Details for: ATOH1

Gene ID: 474

Symbol: ATOH1

Ensembl ID: ENSG00000172238

Description: atonal bHLH transcription factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 6.6913
    Cell Significance Index: -4.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 3.4208
    Cell Significance Index: 651.0000
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 3.0532
    Cell Significance Index: 33.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.8779
    Cell Significance Index: 1695.5600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4067
    Cell Significance Index: 153.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2586
    Cell Significance Index: 75.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2360
    Cell Significance Index: 201.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 1.0540
    Cell Significance Index: 37.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8076
    Cell Significance Index: 55.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7914
    Cell Significance Index: 78.2900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.5913
    Cell Significance Index: 9.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3144
    Cell Significance Index: 14.2500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.1637
    Cell Significance Index: 1.6200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1413
    Cell Significance Index: 2.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0819
    Cell Significance Index: 2.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0368
    Cell Significance Index: 0.9200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.0317
    Cell Significance Index: 0.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0254
    Cell Significance Index: 0.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0234
    Cell Significance Index: 0.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0047
    Cell Significance Index: 0.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0011
    Cell Significance Index: 0.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0020
    Cell Significance Index: -0.0500
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.0021
    Cell Significance Index: -0.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0026
    Cell Significance Index: -1.4400
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0046
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0072
    Cell Significance Index: -0.8300
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0082
    Cell Significance Index: -0.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0136
    Cell Significance Index: -4.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0231
    Cell Significance Index: -4.6400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0510
    Cell Significance Index: -0.7300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0518
    Cell Significance Index: -0.5500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0561
    Cell Significance Index: -0.6600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0615
    Cell Significance Index: -0.8000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0646
    Cell Significance Index: -1.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0780
    Cell Significance Index: -1.6900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0840
    Cell Significance Index: -0.8700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0851
    Cell Significance Index: -1.0300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0855
    Cell Significance Index: -2.0500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0874
    Cell Significance Index: -1.2900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0928
    Cell Significance Index: -1.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0969
    Cell Significance Index: -5.4400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0997
    Cell Significance Index: -2.4900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1052
    Cell Significance Index: -2.2000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1080
    Cell Significance Index: -1.1600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1136
    Cell Significance Index: -1.3800
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1219
    Cell Significance Index: -1.1400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1228
    Cell Significance Index: -1.3000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1289
    Cell Significance Index: -1.1100
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.1432
    Cell Significance Index: -1.3000
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.1484
    Cell Significance Index: -1.3300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1523
    Cell Significance Index: -3.8800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1552
    Cell Significance Index: -5.0800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1556
    Cell Significance Index: -4.4400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1598
    Cell Significance Index: -5.0900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.1704
    Cell Significance Index: -2.1400
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.1780
    Cell Significance Index: -1.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1796
    Cell Significance Index: -2.4500
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1825
    Cell Significance Index: -1.3600
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1899
    Cell Significance Index: -1.6900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1900
    Cell Significance Index: -2.4800
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.1927
    Cell Significance Index: -2.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1941
    Cell Significance Index: -4.2500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1944
    Cell Significance Index: -4.2000
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1965
    Cell Significance Index: -1.9100
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.1990
    Cell Significance Index: -2.4500
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.2020
    Cell Significance Index: -1.7400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2064
    Cell Significance Index: -2.8300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2156
    Cell Significance Index: -4.3000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2171
    Cell Significance Index: -3.7200
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: -0.2194
    Cell Significance Index: -2.0300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2211
    Cell Significance Index: -2.5800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.2229
    Cell Significance Index: -1.4800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2233
    Cell Significance Index: -3.8200
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.2238
    Cell Significance Index: -2.1400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2286
    Cell Significance Index: -2.4900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2303
    Cell Significance Index: -2.5000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2311
    Cell Significance Index: -4.6400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2342
    Cell Significance Index: -4.5800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2357
    Cell Significance Index: -4.6600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2403
    Cell Significance Index: -2.7500
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.2457
    Cell Significance Index: -1.5700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.2471
    Cell Significance Index: -2.4900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2501
    Cell Significance Index: -4.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2555
    Cell Significance Index: -8.8800
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2584
    Cell Significance Index: -1.7200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2856
    Cell Significance Index: -4.2800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2858
    Cell Significance Index: -4.3400
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.2872
    Cell Significance Index: -3.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2892
    Cell Significance Index: -4.8400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2914
    Cell Significance Index: -4.1400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2950
    Cell Significance Index: -4.3000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3005
    Cell Significance Index: -8.8500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3010
    Cell Significance Index: -3.9500
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.3028
    Cell Significance Index: -1.9700
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.3028
    Cell Significance Index: -3.3900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3054
    Cell Significance Index: -4.2800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3168
    Cell Significance Index: -4.6000
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.3179
    Cell Significance Index: -2.8900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3238
    Cell Significance Index: -5.5000
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.3239
    Cell Significance Index: -3.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcription Factor**: ATOH1 is a member of the basic helix-loop-helix (bHLH) transcription factor family, which plays a critical role in regulating gene expression by binding to specific DNA sequences. 2. **Cell Type Specificity**: ATOH1 is significantly expressed in various cell types, including glutamatergic neurons, microglial cells, blood vessel endothelial cells, T cells, and goblet cells, suggesting its role in regulating the development and function of these cells. 3. **Regulatory Functions**: ATOH1 is involved in regulating cell fate determination, differentiation, and survival by controlling the expression of target genes involved in these processes. 4. **Pathway Involvement**: ATOH1 is implicated in various signaling pathways, including Notch signaling, which is crucial for cell fate determination and differentiation. **Pathways and Functions** 1. **Auditory Receptor Cell Fate Determination**: ATOH1 regulates the expression of genes involved in the development and differentiation of auditory receptor cells, highlighting its role in hearing and balance. 2. **Neuron Fate Commitment**: ATOH1 is involved in regulating the expression of genes involved in neuron differentiation and survival, suggesting its role in maintaining neural tissue homeostasis. 3. **Axon Development and Guidance**: ATOH1 is implicated in regulating the expression of genes involved in axon development and guidance, highlighting its role in neural circuit formation. 4. **Notch Signaling Pathway**: ATOH1 is a key regulator of the Notch signaling pathway, which is crucial for cell fate determination and differentiation. **Clinical Significance** 1. **Neurological Disorders**: Dysregulation of ATOH1 has been implicated in several neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia, highlighting the importance of this gene in maintaining neural tissue homeostasis. 2. **Cancer**: ATOH1 has been found to be overexpressed in certain types of cancer, including glioblastoma and colorectal cancer, suggesting its role in tumorigenesis and cancer progression. 3. **Hearing Loss**: Dysregulation of ATOH1 has been implicated in hearing loss, highlighting the importance of this gene in auditory system development and function. 4. **Immunological Disorders**: ATOH1 is significantly expressed in T cells and microglial cells, suggesting its role in regulating immune responses and preventing immunological disorders. In conclusion, ATOH1 is a critical transcription factor involved in regulating cell fate determination, differentiation, and survival in various cell types. Its dysregulation has been implicated in several neurological disorders and cancers, highlighting the importance of this gene in maintaining tissue homeostasis and preventing disease. Further studies are needed to fully elucidate the roles of ATOH1 in human disease and to develop therapeutic strategies targeting this gene.

