Details for: ATP2A3

Gene ID: 489

Symbol: ATP2A3

Ensembl ID: ENSG00000074370

Description: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.85
    Marker Score: 1472.5
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.88
    Marker Score: 749
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.86
    Marker Score: 589
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.79
    Marker Score: 4088
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.79
    Marker Score: 11445
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.77
    Marker Score: 5257
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.57
    Marker Score: 1501
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168433
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.42
    Marker Score: 501
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.41
    Marker Score: 695
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.38
    Marker Score: 833
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.36
    Marker Score: 1341
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.32
    Marker Score: 1238
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.26
    Marker Score: 2197
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.26
    Marker Score: 587
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.25
    Marker Score: 288
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.23
    Marker Score: 12650
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.13
    Marker Score: 4742
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.13
    Marker Score: 11429
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.1
    Marker Score: 443
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.1
    Marker Score: 981
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.09
    Marker Score: 824
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.08
    Marker Score: 988
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.04
    Marker Score: 449
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.02
    Marker Score: 2774
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.01
    Marker Score: 15818
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.01
    Marker Score: 617
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1
    Marker Score: 1046
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71725
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47949.5
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.99
    Marker Score: 3122
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.98
    Marker Score: 424
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30398
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.98
    Marker Score: 983
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.98
    Marker Score: 309
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.97
    Marker Score: 2135
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.97
    Marker Score: 2726
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2401
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.93
    Marker Score: 2271
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.92
    Marker Score: 671
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.92
    Marker Score: 609
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.92
    Marker Score: 1350
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.91
    Marker Score: 1906
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2722
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.9
    Marker Score: 3680
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.9
    Marker Score: 547
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5115
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5244
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.86
    Marker Score: 752
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.84
    Marker Score: 1123
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.83
    Marker Score: 826
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.83
    Marker Score: 290
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.83
    Marker Score: 285
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.82
    Marker Score: 343
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.82
    Marker Score: 405
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.81
    Marker Score: 8065
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.81
    Marker Score: 193
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.81
    Marker Score: 2546
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.8
    Marker Score: 292
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.79
    Marker Score: 246
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.79
    Marker Score: 253
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.79
    Marker Score: 188
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.77
    Marker Score: 461
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.77
    Marker Score: 717
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.76
    Marker Score: 649
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.76
    Marker Score: 483
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 580
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.75
    Marker Score: 532
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.75
    Marker Score: 511
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.73
    Marker Score: 1007
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.73
    Marker Score: 253
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.73
    Marker Score: 2496
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 290
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.72
    Marker Score: 38097
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.72
    Marker Score: 440
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.71
    Marker Score: 414
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.7
    Marker Score: 405
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.7
    Marker Score: 355
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2947
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.7
    Marker Score: 158
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.69
    Marker Score: 217
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.69
    Marker Score: 182
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.69
    Marker Score: 578
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.69
    Marker Score: 497
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.68
    Marker Score: 652
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.68
    Marker Score: 1445
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.68
    Marker Score: 283
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.67
    Marker Score: 186
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.67
    Marker Score: 5892
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.67
    Marker Score: 491
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.66
    Marker Score: 386
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.65
    Marker Score: 323
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.65
    Marker Score: 5514

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Other Information

**Key characteristics:** - The protein is a member of the ATPase superfamily of proteins. - It is expressed in high levels in cardiac muscle and other cells that require calcium for contraction. - It is a key regulator of cardiac conduction and muscle contraction. **Pathways and functions:** - The protein transports calcium ions from the cytoplasm to the sarcoplasmic reticulum. - It is involved in calcium signaling, cardiac conduction, and muscle contraction. - It is also involved in apoptosis, platelet homeostasis, and pre-notch processing. **Clinical significance:** - Mutations in the ATP2A3 gene have been linked to a number of human diseases, including hypertrophic cardiomyopathy, heart failure, and stroke. - These mutations can lead to a decrease in the expression of the protein, which can result in a decrease in calcium transport and a variety of symptoms, including heart failure, muscle weakness, and stroke. **Additional notes:** - The ATP2A3 gene is also known as ANKRD34A. - It is a highly conserved protein, with a similar protein found in mammals, birds, and reptiles. - The protein is a relatively new protein, with the gene first identified in humans in 2004.

