Details for: ACO1

Gene ID: 48

Symbol: ACO1

Ensembl ID: ENSG00000122729

Description: aconitase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 204.9886
    Cell Significance Index: -31.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 124.1507
    Cell Significance Index: -31.4900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 71.0880
    Cell Significance Index: -28.8800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 30.2856
    Cell Significance Index: -28.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.5338
    Cell Significance Index: -32.7200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.2067
    Cell Significance Index: -32.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.2868
    Cell Significance Index: -32.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.5343
    Cell Significance Index: 244.4200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5977
    Cell Significance Index: 173.7800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.4414
    Cell Significance Index: 18.1500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.4274
    Cell Significance Index: 24.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2303
    Cell Significance Index: 244.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7821
    Cell Significance Index: 156.8900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7680
    Cell Significance Index: 14.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7214
    Cell Significance Index: 15.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7052
    Cell Significance Index: 18.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6357
    Cell Significance Index: 18.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5590
    Cell Significance Index: 42.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5346
    Cell Significance Index: 482.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5060
    Cell Significance Index: 69.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3869
    Cell Significance Index: 11.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3749
    Cell Significance Index: 10.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3726
    Cell Significance Index: 67.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3623
    Cell Significance Index: 250.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3256
    Cell Significance Index: 32.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3009
    Cell Significance Index: 164.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2820
    Cell Significance Index: 48.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2625
    Cell Significance Index: 5.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2553
    Cell Significance Index: 91.5800
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.2504
    Cell Significance Index: 1.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2427
    Cell Significance Index: 29.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2369
    Cell Significance Index: 10.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1866
    Cell Significance Index: 8.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1571
    Cell Significance Index: 8.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1196
    Cell Significance Index: 6.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1094
    Cell Significance Index: 206.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1019
    Cell Significance Index: 6.8600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0882
    Cell Significance Index: 11.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0866
    Cell Significance Index: 133.2900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0841
    Cell Significance Index: 2.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0765
    Cell Significance Index: 12.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0725
    Cell Significance Index: 133.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0662
    Cell Significance Index: 29.2800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0403
    Cell Significance Index: 7.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0366
    Cell Significance Index: 23.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0186
    Cell Significance Index: 25.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0030
    Cell Significance Index: 1.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0128
    Cell Significance Index: -9.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0134
    Cell Significance Index: -9.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0137
    Cell Significance Index: -8.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0197
    Cell Significance Index: -14.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0268
    Cell Significance Index: -3.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0270
    Cell Significance Index: -1.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0381
    Cell Significance Index: -1.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0408
    Cell Significance Index: -23.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0463
    Cell Significance Index: -2.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0483
    Cell Significance Index: -1.8300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0580
    Cell Significance Index: -4.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0840
    Cell Significance Index: -8.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0989
    Cell Significance Index: -20.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1001
    Cell Significance Index: -28.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1024
    Cell Significance Index: -6.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1207
    Cell Significance Index: -13.8300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1362
    Cell Significance Index: -2.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1530
    Cell Significance Index: -17.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1615
    Cell Significance Index: -20.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1715
    Cell Significance Index: -2.8700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1968
    Cell Significance Index: -22.4600
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.2106
    Cell Significance Index: -1.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2442
    Cell Significance Index: -15.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2454
    Cell Significance Index: -28.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2499
    Cell Significance Index: -19.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2614
    Cell Significance Index: -19.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2630
    Cell Significance Index: -27.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2636
    Cell Significance Index: -13.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2789
    Cell Significance Index: -4.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2798
    Cell Significance Index: -7.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3044
    Cell Significance Index: -7.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3141
    Cell Significance Index: -20.2700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3291
    Cell Significance Index: -7.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3357
    Cell Significance Index: -8.6300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3392
    Cell Significance Index: -4.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3421
    Cell Significance Index: -7.1600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3466
    Cell Significance Index: -5.8300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3549
    Cell Significance Index: -5.2400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4345
    Cell Significance Index: -15.1000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4413
    Cell Significance Index: -5.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4414
    Cell Significance Index: -22.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4588
    Cell Significance Index: -28.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4734
    Cell Significance Index: -12.8900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4794
    Cell Significance Index: -10.1800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5349
    Cell Significance Index: -14.0700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5521
    Cell Significance Index: -13.2400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5777
    Cell Significance Index: -5.3200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5972
    Cell Significance Index: -6.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5975
    Cell Significance Index: -17.0500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6136
    Cell Significance Index: -31.0100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.6404
    Cell Significance Index: -6.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6484
    Cell Significance Index: -21.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6487
    Cell Significance Index: -8.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Iron-Sulfur Cluster Binding:** ACO1 contains four iron-sulfur clusters, which are essential for its enzymatic activity. These clusters play a critical role in stabilizing the enzyme and facilitating the hydration of aconitate to citrate. 2. **Citrate Metabolic Process:** ACO1 is involved in the conversion of citrate to isocitrate, a key step in the TCA cycle. This process is crucial for energy production in cells. 3. **Intracellular Iron Ion Homeostasis:** ACO1 helps regulate intracellular iron ion homeostasis by facilitating the uptake and storage of iron. This is essential for maintaining proper iron levels within cells. 4. **Regulation of Translation:** ACO1 has been shown to regulate translation initiation, which is critical for protein synthesis and cell growth. **Pathways and Functions:** 1. **Iron-Responsive Element Binding:** ACO1 contains iron-responsive elements (IREs) in its promoter region, which are activated in response to changes in iron levels. This allows ACO1 to be regulated in response to changes in iron availability. 2. **Intracellular Iron Uptake and Transport:** ACO1 plays a critical role in the uptake and storage of iron within cells. It helps regulate the transport of iron across cell membranes and into the cytoplasm. 3. **Tricarboxylic Acid Cycle:** ACO1 is involved in the TCA cycle, which is a key metabolic pathway for energy production in cells. 4. **Regulation of Translation:** ACO1 has been shown to regulate translation initiation, which is critical for protein synthesis and cell growth. **Clinical Significance:** 1. **Iron-Related Disorders:** Mutations in the ACO1 gene have been associated with iron-related disorders, such as hereditary hemochromatosis and sideroblastic anemia. 2. **Cancer:** ACO1 has been implicated in cancer development and progression, particularly in cases where iron metabolism is disrupted. 3. **Neurodegenerative Diseases:** ACO1 has been shown to play a role in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where iron metabolism is disrupted. 4. **Metabolic Disorders:** ACO1 has been implicated in metabolic disorders, such as type 2 diabetes and obesity, where iron metabolism is disrupted. In conclusion, ACO1 is a critical enzyme involved in iron metabolism and the citric acid cycle. Its dysregulation has been implicated in various diseases, including iron-related disorders, cancer, neurodegenerative diseases, and metabolic disorders. Further research is needed to fully understand the role of ACO1 in human health and disease.

