Details for: ATP1B3

Gene ID: 483

Symbol: ATP1B3

Ensembl ID: ENSG00000069849

Description: ATPase Na+/K+ transporting subunit beta 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 412.9989
    Cell Significance Index: -64.2400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 277.6339
    Cell Significance Index: -70.4200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 175.6111
    Cell Significance Index: -82.9100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 156.0504
    Cell Significance Index: -80.2700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 124.0496
    Cell Significance Index: -83.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 65.5336
    Cell Significance Index: -80.8000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 25.9103
    Cell Significance Index: -69.4100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 21.4316
    Cell Significance Index: -84.5700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 19.5738
    Cell Significance Index: -60.1200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.5733
    Cell Significance Index: -31.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 7.8894
    Cell Significance Index: 14854.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 5.0533
    Cell Significance Index: 3209.3900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 4.3913
    Cell Significance Index: 9.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.6870
    Cell Significance Index: 103.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.6347
    Cell Significance Index: 70.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.5700
    Cell Significance Index: 73.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.5532
    Cell Significance Index: 1128.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1215
    Cell Significance Index: 425.5800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.9981
    Cell Significance Index: 14.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.8576
    Cell Significance Index: 87.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.6955
    Cell Significance Index: 3126.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.6125
    Cell Significance Index: 206.7100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.5625
    Cell Significance Index: 100.8100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.3652
    Cell Significance Index: 36.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3299
    Cell Significance Index: 163.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2812
    Cell Significance Index: 230.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.2433
    Cell Significance Index: 1914.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2363
    Cell Significance Index: 33.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2340
    Cell Significance Index: 200.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.0308
    Cell Significance Index: 45.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0147
    Cell Significance Index: 131.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9707
    Cell Significance Index: 530.1400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.8952
    Cell Significance Index: 10.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8772
    Cell Significance Index: 62.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8769
    Cell Significance Index: 314.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8041
    Cell Significance Index: 30.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6671
    Cell Significance Index: 132.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5996
    Cell Significance Index: 41.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4212
    Cell Significance Index: 380.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4110
    Cell Significance Index: 56.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3968
    Cell Significance Index: 39.2500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2810
    Cell Significance Index: 4.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2416
    Cell Significance Index: 328.5700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2264
    Cell Significance Index: 3.8800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2230
    Cell Significance Index: 42.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2076
    Cell Significance Index: 12.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1969
    Cell Significance Index: 9.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1943
    Cell Significance Index: 14.9100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1491
    Cell Significance Index: 3.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0902
    Cell Significance Index: 40.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0680
    Cell Significance Index: 49.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0537
    Cell Significance Index: 2.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0529
    Cell Significance Index: 6.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0407
    Cell Significance Index: 3.0400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0331
    Cell Significance Index: 0.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0002
    Cell Significance Index: 0.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0030
    Cell Significance Index: -0.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0149
    Cell Significance Index: -0.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0315
    Cell Significance Index: -19.6700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0319
    Cell Significance Index: -23.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0752
    Cell Significance Index: -12.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0762
    Cell Significance Index: -5.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0863
    Cell Significance Index: -8.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1071
    Cell Significance Index: -60.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1992
    Cell Significance Index: -9.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2250
    Cell Significance Index: -32.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2403
    Cell Significance Index: -69.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2685
    Cell Significance Index: -31.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2762
    Cell Significance Index: -58.1800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2779
    Cell Significance Index: -31.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3569
    Cell Significance Index: -4.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3586
    Cell Significance Index: -21.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3598
    Cell Significance Index: -18.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3862
    Cell Significance Index: -12.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3931
    Cell Significance Index: -45.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3950
    Cell Significance Index: -6.6100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4040
    Cell Significance Index: -14.0400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5351
    Cell Significance Index: -9.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5444
    Cell Significance Index: -56.6800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5565
    Cell Significance Index: -15.8800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6985
    Cell Significance Index: -18.6900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6997
    Cell Significance Index: -20.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.7226
    Cell Significance Index: -20.8200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8272
    Cell Significance Index: -19.1100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.8559
    Cell Significance Index: -12.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9033
    Cell Significance Index: -71.5400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.9516
    Cell Significance Index: -24.3100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9952
    Cell Significance Index: -61.0200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.0687
    Cell Significance Index: -22.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.1512
    Cell Significance Index: -29.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.1816
    Cell Significance Index: -74.4700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.2117
    Cell Significance Index: -25.9000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.3072
    Cell Significance Index: -31.3500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.3378
    Cell Significance Index: -26.1100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.5261
    Cell Significance Index: -19.0300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.5395
    Cell Significance Index: -40.4800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.5572
    Cell Significance Index: -16.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.6475
    Cell Significance Index: -52.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.6781
    Cell Significance Index: -54.9400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.8385
    Cell Significance Index: -67.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of the Na+/K+ pump**: ATP1B3 is a beta subunit of the Na+/K+ pump, a transmembrane enzyme responsible for maintaining the electrochemical gradient across cell membranes. 2. **Ion homeostasis**: The Na+/K+ pump, in which ATP1B3 plays a crucial role, is essential for regulating the balance of sodium and potassium ions within cells, which in turn affects various cellular processes. 3. **Cell surface interactions**: ATP1B3 is involved in cell surface interactions, including binding to other proteins and lipids, which facilitate its localization to the plasma membrane. 4. **Intracellular signaling**: ATP1B3 can modulate intracellular signaling pathways, influencing the activity of other proteins and enzymes. **Pathways and Functions:** 1. **Ion transport by p-type ATPases**: ATP1B3 is involved in the transport of sodium and potassium ions across cell membranes, using the energy from ATP hydrolysis. 2. **Intracellular potassium ion homeostasis**: The Na+/K+ pump, in which ATP1B3 is a key component, regulates the balance of potassium ions within cells. 3. **Intracellular sodium ion homeostasis**: ATP1B3 also contributes to the regulation of sodium ions within cells. 4. **Cell surface interactions**: ATP1B3 interacts with other proteins and lipids at the cell surface, influencing its localization and function. 5. **Protein localization to plasma membrane**: ATP1B3 is involved in the targeting of the Na+/K+ pump to the plasma membrane, ensuring proper ion transport. 6. **Protein stabilization**: ATP1B3 can stabilize other proteins, influencing their activity and localization. 7. **Regulation of atp-dependent activity**: ATP1B3 can regulate the activity of other ATP-dependent enzymes, modulating their function. **Clinical Significance:** 1. **Cardiac conduction disorders**: Alterations in the Na+/K+ pump, in which ATP1B3 plays a crucial role, can lead to cardiac conduction disorders, such as arrhythmias. 2. **Hypertension**: Dysregulation of the Na+/K+ pump can contribute to hypertension, a condition characterized by elevated blood pressure. 3. **Muscle contraction**: The Na+/K+ pump, in which ATP1B3 is a key component, regulates muscle contraction and relaxation. 4. **SARS-CoV infections**: Recent studies have suggested that ATP1B3 may play a role in the pathogenesis of SARS-CoV infections, highlighting its potential as a therapeutic target. 5. **Cancer**: Alterations in the Na+/K+ pump, in which ATP1B3 is a crucial component, have been observed in various types of cancer, suggesting its potential as a therapeutic target. In conclusion, the ATP1B3 gene encodes for a protein with complex roles in ion homeostasis, cellular processes, and interaction with other molecules. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its functions and potential therapeutic applications.

