ATP12A | ENSG00000075673 | NCBI 479

Details for: ATP12A

Gene ID: 479

Symbol: ATP12A

Ensembl ID: ENSG00000075673

Description: ATPase H+/K+ transporting non-gastric alpha2 subunit

Associated with

Ion channel transport
(R-HSA-983712)
Ion transport by p-type atpases
(R-HSA-936837)
Transport of small molecules
(R-HSA-382551)
Actin cytoskeleton
(GO:0015629)
Apical plasma membrane
(GO:0016324)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Basolateral plasma membrane
(GO:0016323)
Cytosol
(GO:0005829)
Establishment or maintenance of transmembrane electrochemical gradient
(GO:0010248)
Intracellular potassium ion homeostasis
(GO:0030007)
Intracellular sodium ion homeostasis
(GO:0006883)
Metal ion binding
(GO:0046872)
P-type potassium:proton transporter activity
(GO:0008900)
P-type sodium:potassium-exchanging transporter activity
(GO:0005391)
Plasma membrane
(GO:0005886)
Potassium:proton exchanging atpase complex
(GO:0005889)
Potassium ion import across plasma membrane
(GO:1990573)
Proton transmembrane transport
(GO:1902600)
Regulation of ph
(GO:0006885)
Sodium ion export across plasma membrane
(GO:0036376)

Other Information

Proteins

Potassium-transporting ATPase alpha chain 2
B4E0R9_HUMAN

Genular Protein ID: 953807484

Symbol: AT12A_HUMAN

Name: Potassium-transporting ATPase alpha chain 2

UniProtKB Accession Codes:

P54707 Q13816 Q13817 Q16734 Q5W035 Q8N5U2

Database IDs:

Citations:

PubMed ID: 8045293

Title: Cloning and characterization of the entire cDNA encoded by ATP1AL1 -- a member of the human Na,K/H,K-ATPase gene family.

PubMed ID: 8045293

DOI: 10.1016/0014-5793(94)00655-5

PubMed ID: 8838794

Title: Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase.

PubMed ID: 8838794

DOI: 10.1006/geno.1996.0125

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1847115

Title: The family of human Na,K-ATPase genes. ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase.

PubMed ID: 1847115

DOI: 10.1016/0014-5793(91)80091-g

PubMed ID: 3035563

Title: Multiple genes encode the human Na+,K+-ATPase catalytic subunit.

PubMed ID: 3035563

DOI: 10.1073/pnas.84.12.4039

PubMed ID: 3036582

Title: The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit.

PubMed ID: 3036582

DOI: 10.1016/0014-5793(87)80677-4

PubMed ID: 7485470

Title: Human ATP1AL1 gene encodes a ouabain-sensitive H-K-ATPase.

PubMed ID: 7485470

DOI: 10.1152/ajpcell.1995.269.4.c992

PubMed ID: 8853415

Title: Functional expression of the cDNA encoded by the human ATP1AL1 gene.

PubMed ID: 8853415

DOI: 10.1152/ajprenal.1996.271.3.f539

PubMed ID: 9872395

Title: Ouabain-sensitive H,K-ATPase: tissue-specific expression of the mammalian genes encoding the catalytic alpha subunit.

PubMed ID: 9872395

DOI: 10.1016/s0014-5793(98)01483-5

PubMed ID: 9774385

Title: ATP1AL1, a member of the non-gastric H,K-ATPase family, functions as a sodium pump.

PubMed ID: 9774385

DOI: 10.1074/jbc.273.43.27772

PubMed ID: 11341842

Title: Catalytic function of nongastric H,K-ATPase expressed in Sf-21 insect cells.

PubMed ID: 11341842

DOI: 10.1021/bi010191y

PubMed ID: 16914892

Title: An extracellular loop of the human non-gastric H,K-ATPase alpha-subunit is involved in apical plasma membrane polarization.

PubMed ID: 16914892

DOI: 10.1159/000095169

PubMed ID: 22179016

Title: Expression of the non-gastric H+/K+ ATPase ATP12A in normal and pathological human prostate tissue.

PubMed ID: 22179016

DOI: 10.1159/000335860

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29391451

Title: ATP12A promotes mucus dysfunction during Type 2 airway inflammation.

PubMed ID: 29391451

DOI: 10.1038/s41598-018-20444-8

Sequence Information:

Length: 1039
Mass: 115511
Checksum: C906897E11FA406C
Sequence:

