Details for: ACR

Gene ID: 49

Symbol: ACR

Ensembl ID: ENSG00000100312

Description: acrosin

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 856.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7668
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4820
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71832
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48057
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5345
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.94
    Marker Score: 388
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 492
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.67
    Marker Score: 747
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.57
    Marker Score: 367.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 455
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.44
    Marker Score: 204
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.25
    Marker Score: 511.5
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.23
    Marker Score: 81
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.15
    Marker Score: 91
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.13
    Marker Score: 91.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.12
    Marker Score: 112
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.11
    Marker Score: 154
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.1
    Marker Score: 148
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.1
    Marker Score: 255.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1
    Marker Score: 95
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.08
    Marker Score: 75
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.08
    Marker Score: 73
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.07
    Marker Score: 77
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.07
    Marker Score: 135
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.07
    Marker Score: 112
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.06
    Marker Score: 103
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.06
    Marker Score: 53
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.06
    Marker Score: 64
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.06
    Marker Score: 135
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.06
    Marker Score: 30
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.06
    Marker Score: 81
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.05
    Marker Score: 66
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.05
    Marker Score: 149
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.04
    Marker Score: 38
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.04
    Marker Score: 72
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.04
    Marker Score: 89
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.04
    Marker Score: 9
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.04
    Marker Score: 115
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.04
    Marker Score: 64
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.04
    Marker Score: 36
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.04
    Marker Score: 36
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.03
    Marker Score: 11

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Other Information

**Key characteristics:** * The ACR gene is located on chromosome 19p13.1. * It is a large gene with a predicted protein of 1,613 amino acids. * The protein is expressed in high levels in the small intestine, colon, and brain. * It is a transmembrane protein that is localized to the cell surface. **Pathways and functions:** * The ACR protein is involved in the acrosome reaction, a process that is essential for sperm-oocyte fertilization. * It is also involved in the regulation of adenylate cyclase activity, which is a key enzyme in the process of cell signaling. * The ACR protein is also involved in the binding of sperm to the zona pellucida, the outer layer of the egg. **Clinical significance:** * Mutations in the ACR gene have been linked to a number of human diseases, including infertility, colorectal cancer, and cancer of the brain and other organs. * These diseases are caused by mutations in genes that are involved in the early stages of development, when the acrosome reaction is taking place. * Researchers are currently investigating the use of acrosin inhibitors as a treatment for human diseases.

Genular Protein ID: 2403284358

Symbol: ACRO_HUMAN

Name: Acrosin

UniProtKB Accession Codes:

P10323 Q6ICK2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 14 Ensembl 2 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 2493394

Title: Primary structure of human proacrosin deduced from its cDNA sequence.

PubMed ID: 2493394

DOI: 10.1016/0014-5793(89)80549-6

PubMed ID: 2114285

Title: Nucleotide sequence and exon-intron organization of the human proacrosin gene.

PubMed ID: 2114285

DOI: 10.1111/j.1432-1033.1990.tb15564.x

PubMed ID: 2298447

Title: Molecular cloning of human preproacrosin cDNA.

PubMed ID: 2298447

DOI: 10.1007/bf00208925

PubMed ID: 1628652

Title: Molecular cloning, sequencing and restriction mapping of the genomic sequence encoding human proacrosin.

PubMed ID: 1628652

DOI: 10.1111/j.1432-1033.1992.tb17014.x

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 7521127

Title: Inhibition of acrosin by protein C inhibitor and localization of protein C inhibitor to spermatozoa.

PubMed ID: 7521127

DOI: 10.1152/ajpcell.1994.267.2.c466

PubMed ID: 11839395

Title: Evaluation of the proacrosin/acrosin system and its mechanism of activation in human sperm extracts.

PubMed ID: 11839395

DOI: 10.1016/s0165-0378(01)00080-8

Sequence Information:

  • Length: 421
  • Mass: 45847
  • Checksum: 7A2F7ECEC98008FA
  • Sequence:
    • MVEMLPTAIL LVLAVSVVAK DNATCDGPCG LRFRQNPQGG VRIVGGKAAQ HGAWPWMVSL 
QIFTYNSHRY HTCGGSLLNS RWVLTAAHCF VGKNNVHDWR LVFGAKEITY GNNKPVKAPL 
QERYVEKIII HEKYNSATEG NDIALVEITP PISCGRFIGP GCLPHFKAGL PRGSQSCWVA 
GWGYIEEKAP RPSSILMEAR VDLIDLDLCN STQWYNGRVQ PTNVCAGYPV GKIDTCQGDS 
GGPLMCKDSK ESAYVVVGIT SWGVGCARAK RPGIYTATWP YLNWIASKIG SNALRMIQSA 
TPPPPTTRPP PIRPPFSHPI SAHLPWYFQP PPRPLPPRPP AAQPRPPPSP PPPPPPPASP 
LPPPPPPPPP TPSSTTKLPQ GLSFAKRLQQ LIEVLKGKTY SDGKNHYDME TTELPELTST 
S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.