Details for: ATP2A2

Gene ID: 488

Symbol: ATP2A2

Ensembl ID: ENSG00000174437

Description: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 496.4473
    Cell Significance Index: -77.2200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 301.4271
    Cell Significance Index: -76.4600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 191.6749
    Cell Significance Index: -78.9600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 170.1465
    Cell Significance Index: -80.3300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 163.7141
    Cell Significance Index: -66.5100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 149.9265
    Cell Significance Index: -77.1200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 120.0929
    Cell Significance Index: -80.5900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 69.6837
    Cell Significance Index: -66.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 63.8060
    Cell Significance Index: -78.6700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 28.6129
    Cell Significance Index: -76.6500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 23.2626
    Cell Significance Index: -71.4500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.9719
    Cell Significance Index: -78.8100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.6317
    Cell Significance Index: -36.4000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 9.4064
    Cell Significance Index: 229.5100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 6.7437
    Cell Significance Index: 517.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 5.6570
    Cell Significance Index: 2567.5200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 4.6269
    Cell Significance Index: 68.3100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.5013
    Cell Significance Index: 90.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.7545
    Cell Significance Index: 286.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.3079
    Cell Significance Index: 462.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.0739
    Cell Significance Index: 411.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.7126
    Cell Significance Index: 47.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6806
    Cell Significance Index: 182.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6629
    Cell Significance Index: 596.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.3317
    Cell Significance Index: 62.0900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3303
    Cell Significance Index: 36.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2982
    Cell Significance Index: 37.4100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.2796
    Cell Significance Index: 2409.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2751
    Cell Significance Index: 156.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.2667
    Cell Significance Index: 56.0300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2328
    Cell Significance Index: 852.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1470
    Cell Significance Index: 51.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.1318
    Cell Significance Index: 42.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0810
    Cell Significance Index: 23.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0759
    Cell Significance Index: 193.9600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.0646
    Cell Significance Index: 30.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9774
    Cell Significance Index: 533.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9372
    Cell Significance Index: 846.2400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.8284
    Cell Significance Index: 19.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7776
    Cell Significance Index: 343.7900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7501
    Cell Significance Index: 51.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7426
    Cell Significance Index: 38.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7279
    Cell Significance Index: 48.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6934
    Cell Significance Index: 18.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6736
    Cell Significance Index: 37.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5742
    Cell Significance Index: 35.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5537
    Cell Significance Index: 54.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4509
    Cell Significance Index: 61.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3437
    Cell Significance Index: 218.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2841
    Cell Significance Index: 46.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2775
    Cell Significance Index: 9.7500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2662
    Cell Significance Index: 7.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2226
    Cell Significance Index: 16.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2000
    Cell Significance Index: 9.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1985
    Cell Significance Index: 37.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1766
    Cell Significance Index: 30.1500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0962
    Cell Significance Index: 1.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0229
    Cell Significance Index: 1.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0148
    Cell Significance Index: 1.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0022
    Cell Significance Index: 3.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0012
    Cell Significance Index: -2.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0040
    Cell Significance Index: -6.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0363
    Cell Significance Index: -0.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0384
    Cell Significance Index: -28.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0384
    Cell Significance Index: -28.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0439
    Cell Significance Index: -33.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0695
    Cell Significance Index: -43.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0958
    Cell Significance Index: -54.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1260
    Cell Significance Index: -16.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1470
    Cell Significance Index: -17.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1861
    Cell Significance Index: -39.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1889
    Cell Significance Index: -19.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2216
    Cell Significance Index: -4.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2354
    Cell Significance Index: -34.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2401
    Cell Significance Index: -69.0800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3011
    Cell Significance Index: -7.2200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3204
    Cell Significance Index: -36.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3601
    Cell Significance Index: -41.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3942
    Cell Significance Index: -45.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4324
    Cell Significance Index: -5.9000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4464
    Cell Significance Index: -6.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5010
    Cell Significance Index: -32.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6092
    Cell Significance Index: -10.4400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.6373
    Cell Significance Index: -38.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6674
    Cell Significance Index: -35.0400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.6928
    Cell Significance Index: -6.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6999
    Cell Significance Index: -44.1100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7155
    Cell Significance Index: -15.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7575
    Cell Significance Index: -39.4600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.8658
    Cell Significance Index: -7.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8883
    Cell Significance Index: -70.3500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.9241
    Cell Significance Index: -13.6400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.0404
    Cell Significance Index: -22.7800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.1435
    Cell Significance Index: -24.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1625
    Cell Significance Index: -71.2700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.2938
    Cell Significance Index: -34.0200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -1.3332
    Cell Significance Index: -17.1000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.3496
    Cell Significance Index: -26.3400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.3941
    Cell Significance Index: -48.4500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.4015
    Cell Significance Index: -21.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** ATP2A2 is widely expressed in various cell types, including cardiac myocytes, smooth muscle cells, neurons, and epithelial cells. 2. **Function:** ATP2A2 functions as a calcium pump, transporting calcium ions into the sarcoplasmic/endoplasmic reticulum, thereby regulating intracellular calcium levels and maintaining cellular homeostasis. 3. **Transmembrane Transport:** ATP2A2 exhibits p-type calcium transporter activity, allowing for the transport of calcium ions across the cell membrane. 4. **Regulation:** ATP2A2 is regulated by various signaling pathways, including the Notch and ERK signaling cascades, which modulate its expression and activity. **Pathways and Functions:** 1. **Cardiac Conduction:** ATP2A2 plays a crucial role in regulating cardiac muscle contraction and relaxation by controlling calcium ion levels within the cardiac myocyte. 2. **Muscle Contraction:** ATP2A2 is essential for muscle contraction, particularly in smooth muscle cells, where it regulates calcium ion-dependent contraction. 3. **Neurotransmitter Release:** ATP2A2 regulates the exocytosis of neurotransmitters by controlling calcium ion-dependent vesicle fusion. 4. **Cellular Stress Response:** ATP2A2 is involved in the response to endoplasmic reticulum stress, where it helps maintain calcium ion homeostasis and prevent cellular damage. 5. **Cardiac Hypertrophy:** ATP2A2 has been implicated in the development of cardiac hypertrophy, where it regulates calcium ion levels and contributes to the pathogenesis of heart failure. **Clinical Significance:** 1. **Cardiovascular Disorders:** Dysregulation of ATP2A2 has been implicated in various cardiovascular disorders, including hypertension, cardiac hypertrophy, and arrhythmias. 2. **Neurological Disorders:** ATP2A2 has been linked to neurological disorders, such as Alzheimer's disease, Parkinson's disease, and epilepsy, where it regulates calcium ion homeostasis and neuronal function. 3. **Cancer:** ATP2A2 has been identified as a potential oncogene, where it regulates cell growth, differentiation, and survival. In conclusion, ATP2A2 plays a critical role in maintaining calcium homeostasis within cells, particularly in cardiac myocytes, smooth muscle cells, and neurons. Its dysregulation has been implicated in various cardiovascular and neurological disorders, highlighting its importance in maintaining cellular function and overall health. Further research is necessary to elucidate the mechanisms underlying ATP2A2's functions and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 1937224347

