Details for: FXYD2

Gene ID: 486

Symbol: FXYD2

Ensembl ID: ENSG00000137731

Description: FXYD domain containing ion transport regulator 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 24.5835
    Cell Significance Index: 94.1300
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 19.6084
    Cell Significance Index: -3.0500
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 15.9160
    Cell Significance Index: 54.6500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 13.6506
    Cell Significance Index: 108.9900
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 13.3847
    Cell Significance Index: 74.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 12.1430
    Cell Significance Index: -3.0800
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 3.8315
    Cell Significance Index: 32.3000
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 2.7614
    Cell Significance Index: 10.4000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.4737
    Cell Significance Index: -3.0500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.1677
    Cell Significance Index: 27.3900
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 2.1170
    Cell Significance Index: 7.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.7637
    Cell Significance Index: 56.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 1.7307
    Cell Significance Index: 137.0700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 1.7209
    Cell Significance Index: 35.8900
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.1351
    Cell Significance Index: 11.5400
  • Cell Name: kidney cortex collecting duct epithelial cell (CL1000549)
    Fold Change: 0.9689
    Cell Significance Index: 1.0200
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.8796
    Cell Significance Index: 6.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.6135
    Cell Significance Index: 449.7900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.5648
    Cell Significance Index: 14.4300
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.5392
    Cell Significance Index: 4.2900
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.2394
    Cell Significance Index: 2.2800
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.2297
    Cell Significance Index: 2.4800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2079
    Cell Significance Index: 3.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1467
    Cell Significance Index: 27.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1157
    Cell Significance Index: 23.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1032
    Cell Significance Index: 37.0300
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.0956
    Cell Significance Index: 1.1100
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.0825
    Cell Significance Index: 0.5100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0794
    Cell Significance Index: 4.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0646
    Cell Significance Index: 4.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0600
    Cell Significance Index: 6.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0597
    Cell Significance Index: 10.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0464
    Cell Significance Index: 5.0500
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.0408
    Cell Significance Index: 0.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0319
    Cell Significance Index: 4.3800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0286
    Cell Significance Index: 0.8200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0233
    Cell Significance Index: 0.1900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0223
    Cell Significance Index: 1.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0210
    Cell Significance Index: 18.9500
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.0163
    Cell Significance Index: 0.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0160
    Cell Significance Index: 8.7300
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.0155
    Cell Significance Index: 0.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0136
    Cell Significance Index: 2.2200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0108
    Cell Significance Index: 0.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0079
    Cell Significance Index: 2.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0074
    Cell Significance Index: 0.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0054
    Cell Significance Index: 0.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0037
    Cell Significance Index: 0.0800
  • Cell Name: kidney loop of Henle ascending limb epithelial cell (CL1001016)
    Fold Change: 0.0021
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0008
    Cell Significance Index: 0.6200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0005
    Cell Significance Index: -0.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0014
    Cell Significance Index: -0.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0015
    Cell Significance Index: -0.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0015
    Cell Significance Index: -2.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0015
    Cell Significance Index: -2.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0018
    Cell Significance Index: -3.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0025
    Cell Significance Index: -3.3400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0026
    Cell Significance Index: -0.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0027
    Cell Significance Index: -0.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0034
    Cell Significance Index: -0.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0035
    Cell Significance Index: -2.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0041
    Cell Significance Index: -0.8700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0044
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0044
    Cell Significance Index: -0.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0045
    Cell Significance Index: -2.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0049
    Cell Significance Index: -0.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0072
    Cell Significance Index: -0.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0078
