Details for: ATP1B1

Gene ID: 481

Symbol: ATP1B1

Ensembl ID: ENSG00000143153

Description: ATPase Na+/K+ transporting subunit beta 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 723.8409
    Cell Significance Index: -112.5900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 427.4111
    Cell Significance Index: -108.4100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 278.9675
    Cell Significance Index: -114.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 229.6821
    Cell Significance Index: -93.3100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 163.5565
    Cell Significance Index: -109.7500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 97.3665
    Cell Significance Index: -92.9600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 91.4794
    Cell Significance Index: -112.7900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 39.9536
    Cell Significance Index: -107.0300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 33.1993
    Cell Significance Index: -101.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 28.6286
    Cell Significance Index: -112.9700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.0521
    Cell Significance Index: -22.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 8.6851
    Cell Significance Index: 456.0000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 6.9424
    Cell Significance Index: 169.3900
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 5.9519
    Cell Significance Index: 22.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 5.0569
    Cell Significance Index: 3707.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.6623
    Cell Significance Index: 217.3800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 4.0183
    Cell Significance Index: 49.8400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.6715
    Cell Significance Index: 22.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.3144
    Cell Significance Index: 1188.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.9424
    Cell Significance Index: 530.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.7554
    Cell Significance Index: 552.7300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 2.6941
    Cell Significance Index: 43.4700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.4582
    Cell Significance Index: 70.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.3895
    Cell Significance Index: 160.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.3341
    Cell Significance Index: 173.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.1870
    Cell Significance Index: 268.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.0442
    Cell Significance Index: 156.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.9447
    Cell Significance Index: 1062.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.8558
    Cell Significance Index: 53.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8053
    Cell Significance Index: 49.1400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.6419
    Cell Significance Index: 15.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5982
    Cell Significance Index: 83.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.5953
    Cell Significance Index: 1103.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.5823
    Cell Significance Index: 202.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4688
    Cell Significance Index: 189.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.4307
    Cell Significance Index: 67.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.3380
    Cell Significance Index: 82.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3199
    Cell Significance Index: 261.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3160
    Cell Significance Index: 59.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1609
    Cell Significance Index: 513.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0675
    Cell Significance Index: 173.6300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8310
    Cell Significance Index: 21.8500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7768
    Cell Significance Index: 147.8300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.7255
    Cell Significance Index: 57.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5095
    Cell Significance Index: 55.4200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.4179
    Cell Significance Index: 6.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3899
    Cell Significance Index: 734.0900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2483
    Cell Significance Index: 24.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2261
    Cell Significance Index: 204.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2062
    Cell Significance Index: 7.2500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1721
    Cell Significance Index: 2.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1060
    Cell Significance Index: 80.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0970
    Cell Significance Index: 16.5600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0967
    Cell Significance Index: 2.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0523
    Cell Significance Index: 96.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0404
    Cell Significance Index: 25.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0362
    Cell Significance Index: 49.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0141
    Cell Significance Index: 21.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0264
    Cell Significance Index: -19.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0324
    Cell Significance Index: -14.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0601
    Cell Significance Index: -37.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0820
    Cell Significance Index: -8.3800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1144
    Cell Significance Index: -5.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1270
    Cell Significance Index: -71.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1322
    Cell Significance Index: -9.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1675
    Cell Significance Index: -35.2900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1889
    Cell Significance Index: -1.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2710
    Cell Significance Index: -39.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3094
    Cell Significance Index: -9.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.3227
    Cell Significance Index: -44.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3348
    Cell Significance Index: -96.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3614
    Cell Significance Index: -10.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3766
    Cell Significance Index: -14.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4403
    Cell Significance Index: -50.4400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4683
    Cell Significance Index: -10.8200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4832
    Cell Significance Index: -7.2400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4859
    Cell Significance Index: -55.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5108
    Cell Significance Index: -13.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5261
    Cell Significance Index: -13.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6111
    Cell Significance Index: -13.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6171
    Cell Significance Index: -71.9200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7158
    Cell Significance Index: -15.3000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7175
    Cell Significance Index: -9.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7801
    Cell Significance Index: -81.2300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.8349
    Cell Significance Index: -98.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9190
    Cell Significance Index: -51.5700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9258
    Cell Significance Index: -19.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.9559
    Cell Significance Index: -49.7900
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -1.0697
    Cell Significance Index: -9.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.1066
    Cell Significance Index: -78.2600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.1119
    Cell Significance Index: -15.5900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -1.2154
    Cell Significance Index: -18.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.2835
    Cell Significance Index: -21.4800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.4299
    Cell Significance Index: -17.8300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.5192
    Cell Significance Index: -30.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.5628
    Cell Significance Index: -41.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.6171
    Cell Significance Index: -104.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.6288
    Cell Significance Index: -99.8600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.6383
    Cell Significance Index: -22.9800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.7352
    Cell Significance Index: -34.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The ATP1B1 gene is a single-copy gene with a length of approximately 20 kb. It is located on chromosome 12q24.33 and is highly conserved across species, with a high degree of sequence similarity to other Na+/K+ ATPase subunits. The beta 1 subunit is a transmembrane protein that forms a heterodimer with the alpha 1 subunit to create the Na+/K+ ATPase pump. This pump is responsible for pumping sodium ions out of the cell and potassium ions into the cell, establishing a critical electrochemical gradient that regulates various cellular functions. **Pathways and Functions** The ATP1B1 gene is involved in several key cellular pathways, including: 1. **Ion Homeostasis**: The Na+/K+ ATPase pump regulates the concentration of sodium and potassium ions in the cell, which is essential for maintaining proper cellular function. 2. **Cardiac Contraction**: The ATP1B1 gene plays a crucial role in regulating cardiac muscle contraction by maintaining the transmembrane electrochemical gradient. 3. **Cell Surface Interactions**: The beta 1 subunit is involved in cell surface interactions, including adhesion and communication by electrical coupling. 4. **Regulation of Gene Expression**: The ATP1B1 gene is involved in regulating gene expression, particularly in response to changes in ion concentrations. **Clinical Significance** Mutations in the ATP1B1 gene have been associated with several diseases, including: 1. **Hypertension**: Mutations in the ATP1B1 gene have been linked to essential hypertension, a condition characterized by high blood pressure. 2. **Kidney Disease**: The ATP1B1 gene is involved in regulating ion homeostasis in the kidney, and mutations in this gene have been associated with kidney disease. 3. **Cardiac Arrhythmias**: The ATP1B1 gene plays a crucial role in regulating cardiac muscle contraction, and mutations in this gene have been associated with cardiac arrhythmias. 4. **SARS**: The ATP1B1 gene has been identified as a potential therapeutic target for SARS, a viral infection characterized by respiratory symptoms. In conclusion, the ATP1B1 gene plays a critical role in regulating ion homeostasis, cell surface interactions, and cardiac muscle contraction. Mutations in this gene have been associated with several diseases, including hypertension, kidney disease, and cardiac arrhythmias. Further research is needed to fully understand the role of the ATP1B1 gene in human disease and to develop effective therapeutic strategies for its dysregulation.

