Details for: ATP2B2

Gene ID: 491

Symbol: ATP2B2

Ensembl ID: ENSG00000157087

Description: ATPase plasma membrane Ca2+ transporting 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 6.8294
    Cell Significance Index: 149.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 4.3334
    Cell Significance Index: 191.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 4.2981
    Cell Significance Index: 162.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.8834
    Cell Significance Index: 578.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.6085
    Cell Significance Index: 935.6200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 2.4708
    Cell Significance Index: 32.9600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.0599
    Cell Significance Index: 1424.6800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.0047
    Cell Significance Index: 24.8700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.7887
    Cell Significance Index: 51.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.7020
    Cell Significance Index: 114.4400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.6712
    Cell Significance Index: 28.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8422
    Cell Significance Index: 167.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7320
    Cell Significance Index: 44.9900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4874
    Cell Significance Index: 11.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1358
    Cell Significance Index: 6.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0048
    Cell Significance Index: -9.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0228
    Cell Significance Index: -42.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0314
    Cell Significance Index: -48.3700
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0316
    Cell Significance Index: -0.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0365
    Cell Significance Index: -49.6000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0422
    Cell Significance Index: -0.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0590
    Cell Significance Index: -43.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0614
    Cell Significance Index: -38.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0749
    Cell Significance Index: -55.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0923
    Cell Significance Index: -57.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0929
    Cell Significance Index: -42.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0969
    Cell Significance Index: -9.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0986
    Cell Significance Index: -53.8600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0986
    Cell Significance Index: -1.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1014
    Cell Significance Index: -57.1900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1085
    Cell Significance Index: -4.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1409
    Cell Significance Index: -40.5300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1739
    Cell Significance Index: -2.4900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2023
    Cell Significance Index: -2.3600
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.2112
    Cell Significance Index: -2.3300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2197
    Cell Significance Index: -2.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2219
    Cell Significance Index: -32.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.2287
    Cell Significance Index: -41.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2372
    Cell Significance Index: -6.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2716
    Cell Significance Index: -57.2100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3020
    Cell Significance Index: -6.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3263
    Cell Significance Index: -55.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.3561
    Cell Significance Index: -43.7900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3597
    Cell Significance Index: -4.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3620
    Cell Significance Index: -46.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.3921
    Cell Significance Index: -53.8500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3995
    Cell Significance Index: -47.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4051
    Cell Significance Index: -22.7300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.4091
    Cell Significance Index: -5.7200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4119
    Cell Significance Index: -8.2700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.4839
    Cell Significance Index: -3.7300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4916
    Cell Significance Index: -4.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5011
    Cell Significance Index: -57.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5026
    Cell Significance Index: -26.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5079
    Cell Significance Index: -52.8800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.5092
    Cell Significance Index: -12.3400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5755
    Cell Significance Index: -18.3300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5821
    Cell Significance Index: -11.5100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5835
    Cell Significance Index: -14.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5861
    Cell Significance Index: -19.1900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.6239
    Cell Significance Index: -5.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6322
    Cell Significance Index: -47.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6371