Genular Protein ID: 1290922275

Symbol: ATOH1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q92858 Q14CT9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8872459

Title: Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis.

PubMed ID: 8872459

DOI: 10.1093/hmg/5.9.1207

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 33111345

Title: Spectrum of genes for inherited hearing loss in the Israeli Jewish population, including the novel human deafness gene ATOH1.

PubMed ID: 33111345

DOI: 10.1111/cge.13817

Sequence Information:

  • Length: 354
  • Mass: 38160
  • Checksum: AB12F1E917A00A8D
  • Sequence:
    • MSRLLHAEEW AEVKELGDHH RQPQPHHLPQ PPPPPQPPAT LQAREHPVYP PELSLLDSTD 
PRAWLAPTLQ GICTARAAQY LLHSPELGAS EAAAPRDEVD GRGELVRRSS GGASSSKSPG 
PVKVREQLCK LKGGVVVDEL GCSRQRAPSS KQVNGVQKQR RLAANARERR RMHGLNHAFD 
QLRNVIPSFN NDKKLSKYET LQMAQIYINA LSELLQTPSG GEQPPPPPAS CKSDHHHLRT 
AASYEGGAGN ATAAGAQQAS GGSQRPTPPG SCRTRFSAPA SAGGYSVQLD ALHFSTFEDS 
ALTAMMAQKN LSPSLPGSIL QPVQEENSKT SPRSHRSDGE FSPHSHYSDS DEAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.