Details for: RERE

Gene ID: 473

Symbol: RERE

Ensembl ID: ENSG00000142599

Description: arginine-glutamic acid dipeptide repeats

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 829.9837
    Cell Significance Index: -129.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 495.4594
    Cell Significance Index: -125.6700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 272.4292
    Cell Significance Index: -128.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 257.1278
    Cell Significance Index: -104.4600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 235.9904
    Cell Significance Index: -121.3900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 109.6526
    Cell Significance Index: -104.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 105.2187
    Cell Significance Index: -129.7300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 46.3817
    Cell Significance Index: -124.2500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 40.4906
    Cell Significance Index: -124.3700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 35.8770
    Cell Significance Index: -78.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 33.0305
    Cell Significance Index: -130.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 10.3543
    Cell Significance Index: 581.0300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 7.0149
    Cell Significance Index: 431.1700
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 6.7412
    Cell Significance Index: 59.8400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 6.6890
    Cell Significance Index: 160.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 4.6396
    Cell Significance Index: 1664.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 4.3200
    Cell Significance Index: 331.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 4.0678
    Cell Significance Index: 807.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.7128
    Cell Significance Index: 103.7600
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 3.4329
    Cell Significance Index: 21.1800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 3.2991
    Cell Significance Index: 2281.8000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 3.1300
    Cell Significance Index: 76.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.1197
    Cell Significance Index: 625.8000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.8524
    Cell Significance Index: 60.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.2688
    Cell Significance Index: 58.3200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.2642
    Cell Significance Index: 44.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.8485
    Cell Significance Index: 81.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.7710
    Cell Significance Index: 119.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7504
    Cell Significance Index: 79.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.7347
    Cell Significance Index: 312.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.7171
    Cell Significance Index: 3233.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.6082
    Cell Significance Index: 60.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4083
    Cell Significance Index: 173.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.2690
    Cell Significance Index: 805.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.2181
    Cell Significance Index: 1875.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.1094
    Cell Significance Index: 2045.9500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0959
    Cell Significance Index: 119.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9116
    Cell Significance Index: 26.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.9010
    Cell Significance Index: 408.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.8981
    Cell Significance Index: 1221.1700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.8695
    Cell Significance Index: 14.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6897
    Cell Significance Index: 376.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6633
    Cell Significance Index: 14.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.6195
    Cell Significance Index: 17.6800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.6115
    Cell Significance Index: 6.3700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.5350
    Cell Significance Index: 7.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3597
    Cell Significance Index: 68.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3440
    Cell Significance Index: 47.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2866
    Cell Significance Index: 126.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2783
    Cell Significance Index: 45.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1787
    Cell Significance Index: 6.2800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1770
    Cell Significance Index: 2.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1121
    Cell Significance Index: 101.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0968
    Cell Significance Index: 5.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.0460
    Cell Significance Index: 4.7900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0079
    Cell Significance Index: 0.2100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0122
    Cell Significance Index: -0.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0304
    Cell Significance Index: -3.0100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0432
    Cell Significance Index: -0.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0485
    Cell Significance Index: -2.2800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0779
    Cell Significance Index: -1.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0785
    Cell Significance Index: -57.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0856