    Cell Significance Index: -48.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7128
    Cell Significance Index: -45.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7387
    Cell Significance Index: -45.2900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7514
    Cell Significance Index: -17.3600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.7782
    Cell Significance Index: -9.8200
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.8405
    Cell Significance Index: -7.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.8525
    Cell Significance Index: -40.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8535
    Cell Significance Index: -21.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9372
    Cell Significance Index: -59.0700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.9429
    Cell Significance Index: -20.1600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.9743
    Cell Significance Index: -21.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9954
    Cell Significance Index: -34.8700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -1.0056
    Cell Significance Index: -12.1900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.0111
    Cell Significance Index: -25.2200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -1.0160
    Cell Significance Index: -12.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.0349
    Cell Significance Index: -46.9100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.0405
    Cell Significance Index: -17.9900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.1314
    Cell Significance Index: -16.7000
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -1.2063
    Cell Significance Index: -9.7400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.2460
    Cell Significance Index: -45.7400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.2769
    Cell Significance Index: -21.5100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.2907
    Cell Significance Index: -44.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.2926
    Cell Significance Index: -45.4200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.2994
    Cell Significance Index: -27.1200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -1.3366
    Cell Significance Index: -22.4800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.3519
    Cell Significance Index: -9.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.3735
    Cell Significance Index: -71.3500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -1.4212
    Cell Significance Index: -18.9500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -1.5071
    Cell Significance Index: -22.5500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.5426
    Cell Significance Index: -45.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.5740
    Cell Significance Index: -45.3500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.6340
    Cell Significance Index: -51.6800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.6382
    Cell Significance Index: -46.9600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -1.6612
    Cell Significance Index: -22.9700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.7331
    Cell Significance Index: -34.1100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -1.7746
    Cell Significance Index: -20.3100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.8024
    Cell Significance Index: -37.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.8222
    Cell Significance Index: -45.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **P-type calcium transporter activity:** ATP2B2 is a P-type calcium transporter that transports calcium ions across the plasma membrane, regulating cytosolic calcium concentrations. 2. **High affinity for calcium:** ATP2B2 has a high affinity for calcium ions, allowing it to efficiently transport and regulate calcium levels within cells. 3. **Regulation of cytosolic calcium levels:** ATP2B2 plays a critical role in regulating cytosolic calcium levels, which is essential for maintaining proper cellular function and signaling. 4. **Expression in various tissues:** ATP2B2 is significantly expressed in the kidney, brain, and inner ear, where it is essential for maintaining proper calcium levels and regulating cellular activity. **Pathways and Functions:** 1. **Calcium homeostasis:** ATP2B2 is involved in regulating cytosolic calcium levels, which is essential for maintaining proper cellular function and signaling. 2. **Muscle contraction:** ATP2B2 regulates muscle contraction by maintaining proper calcium levels within muscle cells. 3. **Neuronal signaling:** ATP2B2 plays a critical role in regulating neuronal signaling by maintaining proper calcium levels within neurons. 4. **Sensory perception:** ATP2B2 is essential for maintaining proper calcium levels within the inner ear, where it is involved in sensory perception of sound. 5. **Cardiac conduction:** ATP2B2 regulates cardiac conduction by maintaining proper calcium levels within cardiac cells. **Clinical Significance:** Dysregulation of ATP2B2 has been implicated in various diseases, including: 1. **Hypertension:** Dysregulation of ATP2B2 has been linked to hypertension, as it can lead to impaired calcium homeostasis and increased blood pressure. 2. **Cardiac arrhythmias:** ATP2B2 dysregulation can lead to cardiac arrhythmias, as it can disrupt normal cardiac conduction and calcium homeostasis. 3. **Neurological disorders:** ATP2B2 dysregulation has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and hearing loss. 4. **Kidney disease:** ATP2B2 dysregulation can lead to kidney disease, as it can disrupt normal calcium homeostasis and lead to impaired kidney function. In conclusion, ATP2B2 is a critical gene involved in regulating calcium homeostasis and maintaining proper cellular function. Its dysregulation can lead to various diseases, highlighting the importance of this gene in maintaining overall health.

