Details for: ATP1B2

Gene ID: 482

Symbol: ATP1B2

Ensembl ID: ENSG00000129244

Description: ATPase Na+/K+ transporting subunit beta 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 125.5905
    Cell Significance Index: -19.5400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 103.6889
    Cell Significance Index: -26.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.6171
    Cell Significance Index: -25.4200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.8273
    Cell Significance Index: -18.9300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 13.7593
    Cell Significance Index: 106.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 9.3538
    Cell Significance Index: 589.5400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 3.8132
    Cell Significance Index: 32.0300
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 2.7540
    Cell Significance Index: 24.2600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 2.6395
    Cell Significance Index: 36.9100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.3079
    Cell Significance Index: 32.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.5666
    Cell Significance Index: 82.2500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.3842
    Cell Significance Index: 30.3100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 1.2886
    Cell Significance Index: 15.6200
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.2536
    Cell Significance Index: 13.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0354
    Cell Significance Index: 46.9300
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.8470
    Cell Significance Index: 5.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7135
    Cell Significance Index: 255.9200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.7055
    Cell Significance Index: 8.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5673
    Cell Significance Index: 72.7200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.3771
    Cell Significance Index: 6.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2945
    Cell Significance Index: 18.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1743
    Cell Significance Index: 9.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1704
    Cell Significance Index: 2.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1339
    Cell Significance Index: 18.3900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1272
    Cell Significance Index: 3.0500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1207
    Cell Significance Index: 83.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1055
    Cell Significance Index: 65.8600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1049
    Cell Significance Index: 1.2500
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0806
    Cell Significance Index: 0.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0740
    Cell Significance Index: 14.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0235
    Cell Significance Index: 44.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0041
    Cell Significance Index: -3.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0096
    Cell Significance Index: -5.4200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0104
    Cell Significance Index: -0.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0104
    Cell Significance Index: -15.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0113
    Cell Significance Index: -7.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0118
    Cell Significance Index: -8.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0118
    Cell Significance Index: -21.8100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0195
    Cell Significance Index: -8.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0196
    Cell Significance Index: -26.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0332
    Cell Significance Index: -15.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0359
    Cell Significance Index: -27.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0414
    Cell Significance Index: -22.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0528
    Cell Significance Index: -9.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0570
    Cell Significance Index: -9.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0599
    Cell Significance Index: -12.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0626
    Cell Significance Index: -7.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0722
    Cell Significance Index: -20.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0748
    Cell Significance Index: -2.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0751
    Cell Significance Index: -10.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0902
    Cell Significance Index: -17.9100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0977
    Cell Significance Index: -1.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1021
    Cell Significance Index: -16.6100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1118
    Cell Significance Index: -1.2800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1355
    Cell Significance Index: -2.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1444
    Cell Significance Index: -17.7600
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1656
    Cell Significance Index: -1.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1675
    Cell Significance Index: -21.6400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1682
    Cell Significance Index: -19.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1786
    Cell Significance Index: -5.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1833
    Cell Significance Index: -21.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1999
    Cell Significance Index: -23.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2024
    Cell Significance Index: -20.6800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2198
    Cell Significance Index: -4.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2393
    Cell Significance Index: -14.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2440
    Cell Significance Index: -25.4100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2621
    Cell Significance Index: -20.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2635
    Cell Significance Index: -4.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2848
    Cell Significance Index: -7.4900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2907
    Cell Significance Index: -6.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2951
    Cell Significance Index: -21.9900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2996
    Cell Significance Index: -20.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3124
    Cell Significance Index: -16.2300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3262
    Cell Significance Index: -6.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3382
    Cell Significance Index: -25.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3432
    Cell Significance Index: -23.0800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3479
    Cell Significance Index: -18.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3492
    Cell Significance Index: -16.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3500
    Cell Significance Index: -21.4600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3537
    Cell Significance Index: -4.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3554
    Cell Significance Index: -22.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3650
    Cell Significance Index: -10.2000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3908
    Cell Significance Index: -5.6000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4033
    Cell Significance Index: -8.5600
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.4248
    Cell Significance Index: -4.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4346
    Cell Significance Index: -15.2700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4586
    Cell Significance Index: -5.3500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4708
    Cell Significance Index: -11.4100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4832
    Cell Significance Index: -15.8200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5041
    Cell Significance Index: -10.5200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5155
    Cell Significance Index: -12.8600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5272
    Cell Significance Index: -11.2700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5591
    Cell Significance Index: -5.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5640
    Cell Significance Index: -19.6000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.5789
    Cell Significance Index: -3.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5800
    Cell Significance Index: -27.0400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5816
    Cell Significance Index: -21.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6005
    Cell Significance Index: -26.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6056
    Cell Significance Index: -17.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6279
    Cell Significance Index: -22.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of the Sodium-Potassium Pump:** The ATP1B2 gene encodes the beta-2 subunit of the sodium-potassium pump, a transmembrane enzyme responsible for pumping sodium ions out of cells and potassium ions into cells. 2. **Ion Homeostasis:** The ATP1B2 gene plays a critical role in maintaining ion homeostasis, particularly in the regulation of sodium and potassium ion concentrations across cell membranes. 3. **Cellular Localization:** The ATP1B2 gene is expressed in various cell types, including astrocytes, photoreceptor cells, and erythroblast cells, indicating its widespread importance in maintaining cellular homeostasis. 4. **Regulation of Cellular Processes:** The ATP1B2 gene is involved in regulating various cellular processes, including muscle contraction, neuronal-glial interaction, and photoreceptor cell maintenance. **Pathways and Functions:** 1. **Ion Channel Transport:** The ATP1B2 gene is involved in ion channel transport, particularly in the regulation of sodium and potassium ion concentrations across cell membranes. 2. **Sodium-Potassium Exchanging ATPase Complex:** The ATP1B2 gene is part of the sodium-potassium exchanging ATPase complex, which plays a critical role in maintaining ion homeostasis and regulating various cellular processes. 3. **Cellular Signaling:** The ATP1B2 gene is involved in cellular signaling pathways, including the regulation of neuronal-glial interaction and photoreceptor cell maintenance. 4. **Gene Regulation:** The ATP1B2 gene is regulated by various transcription factors and post-translational modifications, which control its expression and activity. **Clinical Significance:** 1. **Neurological Disorders:** Mutations or alterations in the ATP1B2 gene have been implicated in various neurological disorders, including glial cell migration disorders and infectious diseases. 2. **Infectious Diseases:** The ATP1B2 gene has been identified as a potential target for therapeutic interventions against SARS-CoV infections. 3. **Photoreceptor Cell Diseases:** The ATP1B2 gene plays a critical role in maintaining photoreceptor cell homeostasis, and mutations or alterations in this gene have been implicated in photoreceptor cell diseases. 4. **Cardiac Conduction:** The ATP1B2 gene is involved in regulating cardiac conduction, and alterations in this gene have been implicated in cardiac conduction disorders. In conclusion, the ATP1B2 gene plays a critical role in maintaining ion homeostasis and regulating various cellular processes. Its expression and activity are essential for maintaining cellular homeostasis, and alterations in this gene have been implicated in various diseases, including neurological disorders, infectious diseases, and photoreceptor cell diseases. Further research is needed to fully understand the mechanisms of the ATP1B2 gene and its role in regulating cellular processes.

