Details for: ATP2B2

Gene ID: 491

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ATP2B2

Ensembl ID: ENSG00000157087

Description: ATPase plasma membrane Ca2+ transporting 2

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • pvalb GABAergic cortical interneuron CL4023018
    CSI 54.72
    rCSI 68.08%
    PRS 98.86
  • cerebellar granule cell CL0001031
    CSI 50.54
    rCSI 74.3%
    PRS 99.21
  • VIP GABAergic cortical interneuron CL4023016
    CSI 45.94
    rCSI 54.87%
    PRS 98.93
  • choroid plexus epithelial cell CL0000706
    CSI 43.47
    rCSI 71.19%
    PRS 99.11
  • sst GABAergic cortical interneuron CL4023017
    CSI 39.89
    rCSI 51.42%
    PRS 99.21
  • sncg GABAergic cortical interneuron CL4023015
    CSI 33.65
    rCSI 54.12%
    PRS 98.81
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 31.1
    rCSI 52.2%
    PRS 98.97
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 31.06
    rCSI 54.86%
    PRS 98.94
  • interneuron CL0000099
    CSI 30.11
    rCSI 60.46%
    PRS 99.41
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 27.13
    rCSI 58.86%
    PRS 98.57
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 25.36
    rCSI 61.62%
    PRS 98.49
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 24.04
    rCSI 57.5%
    PRS 98.72
  • rod bipolar cell CL0000751
    CSI 21.87
    rCSI 39.29%
    PRS 99.37
  • glioblast CL0000030
    CSI 21.78
    rCSI 34.75%
    PRS 99.22
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 21.45
    rCSI 67.07%
    PRS 99.08
  • L6b glutamatergic cortical neuron CL4023038
    CSI 21.33
    rCSI 66.67%
    PRS 98.91
  • inhibitory interneuron CL0000498
    CSI 21.22
    rCSI 49%
    PRS 99.1
  • Mueller cell CL0000636
    CSI 20.56
    rCSI 46.91%
    PRS 99.23
  • neuron CL0000540
    CSI 19.98
    rCSI 53.21%
    PRS 98.31
  • ependymal cell CL0000065
    CSI 19.65
    rCSI 39.88%
    PRS 97.51
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 19.18
    rCSI 69.02%
    PRS 98.72
  • retinal bipolar neuron CL0000748
    CSI 19.15
    rCSI 35.86%
    PRS 98.99
  • glutamatergic neuron CL0000679
    CSI 18.92
    rCSI 38.88%
    PRS 97.73
  • midzonal region hepatocyte CL0019028
    CSI 18.87
    rCSI 44.28%
    PRS 99.49
  • astrocyte of the cerebral cortex CL0002605
    CSI 18.45
    rCSI 41.36%
    PRS 99.03
  • cerebral cortex neuron CL0010012
    CSI 18.01
    rCSI 73.39%
    PRS 99
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 17.73
    rCSI 67%
    PRS 98.64
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 17.39
    rCSI 57.15%
    PRS 98.46
  • ON-bipolar cell CL0000749
    CSI 17.33
    rCSI 25.75%
    PRS 99.42
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 16.14
    rCSI 20.71%
    PRS 99.57
  • retina horizontal cell CL0000745