Genular Protein ID: 1546578330

Symbol: AT2B2_HUMAN

Name: Plasma membrane calcium-transporting ATPase 2

UniProtKB Accession Codes:

Q01814 O00766 Q12994 Q16818

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 1 ELM 1 EMBL 7 Ensembl 8 ExpressionAtlas 1 GO 29 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 RNAct 1 Reactome 5 RefSeq 11 Rhea 2 SFLD 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1427863

Title: Determination of the nucleotide sequence and chromosomal localization of the ATP2B2 gene encoding human Ca(2+)-pumping ATPase isoform PMCA2.

PubMed ID: 1427863

DOI: 10.1016/s0888-7543(05)80246-0

PubMed ID: 8428366

Title: von Hippel-Lindau syndrome: cloning and identification of the plasma membrane Ca(++)-transporting ATPase isoform 2 gene that resides in the von Hippel-Lindau gene region.

PubMed ID: 8428366

PubMed ID: 1313367

Title: Microdiversity of human-plasma-membrane calcium-pump isoform 2 generated by alternative RNA splicing in the N-terminal coding region.

PubMed ID: 1313367

DOI: 10.1111/j.1432-1033.1992.tb16784.x

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 8245032

Title: Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.

PubMed ID: 8245032

DOI: 10.1016/s0021-9258(19)74484-6

PubMed ID: 7989379

Title:

PubMed ID: 7989379

DOI: 10.1016/s0021-9258(18)31797-6

PubMed ID: 12763866

Title: Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variants.

PubMed ID: 12763866

DOI: 10.1111/j.1749-6632.2003.tb07230.x

PubMed ID: 12624087

Title: Alternative splicing of the first intracellular loop of plasma membrane Ca2+-ATPase isoform 2 alters its membrane targeting.

PubMed ID: 12624087

DOI: 10.1074/jbc.m301482200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25690014

Title: Plasma membrane Ca2+-ATPases can shape the pattern of Ca2+ transients induced by store-operated C2+ entry.

PubMed ID: 25690014

DOI: 10.1126/scisignal.2005672

PubMed ID: 15829536

Title: Modification of human hearing loss by plasma-membrane calcium pump PMCA2.

PubMed ID: 15829536

DOI: 10.1056/nejmoa043899

PubMed ID: 17234811

Title: A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafness.

PubMed ID: 17234811

DOI: 10.1073/pnas.0609775104

PubMed ID: 30535804

Title: De novo and inherited loss-of-function variants of ATP2B2 are associated with rapidly progressive hearing impairment.

PubMed ID: 30535804

DOI: 10.1007/s00439-018-1965-1

Sequence Information:

  • Length: 1243
  • Mass: 136876
  • Checksum: 7F10221B7B9AC3A2
  • Sequence:
    • MGDMTNSDFY SKNQRNESSH GGEFGCTMEE LRSLMELRGT EAVVKIKETY GDTEAICRRL 
KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG 
LSFYHPPGEG NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR 
GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQVKYGD LLPADGLFIQ GNDLKIDESS 
LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MLVTAVGVNS QTGIIFTLLG AGGEEEEKKD 
KKGVKKGDGL QLPAADGAAA SNAADSANAS LVNGKMQDGN VDASQSKAKQ QDGAAAMEMQ 
PLKSAEGGDA DDRKKASMHK KEKSVLQGKL TKLAVQIGKA GLVMSAITVI ILVLYFTVDT 
FVVNKKPWLP ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP LAVTISLAYS VKKMMKDNNL 
VRHLDACETM GNATAICSDK TGTLTTNRMT VVQAYVGDVH YKEIPDPSSI NTKTMELLIN 
AIAINSAYTT KILPPEKEGA LPRQVGNKTE CGLLGFVLDL KQDYEPVRSQ MPEEKLYKVY 
TFNSVRKSMS TVIKLPDESF RMYSKGASEI VLKKCCKILN GAGEPRVFRP RDRDEMVKKV 
IEPMACDGLR TICVAYRDFP SSPEPDWDNE NDILNELTCI CVVGIEDPVR PEVPEAIRKC 
QRAGITVRMV TGDNINTARA IAIKCGIIHP GEDFLCLEGK EFNRRIRNEK GEIEQERIDK 
IWPKLRVLAR SSPTDKHTLV KGIIDSTHTE QRQVVAVTGD GTNDGPALKK ADVGFAMGIA 
GTDVAKEASD IILTDDNFSS IVKAVMWGRN VYDSISKFLQ FQLTVNVVAV IVAFTGACIT 
QDSPLKAVQM LWVNLIMDTF ASLALATEPP TETLLLRKPY GRNKPLISRT MMKNILGHAV 
YQLALIFTLL FVGEKMFQID SGRNAPLHSP PSEHYTIIFN TFVMMQLFNE INARKIHGER 
NVFDGIFRNP IFCTIVLGTF AIQIVIVQFG GKPFSCSPLQ LDQWMWCIFI GLGELVWGQV 
IATIPTSRLK FLKEAGRLTQ KEEIPEEELN EDVEEIDHAE RELRRGQILW FRGLNRIQTQ 
IRVVKAFRSS LYEGLEKPES RTSIHNFMAH PEFRIEDSQP HIPLIDDTDL EEDAALKQNS 
SPPSSLNKNN SAIDSGINLT TDTSKSATSS SPGSPIHSLE TSL

