ATP2A2 | ENSG00000174437 | NCBI 488

Details for: ATP2A2

Gene ID: 488

Symbol: ATP2A2

Ensembl ID: ENSG00000174437

Description: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

Associated with

Cardiac conduction
(R-HSA-5576891)
Hemostasis
(R-HSA-109582)
Ion channel transport
(R-HSA-983712)
Ion homeostasis
(R-HSA-5578775)
Ion transport by p-type atpases
(R-HSA-936837)
Muscle contraction
(R-HSA-397014)
Platelet calcium homeostasis
(R-HSA-418360)
Platelet homeostasis
(R-HSA-418346)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch processing in golgi
(R-HSA-1912420)
Reduction of cytosolic ca++ levels
(R-HSA-418359)
Signaling by notch
(R-HSA-157118)
Signal transduction
(R-HSA-162582)
Transport of small molecules
(R-HSA-382551)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Autophagosome assembly
(GO:0000045)
Autophagosome membrane docking
(GO:0016240)
Calcium ion binding
(GO:0005509)
Calcium ion import into sarcoplasmic reticulum
(GO:1990036)
Calcium ion transmembrane transport
(GO:0070588)
Calcium ion transport from cytosol to endoplasmic reticulum
(GO:1903515)
Cardiac muscle hypertrophy in response to stress
(GO:0014898)
Cell adhesion
(GO:0007155)
Cellular response to oxidative stress
(GO:0034599)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum calcium ion homeostasis
(GO:0032469)
Endoplasmic reticulum membrane
(GO:0005789)
Enzyme binding
(GO:0019899)
Epidermis development
(GO:0008544)
Er-nucleus signaling pathway
(GO:0006984)
Intracellular calcium ion homeostasis
(GO:0006874)
Lncrna binding
(GO:0106222)
Membrane
(GO:0016020)
Mitochondrion-endoplasmic reticulum membrane tethering
(GO:1990456)
Monoatomic ion transmembrane transport
(GO:0034220)
Negative regulation of heart contraction
(GO:0045822)
Negative regulation of receptor binding
(GO:1900121)
Neuron cellular homeostasis
(GO:0070050)
Organelle localization by membrane tethering
(GO:0140056)
P-type calcium transporter activity
(GO:0005388)
P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential
(GO:0086039)
Plasma membrane
(GO:0005886)
Platelet dense tubular network membrane
(GO:0031095)
Positive regulation of cardiac muscle cell apoptotic process
(GO:0010666)
Positive regulation of endoplasmic reticulum calcium ion concentration
(GO:0032470)
Positive regulation of heart rate
(GO:0010460)
Protein binding
(GO:0005515)
Regulation of calcium ion-dependent exocytosis of neurotransmitter
(GO:1903233)
Regulation of cardiac conduction
(GO:1903779)
Regulation of cardiac muscle cell action potential involved in regulation of contraction
(GO:0098909)
Regulation of cardiac muscle cell membrane potential
(GO:0086036)
Regulation of cardiac muscle contraction by calcium ion signaling
(GO:0010882)
Regulation of the force of heart contraction
(GO:0002026)
Response to endoplasmic reticulum stress
(GO:0034976)
Ribbon synapse
(GO:0097470)
S100 protein binding
(GO:0044548)
Sarcoplasmic reticulum
(GO:0016529)
Sarcoplasmic reticulum calcium ion transport
(GO:0070296)
Sarcoplasmic reticulum membrane
(GO:0033017)
T-tubule organization
(GO:0033292)
Transition between fast and slow fiber
(GO:0014883)
Transmembrane transporter binding
(GO:0044325)

Other Information

Proteins

Calcium pump 2

Genular Protein ID: 1937224347

Symbol: AT2A2_HUMAN

Name: Calcium pump 2

UniProtKB Accession Codes:

P16615 A6NDN7 B4DF05 P16614 Q86VJ2

Database IDs:

Citations:

PubMed ID: 2844796

Title: Molecular cloning of cDNAs from human kidney coding for two alternatively spliced products of the cardiac Ca2+-ATPase gene.

PubMed ID: 2844796

DOI: 10.1016/s0021-9258(18)68141-4

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12659872

Title: Identification of a new SERCA2 splice variant regulated during monocytic differentiation.