    CSI 15.77
    rCSI 24.04%
    PRS 99.56
  • neural cell CL0002319
    CSI 14.99
    rCSI 56.57%
    PRS 98.37
  • glial cell CL0000125
    CSI 14.74
    rCSI 56.11%
    PRS 98.87
  • retinal ganglion cell CL0000740
    CSI 14.04
    rCSI 31.02%
    PRS 98.97
  • hepatocyte CL0000182
    CSI 13.89
    rCSI 24.86%
    PRS 99.32
  • cerebral cortex endothelial cell CL1001602
    CSI 12.93
    rCSI 22.36%
    PRS 99.31
  • periportal region hepatocyte CL0019026
    CSI 12.03
    rCSI 46.77%
    PRS 99.33
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 11.54
    rCSI 67.92%
    PRS 98.73
  • Bergmann glial cell CL0000644
    CSI 11.38
    rCSI 15.58%
    PRS 99.18
  • amacrine cell CL0000561
    CSI 10.9
    rCSI 31.6%
    PRS 99.15
  • GABAergic neuron CL0000617
    CSI 10.85
    rCSI 36.35%
    PRS 97.54
  • mature astrocyte CL0002627
    CSI 10.47
    rCSI 44.5%
    PRS 99.62
  • glycinergic amacrine cell CL4030028
    CSI 9.56
    rCSI 24.9%
    PRS 98.97
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 9.42
    rCSI 17.12%
    PRS 99.33
  • serotonergic neuron CL0000850
    CSI 9.26
    rCSI 41.38%
    PRS 97.95
  • dopaminergic neuron CL0000700
    CSI 8.71
    rCSI 49.25%
    PRS 98.71
  • vascular leptomeningeal cell CL4023051
    CSI 8.49
    rCSI 14.89%
    PRS 99.49
  • OFF-bipolar cell CL0000750
    CSI 8.36
    rCSI 11.43%
    PRS 99.44
  • GABAergic amacrine cell CL4030027
    CSI 7.66
    rCSI 26.22%
    PRS 98.55
  • central nervous system neuron CL2000029
    CSI 7.39
    rCSI 54.34%
    PRS 99.11
  • neural progenitor cell CL0011020
    CSI 6.9
    rCSI 30.38%
    PRS 97.17
  • medium spiny neuron CL1001474
    CSI 6.82
    rCSI 58.74%
    PRS 99.06
  • centrilobular region hepatocyte CL0019029
    CSI 6.42
    rCSI 16.74%
    PRS 99.23
  • renal beta-intercalated cell CL0002201
    CSI 6.2
    rCSI 14.78%
    PRS 99.72
  • H2 horizontal cell CL0004218
    CSI 5.51
    rCSI 27.38%
    PRS 99.27
  • H1 horizontal cell CL0004217
    CSI 5.45
    rCSI 21.57%
    PRS 99.04
  • diffuse bipolar 3a cell CL4033029
    CSI 5.27
    rCSI 35.9%
    PRS 98.55
  • cerebellar neuron CL1001611
    CSI 4.93
    rCSI 43.36%
    PRS 98.49
  • ON parasol ganglion cell CL4033052
    CSI 4.81
    rCSI 68.25%
    PRS 98.99
  • retinal pigment epithelial cell CL0002586
    CSI 4.5
    rCSI 8.94%
    PRS 99.27
  • ON midget ganglion cell CL4033046
    CSI 3.57
    rCSI 72.69%
    PRS 98.92
  • OFF midget ganglion cell CL4033047
    CSI 3.45
    rCSI 70.26%
    PRS 98.99
  • invaginating midget bipolar cell CL4033034
    CSI 3.25
    rCSI 19.17%
    PRS 98.51
  • direct pathway medium spiny neuron CL4023026
    CSI 3.21
    rCSI 76.75%
    PRS 98.09
  • indirect pathway medium spiny neuron CL4023029
    CSI 3.17
    rCSI 76.49%
    PRS 98.11

