ATP citrate lyase.

PubMed ID: 19286649

DOI: 10.1194/jlr.d900008-jlr200

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23932781

Title: Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth.

PubMed ID: 23932781

DOI: 10.1016/j.molcel.2013.07.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27664236

Title: Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression.

PubMed ID: 27664236

DOI: 10.1101/gad.283283.116

PubMed ID: 29779826

Title: The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.

PubMed ID: 29779826

DOI: 10.1016/j.cmet.2018.04.015

PubMed ID: 34491895

Title: ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation.

PubMed ID: 34491895

DOI: 10.7554/elife.62394

PubMed ID: 20558738

Title: Identification of the citrate-binding site of human ATP-citrate lyase using X-ray crystallography.

PubMed ID: 20558738

DOI: 10.1074/jbc.m109.078667

PubMed ID: 22102020

Title: ADP-Mg2+ bound to the ATP-grasp domain of ATP-citrate lyase.

PubMed ID: 22102020

DOI: 10.1107/s1744309111028363

Sequence Information:

  • Length: 1101
  • Mass: 120839
  • Checksum: 12BB4416A30DC30C
  • Sequence:
    • MSAKAISEQT GKELLYKFIC TTSAIQNRFK YARVTPDTDW ARLLQDHPWL LSQNLVVKPD 
QLIKRRGKLG LVGVNLTLDG VKSWLKPRLG QEATVGKATG FLKNFLIEPF VPHSQAEEFY 
VCIYATREGD YVLFHHEGGV DVGDVDAKAQ KLLVGVDEKL NPEDIKKHLL VHAPEDKKEI 
LASFISGLFN FYEDLYFTYL EINPLVVTKD GVYVLDLAAK VDATADYICK VKWGDIEFPP 
PFGREAYPEE AYIADLDAKS GASLKLTLLN PKGRIWTMVA GGGASVVYSD TICDLGGVNE 
LANYGEYSGA PSEQQTYDYA KTILSLMTRE KHPDGKILII GGSIANFTNV AATFKGIVRA 
IRDYQGPLKE HEVTIFVRRG GPNYQEGLRV MGEVGKTTGI PIHVFGTETH MTAIVGMALG 
HRPIPNQPPT AAHTANFLLN ASGSTSTPAP SRTASFSESR ADEVAPAKKA KPAMPQDSVP 
SPRSLQGKST TLFSRHTKAI VWGMQTRAVQ GMLDFDYVCS RDEPSVAAMV YPFTGDHKQK 
FYWGHKEILI PVFKNMADAM RKHPEVDVLI NFASLRSAYD STMETMNYAQ IRTIAIIAEG 
IPEALTRKLI KKADQKGVTI IGPATVGGIK PGCFKIGNTG GMLDNILASK LYRPGSVAYV 
SRSGGMSNEL NNIISRTTDG VYEGVAIGGD RYPGSTFMDH VLRYQDTPGV KMIVVLGEIG 
GTEEYKICRG IKEGRLTKPI VCWCIGTCAT MFSSEVQFGH AGACANQASE TAVAKNQALK 
EAGVFVPRSF DELGEIIQSV YEDLVANGVI VPAQEVPPPT VPMDYSWARE LGLIRKPASF 
MTSICDERGQ ELIYAGMPIT EVFKEEMGIG GVLGLLWFQK RLPKYSCQFI EMCLMVTADH 
GPAVSGAHNT IICARAGKDL VSSLTSGLLT IGDRFGGALD AAAKMFSKAF DSGIIPMEFV 
NKMKKEGKLI MGIGHRVKSI NNPDMRVQIL KDYVRQHFPA TPLLDYALEV EKITTSKKPN 
LILNVDGLIG VAFVDMLRNC GSFTREEADE YIDIGALNGI FVLGRSMGFI GHYLDQKRLK 
QGLYRHPWDD ISYVLPEHMS M

Genular Protein ID: 267288009

Symbol: Q4LE36_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4LE36

Database IDs:

ARBA 17 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 7 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 GO 7 Gene3D 4 GenomeRNAi 1 IntAct 1 InterPro 12 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PROSITE 3 PeptideAtlas 1 Pfam 4 RefSeq 2 Rhea 2 SAM 1 SMART 2 SUPFAM 4

Sequence Information:

  • Length: 1137
  • Mass: 124557
  • Checksum: E634EE8F9AEDB882
  • Sequence:
    • LPAAGVLRIL RGSSGLWKKR RARTSAETGR AGLSAAMSAK AISEQTGKEL LYKFICTTSA 
IQNRFKYARV TPDTDWARLL QDHPWLLSQN LVVKPDQLIK RRGKLGLVGV NLTLDGVKSW 
LKPRLGQEAT VGKATGFLKN FLIEPFVPHS QAEEFYVCIY ATREGDYVLF HHEGGVDVGD 
VDAKAQKLLV GVDEKLNPED IKKHLLVHAP EDKKEILASF ISGLFNFYED LYFTYLEINP 
LVVTKDGVYV LDLAAKVDAT ADYICKVKWG DIEFPPPFGR EAYPEEAYIA DLDAKSGASL 
KLTLLNPKGR IWTMVAGGGA SVVYSDTICD LGGVNELANY GEYSGAPSEQ QTYDYAKTIL 
SLMTREKHPD GKILIIGGSI ANFTNVAATF KGIVRAIRDY QGPLKEHEVT IFVRRGGPNY 
QEGLRVMGEV GKTTGIPIHV FGTETHMTAI VGMALGHRPI PNQPPTAAHT ANFLLNASGS 
TSTPAPSRTA SFSESRADEV APAKKAKPAM PQDSVPSPRS LQGKSTTLFS RHTKAIVWGM 
QTRAVQGMLD FDYVCSRDEP SVAAMVYPFT GDHKQKFYWG HKEILIPVFK NMADAMRKHP 
EVDVLINFAS LRSAYDSTME TMNYAQIRTI AIIAEGIPEA LTRKLIKKAD QKGVTIIGPA 
TVGGIKPGCF KIGNTGGMLD NILASKLYRP GSVAYVSRSG GMSNELNNII SRTTDGVYEG 
VAIGGDRYPG STFMDHVLRY QDTPGVKMIV VLGEIGGTEE YKICRGIKEG RLTKPIVCWC 
IGTCATMFSS EVQFGHAGAC ANQASETAVA KNQALKEAGV FVPRSFDELG EIIQSVYEDL 
VANGVIVPAQ EVPPPTVPMD YSWARELGLI RKPASFMTSI CDERGQELIY AGMPITEVFK 
EEMGIGGVLG LLWFQKRLPK YSCQFIEMCL MVTADHGPAV SGAHNTIICA RAGKDLVSSL 
TSGLLTIGDR FGGALDAAAK MFSKAFDSGI IPMEFVNKMK KEGKLIMGIG HRVKSINNPD 
MRVQILKDYV RQHFPATPLL DYALEVEKIT TSKKPNLILN VDGLIGVAFV DMLRNCGSFT 
REEADEYIDI GALNGIFVLG RSMGFIGHYL DQKRLKQGLY RHPWDDISYV LPEHMSM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.