    Cell Significance Index: -4.9700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0079
    Cell Significance Index: -3.6000
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: -0.0104
    Cell Significance Index: -0.1000
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0105
    Cell Significance Index: -0.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0119
    Cell Significance Index: -0.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0165
    Cell Significance Index: -1.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0175
    Cell Significance Index: -1.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0176
    Cell Significance Index: -3.1700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0184
    Cell Significance Index: -0.9300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0264
    Cell Significance Index: -1.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0277
    Cell Significance Index: -3.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0279
    Cell Significance Index: -3.6100
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.0281
    Cell Significance Index: -0.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0290
    Cell Significance Index: -3.0200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0292
    Cell Significance Index: -0.4400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0294
    Cell Significance Index: -0.2500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0299
    Cell Significance Index: -0.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0314
    Cell Significance Index: -3.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0322
    Cell Significance Index: -4.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0327
    Cell Significance Index: -1.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0347
    Cell Significance Index: -2.6600
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0388
    Cell Significance Index: -0.5800
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.0398
    Cell Significance Index: -0.4000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0411
    Cell Significance Index: -1.1000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0464
    Cell Significance Index: -0.7800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0468
    Cell Significance Index: -3.1500
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0472
    Cell Significance Index: -0.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0472
    Cell Significance Index: -1.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0483
    Cell Significance Index: -3.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0516
    Cell Significance Index: -2.7100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0574
    Cell Significance Index: -1.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0574
    Cell Significance Index: -2.7000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0580
    Cell Significance Index: -0.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **FXYD domain**: The FXYD domain is a protein-protein interaction domain that facilitates the interaction between the FXYD2 protein and the Na+/K+-ATPase complex, modulating its activity. 2. **Ion homeostasis**: FXYD2 regulates the balance of ions across cell membranes, particularly sodium and potassium, which is essential for maintaining proper cellular function and overall health. 3. **Epithelial tissues**: FXYD2 is highly expressed in epithelial tissues, including the kidneys, lungs, and gut, where it plays a crucial role in maintaining ion homeostasis and regulating fluid balance. 4. **Regulatory subunit**: FXYD2 acts as a regulatory subunit of the Na+/K+-ATPase complex, modulating its activity and ensuring proper ion transport. **Pathways and Functions:** 1. **Na+/K+-ATPase complex**: FXYD2 interacts with the Na+/K+-ATPase complex to modulate its activity, ensuring proper ion transport across cell membranes. 2. **Ion homeostasis**: FXYD2 regulates the balance of ions across cell membranes, maintaining proper fluid balance and cellular function. 3. **Cardiac conduction**: FXYD2 is involved in regulating cardiac conduction, ensuring proper transmission of electrical signals across the heart. 4. **Infectious disease**: FXYD2 has been implicated in the regulation of viral infections, including SARS-CoV, and may serve as a potential therapeutic target. **Clinical Significance:** 1. **Cardiovascular disorders**: Dysregulation of FXYD2 has been implicated in various cardiovascular disorders, including hypertension, heart failure, and cardiac arrhythmias. 2. **Respiratory infections**: FXYD2 has been shown to play a role in regulating respiratory infections, including SARS-CoV and influenza. 3. **Cancer**: FXYD2 has been implicated in the regulation of cancer cell growth and metastasis. 4. **Therapeutic applications**: FXYD2 may serve as a potential therapeutic target for the treatment of various diseases, including cardiovascular disorders and infectious diseases. In conclusion, the FXYD2 gene plays a critical role in regulating ion homeostasis and maintaining proper cellular function. Dysregulation of FXYD2 has been implicated in various diseases, and its therapeutic potential is an area of ongoing research. Further studies are needed to fully elucidate the mechanisms by which FXYD2 regulates ion homeostasis and its implications in disease.

Genular Protein ID: 2419126924

Symbol: ATNG_HUMAN

Name: Sodium/potassium-transporting ATPase subunit gamma

UniProtKB Accession Codes:

P54710 Q15332 Q53YC1 Q9GZP3 Q9GZQ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EMBL 10 EMDB 3 Ensembl 4 EvolutionaryTrace 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9048881

Title: Cloning and expression of human cDNA encoding Na+, K(+)-ATPase gamma-subunit.

PubMed ID: 9048881

DOI: 10.1016/s0167-4781(96)00219-9

PubMed ID: 11112438

Title: Genomic organization of the human FXYD2 gene encoding the gamma subunit of the Na,K-ATPase.

PubMed ID: 11112438

DOI: 10.1006/bbrc.2000.3907

PubMed ID: 11062458

Title: Dominant isolated renal magnesium loss is caused by misrouting of the Na+,K+-ATPase gamma-subunit.

PubMed ID: 11062458

DOI: 10.1038/81543

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 66
  • Mass: 7283
  • Checksum: D00F21B5C01ACE75
  • Sequence:
    • MTGLSMDGGG SPKGDVDPFY YDYETVRNGG LIFAGLAFIV GLLILLSRRF RCGGNKKRRQ 
INEDEP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.