MHQKTPEIYS VELSGTKDIV KTDKGDGKEK YRGLKNNCLE LKKKNHKEEF QKELHLDDHK 
LSNRELEEKY GTDIIMGLSS TRAAELLARD GPNSLTPPKQ TPEIVKFLKQ MVGGFSILLW 
VGAFLCWIAY GIQYSSDKSA SLNNVYLGCV LGLVVILTGI FAYYQEAKST NIMSSFNKMI 
PQQALVIRDS EKKTIPSEQL VVGDIVEVKG GDQIPADIRV LSSQGCRVDN SSLTGESEPQ 
PRSSEFTHEN PLETKNICFY STTCLEGTVT GMVINTGDRT IIGHIASLAS GVGNEKTPIA 
IEIEHFVHIV AGVAVSIGIL FFIIAVSLKY QVLDSIIFLI GIIVANVPEG LLATVTVTLS 
LTAKRMAKKN CLVKNLEAVE TLGSTSIICS DKTGTLTQNR MTVAHLWFDN QIFVADTSED 
HSNQVFDQSS RTWASLSKII TLCNRAEFKP GQENVPIMKK AVIGDASETA LLKFSEVILG 
DVMEIRKRNR KVAEIPFNST NKFQLSIHEM DDPHGKRFLM VMKGAPERIL EKCSTIMING 
EEHPLDKSTA KTFHTAYMEL GGLGERVLGF CHLYLPADEF PETYSFDIDA MNFPTSNLCF 
VGLLSMIDPP RSTVPDAVTK CRSAGIKVIM VTGDHPITAK AIAKSVGIIS ANSETVEDIA 
HRLNIAVEQV NKRDAKAAVV TGMELKDMSS EQLDEILANY QEIVFARTSP QQKLIIVEGC 
QRQDAVVAVT GDGVNDSPAL KKADIGIAMG IAGSDAAKNA ADMVLLDDNF ASIVTGVEEG 
RLIFDNLKKT IAYSLTKNIA ELCPFLIYII VGLPLPIGTI TILFIDLGTD IIPSIALAYE 
KAESDIMNRK PRHKNKDRLV NQPLAVYSYL HIGLMQALGA FLVYFTVYAQ EGFLPRTLIN 
LRVEWEKDYV NDLKDSYGQE WTRYQREYLE WTGYTAFFVG ILVQQIADLI IRKTRRNSIF 
QQGLFRNKVI WVGITSQIII GLILSYGLGS VTALSFTMLR AQYWFVAVPH AILIWVYDEV 
RKLFIRLYPG SWWDKNMYY

Genular Protein ID: 4267167982

Symbol: B4E0R9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E0R9

Database IDs:

Sequence Information:

Length: 674
Mass: 75572
Checksum: 963FA54CEBE95C19
Sequence:

MAKKNCLVKN LEAVETLGST SIICSDKTGT LTQNRMTVAH LWFDNQIFVA DTSEDHSNQV 
FDQSSRTWAS LSKIITLCNR AEFKPGQENV PIMKKAVIGD ASETALLKFS EVILGDVMEI 
RKRNRKVAEI PFNSTNKFQL SIHEMDDPHG KRFLMVMKGA PERILEKCST IMINGEEHLL 
DKSTAKTFHT AYMELGGLGE RVLGFCHLYL PADEFPETYS FDIDAMNFPT SNLCFVGLLS 
MIDPPRSTVP DAVTKCRSAG IKVIMVTGDH PITAKAIAKS VGIISANSET VEDIAHRLNI 
AVEQVNKRDA KAAVVTSMEL KDMSSEQLDE ILANYQEIVF ARTSPQQKLI IVEGCQRQDA 
VVAVTGDGVN DSPALKKADI GIAMGIAGSD AAKNAADMVL LDDNFASTVT GVEEGRLIFD 
NLKKTIAYSL TKNIAELCPF LIYIIVGLPL PIGTITILFI DLGTDIIPSI ALAYEKAESD 
IMNRKPRHKN KDRLVNQPLA VYSYLHIGLM QALGAFLVYF TVYAQEGFLP RTLINLRVEW 
EKDYVNDLKD SYGQEWTRYQ REYLEWTGYT AFFVGILVQQ IADLIIRKTR RNSIFQQGLF 
RNKVIWVGIT SQIIIGLILS YGLGSVTALS FTMLRAQYWF VAVPHAILIW VYDEVRKLFI 
RLYPGSWWDK NMYY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ATP12A

Associated with

Other Information

Cloning and characterization of the entire cDNA encoded by ATP1AL1 -- a member of the human Na,K/H,K-ATPase gene family. PubMed ID: 8045293

Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase. PubMed ID: 8838794

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 13. PubMed ID: 15057823

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The family of human Na,K-ATPase genes. ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase. PubMed ID: 1847115

Multiple genes encode the human Na+,K+-ATPase catalytic subunit. PubMed ID: 3035563

The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit. PubMed ID: 3036582

Human ATP1AL1 gene encodes a ouabain-sensitive H-K-ATPase. PubMed ID: 7485470

Functional expression of the cDNA encoded by the human ATP1AL1 gene. PubMed ID: 8853415

Ouabain-sensitive H,K-ATPase: tissue-specific expression of the mammalian genes encoding the catalytic alpha subunit. PubMed ID: 9872395

ATP1AL1, a member of the non-gastric H,K-ATPase family, functions as a sodium pump. PubMed ID: 9774385

Catalytic function of nongastric H,K-ATPase expressed in Sf-21 insect cells. PubMed ID: 11341842

An extracellular loop of the human non-gastric H,K-ATPase alpha-subunit is involved in apical plasma membrane polarization. PubMed ID: 16914892

Expression of the non-gastric H+/K+ ATPase ATP12A in normal and pathological human prostate tissue. PubMed ID: 22179016

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

ATP12A promotes mucus dysfunction during Type 2 airway inflammation. PubMed ID: 29391451