ATP2B4 | ENSG00000058668 | NCBI 493

Details for: ATP2B4

Gene ID: 493

Symbol: ATP2B4

Ensembl ID: ENSG00000058668

Description: ATPase plasma membrane Ca2+ transporting 4

Associated with

Cardiac conduction
(R-HSA-5576891)
Hemostasis
(R-HSA-109582)
Ion channel transport
(R-HSA-983712)
Ion homeostasis
(R-HSA-5578775)
Ion transport by p-type atpases
(R-HSA-936837)
Muscle contraction
(R-HSA-397014)
Platelet calcium homeostasis
(R-HSA-418360)
Platelet homeostasis
(R-HSA-418346)
Reduction of cytosolic ca++ levels
(R-HSA-418359)
Transport of small molecules
(R-HSA-382551)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Basolateral plasma membrane
(GO:0016323)
Calcium ion export
(GO:1901660)
Calcium ion import across plasma membrane
(GO:0098703)
Calcium ion transmembrane import into cytosol
(GO:0097553)
Calcium ion transmembrane transport
(GO:0070588)
Calcium ion transmembrane transporter activity
(GO:0015085)
Calmodulin binding
(GO:0005516)
Caveola
(GO:0005901)
Cellular response to acetylcholine
(GO:1905145)
Cellular response to epinephrine stimulus
(GO:0071872)
Flagellated sperm motility
(GO:0030317)
Glutamatergic synapse
(GO:0098978)
Hippocampus development
(GO:0021766)
Intracellular calcium ion homeostasis
(GO:0006874)
Intracellular membrane-bounded organelle
(GO:0043231)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Metal ion binding
(GO:0046872)
Monoatomic ion transmembrane transport
(GO:0034220)
Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
(GO:0071878)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of arginine catabolic process
(GO:1900082)
Negative regulation of blood vessel endothelial cell migration
(GO:0043537)
Negative regulation of calcineurin-nfat signaling cascade
(GO:0070885)
Negative regulation of cardiac muscle hypertrophy in response to stress
(GO:1903243)
Negative regulation of cellular response to vascular endothelial growth factor stimulus
(GO:1902548)
Negative regulation of citrulline biosynthetic process
(GO:1903249)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of nitric-oxide synthase activity
(GO:0051001)
Negative regulation of nitric oxide biosynthetic process
(GO:0045019)
Negative regulation of nitric oxide mediated signal transduction
(GO:0010751)
Negative regulation of peptidyl-cysteine s-nitrosylation
(GO:1902083)
Negative regulation of the force of heart contraction
(GO:0098736)
Neural retina development
(GO:0003407)
Nitric-oxide synthase binding
(GO:0050998)
Nitric-oxide synthase inhibitor activity
(GO:0036487)
P-type calcium transporter activity
(GO:0005388)
Pdz domain binding
(GO:0030165)
Plasma membrane
(GO:0005886)
Positive regulation of camp-dependent protein kinase activity
(GO:2000481)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of protein localization to plasma membrane
(GO:1903078)
Presynaptic active zone membrane
(GO:0048787)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein phosphatase 2b binding
(GO:0030346)
Regulation of cardiac conduction
(GO:1903779)
Regulation of cell cycle g1/s phase transition
(GO:1902806)
Regulation of cytosolic calcium ion concentration
(GO:0051480)
Regulation of sodium ion transmembrane transport
(GO:1902305)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to hydrostatic pressure
(GO:0051599)
Scaffold protein binding
(GO:0097110)
Sodium channel regulator activity
(GO:0017080)
Spermatogenesis
(GO:0007283)
Sperm flagellum
(GO:0036126)
Sperm principal piece
(GO:0097228)
T-tubule
(GO:0030315)
Transport across blood-brain barrier
(GO:0150104)
Urinary bladder smooth muscle contraction
(GO:0014832)
Z disc
(GO:0030018)

Other Information

Proteins

Matrix-remodeling-associated protein 1

Genular Protein ID: 2807099904

Symbol: AT2B4_HUMAN

Name: Matrix-remodeling-associated protein 1

UniProtKB Accession Codes:

P23634 B1APW5 B1APW6 Q13450 Q13452 Q13455 Q16817 Q7Z3S1

Database IDs:

Citations:

PubMed ID: 2137451

Title: Peptide sequence analysis and molecular cloning reveal two calcium pump isoforms in the human erythrocyte membrane.

PubMed ID: 2137451

DOI: 10.1016/s0021-9258(19)39877-1

PubMed ID: 1531651

Title: Analysis of the tissue-specific distribution of mRNAs encoding the plasma membrane calcium-pumping ATPases and characterization of an alternately spliced form of PMCA4 at the cDNA and genomic levels.

PubMed ID: 1531651

DOI: 10.1016/s0021-9258(18)42846-3

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8700162

Title: Analysis of mRNA expression and cloning of a novel plasma membrane Ca(2+)-ATPase splice variant in human heart.

PubMed ID: 8700162

DOI: 10.1007/bf00229314

PubMed ID: 2963820

Title: Identification and primary structure of a calmodulin binding domain of the Ca2+ pump of human erythrocytes.

