Details for: ATP1A4

Gene ID: 480

Symbol: ATP1A4

Ensembl ID: ENSG00000132681

Description: ATPase Na+/K+ transporting subunit alpha 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 11.5418
    Cell Significance Index: 599.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 10.2112
    Cell Significance Index: -2.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 6.4602
    Cell Significance Index: -3.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9674
    Cell Significance Index: 25.8300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.3718
    Cell Significance Index: 2.3100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2905
    Cell Significance Index: 2.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2472
    Cell Significance Index: 44.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2149
    Cell Significance Index: 26.4300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.2049
    Cell Significance Index: 5.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1493
    Cell Significance Index: 9.4100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1454
    Cell Significance Index: 3.6300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.1382
    Cell Significance Index: 2.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1304
    Cell Significance Index: 9.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1222
    Cell Significance Index: 3.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1181
    Cell Significance Index: 8.3500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0858
    Cell Significance Index: 1.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0856
    Cell Significance Index: 2.3300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.0473
    Cell Significance Index: 0.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0312
    Cell Significance Index: 6.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0307
    Cell Significance Index: 1.3600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0231
    Cell Significance Index: 0.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0230
    Cell Significance Index: 0.8700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0117
    Cell Significance Index: 5.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0052
    Cell Significance Index: 3.6000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.0047
    Cell Significance Index: 0.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0031
    Cell Significance Index: 1.4200
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0003
    Cell Significance Index: -0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0006
    Cell Significance Index: -0.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0007
    Cell Significance Index: -0.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0007
    Cell Significance Index: -1.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0007
    Cell Significance Index: -1.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0009
    Cell Significance Index: -0.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0013
    Cell Significance Index: -1.7900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0027
    Cell Significance Index: -0.0400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0032
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0041
    Cell Significance Index: -3.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0043
    Cell Significance Index: -3.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0047
    Cell Significance Index: -2.5700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0049
    Cell Significance Index: -0.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0052
    Cell Significance Index: -2.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0074
    Cell Significance Index: -0.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0080
    Cell Significance Index: -2.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0089
    Cell Significance Index: -1.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0098
    Cell Significance Index: -0.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0100
    Cell Significance Index: -1.7000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0150
    Cell Significance Index: -3.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0170
    Cell Significance Index: -0.4800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0175
    Cell Significance Index: -0.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0175
    Cell Significance Index: -2.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0177
    Cell Significance Index: -2.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0187
    Cell Significance Index: -2.1400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0214
    Cell Significance Index: -0.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0215
    Cell Significance Index: -2.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0259
    Cell Significance Index: -3.0600
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0259
    Cell Significance Index: -0.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0264
    Cell Significance Index: -2.7000
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0289
    Cell Significance Index: -0.2500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0315
    Cell Significance Index: -0.3600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0321
    Cell Significance Index: -0.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0349
    Cell Significance Index: -1.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0383
    Cell Significance Index: -2.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0384
    Cell Significance Index: -2.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0390
    Cell Significance Index: -2.0500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0391
    Cell Significance Index: -1.2800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0398
    Cell Significance Index: -1.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0421
    Cell Significance Index: -2.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0426
    Cell Significance Index: -2.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0473
    Cell Significance Index: -3.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0494
    Cell Significance Index: -1.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0501
    Cell Significance Index: -1.4800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0506
    Cell Significance Index: -1.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0535
    Cell Significance Index: -2.5200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0576
    Cell Significance Index: -1.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0618
    Cell Significance Index: -2.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0635
    Cell Significance Index: -1.8300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0658
    Cell Significance Index: -1.0000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0662
    Cell Significance Index: -0.4500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0662
    Cell Significance Index: -0.9400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0680
    Cell Significance Index: -2.1500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0684
    Cell Significance Index: -2.5100
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0707
    Cell Significance Index: -0.9100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0712
    Cell Significance Index: -1.7800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0716
    Cell Significance Index: -3.6200
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0722
    Cell Significance Index: -1.0100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0734
    Cell Significance Index: -1.0700
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0759
    Cell Significance Index: -0.9600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0768
    Cell Significance Index: -1.6300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0782
    Cell Significance Index: -1.0100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0810
    Cell Significance Index: -1.7500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0823
    Cell Significance Index: -3.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0863
    Cell Significance Index: -1.8700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0868
    Cell Significance Index: -1.9000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0877
    Cell Significance Index: -1.1300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0881
    Cell Significance Index: -1.3000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0884
    Cell Significance Index: -1.8500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0894
    Cell Significance Index: -1.2100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0912
    Cell Significance Index: -1.8300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0928
    Cell Significance Index: -1.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transmembrane protein**: The ATP1A4 gene encodes for a transmembrane protein that spans the plasma membrane, allowing it to regulate the movement of ions across the membrane. 2. **Sodium-potassium pump**: The alpha-4 subunit is a component of the sodium-potassium pump, a crucial enzyme responsible for maintaining the ionic balance across cell membranes. 3. **P-type ATPase**: The ATP1A4 gene belongs to the P-type ATPase family, which uses ATP hydrolysis to drive the movement of ions across the membrane. 4. **Ion homeostasis**: The ATP1A4 protein plays a crucial role in maintaining ion homeostasis, regulating the movement of sodium and potassium ions across the plasma membrane. **Pathways and Functions** The ATP1A4 gene is involved in various cellular pathways, including: 1. **Cardiac conduction**: The ATP1A4 protein is expressed in cardiac cells and plays a crucial role in regulating the electrical activity of the heart. 2. **Cell signaling**: The ATP1A4 protein is involved in cell signaling pathways, including the regulation of neurotransmitter release and synaptic plasticity. 3. **Muscle contraction**: The ATP1A4 protein is essential for muscle contraction, as it regulates the movement of ions across the plasma membrane to drive muscle contraction. 4. **Ion homeostasis**: The ATP1A4 protein maintains ion homeostasis by regulating the movement of sodium and potassium ions across the plasma membrane. **Clinical Significance** Dysregulation of the ATP1A4 gene has been implicated in various diseases, including: 1. **Cardiac arrhythmias**: Mutations in the ATP1A4 gene have been associated with cardiac arrhythmias, including atrial fibrillation and ventricular tachycardia. 2. **Muscle disorders**: The ATP1A4 gene is involved in the regulation of muscle contraction, and mutations in the gene have been associated with muscle disorders, including hypertrophic cardiomyopathy and myotonia congenita. 3. **Neurological disorders**: The ATP1A4 gene is expressed in neurons, and dysregulation of the gene has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **SARS-CoV-2 infections**: The ATP1A4 protein has been identified as a potential target for therapeutic interventions against SARS-CoV-2 infections. In conclusion, the ATP1A4 gene plays a crucial role in maintaining ion homeostasis and regulating various cellular processes, including muscle contraction, cell signaling, and cardiac conduction. Dysregulation of the gene has been implicated in various diseases, highlighting the importance of understanding the function and regulation of the ATP1A4 gene in human health and disease.