Symbol: AT2A2_HUMAN

Name: Calcium pump 2

UniProtKB Accession Codes:

P16615 A6NDN7 B4DF05 P16614 Q86VJ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 32 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 1 EMBL 9 EMDB 12 Ensembl 2 ExpressionAtlas 1 GO 51 Gene3D 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 15 PIR 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 4 RefSeq 4 Rhea 2 SFLD 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2844796

Title: Molecular cloning of cDNAs from human kidney coding for two alternatively spliced products of the cardiac Ca2+-ATPase gene.

PubMed ID: 2844796

DOI: 10.1016/s0021-9258(18)68141-4

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12659872

Title: Identification of a new SERCA2 splice variant regulated during monocytic differentiation.

PubMed ID: 12659872

DOI: 10.1016/s0006-291x(03)00405-4

PubMed ID: 12804600

Title: Ca2+ -dependent interaction of S100A1 with the sarcoplasmic reticulum Ca2+ -ATPase2a and phospholamban in the human heart.

PubMed ID: 12804600

DOI: 10.1016/s0006-291x(03)00987-2

PubMed ID: 14749390

Title: TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis.

PubMed ID: 14749390

DOI: 10.1128/mcb.24.4.1758-1768.2004

PubMed ID: 16399855

Title: Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging.

PubMed ID: 16399855

DOI: 10.1152/ajpheart.01293.2005

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18971376

Title: The anti-apoptotic protein HAX-1 interacts with SERCA2 and regulates its protein levels to promote cell survival.

PubMed ID: 18971376

DOI: 10.1091/mbc.e08-06-0587

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22084111

Title: POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters.

PubMed ID: 22084111

DOI: 10.1073/pnas.1117231108

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25996873

Title: TMEM203 is a novel regulator of intracellular calcium homeostasis and is required for spermatogenesis.

PubMed ID: 25996873

DOI: 10.1371/journal.pone.0127480

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27502484

Title: TMX1 determines cancer cell metabolism as a thiol-based modulator of ER-mitochondria Ca2+ flux.

PubMed ID: 27502484

DOI: 10.1083/jcb.201512077

PubMed ID: 10441323

Title: Spectrum of novel ATP2A2 mutations in patients with Darier's disease.