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ATP2B2](/details-gene/491), or ATPase Plasma Membrane Ca2+ Transporting 2, encodes a crucial P-type ATPase known as PMCA2. This enzyme is primarily responsible for the ATP-dependent extrusion of calcium ions from the cytosol, a fundamental process for maintaining intracellular calcium homeostasis. **Overall**, expression data reveals that [ATP2B2](/details-gene/491) is a highly significant gene in the central nervous system, showing prominent expression in a wide array of neuronal subtypes, including various GABAergic interneurons and [cerebellar granule cell](/details-cell/CL0001031). Functionally, it is integral to processes such as synaptic transmission, neural development, and sensory perception. Clinically, loss-of-function variants in [ATP2B2](/details-gene/491) are strongly associated with progressive hearing impairment ([OMIM:108733](https://omim.org/entry/108733)), highlighting its indispensable role in the auditory system. ## Cellular Roles and Expression Landscape The expression profile of [ATP2B2](/details-gene/491) underscores its specialized function within the nervous system. **Overall**, the gene exhibits its highest significance in diverse neuronal populations, indicating a widespread role in regulating neuronal excitability. It is a defining marker for several inhibitory interneuron classes, including [pvalb GABAergic cortical interneuron](/details-cell/CL4023018), [VIP GABAergic cortical interneuron](/details-cell/CL4023016), and [sst GABAergic cortical interneuron](/details-cell/CL4023017), as well as excitatory neurons such as the [cerebellar granule cell](/details-cell/CL0001031) and various intratelencephalic projecting glutamatergic neurons. Beyond major neuronal classes, its high significance in specialized cell types such as the [choroid plexus epithelial cell](/details-cell/CL0000706), which is involved in cerebrospinal fluid production, and the [rod bipolar cell](/details-cell/CL0000751) of the retina, suggests more specific roles in regulating calcium gradients in distinct physiological contexts. This broad yet specific expression pattern within the nervous system positions [ATP2B2](/details-gene/491) as a key manager of calcium signaling essential for normal neuronal function. ## Pathways and Molecular Function The molecular functions of [ATP2B2](/details-gene/491) are centered on its identity as a P-type calcium transporter. Its activity ([GO:0005388](https://www.ebi.ac.uk/QuickGO/term/GO:0005388)) is fueled by ATP hydrolysis ([GO:0016887](https://www.ebi.ac.uk/QuickGO/term/GO:0016887)) and is modulated by binding to calmodulin ([GO:0005516](https://www.ebi.ac.uk/QuickGO/term/GO:0005516)). This machinery is primarily deployed at the plasma membrane ([GO:0005886](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)), including specialized synaptic locations like the dendritic spine membrane ([GO:0032591](https://www.ebi.ac.uk/QuickGO/term/GO:0032591)) and postsynaptic density ([GO:0098839](https://www.ebi.ac.uk/QuickGO/term/GO:0098839)). Consistent with its high expression in neurons, [ATP2B2](/details-gene/491) is a key participant in biological processes governing neuronal activity, such as the 'Regulation of postsynaptic cytosolic calcium ion concentration' ([GO:0099566](https://www.ebi.ac.uk/QuickGO/term/GO:0099566)) and 'Neuron differentiation' ([GO:0030182](https://www.ebi.ac.uk/QuickGO/term/GO:0030182)). Reactome pathway analysis reinforces this, placing the gene in the 'Reduction of cytosolic ca++ levels' pathway ([R-HSA-418359](https://reactome.org/content/detail/R-HSA-418359)). Critically, its involvement in 'Sensory processing of sound by inner hair cells of the cochlea' ([R-HSA-9662360](https://reactome.org/content/detail/R-HSA-9662360)) directly reflects the clinical phenotype of deafness associated with its mutation, as documented in several studies ([Link](https://doi.org/10.1056/nejmoa043899), [Link](https://doi.org/10.1073/pnas.0609775104)). Its annotation in broader pathways like 'Cardiac conduction' ([R-HSA-5576891](https://reactome.org/content/detail/R-HSA-5576891)) and 'Muscle contraction' ([R-HSA-397014](https://reactome.org/content/detail/R-HSA-397014)) suggests a conserved role in managing calcium dynamics across multiple excitable tissues. ## Research Directions The well-defined role of [ATP2B2](/details-gene/491) in calcium homeostasis, combined with its specific expression patterns and clinical relevance, gives rise to several testable hypotheses. 1. **Hypothesis 1:** Given the existence of multiple splice variants ([Link](https://doi.org/10.1111/j.1432-1033.1992.tb16784.x)), it is hypothesized that distinct neuronal subtypes ([e.g.](/details-cell/CL4023018), [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) vs. [L2/3 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4030059)) express specific [ATP2B2](/details-gene/491) isoforms that possess different kinetic properties or regulatory interactions, thereby providing a mechanism for cell-type-specific fine-tuning of synaptic transmission and calcium signaling. 2. **Hypothesis 2:** The progressive nature of hearing loss associated with [ATP2B2](/details-gene/491) mutations ([Link](https://doi.org/10.1007/s00439-018-1965-1)) suggests that even partial loss of calcium extrusion capacity in cochlear hair cells leads to chronic, low-level calcium overload. This sub-lethal stress may not cause immediate cell death but instead triggers downstream pathological pathways, such as mitochondrial dysfunction or increased oxidative stress, that culminate in the gradual degeneration of these sensory cells. To investigate the first hypothesis, a compelling experimental approach would be to perform isoform-resolved spatial transcriptomics on brain tissue sections. This would allow for the simultaneous mapping of specific [ATP2B2](/details-gene/491) splice variants to their corresponding neuronal cell types in their native anatomical context. These findings could be validated using isoform-specific antibodies or in-situ hybridization, followed by functional characterization of the dominant isoforms via heterologous expression and electrophysiological analysis to determine differences in their calcium transport kinetics. Regarding therapeutic potential, [ATP2B2](/details-gene/491) is an attractive target for restorative therapies rather than inhibition. Since the primary pathology is hearing loss caused by loss-of-function mutations, strategies would focus on **activation** or **gene replacement**. For monogenic forms of deafness caused by [ATP2B2](/details-gene/491) deficiency, AAV-mediated gene therapy aimed at delivering a functional copy of the gene specifically to the inner hair cells of the cochlea represents a promising therapeutic avenue. Such a targeted approach could potentially restore calcium homeostasis and prevent or halt the progression of hearing impairment.