Genular Protein ID: 3869103526

Symbol: AT1B1_HUMAN

Name: Sodium/potassium-transporting ATPase subunit beta-1

UniProtKB Accession Codes:

P05026 Q5TGZ3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 7 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 8 EMDB 8 Ensembl 4 ExpressionAtlas 1 GO 48 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3008098

Title: Molecular cloning and sequence analysis of human Na,K-ATPase beta-subunit.

PubMed ID: 3008098

DOI: 10.1093/nar/14.7.2833

PubMed ID: 2559024

Title: Characterization of two genes for the human Na,K-ATPase beta subunit.

PubMed ID: 2559024

DOI: 10.1016/0888-7543(89)90008-6

PubMed ID: 7536695

Title: Characterization and quantification of full-length and truncated Na,K-ATPase alpha 1 and beta 1 RNA transcripts expressed in human retinal pigment epithelium.

PubMed ID: 7536695

DOI: 10.1016/0378-1119(94)00812-7

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2555225

Title: Human Na(+), K(+)-ATPase genes. Beta subunit gene family contains at least one gene and one pseudogene.

PubMed ID: 2555225

DOI: 10.1016/0014-5793(89)81591-1

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 19694409

Title: A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules.

PubMed ID: 19694409

DOI: 10.1021/bi900868e

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22328087

Title: Megalencephalic leukoencephalopathy with subcortical cysts protein 1 functionally cooperates with the TRPV4 cation channel to activate the response of astrocytes to osmotic stress: dysregulation by pathological mutations.

PubMed ID: 22328087

DOI: 10.1093/hmg/dds032

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25902260

Title: Autism and intellectual disability-associated KIRREL3 interacts with neuronal proteins MAP1B and MYO16 with potential roles in neurodevelopment.

PubMed ID: 25902260

DOI: 10.1371/journal.pone.0123106

PubMed ID: 34011520

Title: Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6.

PubMed ID: 34011520

DOI: 10.4049/jimmunol.2001262

Sequence Information:

  • Length: 303
  • Mass: 35061
  • Checksum: 107D3C04394F2D11
  • Sequence:
    • MARGKAKEEG SWKKFIWNSE KKEFLGRTGG SWFKILLFYV IFYGCLAGIF IGTIQVMLLT 
ISEFKPTYQD RVAPPGLTQI PQIQKTEISF RPNDPKSYEA YVLNIVRFLE KYKDSAQRDD 
MIFEDCGDVP SEPKERGDFN HERGERKVCR FKLEWLGNCS GLNDETYGYK EGKPCIIIKL 
NRVLGFKPKP PKNESLETYP VMKYNPNVLP VQCTGKRDED KDKVGNVEYF GLGNSPGFPL 
QYYPYYGKLL QPKYLQPLLA VQFTNLTMDT EIRIECKAYG ENIGYSEKDR FQGRFDVKIE 
VKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.