Genular Protein ID: 3365141988

Symbol: AT1B2_HUMAN

Name: Sodium/potassium-transporting ATPase subunit beta-2

UniProtKB Accession Codes:

P14415 A0AV17 A8K278 D3DTQ2 O60444

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 40 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 2 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8305453

Title: Nucleotide sequence of a cDNA for the beta 2 subunit isoform of Na+,K(+)-ATPase from human retina.

PubMed ID: 8305453

DOI: 10.1016/0005-2736(94)90287-9

PubMed ID: 8918259

Title: Expression and synthesis of the Na,K-ATPase beta 2 subunit in human retinal pigment epithelium.

PubMed ID: 8918259

DOI: 10.1016/0378-1119(96)00258-2

PubMed ID: 9524271

Title: Structure and expression of the human Na,K-ATPase beta 2-subunit gene.

PubMed ID: 9524271

DOI: 10.1016/s0378-1119(97)00661-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2538450

Title: Identification of a putative isoform of the Na,K-ATPase beta subunit. Primary structure and tissue-specific expression.

PubMed ID: 2538450

DOI: 10.1016/s0021-9258(18)83787-5

PubMed ID: 19694409

Title: A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules.

PubMed ID: 19694409

DOI: 10.1021/bi900868e

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

Sequence Information:

  • Length: 290
  • Mass: 33367
  • Checksum: CC5BFBB6D01347F1
  • Sequence:
    • MVIQKEKKSC GQVVEEWKEF VWNPRTHQFM GRTGTSWAFI LLFYLVFYGF LTAMFTLTMW 
VMLQTVSDHT PKYQDRLATP GLMIRPKTEN LDVIVNVSDT ESWDQHVQKL NKFLEPYNDS 
IQAQKNDVCR PGRYYEQPDN GVLNYPKRAC QFNRTQLGNC SGIGDSTHYG YSTGQPCVFI 
KMNRVINFYA GANQSMNVTC AGKRDEDAEN LGNFVMFPAN GNIDLMYFPY YGKKFHVNYT 
QPLVAVKFLN VTPNVEVNVE CRINAANIAT DDERDKFAGR VAFKLRINKT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.