Gene ATOH1 - ENSG00000172238 | NCBI Gene ID: 474

Details for: ATOH1

Gene ID: 474

Symbol: ATOH1

Ensembl ID: ENSG00000172238

Description: atonal bHLH transcription factor 1

Associated with

Auditory receptor cell fate determination
(GO:0042668)
Auditory receptor cell fate specification
(GO:0042667)
Axon development
(GO:0061564)
Axon guidance
(GO:0007411)
Central nervous system development
(GO:0007417)
Cerebral cortex development
(GO:0021987)
Chromatin
(GO:0000785)
Chromatin dna binding
(GO:0031490)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
E-box binding
(GO:0070888)
Epithelial cell apoptotic process
(GO:1904019)
Inner ear morphogenesis
(GO:0042472)
Negative regulation of epithelial cell apoptotic process
(GO:1904036)
Negative regulation of gliogenesis
(GO:0014014)
Neuroblast migration
(GO:0097402)
Neuron fate commitment
(GO:0048663)
Neuron migration
(GO:0001764)
Notch signaling pathway
(GO:0007219)
Nucleus
(GO:0005634)
Positive regulation of inner ear auditory receptor cell differentiation
(GO:0045609)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein dimerization activity
(GO:0046983)
Sensory organ development
(GO:0007423)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription by rna polymerase ii
(GO:0006366)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 15.98
Marker Score: 162043
Cell Name: microglial cell (CL0000129)
Fold Change: 3.75
Marker Score: 6820
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 3.14
Marker Score: 3164
Cell Name: T cell (CL0000084)
Fold Change: 2.4
Marker Score: 4144
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 1.98
Marker Score: 1899
Cell Name: plasma cell (CL0000786)
Fold Change: 1.87
Marker Score: 2094
Cell Name: B cell (CL0000236)
Fold Change: 1.19
Marker Score: 1135
Cell Name: goblet cell (CL0000160)
Fold Change: 1.1
Marker Score: 7329
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.05
Marker Score: 1990
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71791
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48023
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1
Marker Score: 514
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.99
Marker Score: 467
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.92
Marker Score: 331
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2742
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5217
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.91
Marker Score: 364
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.88
Marker Score: 1797
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5295
Cell Name: mast cell (CL0000097)
Fold Change: 0.85
Marker Score: 494
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1268
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 712
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.78
Marker Score: 402
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.77
Marker Score: 12022
Cell Name: pericyte (CL0000669)
Fold Change: 0.75
Marker Score: 440
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.73
Marker Score: 1177
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 458
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.71
Marker Score: 479
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.69
Marker Score: 499
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.69
Marker Score: 412
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.68
Marker Score: 2858
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.64
Marker Score: 509
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 173
Cell Name: fibroblast (CL0000057)
Fold Change: 0.53
Marker Score: 515
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.52
Marker Score: 215
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.51
Marker Score: 813.5
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.48
Marker Score: 128
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.47
Marker Score: 283
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.42
Marker Score: 2517
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.42
Marker Score: 375
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.41
Marker Score: 438.5
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4
Marker Score: 401
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.3
Marker Score: 626
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.3
Marker Score: 136
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.29
Marker Score: 139
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.27
Marker Score: 334
Cell Name: stromal cell (CL0000499)
Fold Change: 0.27
Marker Score: 316
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.25
Marker Score: 54
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 0.24
Marker Score: 77
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.24
Marker Score: 68
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.23
Marker Score: 359
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.23
Marker Score: 78
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.22
Marker Score: 70
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.22
Marker Score: 56.5
Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 0.22
Marker Score: 54
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.21
Marker Score: 93
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.21
Marker Score: 54
Cell Name: epithelial fate stem cell (CL0000036)
Fold Change: 0.2
Marker Score: 57
Cell Name: glial cell (CL0000125)
Fold Change: 0.2
Marker Score: 217
Cell Name: stem cell (CL0000034)
Fold Change: 0.19
Marker Score: 461
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.19
Marker Score: 48
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.19
Marker Score: 512
Cell Name: type D enteroendocrine cell (CL0000502)
Fold Change: 0.19
Marker Score: 58
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.18
Marker Score: 97
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.18
Marker Score: 52.5
Cell Name: epithelial cell of thymus (CL0002293)
Fold Change: 0.18
Marker Score: 58
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.18
Marker Score: 43
Cell Name: paneth cell (CL0000510)
Fold Change: 0.18
Marker Score: 123
Cell Name: neural cell (CL0002319)
Fold Change: 0.17
Marker Score: 84
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.17
Marker Score: 97
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 0.17
Marker Score: 58
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.16
Marker Score: 52
Cell Name: leukocyte (CL0000738)
Fold Change: 0.16
Marker Score: 92
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.16
Marker Score: 49
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.15
Marker Score: 46
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.15
Marker Score: 59
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.15
Marker Score: 54
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.14
Marker Score: 58
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.14
Marker Score: 48
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.13
Marker Score: 58
Cell Name: granulocyte (CL0000094)
Fold Change: 0.13
Marker Score: 57
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.12
Marker Score: 47
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.12
Marker Score: 57
Cell Name: secretory cell (CL0000151)
Fold Change: 0.12
Marker Score: 225
Cell Name: podocyte (CL0000653)
Fold Change: 0.12
Marker Score: 45.5
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.12
Marker Score: 44.5
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.11
Marker Score: 112
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.1
Marker Score: 46.5
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 0.1
Marker Score: 50.5
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.1
Marker Score: 59
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.1
Marker Score: 58
Cell Name: motor neuron (CL0000100)
Fold Change: 0.1
Marker Score: 58.5
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.1
Marker Score: 53
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.09
Marker Score: 79
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.09
Marker Score: 59
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.09
Marker Score: 52
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.09
Marker Score: 60
Cell Name: Unknown (CL0000003)
Fold Change: 0.09
Marker Score: 263