    Cell Significance Index: -4.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0947
    Cell Significance Index: -70.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1200
    Cell Significance Index: -3.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1499
    Cell Significance Index: -113.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1526
    Cell Significance Index: -95.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1706
    Cell Significance Index: -21.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1779
    Cell Significance Index: -100.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1971
    Cell Significance Index: -9.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2174
    Cell Significance Index: -37.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3273
    Cell Significance Index: -47.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3921
    Cell Significance Index: -82.5800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.3950
    Cell Significance Index: -6.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3971
    Cell Significance Index: -114.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4219
    Cell Significance Index: -49.7500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5060
    Cell Significance Index: -4.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.5871
    Cell Significance Index: -59.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6997
    Cell Significance Index: -52.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.7321
    Cell Significance Index: -94.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.7611
    Cell Significance Index: -88.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7833
    Cell Significance Index: -49.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.8133
    Cell Significance Index: -93.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.0901
    Cell Significance Index: -70.3300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.0907
    Cell Significance Index: -6.5900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.1118
    Cell Significance Index: -126.9100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.1821
    Cell Significance Index: -7.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.2099
    Cell Significance Index: -85.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.3596
    Cell Significance Index: -107.6800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.3641
    Cell Significance Index: -17.0100
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -1.4430
    Cell Significance Index: -18.1700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.6656
    Cell Significance Index: -36.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.7028
    Cell Significance Index: -104.4000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.7224
    Cell Significance Index: -23.5000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.7613
    Cell Significance Index: -22.2300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.7868
    Cell Significance Index: -35.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.9246
    Cell Significance Index: -66.8800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.9741
    Cell Significance Index: -29.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.9836
    Cell Significance Index: -56.8600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -2.0208
    Cell Significance Index: -66.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RERE is a small, non-coding protein composed of arginine-glutamic acid dipeptide repeats. It exhibits a unique structure, with multiple repeats that allow it to interact with various proteins and DNA sequences. The protein's ability to bind to chromatin and regulate transcriptional processes has been well-documented. RERE's expression is highly tissue-specific, with significant levels observed in photoreceptor cells, neurons, and epithelial cells. This tissue-specific expression is thought to be crucial for the regulation of cellular differentiation and development. **Pathways and Functions** RERE's involvement in various cellular processes can be attributed to its ability to interact with multiple proteins and DNA sequences. Its primary functions include: 1. **Chromatin remodeling**: RERE's interaction with histone deacetylase complexes allows it to regulate chromatin structure, influencing gene expression and cellular differentiation. 2. **Transcriptional regulation**: RERE acts as a transcriptional coactivator or corepressor, modulating the expression of target genes involved in developmental processes and cellular differentiation. 3. **Cellular differentiation**: RERE's expression in specific cell types, such as photoreceptor cells and neurons, suggests its role in regulating cellular differentiation and development. 4. **Neurodevelopmental processes**: RERE's involvement in the radial glia-guided migration of Purkinje cells indicates its importance in the development of the cerebellum. **Clinical Significance** The RERE gene has been implicated in various neurological disorders, including: 1. **Cerebellar disorders**: Mutations in RERE have been associated with cerebellar ataxia and other cerebellar disorders, highlighting its critical role in cerebellar development and function. 2. **Neurodevelopmental disorders**: RERE's involvement in neurodevelopmental processes suggests its potential role in disorders such as autism spectrum disorder and schizophrenia. 3. **Cancer**: RERE's ability to regulate transcriptional processes has led to its investigation as a potential oncogene in various cancers, including breast and lung cancer. In conclusion, the RERE gene is a critical regulator of developmental processes, cellular differentiation, and transcriptional control. Its unique structure and tissue-specific expression make it an attractive target for further investigation into its role in various diseases, including neurological disorders and cancer.

