Details for: ATP12A

Gene ID: 479

Symbol: ATP12A

Ensembl ID: ENSG00000075673

Description: ATPase H+/K+ transporting non-gastric alpha2 subunit

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 7.95
    Marker Score: 11029
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 5.97
    Marker Score: 17412
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 5.68
    Marker Score: 16855
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.87
    Marker Score: 32692
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.52
    Marker Score: 10097.5
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 3.22
    Marker Score: 3087
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.6
    Marker Score: 7411
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.35
    Marker Score: 1055
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2
    Marker Score: 987
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1164
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169949
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 853
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.24
    Marker Score: 2358
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 487
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4807
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.1
    Marker Score: 319
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.09
    Marker Score: 657
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.09
    Marker Score: 277
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.07
    Marker Score: 1961
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.03
    Marker Score: 282
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71817
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48042
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5325
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.93
    Marker Score: 425.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.86
    Marker Score: 13518
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.86
    Marker Score: 1748
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.85
    Marker Score: 762
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.85
    Marker Score: 647
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.81
    Marker Score: 380
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179.5
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.68
    Marker Score: 791
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.65
    Marker Score: 236
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.62
    Marker Score: 1572.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.61
    Marker Score: 391
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.58
    Marker Score: 816.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 450
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.55
    Marker Score: 1896
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.54
    Marker Score: 157
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.49
    Marker Score: 3288
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 475
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.47
    Marker Score: 317
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.44
    Marker Score: 3816
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.44
    Marker Score: 116
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.44
    Marker Score: 276
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.43
    Marker Score: 287
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.42
    Marker Score: 245
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.42
    Marker Score: 3116
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.41
    Marker Score: 128.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.39
    Marker Score: 187
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.37
    Marker Score: 246.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.36
    Marker Score: 4810
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.33
    Marker Score: 214
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.32
    Marker Score: 351
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.31
    Marker Score: 237
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.31
    Marker Score: 60
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.3
    Marker Score: 268
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.3
    Marker Score: 1773
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.28
    Marker Score: 238
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.27
    Marker Score: 764.5
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.27
    Marker Score: 78
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.26
    Marker Score: 246
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.26
    Marker Score: 113
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.25
    Marker Score: 479
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.25
    Marker Score: 171
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.23
    Marker Score: 304
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.23
    Marker Score: 721
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.23
    Marker Score: 200
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.22
    Marker Score: 529
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.22
    Marker Score: 93
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.22
    Marker Score: 287
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 118
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.21
    Marker Score: 67
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.21
    Marker Score: 333
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.21
    Marker Score: 120
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.18
    Marker Score: 204.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.18
    Marker Score: 185
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.17
    Marker Score: 166
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.17
    Marker Score: 96
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.17
    Marker Score: 68
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.17
    Marker Score: 276
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.16
    Marker Score: 678
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.16
    Marker Score: 92

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Other Information

**Key characteristics:** * The gene is located on chromosome 17q21.1. * It is a large gene with a total length of 2.2 kb. * It encodes for a protein of 126 amino acids. * The protein is expressed in a variety of cell types, including epithelial cells of the lung, retinal cells, and colon cells. **Pathways and functions:** * ATP12A is involved in a variety of cellular processes, including cell cycle regulation, cell signaling, and fluid transport. * It is a key regulator of ion transport in cells. * It is involved in maintaining the electrochemical gradient across the plasma membrane, which is essential for many cellular processes. * It is also involved in the regulation of ph and sodium ion transport. **Clinical significance:** * Mutations in the ATP12A gene have been linked to a number of human diseases, including retinal diseases, renal diseases, and cancer. * These diseases are characterized by abnormal ion transport and cellular dysfunction. * Targeting ATP12A has been investigated as a therapeutic strategy for these diseases. **Additional information:** * ATP12A is a highly conserved protein, with similar genes found in other species. * It is a member of the ATP-binding protein family of proteins. * It is a key regulator of the cellular calcium concentration.