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**Key characteristics:** * The ATOH1 gene is a large protein with a molecular weight of approximately 130 kDa. * It is expressed in a variety of cell types in the inner ear, including neurons, glia, and blood vessels. * ATOH1 is a key regulator of auditory receptor cell fate determination. * It is involved in the specification of the inner ear identity and the differentiation of auditory receptor cells from other neural cell types. **Pathways and functions:** * ATOH1 is a key regulator of auditory receptor cell fate determination. * It is expressed in auditory receptor cells and is required for the proper development and maintenance of these cells. * It is involved in the specification of the inner ear identity and the differentiation of auditory receptor cells from other neural cell types. * It also plays a role in the maintenance of auditory receptor cell survival and function. **Clinical significance:** * Mutations in the ATOH1 gene have been linked to a number of human diseases of the inner ear, including Usher's syndrome and Meniere's disease. * These diseases are characterized by a loss of auditory receptor cells in the inner ear, which can lead to hearing loss and other symptoms. * Targeting the ATOH1 gene has been investigated as a potential therapeutic strategy for these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

ATOH1_HUMAN

Genular Protein ID: 1290922275

Symbol: ATOH1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q92858 Q14CT9

Database IDs:

Citations:

PubMed ID: 8872459

Title: Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis.

PubMed ID: 8872459

DOI: 10.1093/hmg/5.9.1207

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 33111345

Title: Spectrum of genes for inherited hearing loss in the Israeli Jewish population, including the novel human deafness gene ATOH1.

PubMed ID: 33111345

DOI: 10.1111/cge.13817

Sequence Information:

Length: 354
Mass: 38160
Checksum: AB12F1E917A00A8D
Sequence:

MSRLLHAEEW AEVKELGDHH RQPQPHHLPQ PPPPPQPPAT LQAREHPVYP PELSLLDSTD 
PRAWLAPTLQ GICTARAAQY LLHSPELGAS EAAAPRDEVD GRGELVRRSS GGASSSKSPG 
PVKVREQLCK LKGGVVVDEL GCSRQRAPSS KQVNGVQKQR RLAANARERR RMHGLNHAFD 
QLRNVIPSFN NDKKLSKYET LQMAQIYINA LSELLQTPSG GEQPPPPPAS CKSDHHHLRT 
AASYEGGAGN ATAAGAQQAS GGSQRPTPPG SCRTRFSAPA SAGGYSVQLD ALHFSTFEDS 
ALTAMMAQKN LSPSLPGSIL QPVQEENSKT SPRSHRSDGE FSPHSHYSDS DEAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.