Details for: ATP2A1

Gene ID: 487

Symbol: ATP2A1

Ensembl ID: ENSG00000196296

Description: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 3.7
    Marker Score: 2813
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1170
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.54
    Marker Score: 2914
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169670
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 855
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.15
    Marker Score: 518
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1
    Marker Score: 15717
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.98
    Marker Score: 2022.5
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.96
    Marker Score: 2402
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5342
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.92
    Marker Score: 381.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.9
    Marker Score: 1832
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.88
    Marker Score: 1936.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.84
    Marker Score: 252
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 592
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 396.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.75
    Marker Score: 3136
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.73
    Marker Score: 440
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.62
    Marker Score: 297
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.59
    Marker Score: 1030
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 360
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 206.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.47
    Marker Score: 150
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.44
    Marker Score: 628
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.42
    Marker Score: 406
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.39
    Marker Score: 606
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.37
    Marker Score: 164
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.36
    Marker Score: 2140
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.33
    Marker Score: 448.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.32
    Marker Score: 103
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.31
    Marker Score: 204
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.28
    Marker Score: 88
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.28
    Marker Score: 90
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.28
    Marker Score: 695
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.26
    Marker Score: 615
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.25
    Marker Score: 66
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.25
    Marker Score: 112
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.23
    Marker Score: 98
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.23
    Marker Score: 74
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.22
    Marker Score: 306.5
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.21
    Marker Score: 61
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.2
    Marker Score: 828
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2
    Marker Score: 2028
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2
    Marker Score: 2053
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.2
    Marker Score: 80
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.19
    Marker Score: 318.5
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.18
    Marker Score: 64
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.18
    Marker Score: 59
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.17
    Marker Score: 1646
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.17
    Marker Score: 61
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.17
    Marker Score: 50
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.17
    Marker Score: 46
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.16
    Marker Score: 10091
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.16
    Marker Score: 5937
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.16
    Marker Score: 1378
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.16
    Marker Score: 171.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.16
    Marker Score: 94.5
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.16
    Marker Score: 145
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.16
    Marker Score: 102
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.15
    Marker Score: 78
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.15
    Marker Score: 190
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.15
    Marker Score: 40
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.15
    Marker Score: 135
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.15
    Marker Score: 129
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.15
    Marker Score: 1396
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.14
    Marker Score: 98
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.14
    Marker Score: 574
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.14
    Marker Score: 64
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.14
    Marker Score: 3085
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.14
    Marker Score: 2932
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.14
    Marker Score: 528
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.14
    Marker Score: 66
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.13
    Marker Score: 92
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.13
    Marker Score: 1111
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.13
    Marker Score: 69
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.13
    Marker Score: 88
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.13
    Marker Score: 61
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.13
    Marker Score: 161
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.13
    Marker Score: 84
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.13
    Marker Score: 46
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.13
    Marker Score: 44

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Other Information

**Key characteristics:** * The protein is a type of ATPase, which are proteins that facilitate the movement of molecules across a cell membrane. * ATP2A1 is a calcium pump, which means that it transports calcium ions across the cell membrane from an area of higher calcium concentration to an area of lower calcium concentration. * The protein is also involved in signal transduction, as it is a key regulator of cardiac contraction. **Pathways and functions:** * The protein is involved in a variety of cellular processes, including cardiac conduction, muscle contraction, and blood clotting. * In cardiac conduction, ATP2A1 helps to maintain the resting membrane potential of cardiac cells and to regulate the heart rate. * In muscle contraction, ATP2A1 is responsible for the cycling of calcium ions between the sarcoplasmic reticulum and the cytoplasm. This cycling is essential for muscle contraction. * In blood clotting, ATP2A1 is involved in the regulation of hemostasis. **Clinical significance:** Mutations in the ATP2A1 gene have been linked to a number of human diseases, including hypertrophic cardiomyopathy, cardiac arrhythmias, and pulmonary hypertension. These diseases are characterized by abnormal heart function and blood pressure.

Genular Protein ID: 51386993

Symbol: AT2A1_HUMAN

Name: Calcium pump 1

UniProtKB Accession Codes:

O14983 A8K5J9 B3KY17 O14984

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEBI 32 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 8 EC 1 EMBL 22 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 38 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 4 RefSeq 3 Rhea 2 SFLD 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8825625

Title: Characterization of cDNA and genomic DNA encoding SERCA1, the Ca(2+)-ATPase of human fast-twitch skeletal muscle sarcoplasmic reticulum, and its elimination as a candidate gene for Brody disease.

PubMed ID: 8825625

DOI: 10.1006/geno.1995.1259

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 28890335

Title: The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation.

PubMed ID: 28890335

DOI: 10.1016/j.molcel.2017.08.005

PubMed ID: 10914677

Title: The mutation of Pro(789) to Leu reduces the activity of the fast-twitch skeletal muscle sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA1) and is associated with Brody disease.

