ATP2B2 | ENSG00000157087 | NCBI 491

Details for: ATP2B2

Gene ID: 491

Symbol: ATP2B2

Ensembl ID: ENSG00000157087

Description: ATPase plasma membrane Ca2+ transporting 2

Associated with

Cardiac conduction
(R-HSA-5576891)
Hemostasis
(R-HSA-109582)
Ion channel transport
(R-HSA-983712)
Ion homeostasis
(R-HSA-5578775)
Ion transport by p-type atpases
(R-HSA-936837)
Muscle contraction
(R-HSA-397014)
Platelet calcium homeostasis
(R-HSA-418360)
Platelet homeostasis
(R-HSA-418346)
Reduction of cytosolic ca++ levels
(R-HSA-418359)
Sensory perception
(R-HSA-9709957)
Sensory processing of sound
(R-HSA-9659379)
Sensory processing of sound by inner hair cells of the cochlea
(R-HSA-9662360)
Sensory processing of sound by outer hair cells of the cochlea
(R-HSA-9662361)
Transport of small molecules
(R-HSA-382551)
Apical plasma membrane
(GO:0016324)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Basolateral plasma membrane
(GO:0016323)
Calcium ion binding
(GO:0005509)
Calcium ion transmembrane transport
(GO:0070588)
Calcium ion transport
(GO:0006816)
Calmodulin binding
(GO:0005516)
Cytoplasm
(GO:0005737)
Dendritic spine membrane
(GO:0032591)
Extracellular exosome
(GO:0070062)
Gaba-ergic synapse
(GO:0098982)
Glutamate receptor binding
(GO:0035254)
Glutamatergic synapse
(GO:0098978)
Intracellular membrane-bounded organelle
(GO:0043231)
Metal ion binding
(GO:0046872)
Monoatomic ion transmembrane transport
(GO:0034220)
Neural retina development
(GO:0003407)
Neuronal cell body membrane
(GO:0032809)
Neuron differentiation
(GO:0030182)
P-type calcium transporter activity
(GO:0005388)
P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
(GO:1905059)
Parallel fiber to purkinje cell synapse
(GO:0098688)
Pdz domain binding
(GO:0030165)
Plasma membrane
(GO:0005886)
Postsynaptic density membrane
(GO:0098839)
Presynaptic active zone membrane
(GO:0048787)
Protein binding
(GO:0005515)
Regulation of cardiac conduction
(GO:1903779)
Regulation of cytosolic calcium ion concentration
(GO:0051480)
Regulation of postsynaptic cytosolic calcium ion concentration
(GO:0099566)
Sensory perception of sound
(GO:0007605)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.49
Cell Significance Index: 2
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.34
Cell Significance Index: 2
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.31
Cell Significance Index: 2
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1
Cell Significance Index: 1
Cell Name: cell (CL0000000)
Fold Change: 1
Cell Significance Index: 1
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 1
Cell Significance Index: 1
Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
Fold Change: 1
Cell Significance Index: 1
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1
Cell Significance Index: 1
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1
Cell Significance Index: 1
Cell Name: chandelier cell (CL4023083)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neuron (CL0000540)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neural cell (CL0002319)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: secretory cell (CL0000151)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: glioblast (CL0000030)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: astrocyte (CL0000127)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: contractile cell (CL0000183)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: perivascular cell (CL4033054)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: malignant cell (CL0001064)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: activated type II NK T cell (CL0000931)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: peg cell (CL4033014)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: enterocyte (CL0000584)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: fibroblast (CL0000057)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: supporting cell (CL0000630)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: pulmonary alveolar type 2 cell (CL0002063)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.99
Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** 1. **P-type calcium transporter activity:** ATP2B2 is a P-type calcium transporter that transports calcium ions across the plasma membrane, regulating cytosolic calcium concentrations. 2. **High affinity for calcium:** ATP2B2 has a high affinity for calcium ions, allowing it to efficiently transport and regulate calcium levels within cells. 3. **Regulation of cytosolic calcium levels:** ATP2B2 plays a critical role in regulating cytosolic calcium levels, which is essential for maintaining proper cellular function and signaling. 4. **Expression in various tissues:** ATP2B2 is significantly expressed in the kidney, brain, and inner ear, where it is essential for maintaining proper calcium levels and regulating cellular activity. **Pathways and Functions:** 1. **Calcium homeostasis:** ATP2B2 is involved in regulating cytosolic calcium levels, which is essential for maintaining proper cellular function and signaling. 2. **Muscle contraction:** ATP2B2 regulates muscle contraction by maintaining proper calcium levels within muscle cells. 3. **Neuronal signaling:** ATP2B2 plays a critical role in regulating neuronal signaling by maintaining proper calcium levels within neurons. 4. **Sensory perception:** ATP2B2 is essential for maintaining proper calcium levels within the inner ear, where it is involved in sensory perception of sound. 5. **Cardiac conduction:** ATP2B2 regulates cardiac conduction by maintaining proper calcium levels within cardiac cells. **Clinical Significance:** Dysregulation of ATP2B2 has been implicated in various diseases, including: 1. **Hypertension:** Dysregulation of ATP2B2 has been linked to hypertension, as it can lead to impaired calcium homeostasis and increased blood pressure. 2. **Cardiac arrhythmias:** ATP2B2 dysregulation can lead to cardiac arrhythmias, as it can disrupt normal cardiac conduction and calcium homeostasis. 3. **Neurological disorders:** ATP2B2 dysregulation has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and hearing loss. 4. **Kidney disease:** ATP2B2 dysregulation can lead to kidney disease, as it can disrupt normal calcium homeostasis and lead to impaired kidney function. In conclusion, ATP2B2 is a critical gene involved in regulating calcium homeostasis and maintaining proper cellular function. Its dysregulation can lead to various diseases, highlighting the importance of this gene in maintaining overall health.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.