PubMed ID: 2963820

DOI: 10.1016/s0021-9258(18)69154-9

PubMed ID: 2966397

Title: A C-terminal, calmodulin-like regulatory domain from the plasma membrane Ca2+-pumping ATPase.

PubMed ID: 2966397

DOI: 10.1073/pnas.85.9.2914

PubMed ID: 8245032

Title: Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.

PubMed ID: 8245032

DOI: 10.1016/s0021-9258(19)74484-6

PubMed ID: 7989379

Title:

PubMed ID: 7989379

DOI: 10.1016/s0021-9258(18)31797-6

PubMed ID: 8530416

Title: Mutants in the putative nucleotide-binding region of the plasma membrane Ca(2+)-pump. A reduction in activity due to slow dephosphorylation.

PubMed ID: 8530416

DOI: 10.1074/jbc.270.50.30111

PubMed ID: 12763866

Title: Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variants.

PubMed ID: 12763866

DOI: 10.1111/j.1749-6632.2003.tb07230.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22084111

Title: POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters.

PubMed ID: 22084111

DOI: 10.1073/pnas.1117231108

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10493800

Title: NMR solution structure of a complex of calmodulin with a binding peptide of the Ca(2+) pump.

PubMed ID: 10493800

DOI: 10.1021/bi9908235

Sequence Information:

Length: 1241
Mass: 137920
Checksum: 568544103CD5F494
Sequence:

MTNPSDRVLP ANSMAESREG DFGCTVMELR KLMELRSRDA LTQINVHYGG VQNLCSRLKT 
SPVEGLSGNP ADLEKRRQVF GHNVIPPKKP KTFLELVWEA LQDVTLIILE IAAIISLVLS 
FYRPAGEENE LCGQVATTPE DENEAQAGWI EGAAILFSVI IVVLVTAFND WSKEKQFRGL 
QCRIEQEQKF SIIRNGQLIQ LPVAEIVVGD IAQVKYGDLL PADGILIQGN DLKIDESSLT 
GESDHVKKSL DKDPMLLSGT HVMEGSGRMV VTAVGVNSQT GIILTLLGVN EDDEGEKKKK 
GKKQGVPENR NKAKTQDGVA LEIQPLNSQE GIDNEEKDKK AVKVPKKEKS VLQGKLTRLA 
VQIGKAGLLM SALTVFILIL YFVIDNFVIN RRPWLPECTP IYIQYFVKFF IIGITVLVVA 
VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL TMNRMTVVQA 
YIGGIHYRQI PSPDVFLPKV LDLIVNGISI NSAYTSKILP PEKEGGLPRQ VGNKTECALL 
GFVTDLKQDY QAVRNEVPEE KLYKVYTFNS VRKSMSTVIR NPNGGFRMYS KGASEIILRK 
CNRILDRKGE AVPFKNKDRD DMVRTVIEPM ACDGLRTICI AYRDFDDTEP SWDNENEILT 
ELTCIAVVGI EDPVRPEVPD AIAKCKQAGI TVRMVTGDNI NTARAIATKC GILTPGDDFL 
CLEGKEFNRL IRNEKGEVEQ EKLDKIWPKL RVLARSSPTD KHTLVKGIID STVGEHRQVV 
AVTGDGTNDG PALKKADVGF AMGIAGTDVA KEASDIILTD DNFTSIVKAV MWGRNVYDSI 
SKFLQFQLTV NVVAVIVAFT GACITQDSPL KAVQMLWVNL IMDTFASLAL ATEPPTESLL 
KRRPYGRNKP LISRTMMKNI LGHAFYQLIV IFILVFAGEK FFDIDSGRKA PLHSPPSQHY 
TIVFNTFVLM QLFNEINSRK IHGEKNVFSG IYRNIIFCSV VLGTFICQIF IVEFGGKPFS 
CTSLSLSQWL WCLFIGIGEL LWGQFISAIP TRSLKFLKEA GHGTTKEEIT KDAEGLDEID 
HAEMELRRGQ ILWFRGLNRI QTQIDVINTF QTGASFKGVL RRQNMGQHLD VKLVPSSSYI 
KVVKAFHSSL HESIQKPYNQ KSIHSFMTHP EFAIEEELPR TPLLDEEEEE NPDKASKFGT 
RVLLLDGEVT PYANTNNNAV DCNQVQLPQS DSSLQSLETS V

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ATP2B4

Associated with

Other Information

Peptide sequence analysis and molecular cloning reveal two calcium pump isoforms in the human erythrocyte membrane. PubMed ID: 2137451

Analysis of the tissue-specific distribution of mRNAs encoding the plasma membrane calcium-pumping ATPases and characterization of an alternately spliced form of PMCA4 at the cDNA and genomic levels. PubMed ID: 1531651

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Analysis of mRNA expression and cloning of a novel plasma membrane Ca(2+)-ATPase splice variant in human heart. PubMed ID: 8700162

Identification and primary structure of a calmodulin binding domain of the Ca2+ pump of human erythrocytes. PubMed ID: 2963820

A C-terminal, calmodulin-like regulatory domain from the plasma membrane Ca2+-pumping ATPase. PubMed ID: 2966397

Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes. PubMed ID: 8245032