Details for: ATP2B1

Gene ID: 490

Symbol: ATP2B1

Ensembl ID: ENSG00000070961

Description: ATPase plasma membrane Ca2+ transporting 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 477.0960
    Cell Significance Index: -74.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 281.6947
    Cell Significance Index: -71.4500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 175.7382
    Cell Significance Index: -82.9700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 166.9632
    Cell Significance Index: -67.8300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 151.5401
    Cell Significance Index: -77.9500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 71.3805
    Cell Significance Index: -68.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 28.6167
    Cell Significance Index: -76.6600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 24.2003
    Cell Significance Index: -74.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.7920
    Cell Significance Index: -78.1000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.9248
    Cell Significance Index: -39.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 6.3643
    Cell Significance Index: 281.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 6.1496
    Cell Significance Index: 232.8700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 4.8271
    Cell Significance Index: 137.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 4.0662
    Cell Significance Index: 273.4100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 3.2736
    Cell Significance Index: 56.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.2257
    Cell Significance Index: 647.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.5368
    Cell Significance Index: 909.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.4426
    Cell Significance Index: 284.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9539
    Cell Significance Index: 387.7600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.8085
    Cell Significance Index: 13.9400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.7946
    Cell Significance Index: 23.9400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.6051
    Cell Significance Index: 1110.1400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.4076
    Cell Significance Index: 48.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.3437
    Cell Significance Index: 75.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.3040
    Cell Significance Index: 80.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1314
    Cell Significance Index: 203.9500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.0914
    Cell Significance Index: 13.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.0645
    Cell Significance Index: 55.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0169
    Cell Significance Index: 52.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9469
    Cell Significance Index: 116.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8443
    Cell Significance Index: 24.3300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7674
    Cell Significance Index: 17.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7659
    Cell Significance Index: 105.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7546
    Cell Significance Index: 20.1500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7057
    Cell Significance Index: 13.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6736
    Cell Significance Index: 367.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6547
    Cell Significance Index: 289.4700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6152
    Cell Significance Index: 72.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.6148
    Cell Significance Index: 12.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4713
    Cell Significance Index: 10.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3804
    Cell Significance Index: 343.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3666
    Cell Significance Index: 19.0400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3471
    Cell Significance Index: 8.3300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3139
    Cell Significance Index: 4.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2939
    Cell Significance Index: 55.9400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2517
    Cell Significance Index: 17.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1325
    Cell Significance Index: 8.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0411
    Cell Significance Index: 26.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0396
    Cell Significance Index: 1.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0384
    Cell Significance Index: 72.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0221
    Cell Significance Index: 34.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0202
    Cell Significance Index: 37.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0201
    Cell Significance Index: 0.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0166
    Cell Significance Index: -12.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0200
    Cell Significance Index: -3.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0269
    Cell Significance Index: -19.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0318
    Cell Significance Index: -43.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0444
    Cell Significance Index: -20.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0570
    Cell Significance Index: -5.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0680
    Cell Significance Index: -5.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0714
    Cell Significance Index: -54.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0771
    Cell Significance Index: -48.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0832
    Cell Significance Index: -9.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1085
    Cell Significance Index: -61.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1200
    Cell Significance Index: -17.4500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1269
    Cell Significance Index: -3.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1579
    Cell Significance Index: -25.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1727
    Cell Significance Index: -2.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2019
    Cell Significance Index: -42.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2109
    Cell Significance Index: -21.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2112
    Cell Significance Index: -27.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2196
    Cell Significance Index: -14.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2359
    Cell Significance Index: -67.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3136
    Cell Significance Index: -40.5200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3318
    Cell Significance Index: -37.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3360
    Cell Significance Index: -25.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4408
    Cell Significance Index: -12.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4697
    Cell Significance Index: -53.8200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5824
    Cell Significance Index: -12.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5926
    Cell Significance Index: -12.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6550
    Cell Significance Index: -13.7100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6738
    Cell Significance Index: -17.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6784
    Cell Significance Index: -70.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.7413
    Cell Significance Index: -34.8400
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.7869
    Cell Significance Index: -8.8900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.8723
    Cell Significance Index: -8.3000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8744
    Cell Significance Index: -11.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9158
    Cell Significance Index: -72.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.9254
    Cell Significance Index: -25.1900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9489
    Cell Significance Index: -20.1400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.9821
    Cell Significance Index: -10.7000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9863
    Cell Significance Index: -31.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9951
    Cell Significance Index: -32.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0135
    Cell Significance Index: -62.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0305
    Cell Significance Index: -32.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.1329
    Cell Significance Index: -51.3500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.1426
    Cell Significance Index: -22.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.1777
    Cell Significance Index: -54.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.1941
    Cell Significance Index: -34.2300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.2016
    Cell Significance Index: -23.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The ATP2B1 gene exhibits several key characteristics that distinguish it from other calcium-transporting ATPases: 1. **High calcium transport capacity**: ATP2B1 has a high calcium transport capacity, allowing it to regulate calcium ion homeostasis in cells with high calcium requirements. 2. **Efficient ATP hydrolysis**: The ATP2B1 protein utilizes efficient ATP hydrolysis to pump calcium ions out of the cytosol, minimizing energy expenditure and maximizing calcium transport. 3. **Wide tissue expression**: ATP2B1 is widely expressed in various tissues, including neuronal, muscle, and vascular cells, highlighting its broad physiological significance. 4. **Regulation of calcium-dependent processes**: ATP2B1 regulates a range of calcium-dependent processes, including muscle contraction, synaptic transmission, and blood pressure control. **Pathways and Functions** ATP2B1 plays a critical role in various cellular pathways and processes, including: 1. **Calcium homeostasis**: ATP2B1 regulates calcium ion homeostasis across cellular membranes, maintaining the delicate balance of calcium ions within cells. 2. **Muscle contraction**: ATP2B1 is essential for regulating muscle contraction by controlling calcium ion release from the sarcoplasmic reticulum. 3. **Synaptic transmission**: ATP2B1 plays a crucial role in regulating synaptic transmission by controlling calcium ion influx into neurons. 4. **Blood pressure control**: ATP2B1 helps regulate blood pressure by controlling calcium ion influx into smooth muscle cells, leading to vasodilation. 5. **Neurotransmission**: ATP2B1 is involved in regulating neurotransmitter release by controlling calcium ion influx into neurons. **Clinical Significance** Dysregulation of the ATP2B1 gene has been implicated in various diseases, including: 1. **Hypertension**: Abnormal ATP2B1 expression has been linked to hypertension, highlighting the gene's role in blood pressure regulation. 2. **Muscular dystrophy**: Mutations in the ATP2B1 gene have been associated with muscular dystrophy, underscoring the gene's importance in muscle function. 3. **Neurological disorders**: ATP2B1 dysregulation has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 4. **Cardiac arrhythmias**: Abnormal ATP2B1 expression has been linked to cardiac arrhythmias, highlighting the gene's role in regulating cardiac ion channels. In conclusion, the ATP2B1 gene plays a critical role in regulating calcium ion homeostasis across cellular membranes, influencing a range of physiological processes, including muscle contraction, synaptic transmission, and blood pressure control. Dysregulation of the ATP2B1 gene has been implicated in various diseases, highlighting the gene's importance in maintaining cellular calcium balance and overall health.

