Details for: ATOX1

Gene ID: 475

Symbol: ATOX1

Ensembl ID: ENSG00000177556

Description: antioxidant 1 copper chaperone

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 5.78
    Marker Score: 5663
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.32
    Marker Score: 11793.5
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.05
    Marker Score: 6448
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.86
    Marker Score: 4740
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.67
    Marker Score: 2088
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.55
    Marker Score: 12231
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.55
    Marker Score: 1016
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.47
    Marker Score: 6241
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.45
    Marker Score: 6578
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.44
    Marker Score: 3763
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.41
    Marker Score: 1005
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.39
    Marker Score: 10289
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.37
    Marker Score: 82056
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.36
    Marker Score: 4315
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.36
    Marker Score: 5369
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.35
    Marker Score: 60262
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.34
    Marker Score: 14951
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.33
    Marker Score: 8637
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.28
    Marker Score: 16966
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.28
    Marker Score: 17782
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.25
    Marker Score: 2248.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.24
    Marker Score: 125433
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.24
    Marker Score: 1231
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.22
    Marker Score: 1484
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.21
    Marker Score: 2305
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.21
    Marker Score: 24841
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.2
    Marker Score: 3390.5
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.2
    Marker Score: 2068
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.19
    Marker Score: 25484.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.17
    Marker Score: 28609
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.16
    Marker Score: 2190
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.15
    Marker Score: 4492
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.15
    Marker Score: 2956
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.13
    Marker Score: 1241
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.13
    Marker Score: 18352
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.12
    Marker Score: 2380
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.1
    Marker Score: 473
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.07
    Marker Score: 7985
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.07
    Marker Score: 2193
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.04
    Marker Score: 2891
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.04
    Marker Score: 12114.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.03
    Marker Score: 17678
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.03
    Marker Score: 950
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.01
    Marker Score: 3290
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2
    Marker Score: 1785
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.99
    Marker Score: 4674
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.98
    Marker Score: 3855
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.98
    Marker Score: 859
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.97
    Marker Score: 2086
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.97
    Marker Score: 1644
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.97
    Marker Score: 1049
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.97
    Marker Score: 3925
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.96
    Marker Score: 1393
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.96
    Marker Score: 695
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.95
    Marker Score: 12658
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.94
    Marker Score: 968
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.94
    Marker Score: 2091
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.93
    Marker Score: 548
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.93
    Marker Score: 2078.5
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.93
    Marker Score: 1218
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.93
    Marker Score: 2204
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.91
    Marker Score: 985
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.91
    Marker Score: 464
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.9
    Marker Score: 774
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.87
    Marker Score: 4248
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.86
    Marker Score: 11915
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.86
    Marker Score: 2737
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.86
    Marker Score: 640
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.84
    Marker Score: 1649
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.83
    Marker Score: 4565.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.83
    Marker Score: 7182
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.83
    Marker Score: 4641
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.82
    Marker Score: 11081
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.82
    Marker Score: 585
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.82
    Marker Score: 1831
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.81
    Marker Score: 3084
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.81
    Marker Score: 2602
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.8
    Marker Score: 1536
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.8
    Marker Score: 2898
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.8
    Marker Score: 888
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.8
    Marker Score: 1723
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.79
    Marker Score: 695
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.79
    Marker Score: 4241.5
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.77
    Marker Score: 1883
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.77
    Marker Score: 17796.5
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.76
    Marker Score: 1210
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.76
    Marker Score: 648
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.75
    Marker Score: 653
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.75
    Marker Score: 3280
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.75
    Marker Score: 863
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.74
    Marker Score: 409
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.74
    Marker Score: 584
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.74
    Marker Score: 4729
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.72
    Marker Score: 1558
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.72
    Marker Score: 498
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 1.72
    Marker Score: 630
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.72
    Marker Score: 816
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.71
    Marker Score: 3027
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.7
    Marker Score: 882
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.7
    Marker Score: 492

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Other Information

**Key characteristics:** - It is a copper chaperone, which means it binds to copper ions and facilitates their transport or exchange with other molecules. - It is involved in various cellular processes, including antioxidant defense, immune responses, and stress tolerance. - It is known to interact with other proteins involved in copper transport, cellular stress response, and immune regulation. **Pathways and functions:** - **Antioxidant defense:** ATOX1 acts as a copper chaperone, binding to copper ions and preventing their interaction with reactive oxygen species (ROS), which can damage cellular components and contribute to various diseases. - **Immune responses:** It plays a role in the innate immune system by binding to copper ions in immune complexes, thereby modulating their activity and signaling. - **Stress tolerance:** ATOX1 helps cells adapt to stress conditions by binding to copper ions and facilitating their transport to other cellular compartments, where they can be used for various cellular functions. - **Copper transport:** It mediates the transport of copper ions between the cytosol and the extracellular environment, which is crucial for various cellular processes, including enzyme activity and DNA repair. - **Immune system:** ATOX1 is involved in the regulation of immune responses by binding to copper ions in immune complexes and modulating their activity. **Clinical significance:** - Mutations in the ATOX1 gene have been linked to several human diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer. - Studies have shown that targeting ATOX1 can mitigate the detrimental effects of ROS and improve cellular survival in models of various diseases. - Therefore, ATOX1 is a potential therapeutic target for diseases characterized by oxidative stress and inflammation.

Genular Protein ID: 179751385

Symbol: ATOX1_HUMAN

Name: Metal transport protein ATX1

UniProtKB Accession Codes:

O00244 A8KAJ8 D3DQI2 Q2M1R6 Q56AP3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 2 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 9 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 17 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9083055

Title: Identification and functional expression of HAH1, a novel human gene involved in copper homeostasis.

PubMed ID: 9083055

DOI: 10.1074/jbc.272.14.9221

PubMed ID: 12594858

Title: Genomic organization of ATOX1, a human copper chaperone.

PubMed ID: 12594858

DOI: 10.1186/1471-2156-4-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21667063

Title: The copper-transporting capacity of ATP7A mutants associated with Menkes disease is ameliorated by COMMD1 as a result of improved protein expression.

PubMed ID: 21667063

DOI: 10.1007/s00018-011-0743-1

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24837030

Title: Probing the structural flexibility of the human copper metallochaperone Atox1 dimer and its interaction with the CTR1 c-terminal domain.

PubMed ID: 24837030

DOI: 10.1021/jp412589b

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26745413

Title: The C-Terminus of Human Copper Importer Ctr1 Acts as a Binding Site and Transfers Copper to Atox1.

PubMed ID: 26745413

DOI: 10.1016/j.bpj.2015.11.016

PubMed ID: 10966647

Title: Structural basis for copper transfer by the metallochaperone for the Menkes/Wilson disease proteins.

PubMed ID: 10966647

DOI: 10.1038/78999

PubMed ID: 19453293

Title: Copper(I)-mediated protein-protein interactions result from suboptimal interaction surfaces.

PubMed ID: 19453293

DOI: 10.1042/bj20090422

PubMed ID: 31283225

Title: Mechanistic and Structural Basis for Inhibition of Copper Trafficking by Platinum Anticancer Drugs.

PubMed ID: 31283225

DOI: 10.1021/jacs.9b05550

Sequence Information:

  • Length: 68
  • Mass: 7402
  • Checksum: 0B364B1BD1279314
  • Sequence:
    • MPKHEFSVDM TCGGCAEAVS RVLNKLGGVK YDIDLPNKKV CIESEHSMDT LLATLKKTGK 
TVSYLGLE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.