ATOX1 | ENSG00000177556 | NCBI 475

Details for: ATOX1

Gene ID: 475

Symbol: ATOX1

Ensembl ID: ENSG00000177556

Description: antioxidant 1 copper chaperone

Associated with

Antimicrobial peptides
(R-HSA-6803157)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Detoxification of reactive oxygen species
(R-HSA-3299685)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Ion influx/efflux at host-pathogen interface
(R-HSA-6803544)
Copper-dependent protein binding
(GO:0032767)
Copper chaperone activity
(GO:0016531)
Copper ion binding
(GO:0005507)
Copper ion transport
(GO:0006825)
Cuprous ion binding
(GO:1903136)
Cytosol
(GO:0005829)
Intracellular copper ion homeostasis
(GO:0006878)
Metallochaperone activity
(GO:0016530)
Protein binding
(GO:0005515)
Response to oxidative stress
(GO:0006979)

Other Information

Proteins

Metal transport protein ATX1

Genular Protein ID: 179751385

Symbol: ATOX1_HUMAN

Name: Metal transport protein ATX1

UniProtKB Accession Codes:

O00244 A8KAJ8 D3DQI2 Q2M1R6 Q56AP3

Database IDs:

Citations:

PubMed ID: 9083055

Title: Identification and functional expression of HAH1, a novel human gene involved in copper homeostasis.

PubMed ID: 9083055

DOI: 10.1074/jbc.272.14.9221

PubMed ID: 12594858

Title: Genomic organization of ATOX1, a human copper chaperone.

PubMed ID: 12594858

DOI: 10.1186/1471-2156-4-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21667063

Title: The copper-transporting capacity of ATP7A mutants associated with Menkes disease is ameliorated by COMMD1 as a result of improved protein expression.

PubMed ID: 21667063

DOI: 10.1007/s00018-011-0743-1

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24837030

Title: Probing the structural flexibility of the human copper metallochaperone Atox1 dimer and its interaction with the CTR1 c-terminal domain.

PubMed ID: 24837030

DOI: 10.1021/jp412589b

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26745413

Title: The C-Terminus of Human Copper Importer Ctr1 Acts as a Binding Site and Transfers Copper to Atox1.

PubMed ID: 26745413

DOI: 10.1016/j.bpj.2015.11.016

PubMed ID: 10966647

Title: Structural basis for copper transfer by the metallochaperone for the Menkes/Wilson disease proteins.

PubMed ID: 10966647

DOI: 10.1038/78999

PubMed ID: 19453293

Title: Copper(I)-mediated protein-protein interactions result from suboptimal interaction surfaces.

PubMed ID: 19453293

DOI: 10.1042/bj20090422

PubMed ID: 31283225

Title: Mechanistic and Structural Basis for Inhibition of Copper Trafficking by Platinum Anticancer Drugs.

PubMed ID: 31283225

DOI: 10.1021/jacs.9b05550

Sequence Information:

Length: 68
Mass: 7402
Checksum: 0B364B1BD1279314
Sequence:

MPKHEFSVDM TCGGCAEAVS RVLNKLGGVK YDIDLPNKKV CIESEHSMDT LLATLKKTGK 
TVSYLGLE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ATOX1

Associated with

Other Information

Identification and functional expression of HAH1, a novel human gene involved in copper homeostasis. PubMed ID: 9083055

Genomic organization of ATOX1, a human copper chaperone. PubMed ID: 12594858

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

The copper-transporting capacity of ATP7A mutants associated with Menkes disease is ameliorated by COMMD1 as a result of improved protein expression. PubMed ID: 21667063

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Probing the structural flexibility of the human copper metallochaperone Atox1 dimer and its interaction with the CTR1 c-terminal domain. PubMed ID: 24837030

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

The C-Terminus of Human Copper Importer Ctr1 Acts as a Binding Site and Transfers Copper to Atox1. PubMed ID: 26745413

Structural basis for copper transfer by the metallochaperone for the Menkes/Wilson disease proteins. PubMed ID: 10966647

Copper(I)-mediated protein-protein interactions result from suboptimal interaction surfaces. PubMed ID: 19453293

Mechanistic and Structural Basis for Inhibition of Copper Trafficking by Platinum Anticancer Drugs. PubMed ID: 31283225