Genular Protein ID: 2980181749

Symbol: AT1A4_HUMAN

Name: Sodium pump subunit alpha-4

UniProtKB Accession Codes:

Q13733 Q504T2 Q7Z4I9 Q8TBN8 Q8WXA7 Q8WXH7 Q8WY13

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 1 EMBL 13 Ensembl 2 ExpressionAtlas 1 GO 31 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 Rhea 2 SFLD 2 SMART 1 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16175638

Title: The human Na,K-ATPase alpha 4 isoform is a ouabain-sensitive alpha isoform that is expressed in sperm.

PubMed ID: 16175638

DOI: 10.1002/mrd.20383

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12119109

Title: Physical mapping and characterization of the human Na,K-ATPase isoform, ATP1A4.

PubMed ID: 12119109

DOI: 10.1016/s0378-1119(02)00647-9

PubMed ID: 7809153

Title: A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis.

PubMed ID: 7809153

DOI: 10.1073/pnas.91.26.12952

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 1029
  • Mass: 114166
  • Checksum: 69958248424D2C0B
  • Sequence:
    • MGLWGKKGTV APHDQSPRRR PKKGLIKKKM VKREKQKRNM EELKKEVVMD DHKLTLEELS 
TKYSVDLTKG HSHQRAKEIL TRGGPNTVTP PPTTPEWVKF CKQLFGGFSL LLWTGAILCF 
VAYSIQIYFN EEPTKDNLYL SIVLSVVVIV TGCFSYYQEA KSSKIMESFK NMVPQQALVI 
RGGEKMQINV QEVVLGDLVE IKGGDRVPAD LRLISAQGCK VDNSSLTGES EPQSRSPDFT 
HENPLETRNI CFFSTNCVEG TARGIVIATG DSTVMGRIAS LTSGLAVGQT PIAAEIEHFI 
HLITVVAVFL GVTFFALSLL LGYGWLEAII FLIGIIVANV PEGLLATVTV CLTLTAKRMA 
RKNCLVKNLE AVETLGSTST ICSDKTGTLT QNRMTVAHMW FDMTVYEADT TEEQTGKTFT 
KSSDTWFMLA RIAGLCNRAD FKANQEILPI AKRATTGDAS ESALLKFIEQ SYSSVAEMRE 
KNPKVAEIPF NSTNKYQMSI HLREDSSQTH VLMMKGAPER ILEFCSTFLL NGQEYSMNDE 
MKEAFQNAYL ELGGLGERVL GFCFLNLPSS FSKGFPFNTD EINFPMDNLC FVGLISMIDP 
PRAAVPDAVS KCRSAGIKVI MVTGDHPITA KAIAKGVGII SEGTETAEEV AARLKIPISK 
VDASAAKAIV VHGAELKDIQ SKQLDQILQN HPEIVFARTS PQQKLIIVEG CQRLGAVVAV 
TGDGVNDSPA LKKADIGIAM GISGSDVSKQ AADMILLDDN FASIVTGVEE GRLIFDNLKK 
SIMYTLTSNI PEITPFLMFI ILGIPLPLGT ITILCIDLGT DMVPAISLAY ESAESDIMKR 
LPRNPKTDNL VNHRLIGMAY GQIGMIQALA GFFTYFVILA ENGFRPVDLL GIRLHWEDKY 
LNDLEDSYGQ QWTYEQRKVV EFTCQTAFFV TIVVVQWADL IISKTRRNSL FQQGMRNKVL 
IFGILEETLL AAFLSYTPGM DVALRMYPLK ITWWLCAIPY SILIFVYDEI RKLLIRQHPD 
GWVERETYY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.