Genular Protein ID: 2932677367

Symbol: AT2A3_HUMAN

Name: Calcium pump 3

UniProtKB Accession Codes:

Q93084 A8MZG0 D3DTJ8 O60900 O60901 O75501 O75502 Q16115 Q6JHX1 Q8TEX5 Q8TEX6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChEBI 32 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 22 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 25 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 Pumba 1 RNAct 1 Reactome 4 RefSeq 7 Rhea 2 SFLD 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8809064

Title: cDNA cloning, expression and chromosomal localization of the human sarco/endoplasmic reticulum Ca(2+)-ATPase 3 gene.

PubMed ID: 8809064

DOI: 10.1042/bj3180689

PubMed ID: 9593748

Title: Structure of the human sarco/endoplasmic reticulum Ca2+-ATPase 3 gene. Promoter analysis and alternative splicing of the SERCA3 pre-mRNA.

PubMed ID: 9593748

DOI: 10.1074/jbc.273.22.13982

PubMed ID: 9843705

Title: Functional characterization of alternatively spliced human SERCA3 transcripts.

PubMed ID: 9843705

DOI: 10.1152/ajpcell.1998.275.6.c1449

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 8288608

Title: A sarco/endoplasmic reticulum Ca(2+)-ATPase 3-type Ca2+ pump is expressed in platelets, in lymphoid cells, and in mast cells.

PubMed ID: 8288608

DOI: 10.1016/s0021-9258(17)42273-3

PubMed ID: 11956212

Title: Three novel sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) 3 isoforms. Expression, regulation, and function of the membranes of the SERCA3 family.

PubMed ID: 11956212

DOI: 10.1074/jbc.m202011200

PubMed ID: 15028735

Title: Identification, expression, function, and localization of a novel (sixth) isoform of the human sarco/endoplasmic reticulum Ca2+ATPase 3 gene.

PubMed ID: 15028735

DOI: 10.1074/jbc.m314286200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28890335

Title: The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation.

PubMed ID: 28890335

DOI: 10.1016/j.molcel.2017.08.005

PubMed ID: 34513312

Title: A putative long noncoding RNA-encoded micropeptide maintains cellular homeostasis in pancreatic beta cells.

PubMed ID: 34513312

DOI: 10.1016/j.omtn.2021.06.027

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 999
  • Mass: 109256
  • Checksum: 44E9F1FBF41FE36A
  • Sequence:
    • MEAAHLLPAA DVLRHFSVTA EGGLSPAQVT GARERYGPNE LPSEEGKSLW ELVLEQFEDL 
LVRILLLAAL VSFVLAWFEE GEETTTAFVE PLVIMLILVA NAIVGVWQER NAESAIEALK 
EYEPEMGKVI RSDRKGVQRI RARDIVPGDI VEVAVGDKVP ADLRLIEIKS TTLRVDQSIL 
TGESVSVTKH TEAIPDPRAV NQDKKNMLFS GTNITSGKAV GVAVATGLHT ELGKIRSQMA 
AVEPERTPLQ RKLDEFGRQL SHAISVICVA VWVINIGHFA DPAHGGSWLR GAVYYFKIAV 
ALAVAAIPEG LPAVITTCLA LGTRRMARKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 
MSVCRMFVVA EADAGSCLLH EFTISGTTYT PEGEVRQGDQ PVRCGQFDGL VELATICALC 
NDSALDYNEA KGVYEKVGEA TETALTCLVE KMNVFDTDLQ ALSRVERAGA CNTVIKQLMR 
KEFTLEFSRD RKSMSVYCTP TRPHPTGQGS KMFVKGAPES VIERCSSVRV GSRTAPLTPT 
SREQILAKIR DWGSGSDTLR CLALATRDAP PRKEDMELDD CSKFVQYETD LTFVGCVGML 
DPPRPEVAAC ITRCYQAGIR VVMITGDNKG TAVAICRRLG IFGDTEDVAG KAYTGREFDD 
LSPEQQRQAC RTARCFARVE PAHKSRIVEN LQSFNEITAM TGDGVNDAPA LKKAEIGIAM 
GSGTAVAKSA AEMVLSDDNF ASIVAAVEEG RAIYSNMKQF IRYLISSNVG EVVCIFLTAI 
LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMEKL PRSPREALIS GWLFFRYLAI 
GVYVGLATVA AATWWFVYDA EGPHINFYQL RNFLKCSEDN PLFAGIDCEV FESRFPTTMA 
LSVLVTIEMC NALNSVSENQ SLLRMPPWMN PWLLVAVAMS MALHFLILLV PPLPLIFQVT 
PLSGRQWVVV LQISLPVILL DEALKYLSRN HMHEEMSQK

