Details for: ATP2B2

Gene ID: 491

Symbol: ATP2B2

Ensembl ID: ENSG00000157087

Description: ATPase plasma membrane Ca2+ transporting 2

Associated with

Other Information

Genular Protein ID: 1546578330

Symbol: AT2B2_HUMAN

Name: Plasma membrane calcium-transporting ATPase 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1427863

Title: Determination of the nucleotide sequence and chromosomal localization of the ATP2B2 gene encoding human Ca(2+)-pumping ATPase isoform PMCA2.

PubMed ID: 1427863

DOI: 10.1016/s0888-7543(05)80246-0

PubMed ID: 8428366

Title: von Hippel-Lindau syndrome: cloning and identification of the plasma membrane Ca(++)-transporting ATPase isoform 2 gene that resides in the von Hippel-Lindau gene region.

PubMed ID: 8428366

PubMed ID: 1313367

Title: Microdiversity of human-plasma-membrane calcium-pump isoform 2 generated by alternative RNA splicing in the N-terminal coding region.

PubMed ID: 1313367

DOI: 10.1111/j.1432-1033.1992.tb16784.x

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 8245032

Title: Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.

PubMed ID: 8245032

DOI: 10.1016/s0021-9258(19)74484-6

PubMed ID: 7989379

Title:

PubMed ID: 7989379

DOI: 10.1016/s0021-9258(18)31797-6

PubMed ID: 12763866

Title: Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variants.

PubMed ID: 12763866

DOI: 10.1111/j.1749-6632.2003.tb07230.x

PubMed ID: 12624087

Title: Alternative splicing of the first intracellular loop of plasma membrane Ca2+-ATPase isoform 2 alters its membrane targeting.

PubMed ID: 12624087

DOI: 10.1074/jbc.m301482200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25690014

Title: Plasma membrane Ca2+-ATPases can shape the pattern of Ca2+ transients induced by store-operated C2+ entry.

PubMed ID: 25690014

DOI: 10.1126/scisignal.2005672

PubMed ID: 15829536

Title: Modification of human hearing loss by plasma-membrane calcium pump PMCA2.

PubMed ID: 15829536

DOI: 10.1056/nejmoa043899

PubMed ID: 17234811

Title: A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafness.

PubMed ID: 17234811

DOI: 10.1073/pnas.0609775104

PubMed ID: 30535804

Title: De novo and inherited loss-of-function variants of ATP2B2 are associated with rapidly progressive hearing impairment.

PubMed ID: 30535804

DOI: 10.1007/s00439-018-1965-1

Sequence Information:

  • Length: 1243
  • Mass: 136876
  • Checksum: 7F10221B7B9AC3A2
  • Sequence:
  • MGDMTNSDFY SKNQRNESSH GGEFGCTMEE LRSLMELRGT EAVVKIKETY GDTEAICRRL 
    KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG 
    LSFYHPPGEG NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR 
    GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQVKYGD LLPADGLFIQ GNDLKIDESS 
    LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MLVTAVGVNS QTGIIFTLLG AGGEEEEKKD 
    KKGVKKGDGL QLPAADGAAA SNAADSANAS LVNGKMQDGN VDASQSKAKQ QDGAAAMEMQ 
    PLKSAEGGDA DDRKKASMHK KEKSVLQGKL TKLAVQIGKA GLVMSAITVI ILVLYFTVDT 
    FVVNKKPWLP ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP LAVTISLAYS VKKMMKDNNL 
    VRHLDACETM GNATAICSDK TGTLTTNRMT VVQAYVGDVH YKEIPDPSSI NTKTMELLIN 
    AIAINSAYTT KILPPEKEGA LPRQVGNKTE CGLLGFVLDL KQDYEPVRSQ MPEEKLYKVY 
    TFNSVRKSMS TVIKLPDESF RMYSKGASEI VLKKCCKILN GAGEPRVFRP RDRDEMVKKV 
    IEPMACDGLR TICVAYRDFP SSPEPDWDNE NDILNELTCI CVVGIEDPVR PEVPEAIRKC 
    QRAGITVRMV TGDNINTARA IAIKCGIIHP GEDFLCLEGK EFNRRIRNEK GEIEQERIDK 
    IWPKLRVLAR SSPTDKHTLV KGIIDSTHTE QRQVVAVTGD GTNDGPALKK ADVGFAMGIA 
    GTDVAKEASD IILTDDNFSS IVKAVMWGRN VYDSISKFLQ FQLTVNVVAV IVAFTGACIT 
    QDSPLKAVQM LWVNLIMDTF ASLALATEPP TETLLLRKPY GRNKPLISRT MMKNILGHAV 
    YQLALIFTLL FVGEKMFQID SGRNAPLHSP PSEHYTIIFN TFVMMQLFNE INARKIHGER 
    NVFDGIFRNP IFCTIVLGTF AIQIVIVQFG GKPFSCSPLQ LDQWMWCIFI GLGELVWGQV 
    IATIPTSRLK FLKEAGRLTQ KEEIPEEELN EDVEEIDHAE RELRRGQILW FRGLNRIQTQ 
    IRVVKAFRSS LYEGLEKPES RTSIHNFMAH PEFRIEDSQP HIPLIDDTDL EEDAALKQNS 
    SPPSSLNKNN SAIDSGINLT TDTSKSATSS SPGSPIHSLE TSL