Genular Protein ID: 3965439129

Symbol: RERE_HUMAN

Name: Arginine-glutamic acid dipeptide repeats protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10814707

Title: Protein binding of a DRPLA family through arginine-glutamic acid dipeptide repeats is enhanced by extended polyglutamine.

PubMed ID: 10814707

DOI: 10.1093/hmg/9.9.1433

PubMed ID: 11331249

Title: Human RERE is localized to nuclear promyelocytic leukemia oncogenic domains and enhances apoptosis.

PubMed ID: 11331249

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 9455484

Title: Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.

PubMed ID: 9455484

DOI: 10.1093/dnares/4.5.345

PubMed ID: 10729226

Title: Identification and characterization of novel genes located at the t(1;15)(p36.2;q24) translocation breakpoint in the neuroblastoma cell line NGP.

PubMed ID: 10729226

DOI: 10.1006/geno.1999.6097

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19131340

Title: Atrophin proteins interact with the Fat1 cadherin and regulate migration and orientation in vascular smooth muscle cells.

PubMed ID: 19131340

DOI: 10.1074/jbc.m809333200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 27087320

Title: De novo mutations of RERE cause a genetic syndrome with features that overlap those associated with proximal 1p36 deletions.

PubMed ID: 27087320

DOI: 10.1016/j.ajhg.2016.03.002

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 1566
  • Mass: 172424
  • Checksum: ECA4A22026E3E96F
  • Sequence:
  • MTADKDKDKD KEKDRDRDRD REREKRDKAR ESENSRPRRS CTLEGGAKNY AESDHSEDED 
    NDNNSATAEE STKKNKKKPP KKKSRYERTD TGEITSYITE DDVVYRPGDC VYIESRRPNT 
    PYFICSIQDF KLVHNSQACC RSPTPALCDP PACSLPVASQ PPQHLSEAGR GPVGSKRDHL 
    LMNVKWYYRQ SEVPDSVYQH LVQDRHNEND SGRELVITDP VIKNRELFIS DYVDTYHAAA 
    LRGKCNISHF SDIFAAREFK ARVDSFFYIL GYNPETRRLN STQGEIRVGP SHQAKLPDLQ 
    PFPSPDGDTV TQHEELVWMP GVNDCDLLMY LRAARSMAAF AGMCDGGSTE DGCVAASRDD 
    TTLNALNTLH ESGYDAGKAL QRLVKKPVPK LIEKCWTEDE VKRFVKGLRQ YGKNFFRIRK 
    ELLPNKETGE LITFYYYWKK TPEAASSRAH RRHRRQAVFR RIKTRTASTP VNTPSRPPSS 
    EFLDLSSASE DDFDSEDSEQ ELKGYACRHC FTTTSKDWHH GGRENILLCT DCRIHFKKYG 
    ELPPIEKPVD PPPFMFKPVK EEDDGLSGKH SMRTRRSRGS MSTLRSGRKK QPASPDGRTS 
    PINEDIRSSG RNSPSAASTS SNDSKAETVK KSAKKVKEEA SSPLKSNKRQ REKVASDTEE 
    ADRTSSKKTK TQEISRPNSP SEGEGESSDS RSVNDEGSSD PKDIDQDNRS TSPSIPSPQD 
    NESDSDSSAQ QQMLQAQPPA LQAPTGVTPA PSSAPPGTPQ LPTPGPTPSA TAVPPQGSPT 
    ASQAPNQPQA PTAPVPHTHI QQAPALHPQR PPSPHPPPHP SPHPPLQPLT GSAGQPSAPS 
    HAQPPLHGQG PPGPHSLQAG PLLQHPGPPQ PFGLPPQASQ GQAPLGTSPA AAYPHTSLQL 
    PASQSALQSQ QPPREQPLPP APLAMPHIKP PPTTPIPQLP APQAHKHPPH LSGPSPFSMN 
    ANLPPPPALK PLSSLSTHHP PSAHPPPLQL MPQSQPLPSS PAQPPGLTQS QNLPPPPASH 
    PPTGLHQVAP QPPFAQHPFV PGGPPPITPP TCPSTSTPPA GPGTSAQPPC SGAAASGGSI 
    AGGSSCPLPT VQIKEEALDD AEEPESPPPP PRSPSPEPTV VDTPSHASQS ARFYKHLDRG 
    YNSCARTDLY FMPLAGSKLA KKREEAIEKA KREAEQKARE EREREKEKEK ERERERERER 
    EAERAAKASS SAHEGRLSDP QLSGPGHMRP SFEPPPTTIA AVPPYIGPDT PALRTLSEYA 
    RPHVMSPTNR NHPFYMPLNP TDPLLAYHMP GLYNVDPTIR ERELREREIR EREIRERELR 
    ERMKPGFEVK PPELDPLHPA ANPMEHFARH SALTIPPTAG PHPFASFHPG LNPLERERLA 
    LAGPQLRPEM SYPDRLAAER IHAERMASLT SDPLARLQMF NVTPHHHQHS HIHSHLHLHQ 
    QDPLHQGSAG PVHPLVDPLT AGPHLARFPY PPGTLPNPLL GQPPHEHEML RHPVFGTPYP 
    RDLPGAIPPP MSAAHQLQAM HAQSAELQRL AMEQQWLHGH PHMHGGHLPS QEDYYSRLKK 
    EGDKQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.