Genular Protein ID: 1546578330

Symbol: AT2B2_HUMAN

Name: Plasma membrane calcium-transporting ATPase 2

UniProtKB Accession Codes:

Q01814 O00766 Q12994 Q16818

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 1 ELM 1 EMBL 7 Ensembl 8 ExpressionAtlas 1 GO 29 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 RNAct 1 Reactome 5 RefSeq 11 Rhea 2 SFLD 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1427863

Title: Determination of the nucleotide sequence and chromosomal localization of the ATP2B2 gene encoding human Ca(2+)-pumping ATPase isoform PMCA2.

PubMed ID: 1427863

DOI: 10.1016/s0888-7543(05)80246-0

PubMed ID: 8428366

Title: von Hippel-Lindau syndrome: cloning and identification of the plasma membrane Ca(++)-transporting ATPase isoform 2 gene that resides in the von Hippel-Lindau gene region.

PubMed ID: 8428366

PubMed ID: 1313367

Title: Microdiversity of human-plasma-membrane calcium-pump isoform 2 generated by alternative RNA splicing in the N-terminal coding region.

PubMed ID: 1313367

DOI: 10.1111/j.1432-1033.1992.tb16784.x

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 8245032

Title: Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.

PubMed ID: 8245032

DOI: 10.1016/s0021-9258(19)74484-6

PubMed ID: 7989379

Title:

PubMed ID: 7989379

DOI: 10.1016/s0021-9258(18)31797-6

PubMed ID: 12763866

Title: Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variants.

PubMed ID: 12763866

DOI: 10.1111/j.1749-6632.2003.tb07230.x

PubMed ID: 12624087

Title: Alternative splicing of the first intracellular loop of plasma membrane Ca2+-ATPase isoform 2 alters its membrane targeting.

PubMed ID: 12624087

DOI: 10.1074/jbc.m301482200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25690014

Title: Plasma membrane Ca2+-ATPases can shape the pattern of Ca2+ transients induced by store-operated C2+ entry.

PubMed ID: 25690014

DOI: 10.1126/scisignal.2005672

PubMed ID: 15829536

Title: Modification of human hearing loss by plasma-membrane calcium pump PMCA2.

PubMed ID: 15829536

DOI: 10.1056/nejmoa043899

PubMed ID: 17234811

Title: A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafness.

PubMed ID: 17234811

DOI: 10.1073/pnas.0609775104

PubMed ID: 30535804

Title: De novo and inherited loss-of-function variants of ATP2B2 are associated with rapidly progressive hearing impairment.

PubMed ID: 30535804

DOI: 10.1007/s00439-018-1965-1

Sequence Information:

  • Length: 1243
  • Mass: 136876
  • Checksum: 7F10221B7B9AC3A2
  • Sequence:
    • MGDMTNSDFY SKNQRNESSH GGEFGCTMEE LRSLMELRGT EAVVKIKETY GDTEAICRRL 
KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG 
LSFYHPPGEG NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR 
GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQVKYGD LLPADGLFIQ GNDLKIDESS 
LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MLVTAVGVNS QTGIIFTLLG AGGEEEEKKD 
KKGVKKGDGL QLPAADGAAA SNAADSANAS LVNGKMQDGN VDASQSKAKQ QDGAAAMEMQ 
PLKSAEGGDA DDRKKASMHK KEKSVLQGKL TKLAVQIGKA GLVMSAITVI ILVLYFTVDT 
FVVNKKPWLP ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP LAVTISLAYS VKKMMKDNNL 
VRHLDACETM GNATAICSDK TGTLTTNRMT VVQAYVGDVH YKEIPDPSSI NTKTMELLIN 
AIAINSAYTT KILPPEKEGA LPRQVGNKTE CGLLGFVLDL KQDYEPVRSQ MPEEKLYKVY 
TFNSVRKSMS TVIKLPDESF RMYSKGASEI VLKKCCKILN GAGEPRVFRP RDRDEMVKKV 
IEPMACDGLR TICVAYRDFP SSPEPDWDNE NDILNELTCI CVVGIEDPVR PEVPEAIRKC 
QRAGITVRMV TGDNINTARA IAIKCGIIHP GEDFLCLEGK EFNRRIRNEK GEIEQERIDK 
IWPKLRVLAR SSPTDKHTLV KGIIDSTHTE QRQVVAVTGD GTNDGPALKK ADVGFAMGIA 
GTDVAKEASD IILTDDNFSS IVKAVMWGRN VYDSISKFLQ FQLTVNVVAV IVAFTGACIT 
QDSPLKAVQM LWVNLIMDTF ASLALATEPP TETLLLRKPY GRNKPLISRT MMKNILGHAV 
YQLALIFTLL FVGEKMFQID SGRNAPLHSP PSEHYTIIFN TFVMMQLFNE INARKIHGER 
NVFDGIFRNP IFCTIVLGTF AIQIVIVQFG GKPFSCSPLQ LDQWMWCIFI GLGELVWGQV 
IATIPTSRLK FLKEAGRLTQ KEEIPEEELN EDVEEIDHAE RELRRGQILW FRGLNRIQTQ 
IRVVKAFRSS LYEGLEKPES RTSIHNFMAH PEFRIEDSQP HIPLIDDTDL EEDAALKQNS 
SPPSSLNKNN SAIDSGINLT TDTSKSATSS SPGSPIHSLE TSL