Genular Protein ID: 2959144980

Symbol: AT1B3_HUMAN

Name: Sodium/potassium-transporting ATPase subunit beta-3

UniProtKB Accession Codes:

P54709 B7Z1N7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 11 Ensembl 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8798450

Title: Identification of the mammalian Na,K-ATPase 3 subunit.

PubMed ID: 8798450

DOI: 10.1074/jbc.271.37.22754

PubMed ID: 9457675

Title: Structural organization and chromosomal localization of the human Na,K- ATPase beta 3 subunit gene and pseudogene.

PubMed ID: 9457675

DOI: 10.1007/s003359900704

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 279
  • Mass: 31513
  • Checksum: D92ECB4F0F6EBFE5
  • Sequence:
    • MTKNEKKSLN QSLAEWKLFI YNPTTGEFLG RTAKSWGLIL LFYLVFYGFL AALFSFTMWV 
MLQTLNDEVP KYRDQIPSPG LMVFPKPVTA LEYTFSRSDP TSYAGYIEDL KKFLKPYTLE 
EQKNLTVCPD GALFEQKGPV YVACQFPISL LQACSGMNDP DFGYSQGNPC ILVKMNRIIG 
LKPEGVPRID CVSKNEDIPN VAVYPHNGMI DLKYFPYYGK KLHVGYLQPL VAVQVSFAPN 
NTGKEVTVEC KIDGSANLKS QDDRDKFLGR VMFKITARA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.