PubMed ID: 10441323

DOI: 10.1093/hmg/8.9.1611

PubMed ID: 10441324

Title: ATP2A2 mutations in Darier's disease: variant cutaneous phenotypes are associated with missense mutations, but neuropsychiatric features are independent of mutation class.

PubMed ID: 10441324

DOI: 10.1093/hmg/8.9.1621

PubMed ID: 10441325

Title: ATP2A2 mutations in Darier's disease and their relationship to neuropsychiatric phenotypes.

PubMed ID: 10441325

DOI: 10.1093/hmg/8.9.1631

PubMed ID: 10080178

Title: Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease.

PubMed ID: 10080178

DOI: 10.1038/6784

PubMed ID: 12542527

Title: Acrokeratosis verruciformis of Hopf is caused by mutation in ATP2A2: evidence that it is allelic to Darier's disease.

PubMed ID: 12542527

DOI: 10.1046/j.1523-1747.2003.t01-1-12045.x

PubMed ID: 16402920

Title: Ca2+-ATPases in non-failing and failing heart: evidence for a novel cardiac sarco/endoplasmic reticulum Ca2+-ATPase 2 isoform (SERCA2c).

PubMed ID: 16402920

DOI: 10.1042/bj20051427

PubMed ID: 28890335

Title: The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation.

PubMed ID: 28890335

DOI: 10.1016/j.molcel.2017.08.005

PubMed ID: 31735293

Title: TMX2 is a crucial regulator of cellular redox state, and its dysfunction causes severe brain developmental abnormalities.

PubMed ID: 31735293

DOI: 10.1016/j.ajhg.2019.10.009

PubMed ID: 19995371

Title: Three-base deletion mutation c.120_122delGTT in ATP2A2 leads to the unique phenotype of comedonal Darier disease.

PubMed ID: 19995371

DOI: 10.1111/j.1365-2133.2009.09580.x

PubMed ID: 28035777

Title: Mendelian Disorders of Cornification Caused by Defects in Intracellular Calcium Pumps: Mutation Update and Database for Variants in ATP2A2 and ATP2C1 associated with Darier disease and Hailey-Hailey disease.

PubMed ID: 28035777

DOI: 10.1002/humu.23164

Sequence Information:

  • Length: 1042
  • Mass: 114757
  • Checksum: 5462FF2DA7FB630A
  • Sequence:
    • MENAHTKTVE EVLGHFGVNE STGLSLEQVK KLKERWGSNE LPAEEGKTLL ELVIEQFEDL 
LVRILLLAAC ISFVLAWFEE GEETITAFVE PFVILLILVA NAIVGVWQER NAENAIEALK 
EYEPEMGKVY RQDRKSVQRI KAKDIVPGDI VEIAVGDKVP ADIRLTSIKS TTLRVDQSIL 
TGESVSVIKH TDPVPDPRAV NQDKKNMLFS GTNIAAGKAM GVVVATGVNT EIGKIRDEMV 
ATEQERTPLQ QKLDEFGEQL SKVISLICIA VWIINIGHFN DPVHGGSWIR GAIYYFKIAV 
ALAVAAIPEG LPAVITTCLA LGTRRMAKKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 
MSVCRMFILD RVEGDTCSLN EFTITGSTYA PIGEVHKDDK PVNCHQYDGL VELATICALC 
NDSALDYNEA KGVYEKVGEA TETALTCLVE KMNVFDTELK GLSKIERANA CNSVIKQLMK 
KEFTLEFSRD RKSMSVYCTP NKPSRTSMSK MFVKGAPEGV IDRCTHIRVG STKVPMTSGV 
KQKIMSVIRE WGSGSDTLRC LALATHDNPL RREEMHLEDS ANFIKYETNL TFVGCVGMLD 
PPRIEVASSV KLCRQAGIRV IMITGDNKGT AVAICRRIGI FGQDEDVTSK AFTGREFDEL 
NPSAQRDACL NARCFARVEP SHKSKIVEFL QSFDEITAMT GDGVNDAPAL KKAEIGIAMG 
SGTAVAKTAS EMVLADDNFS TIVAAVEEGR AIYNNMKQFI RYLISSNVGE VVCIFLTAAL 
GFPEALIPVQ LLWVNLVTDG LPATALGFNP PDLDIMNKPP RNPKEPLISG WLFFRYLAIG 
CYVGAATVGA AAWWFIAADG GPRVSFYQLS HFLQCKEDNP DFEGVDCAIF ESPYPMTMAL 
SVLVTIEMCN ALNSLSENQS LLRMPPWENI WLVGSICLSM SLHFLILYVE PLPLIFQITP 
LNVTQWLMVL KISLPVILMD ETLKFVARNY LEPGKECVQP ATKSCSFSAC TDGISWPFVL 
LIMPLVIWVY STDTNFSDMF WS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.