Details for: RERE

Gene ID: 473

Symbol: RERE

Ensembl ID: ENSG00000142599

Description: arginine-glutamic acid dipeptide repeats

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 6.7
    Marker Score: 5041
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 6.42
    Marker Score: 33688
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 6.29
    Marker Score: 21087
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 6.09
    Marker Score: 108148
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 5.53
    Marker Score: 29680
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 5.51
    Marker Score: 4760
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 5.37
    Marker Score: 22380
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 5.32
    Marker Score: 4367
  • Cell Name: granule cell (CL0000120)
    Fold Change: 5.17
    Marker Score: 38966
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 5.11
    Marker Score: 4529
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 4.96
    Marker Score: 12408
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 4.62
    Marker Score: 3205
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.54
    Marker Score: 153262
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 4.25
    Marker Score: 10177
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 4.23
    Marker Score: 13851
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 4.22
    Marker Score: 9710
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 4.12
    Marker Score: 5545
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 4.05
    Marker Score: 2255
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.93
    Marker Score: 4750.5
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.89
    Marker Score: 87014
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 3.83
    Marker Score: 1842
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 3.71
    Marker Score: 4628
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.64
    Marker Score: 16825
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 3.63
    Marker Score: 5114
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.63
    Marker Score: 6978
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.55
    Marker Score: 7782.5
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.52
    Marker Score: 3992
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 3.52
    Marker Score: 2715
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 3.45
    Marker Score: 1784
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.38
    Marker Score: 14150
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 3.31
    Marker Score: 1645
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 3.28
    Marker Score: 1839
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 3.22
    Marker Score: 1695
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 3.21
    Marker Score: 926
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 3.18
    Marker Score: 3657
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.16
    Marker Score: 3009
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 3.13
    Marker Score: 1825
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 3.11
    Marker Score: 1806
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.09
    Marker Score: 66026
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 3.06
    Marker Score: 893
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.96
    Marker Score: 1082
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.93
    Marker Score: 931
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.88
    Marker Score: 1559
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.87
    Marker Score: 1419
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.83
    Marker Score: 56198
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.82
    Marker Score: 3044
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.82
    Marker Score: 1856
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.81
    Marker Score: 41949
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 2.8
    Marker Score: 926
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.8
    Marker Score: 21471
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.79
    Marker Score: 882
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.77
    Marker Score: 1447.5
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.73
    Marker Score: 1799
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.73
    Marker Score: 987
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.72
    Marker Score: 9657.5
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.68
    Marker Score: 1498
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.68
    Marker Score: 101676
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.66
    Marker Score: 42751
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.63
    Marker Score: 1573
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.63
    Marker Score: 1539
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.6
    Marker Score: 662
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.58
    Marker Score: 1820.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 2.53
    Marker Score: 937
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 2.52
    Marker Score: 3139
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.51
    Marker Score: 10408
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.51
    Marker Score: 4209
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2.5
    Marker Score: 909
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.5
    Marker Score: 7123
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.46
    Marker Score: 3575
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.44
    Marker Score: 938
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.43
    Marker Score: 89582
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.41
    Marker Score: 1008
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.38
    Marker Score: 2062
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.33
    Marker Score: 2884
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.29
    Marker Score: 8855
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.28
    Marker Score: 2441.5
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.28
    Marker Score: 2514
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.25
    Marker Score: 584
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.21
    Marker Score: 7832.5
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 2.16
    Marker Score: 808
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.15
    Marker Score: 20202
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.09
    Marker Score: 2956
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.07
    Marker Score: 127241
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 2.01
    Marker Score: 631
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 2
    Marker Score: 682
  • Cell Name: neuron (CL0000540)
    Fold Change: 2
    Marker Score: 8134
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.97
    Marker Score: 20389
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.94
    Marker Score: 732
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.94
    Marker Score: 942
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.94
    Marker Score: 1967
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.9
    Marker Score: 18017
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.89
    Marker Score: 2779
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.86
    Marker Score: 565
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.84
    Marker Score: 15811
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.83
    Marker Score: 500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.81
    Marker Score: 3685
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.81
    Marker Score: 4840
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.81
    Marker Score: 572
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.79
    Marker Score: 2086
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.78
    Marker Score: 1878

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - RERE is a large gene with a complex structure that includes multiple alternatively spliced transcripts. - It is expressed in a wide range of cell types, including neurons, oligodendrocytes, astrocytes, and ependymal cells. - It is involved in a variety of cellular processes, including branching morphogenesis, neuronal differentiation, and tissue repair. **Pathways and functions:** - RERE is a key regulator of the development and survival of neural stem cells. - It is required for the specification of oligodendrocyte and astrocyte lineages from neural stem cells. - It is also involved in the maintenance of a healthy CNS by promoting the survival of neurons and oligodendrocytes. - RERE is also involved in the development and maintenance of the blood-brain barrier. - It is a key regulator of the development of the cerebral cortex. **Clinical significance:** - Mutations in the RERE gene have been linked to several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). - These mutations can lead to a loss of function of the RERE protein, which can disrupt neural development and function. - Understanding the role of RERE in the CNS could lead to the development of new treatments for neurodegenerative diseases. **Additional information:** - RERE is a member of the RERE gene family, which is a family of proteins that are involved in the regulation of neural stem cell fate and differentiation. - The RERE protein is a protein-coding transcript that is highly conserved across species. - It is a well-characterized protein that has been extensively studied in model systems.