Genular Protein ID: 2821752575

Symbol: AT2B1_HUMAN

Name: Plasma membrane calcium pump isoform 1

UniProtKB Accession Codes:

P20020 Q12992 Q12993 Q13819 Q13820 Q13821 Q16504 Q93082

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 9 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 4 EC 1 EMBL 11 EMDB 1 Ensembl 4 ExpressionAtlas 1 GO 31 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 4 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 Reactome 4 RefSeq 4 Rhea 2 SFLD 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2844759

Title: Complete primary structure of a human plasma membrane Ca2+ pump.

PubMed ID: 2844759

DOI: 10.1016/s0021-9258(18)68198-0

PubMed ID: 8386431

Title: Molecular cloning of a plasma membrane calcium pump from human osteoblasts.

PubMed ID: 8386431

DOI: 10.1002/jbmr.5650080415

PubMed ID: 8396145

Title: Structure of the gene encoding the human plasma membrane calcium pump isoform 1.

PubMed ID: 8396145

DOI: 10.1016/s0021-9258(19)36574-3

PubMed ID: 2528729

Title: mRNAs for plasma membrane calcium pump isoforms differing in their regulatory domain are generated by alternative splicing that involves two internal donor sites in a single exon.

PubMed ID: 2528729

DOI: 10.1073/pnas.86.18.6908

PubMed ID: 1332771

Title: Study of calmodulin binding to the alternatively spliced C-terminal domain of the plasma membrane Ca2+ pump.

PubMed ID: 1332771

DOI: 10.1021/bi00162a016

PubMed ID: 8245032

Title: Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.

PubMed ID: 8245032

DOI: 10.1016/s0021-9258(19)74484-6

PubMed ID: 7989379

Title:

PubMed ID: 7989379

DOI: 10.1016/s0021-9258(18)31797-6

PubMed ID: 7694502

Title: Human and rat intestinal plasma membrane calcium pump isoforms.

PubMed ID: 7694502

DOI: 10.1152/ajpgi.1993.265.5.g917

PubMed ID: 2548572

Title: Primary structure of the cAMP-dependent phosphorylation site of the plasma membrane calcium pump.

PubMed ID: 2548572

DOI: 10.1021/bi00436a020

PubMed ID: 1827443

Title: Protein kinase C phosphorylates the carboxyl terminus of the plasma membrane Ca(2+)-ATPase from human erythrocytes.

