Gene ATP1B3 - ENSG00000069849 | NCBI Gene ID: 483

Details for: ATP1B3

Gene ID: 483

Symbol: ATP1B3

Ensembl ID: ENSG00000069849

Description: ATPase Na+/K+ transporting subunit beta 3

Associated with

Basigin interactions
(R-HSA-210991)
Cardiac conduction
(R-HSA-5576891)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Disease
(R-HSA-1643685)
Hemostasis
(R-HSA-109582)
Infectious disease
(R-HSA-5663205)
Ion channel transport
(R-HSA-983712)
Ion homeostasis
(R-HSA-5578775)
Ion transport by p-type atpases
(R-HSA-936837)
Muscle contraction
(R-HSA-397014)
Potential therapeutics for sars
(R-HSA-9679191)
Sars-cov infections
(R-HSA-9679506)
Transport of small molecules
(R-HSA-382551)
Viral infection pathways
(R-HSA-9824446)
Apical plasma membrane
(GO:0016324)
Atpase activator activity
(GO:0001671)
Atpase binding
(GO:0051117)
Basolateral plasma membrane
(GO:0016323)
Extracellular exosome
(GO:0070062)
Intracellular potassium ion homeostasis
(GO:0030007)
Intracellular sodium ion homeostasis
(GO:0006883)
Melanosome
(GO:0042470)
Membrane repolarization
(GO:0086009)
Plasma membrane
(GO:0005886)
Positive regulation of atp-dependent activity
(GO:0032781)
Positive regulation of potassium ion import across plasma membrane
(GO:1903288)
Positive regulation of potassium ion transmembrane transporter activity
(GO:1901018)
Positive regulation of sodium ion export across plasma membrane
(GO:1903278)
Potassium ion import across plasma membrane
(GO:1990573)
Potassium ion transmembrane transport
(GO:0071805)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein localization to plasma membrane
(GO:0072659)
Protein stabilization
(GO:0050821)
Sodium:potassium-exchanging atpase complex
(GO:0005890)
Sodium ion export across plasma membrane
(GO:0036376)
Sodium ion transmembrane transport
(GO:0035725)
Sperm flagellum
(GO:0036126)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.6
Marker Score: 3070
Cell Name: anterior lens cell (CL0002223)
Fold Change: 3.58
Marker Score: 4819
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.18
Marker Score: 7759
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.9
Marker Score: 1208
Cell Name: lung macrophage (CL1001603)
Fold Change: 2.76
Marker Score: 3162
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.74
Marker Score: 11462
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.72
Marker Score: 92530
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.7
Marker Score: 3053
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 2.63
Marker Score: 3186
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 2.63
Marker Score: 6354
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.62
Marker Score: 767
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.51
Marker Score: 1981
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 2.46
Marker Score: 18321
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 2.44
Marker Score: 588
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 2.41
Marker Score: 599
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 2.39
Marker Score: 808.5
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 2.39
Marker Score: 599
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.36
Marker Score: 41930
Cell Name: basal cell (CL0000646)
Fold Change: 2.35
Marker Score: 3031
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 2.34
Marker Score: 910
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.32
Marker Score: 59511
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 2.3
Marker Score: 2403.5
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.3
Marker Score: 2423
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.29
Marker Score: 7199
Cell Name: late pro-B cell (CL0002048)
Fold Change: 2.27
Marker Score: 2676
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.22
Marker Score: 1298
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.22
Marker Score: 2552
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 2.21
Marker Score: 17258.5
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 2.18
Marker Score: 18825
Cell Name: decidual cell (CL2000002)
Fold Change: 2.18
Marker Score: 9384
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 2.14
Marker Score: 1037
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.1
Marker Score: 8253
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 2.1
Marker Score: 1974
Cell Name: erythroblast (CL0000765)
Fold Change: 2.1
Marker Score: 1308
Cell Name: elicited macrophage (CL0000861)
Fold Change: 2.08
Marker Score: 12664.5
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 2.08
Marker Score: 2207
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 2.07
Marker Score: 5217
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.07
Marker Score: 1180
Cell Name: neural crest cell (CL0011012)
Fold Change: 2.06
Marker Score: 2199
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.05
Marker Score: 2975
Cell Name: enterocyte (CL0000584)
Fold Change: 2.05
Marker Score: 9814.5
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 2.04
Marker Score: 854
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.04
Marker Score: 4066
Cell Name: pro-B cell (CL0000826)
Fold Change: 2.02
Marker Score: 1946
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 2.01
Marker Score: 2840
Cell Name: dendritic cell (CL0000451)
Fold Change: 1.99
Marker Score: 1368
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.97
Marker Score: 2108
Cell Name: microglial cell (CL0000129)
Fold Change: 1.97
Marker Score: 3587
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.96
Marker Score: 1079
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.96
Marker Score: 1959
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.96
Marker Score: 19818
Cell Name: renal principal cell (CL0005009)
Fold Change: 1.95
Marker Score: 1504
Cell Name: ependymal cell (CL0000065)
Fold Change: 1.94
Marker Score: 675
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.93
Marker Score: 9471
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.93
Marker Score: 4994
Cell Name: granulocyte (CL0000094)
Fold Change: 1.92
Marker Score: 859
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.92
Marker Score: 2821
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.89
Marker Score: 451
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.89
Marker Score: 5053
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.87
Marker Score: 1181
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 1.87
Marker Score: 857
Cell Name: secretory cell (CL0000151)
Fold Change: 1.85
Marker Score: 3384
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.85
Marker Score: 3602
Cell Name: stromal cell (CL0000499)
Fold Change: 1.85
Marker Score: 2166
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 1.84
Marker Score: 2834
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 1.84
Marker Score: 1545
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.83
Marker Score: 467
Cell Name: melanocyte (CL0000148)
Fold Change: 1.81
Marker Score: 735
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 1.81
Marker Score: 405
Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.81
Marker Score: 1042
Cell Name: endothelial cell (CL0000115)
Fold Change: 1.8
Marker Score: 1616
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.8
Marker Score: 1827
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.79
Marker Score: 3012
Cell Name: male germ cell (CL0000015)
Fold Change: 1.78
Marker Score: 513
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.78
Marker Score: 18347
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.78
Marker Score: 1673
Cell Name: club cell (CL0000158)
Fold Change: 1.77
Marker Score: 2070
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 1.76
Marker Score: 4483
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 1.76
Marker Score: 1895
Cell Name: oogonial cell (CL0000024)
Fold Change: 1.76
Marker Score: 2532
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.75
Marker Score: 1933
Cell Name: pericyte (CL0000669)
Fold Change: 1.75
Marker Score: 1022
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 1.75
Marker Score: 342
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.74
Marker Score: 4725
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.73
Marker Score: 2169
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 1.72
Marker Score: 784
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.7
Marker Score: 104253
Cell Name: plasmablast (CL0000980)
Fold Change: 1.69
Marker Score: 2245
Cell Name: neuron (CL0000540)
Fold Change: 1.68
Marker Score: 6854
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.68
Marker Score: 1694
Cell Name: B-1b B cell (CL0000821)
Fold Change: 1.68
Marker Score: 386
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.67
Marker Score: 1537
Cell Name: memory T cell (CL0000813)
Fold Change: 1.67
Marker Score: 718
Cell Name: leukocyte (CL0000738)
Fold Change: 1.67
Marker Score: 957
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 1.65
Marker Score: 1035
Cell Name: fibroblast (CL0000057)
Fold Change: 1.64
Marker Score: 1588
Cell Name: osteoblast (CL0000062)
Fold Change: 1.64
Marker Score: 881
Cell Name: preosteoblast (CL0007010)
Fold Change: 1.63
Marker Score: 463
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 1.63
Marker Score: 4513
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.63
Marker Score: 15487