Genular Protein ID: 3965439129

Symbol: RERE_HUMAN

Name: Arginine-glutamic acid dipeptide repeats protein

UniProtKB Accession Codes:

Q9P2R6 O43393 O75046 O75359 Q5VXL9 Q6P6B9 Q9Y2W4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 CarbonylDB 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 6 SAM 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10814707

Title: Protein binding of a DRPLA family through arginine-glutamic acid dipeptide repeats is enhanced by extended polyglutamine.

PubMed ID: 10814707

DOI: 10.1093/hmg/9.9.1433

PubMed ID: 11331249

Title: Human RERE is localized to nuclear promyelocytic leukemia oncogenic domains and enhances apoptosis.

PubMed ID: 11331249

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 9455484

Title: Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.

PubMed ID: 9455484

DOI: 10.1093/dnares/4.5.345

PubMed ID: 10729226

Title: Identification and characterization of novel genes located at the t(1;15)(p36.2;q24) translocation breakpoint in the neuroblastoma cell line NGP.

PubMed ID: 10729226

DOI: 10.1006/geno.1999.6097

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19131340

Title: Atrophin proteins interact with the Fat1 cadherin and regulate migration and orientation in vascular smooth muscle cells.

PubMed ID: 19131340

DOI: 10.1074/jbc.m809333200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 27087320

Title: De novo mutations of RERE cause a genetic syndrome with features that overlap those associated with proximal 1p36 deletions.

PubMed ID: 27087320

DOI: 10.1016/j.ajhg.2016.03.002

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 1566
  • Mass: 172424
  • Checksum: ECA4A22026E3E96F
  • Sequence:
    • MTADKDKDKD KEKDRDRDRD REREKRDKAR ESENSRPRRS CTLEGGAKNY AESDHSEDED 
NDNNSATAEE STKKNKKKPP KKKSRYERTD TGEITSYITE DDVVYRPGDC VYIESRRPNT 
PYFICSIQDF KLVHNSQACC RSPTPALCDP PACSLPVASQ PPQHLSEAGR GPVGSKRDHL 
LMNVKWYYRQ SEVPDSVYQH LVQDRHNEND SGRELVITDP VIKNRELFIS DYVDTYHAAA 
LRGKCNISHF SDIFAAREFK ARVDSFFYIL GYNPETRRLN STQGEIRVGP SHQAKLPDLQ 
PFPSPDGDTV TQHEELVWMP GVNDCDLLMY LRAARSMAAF AGMCDGGSTE DGCVAASRDD 
TTLNALNTLH ESGYDAGKAL QRLVKKPVPK LIEKCWTEDE VKRFVKGLRQ YGKNFFRIRK 
ELLPNKETGE LITFYYYWKK TPEAASSRAH RRHRRQAVFR RIKTRTASTP VNTPSRPPSS 
EFLDLSSASE DDFDSEDSEQ ELKGYACRHC FTTTSKDWHH GGRENILLCT DCRIHFKKYG 
ELPPIEKPVD PPPFMFKPVK EEDDGLSGKH SMRTRRSRGS MSTLRSGRKK QPASPDGRTS 
PINEDIRSSG RNSPSAASTS SNDSKAETVK KSAKKVKEEA SSPLKSNKRQ REKVASDTEE 
ADRTSSKKTK TQEISRPNSP SEGEGESSDS RSVNDEGSSD PKDIDQDNRS TSPSIPSPQD 
NESDSDSSAQ QQMLQAQPPA LQAPTGVTPA PSSAPPGTPQ LPTPGPTPSA TAVPPQGSPT 
ASQAPNQPQA PTAPVPHTHI QQAPALHPQR PPSPHPPPHP SPHPPLQPLT GSAGQPSAPS 
HAQPPLHGQG PPGPHSLQAG PLLQHPGPPQ PFGLPPQASQ GQAPLGTSPA AAYPHTSLQL 
PASQSALQSQ QPPREQPLPP APLAMPHIKP PPTTPIPQLP APQAHKHPPH LSGPSPFSMN 
ANLPPPPALK PLSSLSTHHP PSAHPPPLQL MPQSQPLPSS PAQPPGLTQS QNLPPPPASH 
PPTGLHQVAP QPPFAQHPFV PGGPPPITPP TCPSTSTPPA GPGTSAQPPC SGAAASGGSI 
AGGSSCPLPT VQIKEEALDD AEEPESPPPP PRSPSPEPTV VDTPSHASQS ARFYKHLDRG 
YNSCARTDLY FMPLAGSKLA KKREEAIEKA KREAEQKARE EREREKEKEK ERERERERER 
EAERAAKASS SAHEGRLSDP QLSGPGHMRP SFEPPPTTIA AVPPYIGPDT PALRTLSEYA 
RPHVMSPTNR NHPFYMPLNP TDPLLAYHMP GLYNVDPTIR ERELREREIR EREIRERELR 
ERMKPGFEVK PPELDPLHPA ANPMEHFARH SALTIPPTAG PHPFASFHPG LNPLERERLA 
LAGPQLRPEM SYPDRLAAER IHAERMASLT SDPLARLQMF NVTPHHHQHS HIHSHLHLHQ 
QDPLHQGSAG PVHPLVDPLT AGPHLARFPY PPGTLPNPLL GQPPHEHEML RHPVFGTPYP 
RDLPGAIPPP MSAAHQLQAM HAQSAELQRL AMEQQWLHGH PHMHGGHLPS QEDYYSRLKK 
EGDKQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.