Genular Protein ID: 953807484

Symbol: AT12A_HUMAN

Name: Potassium-transporting ATPase alpha chain 2

UniProtKB Accession Codes:

P54707 Q13816 Q13817 Q16734 Q5W035 Q8N5U2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 21 EPD 1 Ensembl 2 GO 17 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 6 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 Rhea 4 SFLD 2 SMART 1 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8045293

Title: Cloning and characterization of the entire cDNA encoded by ATP1AL1 -- a member of the human Na,K/H,K-ATPase gene family.

PubMed ID: 8045293

DOI: 10.1016/0014-5793(94)00655-5

PubMed ID: 8838794

Title: Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase.

PubMed ID: 8838794

DOI: 10.1006/geno.1996.0125

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1847115

Title: The family of human Na,K-ATPase genes. ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase.

PubMed ID: 1847115

DOI: 10.1016/0014-5793(91)80091-g

PubMed ID: 3035563

Title: Multiple genes encode the human Na+,K+-ATPase catalytic subunit.

PubMed ID: 3035563

DOI: 10.1073/pnas.84.12.4039

PubMed ID: 3036582

Title: The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit.

PubMed ID: 3036582

DOI: 10.1016/0014-5793(87)80677-4

PubMed ID: 7485470

Title: Human ATP1AL1 gene encodes a ouabain-sensitive H-K-ATPase.

PubMed ID: 7485470

DOI: 10.1152/ajpcell.1995.269.4.c992

PubMed ID: 8853415

Title: Functional expression of the cDNA encoded by the human ATP1AL1 gene.

PubMed ID: 8853415

DOI: 10.1152/ajprenal.1996.271.3.f539

PubMed ID: 9872395

Title: Ouabain-sensitive H,K-ATPase: tissue-specific expression of the mammalian genes encoding the catalytic alpha subunit.

PubMed ID: 9872395

DOI: 10.1016/s0014-5793(98)01483-5

PubMed ID: 9774385

Title: ATP1AL1, a member of the non-gastric H,K-ATPase family, functions as a sodium pump.

PubMed ID: 9774385

DOI: 10.1074/jbc.273.43.27772

PubMed ID: 11341842

Title: Catalytic function of nongastric H,K-ATPase expressed in Sf-21 insect cells.

PubMed ID: 11341842

DOI: 10.1021/bi010191y

PubMed ID: 16914892

Title: An extracellular loop of the human non-gastric H,K-ATPase alpha-subunit is involved in apical plasma membrane polarization.

PubMed ID: 16914892

DOI: 10.1159/000095169

PubMed ID: 22179016

Title: Expression of the non-gastric H+/K+ ATPase ATP12A in normal and pathological human prostate tissue.

PubMed ID: 22179016

DOI: 10.1159/000335860

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29391451

Title: ATP12A promotes mucus dysfunction during Type 2 airway inflammation.

PubMed ID: 29391451

DOI: 10.1038/s41598-018-20444-8

Sequence Information:

  • Length: 1039
  • Mass: 115511
  • Checksum: C906897E11FA406C
  • Sequence:
    • MHQKTPEIYS VELSGTKDIV KTDKGDGKEK YRGLKNNCLE LKKKNHKEEF QKELHLDDHK 
LSNRELEEKY GTDIIMGLSS TRAAELLARD GPNSLTPPKQ TPEIVKFLKQ MVGGFSILLW 
VGAFLCWIAY GIQYSSDKSA SLNNVYLGCV LGLVVILTGI FAYYQEAKST NIMSSFNKMI 
PQQALVIRDS EKKTIPSEQL VVGDIVEVKG GDQIPADIRV LSSQGCRVDN SSLTGESEPQ 
PRSSEFTHEN PLETKNICFY STTCLEGTVT GMVINTGDRT IIGHIASLAS GVGNEKTPIA 
IEIEHFVHIV AGVAVSIGIL FFIIAVSLKY QVLDSIIFLI GIIVANVPEG LLATVTVTLS 
LTAKRMAKKN CLVKNLEAVE TLGSTSIICS DKTGTLTQNR MTVAHLWFDN QIFVADTSED 
HSNQVFDQSS RTWASLSKII TLCNRAEFKP GQENVPIMKK AVIGDASETA LLKFSEVILG 
DVMEIRKRNR KVAEIPFNST NKFQLSIHEM DDPHGKRFLM VMKGAPERIL EKCSTIMING 
EEHPLDKSTA KTFHTAYMEL GGLGERVLGF CHLYLPADEF PETYSFDIDA MNFPTSNLCF 
VGLLSMIDPP RSTVPDAVTK CRSAGIKVIM VTGDHPITAK AIAKSVGIIS ANSETVEDIA 
HRLNIAVEQV NKRDAKAAVV TGMELKDMSS EQLDEILANY QEIVFARTSP QQKLIIVEGC 
QRQDAVVAVT GDGVNDSPAL KKADIGIAMG IAGSDAAKNA ADMVLLDDNF ASIVTGVEEG 
RLIFDNLKKT IAYSLTKNIA ELCPFLIYII VGLPLPIGTI TILFIDLGTD IIPSIALAYE 
KAESDIMNRK PRHKNKDRLV NQPLAVYSYL HIGLMQALGA FLVYFTVYAQ EGFLPRTLIN 
LRVEWEKDYV NDLKDSYGQE WTRYQREYLE WTGYTAFFVG ILVQQIADLI IRKTRRNSIF 
QQGLFRNKVI WVGITSQIII GLILSYGLGS VTALSFTMLR AQYWFVAVPH AILIWVYDEV 
RKLFIRLYPG SWWDKNMYY

Genular Protein ID: 4267167982

Symbol: B4E0R9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E0R9

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 5 Gene3D 3 Genevisible 1 GenomeRNAi 1 InterPro 9 KEGG 1 NCBI Taxonomy 1 NCBIfam 2 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 Pfam 4 RefSeq 2 RuleBase 1 SFLD 2 SUPFAM 3

Sequence Information:

  • Length: 674
  • Mass: 75572
  • Checksum: 963FA54CEBE95C19
  • Sequence:
    • MAKKNCLVKN LEAVETLGST SIICSDKTGT LTQNRMTVAH LWFDNQIFVA DTSEDHSNQV 
FDQSSRTWAS LSKIITLCNR AEFKPGQENV PIMKKAVIGD ASETALLKFS EVILGDVMEI 
RKRNRKVAEI PFNSTNKFQL SIHEMDDPHG KRFLMVMKGA PERILEKCST IMINGEEHLL 
DKSTAKTFHT AYMELGGLGE RVLGFCHLYL PADEFPETYS FDIDAMNFPT SNLCFVGLLS 
MIDPPRSTVP DAVTKCRSAG IKVIMVTGDH PITAKAIAKS VGIISANSET VEDIAHRLNI 
AVEQVNKRDA KAAVVTSMEL KDMSSEQLDE ILANYQEIVF ARTSPQQKLI IVEGCQRQDA 
VVAVTGDGVN DSPALKKADI GIAMGIAGSD AAKNAADMVL LDDNFASTVT GVEEGRLIFD 
NLKKTIAYSL TKNIAELCPF LIYIIVGLPL PIGTITILFI DLGTDIIPSI ALAYEKAESD 
IMNRKPRHKN KDRLVNQPLA VYSYLHIGLM QALGAFLVYF TVYAQEGFLP RTLINLRVEW 
EKDYVNDLKD SYGQEWTRYQ REYLEWTGYT AFFVGILVQQ IADLIIRKTR RNSIFQQGLF 
RNKVIWVGIT SQIIIGLILS YGLGSVTALS FTMLRAQYWF VAVPHAILIW VYDEVRKLFI 
RLYPGSWWDK NMYY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.