PubMed ID: 12659872

DOI: 10.1016/s0006-291x(03)00405-4

PubMed ID: 12804600

Title: Ca2+ -dependent interaction of S100A1 with the sarcoplasmic reticulum Ca2+ -ATPase2a and phospholamban in the human heart.

PubMed ID: 12804600

DOI: 10.1016/s0006-291x(03)00987-2

PubMed ID: 14749390

Title: TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis.

PubMed ID: 14749390

DOI: 10.1128/mcb.24.4.1758-1768.2004

PubMed ID: 16399855

Title: Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging.

PubMed ID: 16399855

DOI: 10.1152/ajpheart.01293.2005

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18971376

Title: The anti-apoptotic protein HAX-1 interacts with SERCA2 and regulates its protein levels to promote cell survival.

PubMed ID: 18971376

DOI: 10.1091/mbc.e08-06-0587

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22084111

Title: POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters.

PubMed ID: 22084111

DOI: 10.1073/pnas.1117231108

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25996873

Title: TMEM203 is a novel regulator of intracellular calcium homeostasis and is required for spermatogenesis.

PubMed ID: 25996873

DOI: 10.1371/journal.pone.0127480

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27502484

Title: TMX1 determines cancer cell metabolism as a thiol-based modulator of ER-mitochondria Ca2+ flux.

PubMed ID: 27502484

DOI: 10.1083/jcb.201512077

PubMed ID: 10441323

Title: Spectrum of novel ATP2A2 mutations in patients with Darier's disease.

PubMed ID: 10441323

DOI: 10.1093/hmg/8.9.1611

PubMed ID: 10441324

Title: ATP2A2 mutations in Darier's disease: variant cutaneous phenotypes are associated with missense mutations, but neuropsychiatric features are independent of mutation class.

PubMed ID: 10441324

DOI: 10.1093/hmg/8.9.1621

PubMed ID: 10441325

Title: ATP2A2 mutations in Darier's disease and their relationship to neuropsychiatric phenotypes.

PubMed ID: 10441325

DOI: 10.1093/hmg/8.9.1631

PubMed ID: 10080178

Title: Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease.

PubMed ID: 10080178

DOI: 10.1038/6784

PubMed ID: 12542527

Title: Acrokeratosis verruciformis of Hopf is caused by mutation in ATP2A2: evidence that it is allelic to Darier's disease.

PubMed ID: 12542527

DOI: 10.1046/j.1523-1747.2003.t01-1-12045.x

PubMed ID: 16402920

Title: Ca2+-ATPases in non-failing and failing heart: evidence for a novel cardiac sarco/endoplasmic reticulum Ca2+-ATPase 2 isoform (SERCA2c).

PubMed ID: 16402920

DOI: 10.1042/bj20051427

PubMed ID: 28890335

Title: The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation.

PubMed ID: 28890335

DOI: 10.1016/j.molcel.2017.08.005

PubMed ID: 31735293

Title: TMX2 is a crucial regulator of cellular redox state, and its dysfunction causes severe brain developmental abnormalities.

PubMed ID: 31735293

DOI: 10.1016/j.ajhg.2019.10.009

PubMed ID: 19995371

Title: Three-base deletion mutation c.120_122delGTT in ATP2A2 leads to the unique phenotype of comedonal Darier disease.

PubMed ID: 19995371

DOI: 10.1111/j.1365-2133.2009.09580.x

PubMed ID: 28035777

Title: Mendelian Disorders of Cornification Caused by Defects in Intracellular Calcium Pumps: Mutation Update and Database for Variants in ATP2A2 and ATP2C1 associated with Darier disease and Hailey-Hailey disease.

PubMed ID: 28035777

DOI: 10.1002/humu.23164

Sequence Information:

Length: 1042
Mass: 114757
Checksum: 5462FF2DA7FB630A
Sequence:

MENAHTKTVE EVLGHFGVNE STGLSLEQVK KLKERWGSNE LPAEEGKTLL ELVIEQFEDL 
LVRILLLAAC ISFVLAWFEE GEETITAFVE PFVILLILVA NAIVGVWQER NAENAIEALK 
EYEPEMGKVY RQDRKSVQRI KAKDIVPGDI VEIAVGDKVP ADIRLTSIKS TTLRVDQSIL 
TGESVSVIKH TDPVPDPRAV NQDKKNMLFS GTNIAAGKAM GVVVATGVNT EIGKIRDEMV 
ATEQERTPLQ QKLDEFGEQL SKVISLICIA VWIINIGHFN DPVHGGSWIR GAIYYFKIAV 
ALAVAAIPEG LPAVITTCLA LGTRRMAKKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 
MSVCRMFILD RVEGDTCSLN EFTITGSTYA PIGEVHKDDK PVNCHQYDGL VELATICALC 
NDSALDYNEA KGVYEKVGEA TETALTCLVE KMNVFDTELK GLSKIERANA CNSVIKQLMK 
KEFTLEFSRD RKSMSVYCTP NKPSRTSMSK MFVKGAPEGV IDRCTHIRVG STKVPMTSGV 
KQKIMSVIRE WGSGSDTLRC LALATHDNPL RREEMHLEDS ANFIKYETNL TFVGCVGMLD 
PPRIEVASSV KLCRQAGIRV IMITGDNKGT AVAICRRIGI FGQDEDVTSK AFTGREFDEL 
NPSAQRDACL NARCFARVEP SHKSKIVEFL QSFDEITAMT GDGVNDAPAL KKAEIGIAMG 
SGTAVAKTAS EMVLADDNFS TIVAAVEEGR AIYNNMKQFI RYLISSNVGE VVCIFLTAAL 
GFPEALIPVQ LLWVNLVTDG LPATALGFNP PDLDIMNKPP RNPKEPLISG WLFFRYLAIG 
CYVGAATVGA AAWWFIAADG GPRVSFYQLS HFLQCKEDNP DFEGVDCAIF ESPYPMTMAL 
SVLVTIEMCN ALNSLSENQS LLRMPPWENI WLVGSICLSM SLHFLILYVE PLPLIFQITP 
LNVTQWLMVL KISLPVILMD ETLKFVARNY LEPGKECVQP ATKSCSFSAC TDGISWPFVL 
LIMPLVIWVY STDTNFSDMF WS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ATP2A2

Associated with

Other Information

Molecular cloning of cDNAs from human kidney coding for two alternatively spliced products of the cardiac Ca2+-ATPase gene. PubMed ID: 2844796

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Identification of a new SERCA2 splice variant regulated during monocytic differentiation. PubMed ID: 12659872

Ca2+ -dependent interaction of S100A1 with the sarcoplasmic reticulum Ca2+ -ATPase2a and phospholamban in the human heart. PubMed ID: 12804600

TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. PubMed ID: 14749390

Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging. PubMed ID: 16399855

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

The anti-apoptotic protein HAX-1 interacts with SERCA2 and regulates its protein levels to promote cell survival. PubMed ID: 18971376

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Initial characterization of the human central proteome. PubMed ID: 21269460

POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters. PubMed ID: 22084111

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

TMEM203 is a novel regulator of intracellular calcium homeostasis and is required for spermatogenesis. PubMed ID: 25996873

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

TMX1 determines cancer cell metabolism as a thiol-based modulator of ER-mitochondria Ca2+ flux. PubMed ID: 27502484

Spectrum of novel ATP2A2 mutations in patients with Darier's disease. PubMed ID: 10441323

ATP2A2 mutations in Darier's disease: variant cutaneous phenotypes are associated with missense mutations, but neuropsychiatric features are independent of mutation class. PubMed ID: 10441324

ATP2A2 mutations in Darier's disease and their relationship to neuropsychiatric phenotypes. PubMed ID: 10441325

Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. PubMed ID: 10080178

Acrokeratosis verruciformis of Hopf is caused by mutation in ATP2A2: evidence that it is allelic to Darier's disease. PubMed ID: 12542527

Ca2+-ATPases in non-failing and failing heart: evidence for a novel cardiac sarco/endoplasmic reticulum Ca2+-ATPase 2 isoform (SERCA2c). PubMed ID: 16402920

The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation. PubMed ID: 28890335

TMX2 is a crucial regulator of cellular redox state, and its dysfunction causes severe brain developmental abnormalities. PubMed ID: 31735293

Three-base deletion mutation c.120_122delGTT in ATP2A2 leads to the unique phenotype of comedonal Darier disease. PubMed ID: 19995371

Mendelian Disorders of Cornification Caused by Defects in Intracellular Calcium Pumps: Mutation Update and Database for Variants in ATP2A2 and ATP2C1 associated with Darier disease and Hailey-Hailey disease. PubMed ID: 28035777