Genular Protein ID: 1610431017

Symbol: ACOHC_HUMAN

Name: Citrate hydro-lyase

UniProtKB Accession Codes:

P21399 D3DRK7 Q14652 Q5VZA7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 1 CTD 1 ChEBI 6 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 8 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 MoonDB 1 MoonProt 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 4 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1738601

Title: Expression of active iron regulatory factor from a full-length human cDNA by in vitro transcription/translation.

PubMed ID: 1738601

DOI: 10.1093/nar/20.1.33

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2172968

Title: Cloning of the cDNA encoding an RNA regulatory protein -- the human iron-responsive element-binding protein.

PubMed ID: 2172968

DOI: 10.1073/pnas.87.20.7958

PubMed ID: 1903202

Title: Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase.

PubMed ID: 1903202

DOI: 10.1093/nar/19.8.1739

PubMed ID: 1946430

Title: A regulated RNA binding protein also possesses aconitase activity.

PubMed ID: 1946430

DOI: 10.1073/pnas.88.22.10109

PubMed ID: 1281544

Title: Cellular regulation of the iron-responsive element binding protein: disassembly of the cubane iron-sulfur cluster results in high-affinity RNA binding.

PubMed ID: 1281544

DOI: 10.1073/pnas.89.24.11735

PubMed ID: 8041788

Title: The bifunctional iron-responsive element binding protein/cytosolic aconitase: the role of active-site residues in ligand binding and regulation.

PubMed ID: 8041788

DOI: 10.1073/pnas.91.15.7321

PubMed ID: 19762596

Title: Control of iron homeostasis by an iron-regulated ubiquitin ligase.

PubMed ID: 19762596

DOI: 10.1126/science.1176333

PubMed ID: 19762597

Title: An E3 ligase possessing an iron responsive hemerythrin domain is a regulator of iron homeostasis.

PubMed ID: 19762597

DOI: 10.1126/science.1176326

PubMed ID: 20053667

Title: Molecular control of the cytosolic aconitase/IRP1 switch by extramitochondrial frataxin.

PubMed ID: 20053667

DOI: 10.1093/hmg/ddp592

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23891004

Title: Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.

PubMed ID: 23891004

DOI: 10.1016/j.cmet.2013.06.015

PubMed ID: 29320706

Title: Human CIA2A-FAM96A and CIA2B-FAM96B Integrate Iron Homeostasis and Maturation of Different Subsets of Cytosolic-Nuclear Iron-Sulfur Proteins.

PubMed ID: 29320706

DOI: 10.1016/j.cmet.2017.12.009

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16407072

Title: Crystal structure of human iron regulatory protein 1 as cytosolic aconitase.