Hover over a box to see details here...

**Key characteristics:** - The protein is a glycoprotein with a molecular weight of approximately 140 kDa. - It is a transmembrane protein that is expressed in a variety of cell types. - It is a key regulator of cardiac conduction and cell surface interactions. **Pathways and functions:** - The protein is involved in the regulation of cardiac conduction. - It is a key regulator of cell surface interactions, including those between the vascular wall and the surrounding tissue. - It is involved in the transport of small molecules and ions. **Clinical significance:** - Mutations in the ATP1B3 gene have been linked to a number of human diseases, including prostate cancer, heart disease, and stroke. - Targeting the ATP1B3 protein has been investigated as a therapeutic strategy for these diseases. - ATP1B3 is a potential target for the treatment of heart failure, a condition characterized by the heart's inability to pump blood effectively. **Additional notes:** - The ATP1B3 gene is also known as NKX2.1. - It is a member of the ATPase family of proteins. - It is a highly conserved protein that is found in organisms from yeast to humans.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Sodium/potassium-transporting ATPase subunit beta-3

Genular Protein ID: 2959144980

Symbol: AT1B3_HUMAN

Name: Sodium/potassium-transporting ATPase subunit beta-3

UniProtKB Accession Codes:

P54709 B7Z1N7

Database IDs:

Citations:

PubMed ID: 8798450

Title: Identification of the mammalian Na,K-ATPase 3 subunit.

PubMed ID: 8798450

DOI: 10.1074/jbc.271.37.22754

PubMed ID: 9457675

Title: Structural organization and chromosomal localization of the human Na,K- ATPase beta 3 subunit gene and pseudogene.

PubMed ID: 9457675

DOI: 10.1007/s003359900704

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

Length: 279
Mass: 31513
Checksum: D92ECB4F0F6EBFE5
Sequence:

MTKNEKKSLN QSLAEWKLFI YNPTTGEFLG RTAKSWGLIL LFYLVFYGFL AALFSFTMWV 
MLQTLNDEVP KYRDQIPSPG LMVFPKPVTA LEYTFSRSDP TSYAGYIEDL KKFLKPYTLE 
EQKNLTVCPD GALFEQKGPV YVACQFPISL LQACSGMNDP DFGYSQGNPC ILVKMNRIIG 
LKPEGVPRID CVSKNEDIPN VAVYPHNGMI DLKYFPYYGK KLHVGYLQPL VAVQVSFAPN 
NTGKEVTVEC KIDGSANLKS QDDRDKFLGR VMFKITARA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ATP1B3

Associated with

Cells (max top 100)

Other Information

Identification of the mammalian Na,K-ATPase 3 subunit. PubMed ID: 8798450

Structural organization and chromosomal localization of the human Na,K- ATPase beta 3 subunit gene and pseudogene. PubMed ID: 9457675

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. PubMed ID: 12754519

Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. PubMed ID: 17081065

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712