PubMed ID: 10914677

DOI: 10.1007/s004390000297

Sequence Information:

  • Length: 1001
  • Mass: 110252
  • Checksum: C8F33809B56FDDEE
  • Sequence:
    • MEAAHAKTTE ECLAYFGVSE TTGLTPDQVK RNLEKYGLNE LPAEEGKTLW ELVIEQFEDL 
LVRILLLAAC ISFVLAWFEE GEETITAFVE PFVILLILIA NAIVGVWQER NAENAIEALK 
EYEPEMGKVY RADRKSVQRI KARDIVPGDI VEVAVGDKVP ADIRILAIKS TTLRVDQSIL 
TGESVSVIKH TEPVPDPRAV NQDKKNMLFS GTNIAAGKAL GIVATTGVGT EIGKIRDQMA 
ATEQDKTPLQ QKLDEFGEQL SKVISLICVA VWLINIGHFN DPVHGGSWFR GAIYYFKIAV 
ALAVAAIPEG LPAVITTCLA LGTRRMAKKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 
MSVCKMFIID KVDGDICLLN EFSITGSTYA PEGEVLKNDK PVRPGQYDGL VELATICALC 
NDSSLDFNEA KGVYEKVGEA TETALTTLVE KMNVFNTDVR SLSKVERANA CNSVIRQLMK 
KEFTLEFSRD RKSMSVYCSP AKSSRAAVGN KMFVKGAPEG VIDRCNYVRV GTTRVPLTGP 
VKEKIMAVIK EWGTGRDTLR CLALATRDTP PKREEMVLDD SARFLEYETD LTFVGVVGML 
DPPRKEVTGS IQLCRDAGIR VIMITGDNKG TAIAICRRIG IFGENEEVAD RAYTGREFDD 
LPLAEQREAC RRACCFARVE PSHKSKIVEY LQSYDEITAM TGDGVNDAPA LKKAEIGIAM 
GSGTAVAKTA SEMVLADDNF STIVAAVEEG RAIYNNMKQF IRYLISSNVG EVVCIFLTAA 
LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMDRP PRSPKEPLIS GWLFFRYMAI 
GGYVGAATVG AAAWWFLYAE DGPHVNYSQL THFMQCTEDN THFEGIDCEV FEAPEPMTMA 
LSVLVTIEMC NALNSLSENQ SLLRMPPWVN IWLLGSICLS MSLHFLILYV DPLPMIFKLR 
ALDLTQWLMV LKISLPVIGL DEILKFVARN YLEDPEDERR K

Genular Protein ID: 3303044892

Symbol: Q7Z675_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z675

Database IDs:

ARBA 15 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 7 DNASU 1 EC 1 EMBL 2 GO 4 Gene3D 4 Genevisible 1 GenomeRNAi 1 IntAct 1 InterPro 11 KEGG 1 NCBI Taxonomy 1 NCBIfam 2 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 RefSeq 3 Rhea 2 RuleBase 1 SFLD 2 SMART 2 SMR 1 SUPFAM 4

Sequence Information:

  • Length: 994
  • Mass: 109256
  • Checksum: 460B75B8982246CF
  • Sequence:
    • MEAAHAKTTE ECLAYFGVSE TTGLTPDQVK RNLEKYGLNE LPAEEGKTLW ELVIEQFEDL 
LVRILLLAAC ISFVLAWFEE GEETITAFVE PFVILLILIA NAIVGVWQER NAENAIEALK 
EYEPEMGKVY QADRKSVQRI KARDIVPGDI VEVAVGDKVP ADIRILAIKS TTLRVDQSIL 
TGESVSVIKH TEPVPDPRAV NQDKKNMLFS GTNIAAGKAL GIVATTGVGT EIGKIRDQMA 
ATEQDKTPLQ QKLDEFGEQL SKVISLICVA VWLINIGHFN DPVHGGSWFR GAIYYFKIAV 
ALAVAAIPEG LPAVITTCLA LGTRRMAKKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 
MSVCKMFIID KVDGDICLLN EFSITGSTYA PEGEVLKNDK PVRPGQYDGL VELATICALC 
NDSSLDFNEA KGVYEKVGEA TETALTTLVE KMNVFNTDVR SLSKVERANA CNSVIRQLMK 
KEFTLEFSRD RKSMSVYCSP AKSSRAAVGN KMFVKGAPEG VIDRCNYVRV GTTRVPLTGP 
VKEKIMAVIK EWGTGRDTLR CLALATRDTP PKREEMVLDD SARFLEYETD LTFVGVVGML 
DPPRKEVTGS IQLCRDAGIR VIMITGDNKG TAIAICRRIG IFGENEEVAD RAYTGREFDD 
LPLAEQREAC RRACCFARVE PSHKSKIVEY LQSYDEITAM TGDGVNDAPA LKKAEIGIAM 
GSGTAVAKTA SEMVLADDNF STIVAAVEEG RAIYNNMKQF IRYLISSNVG EVVCIFLTAA 
LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMDRP PRSPEEPLIS GWLFFRYMAI 
GGYVGAATVG AAAWWFLYAE DGPHVNYSQL THFMQCTEDN THFEGIDCEV FEAPEPMTMA 
LSVLVTIEMC NALNSLSENQ SLLRMPPWVN IWLLGSICLS MSLHFLILYV DPLPMIFKLR 
ALDLTQWLMV LKISLPVIGL DEILKFVARN YLEG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.