PubMed ID: 1827443

DOI: 10.1016/s0021-9258(18)31554-0

PubMed ID: 12763866

Title: Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variants.

PubMed ID: 12763866

DOI: 10.1111/j.1749-6632.2003.tb07230.x

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18029012

Title: Inhibitory interaction of the 14-3-3 proteins with ubiquitous (PMCA1) and tissue-specific (PMCA3) isoforms of the plasma membrane Ca2+ pump.

PubMed ID: 18029012

DOI: 10.1016/j.ceca.2007.09.003

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21400627

Title: Coexpression and estrogen-mediated regulation of TRPV6 and PMCA1 in the human endometrium during the menstrual cycle.

PubMed ID: 21400627

DOI: 10.1002/mrd.21303

PubMed ID: 22084111

Title: POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters.

PubMed ID: 22084111

DOI: 10.1073/pnas.1117231108

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29104511

Title: ATP2B1 gene Silencing Increases Insulin Sensitivity through Facilitating Akt Activation via the Ca2+/calmodulin Signaling Pathway and Ca2+-associated eNOS Activation in Endothelial Cells.

PubMed ID: 29104511

DOI: 10.7150/ijbs.19666

PubMed ID: 30190470

Title: Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin.

PubMed ID: 30190470

DOI: 10.1038/s41467-018-06075-7

PubMed ID: 9020386

Title: Investigation of the Met-267 Arg exchange in isoform 1 of the human plasma membrane calcium pump in patients with essential hypertension by the amplification-created restriction site technique.

PubMed ID: 9020386

DOI: 10.1007/s001090050088

PubMed ID: 35358416

Title: De novo variants in ATP2B1 lead to neurodevelopmental delay.

PubMed ID: 35358416

DOI: 10.1016/j.ajhg.2022.03.009

Sequence Information:

  • Length: 1220
  • Mass: 134685
  • Checksum: 7E75C19B1A501423
  • Sequence:
    • MGDMANNSVA YSGVKNSLKE ANHDGDFGIT LAELRALMEL RSTDALRKIQ ESYGDVYGIC 
TKLKTSPNEG LSGNPADLER REAVFGKNFI PPKKPKTFLQ LVWEALQDVT LIILEIAAIV 
SLGLSFYQPP EGDNALCGEV SVGEEEGEGE TGWIEGAAIL LSVVCVVLVT AFNDWSKEKQ 
FRGLQSRIEQ EQKFTVIRGG QVIQIPVADI TVGDIAQVKY GDLLPADGIL IQGNDLKIDE 
SSLTGESDHV KKSLDKDPLL LSGTHVMEGS GRMVVTAVGV NSQTGIIFTL LGAGGEEEEK 
KDEKKKEKKN KKQDGAIENR NKAKAQDGAA MEMQPLKSEE GGDGDEKDKK KANLPKKEKS 
VLQGKLTKLA VQIGKAGLLM SAITVIILVL YFVIDTFWVQ KRPWLAECTP IYIQYFVKFF 
IIGVTVLVVA VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL 
TMNRMTVVQA YINEKHYKKV PEPEAIPPNI LSYLVTGISV NCAYTSKILP PEKEGGLPRH 
VGNKTECALL GLLLDLKRDY QDVRNEIPEE ALYKVYTFNS VRKSMSTVLK NSDGSYRIFS 
KGASEIILKK CFKILSANGE AKVFRPRDRD DIVKTVIEPM ASEGLRTICL AFRDFPAGEP 
EPEWDNENDI VTGLTCIAVV GIEDPVRPEV PDAIKKCQRA GITVRMVTGD NINTARAIAT 
KCGILHPGED FLCLEGKDFN RRIRNEKGEI EQERIDKIWP KLRVLARSSP TDKHTLVKGI 
IDSTVSDQRQ VVAVTGDGTN DGPALKKADV GFAMGIAGTD VAKEASDIIL TDDNFTSIVK 
AVMWGRNVYD SISKFLQFQL TVNVVAVIVA FTGACITQDS PLKAVQMLWV NLIMDTLASL 
ALATEPPTES LLLRKPYGRN KPLISRTMMK NILGHAFYQL VVVFTLLFAG EKFFDIDSGR 
NAPLHAPPSE HYTIVFNTFV LMQLFNEINA RKIHGERNVF EGIFNNAIFC TIVLGTFVVQ 
IIIVQFGGKP FSCSELSIEQ WLWSIFLGMG TLLWGQLIST IPTSRLKFLK EAGHGTQKEE 
IPEEELAEDV EEIDHAEREL RRGQILWFRG LNRIQTQIRV VNAFRSSLYE GLEKPESRSS 
IHNFMTHPEF RIEDSEPHIP LIDDTDAEDD APTKRNSSPP PSPNKNNNAV DSGIHLTIEM 
NKSATSSSPG SPLHSLETSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.