Genular Protein ID: 3104396399

Symbol: Q4LE63_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4LE63

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 4 IntAct 1 InterPro 12 NCBI Taxonomy 1 NCBIfam 2 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 RefSeq 2 SAM 2 SFLD 2 SMART 2 SUPFAM 4 iPTMnet 1

Sequence Information:

  • Length: 1210
  • Mass: 133770
  • Checksum: 57832447CF2C571B
  • Sequence:
    • PLGPARARTA ANMGDMTNSD FYSKNQRNES SHGGEFGCTM EELRSLMELR GTEAVVKIKE 
TYGDTEAICR RLKTSPVEGL PGTAPDLEKR KQIFGQNFIP PKKPKTFLQL VWEALQDVTL 
IILEIAAIIS LGLSFYHPPG EGNEGCATAQ GGAEDEGEAE AGWIEGAAIL LSVICVVLVT 
AFNDWSKEKQ FRGLQSRIEQ EQKFTVVRAG QVVQIPVAEI VVGDIAQVKY GDLLPADGLF 
IQGNDLKIDE SSLTGESDQV RKSVDKDPML LSGTHVMEGS GRMLVTAVGV NSQTGIIFTL 
LGAGGEEEEK KDKKAKQQDG AAAMEMQPLK SAEGGDADDR KKASMHKKEK SVLQGKLTKL 
AVQIGKAGLV MSAITVIILV LYFTVDTFVV NKKPWLPECT PVYVQYFVKF FIIGVTVLVV 
AVPEGLPLAV TISLAYSVKK MMKDNNLVRH LDACETMGNA TAICSDKTGT LTTNRMTVVQ 
AYVGDVHYKE IPDPSSINTK TMELLINAIA INSAYTTKIL PPEKEGALPR QVGNKTECGL 
LGFVLDLKQD YEPVRSQMPE EKLYKVYTFN SVRKSMSTVI KLPDESFRMY SKGASEIVLK 
KCCKILNGAG EPRVFRPRDR DEMVKKVIEP MACDGLRTIC VAYRDFPSSP EPDWDNENDI 
LNELTCICVV GIEDPVRPEV PEAIRKCQRA GITVRMVTGD NINTARAIAI KCGIIHPGED 
FLCLEGKEFN RRIRNEKGEI EQERIDKIWP KLRVLARSSP TDKHTLVKGI IDSTHTEQRQ 
VVAVTGDGTN DGPALKKADV GFAMGIAGTD VAKEASDIIL TDDNFSSIVK AVMWGRNVYD 
SISKFLQFQL TVNVVAVIVA FTGACITQDS PLKAVQMLWV NLIMDTFASL ALATEPPTET 
LLLRKPYGRN KPLISRTMMK NILGHAVYQL ALIFTLLFVG EKMFQIDSGR NAPLHSPPSE 
HYTIIFNTFV MMQLFNEINA RKIHGERNVF DGIFRNPIFC TIVLGTFAIQ IVIVQFGGKP 
FSCSPLQLDQ WMWCIFIGLG ELVWGQVIAT IPTSRLKFLK EAGRLTQKEE IPEEELNEDV 
EEIDHAEREL RRGQILWFRG LNRIQTQIRV VKAFRSSLYE GLEKPESRTS IHNFMAHPEF 
RIEDSQPHIP LIDDTDLEED AALKQNSSPP SSLNKNNSAI DSGINLTTDT SKSATSSSPG 
SPIHSLETSL