Genular Protein ID: 3104396399

Symbol: Q4LE63_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 1210
  • Mass: 133770
  • Checksum: 57832447CF2C571B
  • Sequence:
  • PLGPARARTA ANMGDMTNSD FYSKNQRNES SHGGEFGCTM EELRSLMELR GTEAVVKIKE 
    TYGDTEAICR RLKTSPVEGL PGTAPDLEKR KQIFGQNFIP PKKPKTFLQL VWEALQDVTL 
    IILEIAAIIS LGLSFYHPPG EGNEGCATAQ GGAEDEGEAE AGWIEGAAIL LSVICVVLVT 
    AFNDWSKEKQ FRGLQSRIEQ EQKFTVVRAG QVVQIPVAEI VVGDIAQVKY GDLLPADGLF 
    IQGNDLKIDE SSLTGESDQV RKSVDKDPML LSGTHVMEGS GRMLVTAVGV NSQTGIIFTL 
    LGAGGEEEEK KDKKAKQQDG AAAMEMQPLK SAEGGDADDR KKASMHKKEK SVLQGKLTKL 
    AVQIGKAGLV MSAITVIILV LYFTVDTFVV NKKPWLPECT PVYVQYFVKF FIIGVTVLVV 
    AVPEGLPLAV TISLAYSVKK MMKDNNLVRH LDACETMGNA TAICSDKTGT LTTNRMTVVQ 
    AYVGDVHYKE IPDPSSINTK TMELLINAIA INSAYTTKIL PPEKEGALPR QVGNKTECGL 
    LGFVLDLKQD YEPVRSQMPE EKLYKVYTFN SVRKSMSTVI KLPDESFRMY SKGASEIVLK 
    KCCKILNGAG EPRVFRPRDR DEMVKKVIEP MACDGLRTIC VAYRDFPSSP EPDWDNENDI 
    LNELTCICVV GIEDPVRPEV PEAIRKCQRA GITVRMVTGD NINTARAIAI KCGIIHPGED 
    FLCLEGKEFN RRIRNEKGEI EQERIDKIWP KLRVLARSSP TDKHTLVKGI IDSTHTEQRQ 
    VVAVTGDGTN DGPALKKADV GFAMGIAGTD VAKEASDIIL TDDNFSSIVK AVMWGRNVYD 
    SISKFLQFQL TVNVVAVIVA FTGACITQDS PLKAVQMLWV NLIMDTFASL ALATEPPTET 
    LLLRKPYGRN KPLISRTMMK NILGHAVYQL ALIFTLLFVG EKMFQIDSGR NAPLHSPPSE 
    HYTIIFNTFV MMQLFNEINA RKIHGERNVF DGIFRNPIFC TIVLGTFAIQ IVIVQFGGKP 
    FSCSPLQLDQ WMWCIFIGLG ELVWGQVIAT IPTSRLKFLK EAGRLTQKEE IPEEELNEDV 
    EEIDHAEREL RRGQILWFRG LNRIQTQIRV VKAFRSSLYE GLEKPESRTS IHNFMAHPEF 
    RIEDSQPHIP LIDDTDLEED AALKQNSSPP SSLNKNNSAI DSGINLTTDT SKSATSSSPG 
    SPIHSLETSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.