PubMed ID: 16407072

DOI: 10.1016/j.str.2005.09.009

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

Sequence Information:

  • Length: 889
  • Mass: 98399
  • Checksum: E1A05AF701D46DCB
  • Sequence:
    • MSNPFAHLAE PLDPVQPGKK FFNLNKLEDS RYGRLPFSIR VLLEAAIRNC DEFLVKKQDI 
ENILHWNVTQ HKNIEVPFKP ARVILQDFTG VPAVVDFAAM RDAVKKLGGD PEKINPVCPA 
DLVIDHSIQV DFNRRADSLQ KNQDLEFERN RERFEFLKWG SQAFHNMRII PPGSGIIHQV 
NLEYLARVVF DQDGYYYPDS LVGTDSHTTM IDGLGILGWG VGGIEAEAVM LGQPISMVLP 
QVIGYRLMGK PHPLVTSTDI VLTITKHLRQ VGVVGKFVEF FGPGVAQLSI ADRATIANMC 
PEYGATAAFF PVDEVSITYL VQTGRDEEKL KYIKKYLQAV GMFRDFNDPS QDPDFTQVVE 
LDLKTVVPCC SGPKRPQDKV AVSDMKKDFE SCLGAKQGFK GFQVAPEHHN DHKTFIYDNT 
EFTLAHGSVV IAAITSCTNT SNPSVMLGAG LLAKKAVDAG LNVMPYIKTS LSPGSGVVTY 
YLQESGVMPY LSQLGFDVVG YGCMTCIGNS GPLPEPVVEA ITQGDLVAVG VLSGNRNFEG 
RVHPNTRANY LASPPLVIAY AIAGTIRIDF EKEPLGVNAK GQQVFLKDIW PTRDEIQAVE 
RQYVIPGMFK EVYQKIETVN ESWNALATPS DKLFFWNSKS TYIKSPPFFE NLTLDLQPPK 
SIVDAYVLLN LGDSVTTDHI SPAGNIARNS PAARYLTNRG LTPREFNSYG SRRGNDAVMA 
RGTFANIRLL NRFLNKQAPQ TIHLPSGEIL DVFDAAERYQ QAGLPLIVLA GKEYGAGSSR 
DWAAKGPFLL GIKAVLAESY ERIHRSNLVG MGVIPLEYLP GENADALGLT GQERYTIIIP 
ENLKPQMKVQ VKLDTGKTFQ AVMRFDTDVE LTYFLNGGIL NYMIRKMAK

Genular Protein ID: 574578564

Symbol: Q9HBB2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9HBB2

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 3 InterPro 8 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 4 ProteomicsDB 1 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 2

Citations:

PubMed ID: 10944468

Title: cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs.

PubMed ID: 10944468

DOI: 10.1006/bbrc.2000.3282

Sequence Information:

  • Length: 790
  • Mass: 87089
  • Checksum: 4DEE8385DCA07C77
  • Sequence:
    • MRDAVKKLGG DPEKINPVCP ADLVIDHSIQ VDFNRRADSL QKNQDLEFER NRERFEFLKW 
GSQAFHNMRI IPPGSGIIHQ VNLEYLARVV FDQDGYYYPD SLVGTDSHTT MIDGLGILGW 
GVGGIEAEAV MLGQPISMVL PQVIGYRLMG KPHPLVTSTD IVLTITKHLR QVGVVGKFVE 
FFGPGVAQLS IADRATIANM CPEYGATAAF FPVDEVSITY LVQTGRDEEK LKYIKKYLQA 
VGMFRDFNDP SQDPDFTQVV ELDLKTVVPC CSGPKRPQDK VAVSDMKKDF ESCLGAKQGF 
KGFQVAPEHH NDHKTFIYDN TEFTLAHGSV VIAAITSCTN TSNPSVMLGA GLLAKKAVDA 
GLNVMPYIKT SLSPGSGVVT YYLQESGVMP YLSQLGFDVV GYGCMTCIGN SGPLPEPVVE 
AITQGDLVAV GVLSGNRNFE GRVHPNTRAN YLASPPLVIA YAIAGTIRID FEKEPLGVNA 
KGQQVFLKDI WPTRDEIQAV ERQYVIPGMF KEVYQKIETV NESWNALATP SDKLFFWNSK 
STYIKSPPFF ENLTLDLQPP KSIVDAYVLL NLGDSVTTDH ISPAGNIARN SPAARYLTNR 
GLTPREFNSY GSRRGNDAVM ARGTFANIRL LNRFLNKQAP QTIHLPSGEI LDVFDAAERY 
QQAGLPLIVL AGKEYGAGSS RDWAAKGPFL LGIKAVLAES YERIHRSNLV GMGVIPLEYL 
PGENADALGL TGQERYTIII PENLKPQMKV QVKLDTGKTF QAVMRFDTDV ELTYFLNGGI 
LNYMIRKMAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.