Genular Protein ID: 1110399477

Symbol: A8K9K1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K9K1

Database IDs:

ARBA 16 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 7 DNASU 1 EC 1 EMBL 2 GO 4 Gene3D 4 Genevisible 1 GenomeRNAi 1 InterPro 11 KEGG 1 NCBI Taxonomy 1 NCBIfam 2 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 5 RefSeq 7 Rhea 2 RuleBase 1 SFLD 2 SMART 2 SMR 1 SUPFAM 4

Sequence Information:

  • Length: 998
  • Mass: 109180
  • Checksum: 2AC9E56F59380E6C
  • Sequence:
    • MEAAHLLPAA DVLRHFSVTA EGGLSPAQVT GARERYGPNE LPSEEGKSLW ELVLEQFEDL 
LVRILLLAAL VSFVLAWFEE GEETTTAFVE PLVIMLILVA NAIVGVWQER NAESAIEALK 
EYEPEMGKVI RSDRKGVQRI RARDIVPGDI VEVAVGDKVP ADLRLIEIKS TTLRVDQSIL 
TGESVSVTKH TEAIPDPRAV NQDKKNMLFS GTNITSGKAV GVAVATGLHT ELGKIRSQMA 
AVEPERTPLQ RKLDEFGRQL SHAISVICVA VWVINIGHFA DPAHGGSWLR GAVYYFKIAV 
ALAVAAIPEG LPAVITTCLA LGTRRMARKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 
MSVCRMFVVA EADAGSCLLH EFTISGTTYT PEGEVRQGDQ PVRCGQFDGL VELATICALC 
NDSALDYNEA KGVYEKVGEA TETALTCLVE KMNVFDTDLQ ALSRVERAGA CNTVIKQLMR 
KEFTLEFSRD RKSMSVYCTP TRPHPTGQGS KMFVKGAPES VIERCSSVRV GSRTAPLTPT 
SREQILAKIR DWGSGSDTLR CLALATRDAP PRKEDMELDD CSKFVQYETD LTFVGCVGML 
DPPRPEVAAC ITRCYQAGIR VVMITGDNKG TAVAICRRLG IFGDTEDVAG KAYTGREFDD 
LSPEQQRQAC RTARCFARVE PAHKSRIVEN LQSFNEITAM TGDGVNDAPA LKKAEIGIAM 
GSGTAVAKSA AEMVLSDDNF ASIVAAVEEG RAIYSNMKQF IRYLISSNVG EVVCIFLTAI 
LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMEKL PRSPREALIS GWLFFRYLAI 
GVYVGLATVA AATWWFVYDA EGPHINFYQL RNFLKCSEDN PLFAGIDREV FESRFPTTMA 
LSVLVTIEMC NALNSVSENQ SLLRMPPWMN PWLLVAVAMS MALHFLILLV PPLPLIFQVT 
PLSGRQWVVV LQISLPVILL DEALKYLSRN HMHEMSQK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.