Genular Protein ID: 3104396399

Symbol: Q4LE63_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4LE63

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 4 IntAct 1 InterPro 12 NCBI Taxonomy 1 NCBIfam 2 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 RefSeq 2 SAM 2 SFLD 2 SMART 2 SUPFAM 4 iPTMnet 1

Sequence Information:

  • Length: 1210
  • Mass: 133770
  • Checksum: 57832447CF2C571B
  • Sequence:
    • PLGPARARTA ANMGDMTNSD FYSKNQRNES SHGGEFGCTM EELRSLMELR GTEAVVKIKE 
TYGDTEAICR RLKTSPVEGL PGTAPDLEKR KQIFGQNFIP PKKPKTFLQL VWEALQDVTL 
IILEIAAIIS LGLSFYHPPG EGNEGCATAQ GGAEDEGEAE AGWIEGAAIL LSVICVVLVT 
AFNDWSKEKQ FRGLQSRIEQ EQKFTVVRAG QVVQIPVAEI VVGDIAQVKY GDLLPADGLF 
IQGNDLKIDE SSLTGESDQV RKSVDKDPML LSGTHVMEGS GRMLVTAVGV NSQTGIIFTL 
LGAGGEEEEK KDKKAKQQDG AAAMEMQPLK SAEGGDADDR KKASMHKKEK SVLQGKLTKL 
AVQIGKAGLV MSAITVIILV LYFTVDTFVV NKKPWLPECT PVYVQYFVKF FIIGVTVLVV 
AVPEGLPLAV TISLAYSVKK MMKDNNLVRH LDACETMGNA TAICSDKTGT LTTNRMTVVQ 
AYVGDVHYKE IPDPSSINTK TMELLINAIA INSAYTTKIL PPEKEGALPR QVGNKTECGL 
LGFVLDLKQD YEPVRSQMPE EKLYKVYTFN SVRKSMSTVI KLPDESFRMY SKGASEIVLK 
KCCKILNGAG EPRVFRPRDR DEMVKKVIEP MACDGLRTIC VAYRDFPSSP EPDWDNENDI 
LNELTCICVV GIEDPVRPEV PEAIRKCQRA GITVRMVTGD NINTARAIAI KCGIIHPGED 
FLCLEGKEFN RRIRNEKGEI EQERIDKIWP KLRVLARSSP TDKHTLVKGI IDSTHTEQRQ 
VVAVTGDGTN DGPALKKADV GFAMGIAGTD VAKEASDIIL TDDNFSSIVK AVMWGRNVYD 
SISKFLQFQL TVNVVAVIVA FTGACITQDS PLKAVQMLWV NLIMDTFASL ALATEPPTET 
LLLRKPYGRN KPLISRTMMK NILGHAVYQL ALIFTLLFVG EKMFQIDSGR NAPLHSPPSE 
HYTIIFNTFV MMQLFNEINA RKIHGERNVF DGIFRNPIFC TIVLGTFAIQ IVIVQFGGKP 
FSCSPLQLDQ WMWCIFIGLG ELVWGQVIAT IPTSRLKFLK EAGRLTQKEE IPEEELNEDV 
EEIDHAEREL RRGQILWFRG LNRIQTQIRV VKAFRSSLYE GLEKPESRTS IHNFMAHPEF 
RIEDSQPHIP LIDDTDLEED AALKQNSSPP SSLNKNNSAI DSGINLTTDT SKSATSSSPG 
SPIHSLETSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.