Details for: ATP1A4

Gene ID: 480

Symbol: ATP1A4

Ensembl ID: ENSG00000132681

Description: ATPase Na+/K+ transporting subunit alpha 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.57
    Marker Score: 2306
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 872
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.05
    Marker Score: 6957
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 798
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1
    Marker Score: 2538
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71830
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48055
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5350
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.73
    Marker Score: 11369
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.68
    Marker Score: 2679
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.58
    Marker Score: 385
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.51
    Marker Score: 1057
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.45
    Marker Score: 190
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.42
    Marker Score: 849
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.41
    Marker Score: 183
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.41
    Marker Score: 771
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.38
    Marker Score: 363
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.29
    Marker Score: 6139
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.27
    Marker Score: 88
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.24
    Marker Score: 126
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.23
    Marker Score: 110
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.22
    Marker Score: 70
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.2
    Marker Score: 158
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2
    Marker Score: 765
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.19
    Marker Score: 110
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.18
    Marker Score: 36
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.18
    Marker Score: 82
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.18
    Marker Score: 154
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.17
    Marker Score: 102
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.16
    Marker Score: 92
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.15
    Marker Score: 374
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.14
    Marker Score: 64
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.14
    Marker Score: 42
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.14
    Marker Score: 329
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.13
    Marker Score: 159
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.12
    Marker Score: 256.5
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.12
    Marker Score: 42
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.11
    Marker Score: 102
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.11
    Marker Score: 76
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.11
    Marker Score: 38
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.11
    Marker Score: 37
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.11
    Marker Score: 259
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.11
    Marker Score: 121
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.1
    Marker Score: 150
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.1
    Marker Score: 104
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.1
    Marker Score: 127
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.1
    Marker Score: 88
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.1
    Marker Score: 40
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.09
    Marker Score: 101
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.09
    Marker Score: 18
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.09
    Marker Score: 20
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.09
    Marker Score: 72
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.08
    Marker Score: 92
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.08
    Marker Score: 5061
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.08
    Marker Score: 743
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: group 2 innate lymphoid cell (CL0001069)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.08
    Marker Score: 243
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.08
    Marker Score: 52
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.07
    Marker Score: 46
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.07
    Marker Score: 214
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.07
    Marker Score: 122
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.07
    Marker Score: 65
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.06
    Marker Score: 106
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.06
    Marker Score: 534
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.06
    Marker Score: 66
  • Cell Name: immature neutrophil (CL0000776)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.06
    Marker Score: 36
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.06
    Marker Score: 15

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Other Information

**Key characteristics:** - The ATP1A4 gene is located on chromosome 19q27.1. - It is a large gene, encoding for a protein of 1,344 amino acids. - The protein is a transmembrane protein that is expressed in both the plasma membrane and the intracellular domain of cardiac myocytes. **Pathways and functions:** - The ATP1A4 protein is a key regulator of cellular calcium and potassium ion concentrations. - It is involved in the regulation of cardiac conduction, disease, infectious disease, and muscle contraction. - The protein is also involved in the regulation of the transport of small molecules, viral infection pathways, and protein binding. **Clinical significance:** - Mutations in the ATP1A4 gene have been linked to several human diseases, including sars and cardiac arrhythmias. - Targeting the ATP1A4 protein has been explored as a therapeutic strategy for these diseases.

Genular Protein ID: 2980181749

Symbol: AT1A4_HUMAN

Name: Sodium pump subunit alpha-4

UniProtKB Accession Codes:

Q13733 Q504T2 Q7Z4I9 Q8TBN8 Q8WXA7 Q8WXH7 Q8WY13

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 1 EMBL 13 Ensembl 2 ExpressionAtlas 1 GO 31 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 Rhea 2 SAM 1 SFLD 2 SMART 1 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16175638

Title: The human Na,K-ATPase alpha 4 isoform is a ouabain-sensitive alpha isoform that is expressed in sperm.

PubMed ID: 16175638

DOI: 10.1002/mrd.20383

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12119109

Title: Physical mapping and characterization of the human Na,K-ATPase isoform, ATP1A4.

PubMed ID: 12119109

DOI: 10.1016/s0378-1119(02)00647-9

PubMed ID: 7809153

Title: A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis.

PubMed ID: 7809153

DOI: 10.1073/pnas.91.26.12952

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 1029
  • Mass: 114166
  • Checksum: 69958248424D2C0B
  • Sequence:
    • MGLWGKKGTV APHDQSPRRR PKKGLIKKKM VKREKQKRNM EELKKEVVMD DHKLTLEELS 
TKYSVDLTKG HSHQRAKEIL TRGGPNTVTP PPTTPEWVKF CKQLFGGFSL LLWTGAILCF 
VAYSIQIYFN EEPTKDNLYL SIVLSVVVIV TGCFSYYQEA KSSKIMESFK NMVPQQALVI 
RGGEKMQINV QEVVLGDLVE IKGGDRVPAD LRLISAQGCK VDNSSLTGES EPQSRSPDFT 
HENPLETRNI CFFSTNCVEG TARGIVIATG DSTVMGRIAS LTSGLAVGQT PIAAEIEHFI 
HLITVVAVFL GVTFFALSLL LGYGWLEAII FLIGIIVANV PEGLLATVTV CLTLTAKRMA 
RKNCLVKNLE AVETLGSTST ICSDKTGTLT QNRMTVAHMW FDMTVYEADT TEEQTGKTFT 
KSSDTWFMLA RIAGLCNRAD FKANQEILPI AKRATTGDAS ESALLKFIEQ SYSSVAEMRE 
KNPKVAEIPF NSTNKYQMSI HLREDSSQTH VLMMKGAPER ILEFCSTFLL NGQEYSMNDE 
MKEAFQNAYL ELGGLGERVL GFCFLNLPSS FSKGFPFNTD EINFPMDNLC FVGLISMIDP 
PRAAVPDAVS KCRSAGIKVI MVTGDHPITA KAIAKGVGII SEGTETAEEV AARLKIPISK 
VDASAAKAIV VHGAELKDIQ SKQLDQILQN HPEIVFARTS PQQKLIIVEG CQRLGAVVAV 
TGDGVNDSPA LKKADIGIAM GISGSDVSKQ AADMILLDDN FASIVTGVEE GRLIFDNLKK 
SIMYTLTSNI PEITPFLMFI ILGIPLPLGT ITILCIDLGT DMVPAISLAY ESAESDIMKR 
LPRNPKTDNL VNHRLIGMAY GQIGMIQALA GFFTYFVILA ENGFRPVDLL GIRLHWEDKY 
LNDLEDSYGQ QWTYEQRKVV EFTCQTAFFV TIVVVQWADL IISKTRRNSL FQQGMRNKVL 
IFGILEETLL AAFLSYTPGM DVALRMYPLK ITWWLCAIPY SILIFVYDEI RKLLIRQHPD 
GWVERETYY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.