Details for: ATP2B4

Gene ID: 493

Symbol: ATP2B4

Ensembl ID: ENSG00000058668

Description: ATPase plasma membrane Ca2+ transporting 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.81
    Marker Score: 59928
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.74
    Marker Score: 61242
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.62
    Marker Score: 46592
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.52
    Marker Score: 1658
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.42
    Marker Score: 3011
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.34
    Marker Score: 5133.5
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.28
    Marker Score: 9529
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.15
    Marker Score: 1167
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.09
    Marker Score: 33613
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.08
    Marker Score: 759
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.06
    Marker Score: 1968
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.97
    Marker Score: 1146
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.95
    Marker Score: 119653
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.94
    Marker Score: 2527
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.92
    Marker Score: 18074
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.86
    Marker Score: 17682
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.83
    Marker Score: 2260
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.81
    Marker Score: 1014
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.8
    Marker Score: 15456
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.75
    Marker Score: 987
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.74
    Marker Score: 6183.5
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.73
    Marker Score: 545
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.72
    Marker Score: 10223
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.71
    Marker Score: 4210
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.71
    Marker Score: 1483
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.71
    Marker Score: 1888
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.67
    Marker Score: 2422
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.67
    Marker Score: 424
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.62
    Marker Score: 2177
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.57
    Marker Score: 3702
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.56
    Marker Score: 6337
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.54
    Marker Score: 2231
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.54
    Marker Score: 860
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.54
    Marker Score: 2584
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.52
    Marker Score: 476
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.52
    Marker Score: 4788
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.51
    Marker Score: 5207
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.51
    Marker Score: 2334
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5
    Marker Score: 5812
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.5
    Marker Score: 16910
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.48
    Marker Score: 15261
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.48
    Marker Score: 1553
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.46
    Marker Score: 2749
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.45
    Marker Score: 1750
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166643
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.43
    Marker Score: 551.5
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.43
    Marker Score: 5975
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.43
    Marker Score: 542
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.4
    Marker Score: 706
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.39
    Marker Score: 1572
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.39
    Marker Score: 717
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.38
    Marker Score: 444
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.38
    Marker Score: 907
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.36
    Marker Score: 1565
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.35
    Marker Score: 1747
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.35
    Marker Score: 10023
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.33
    Marker Score: 538
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.32
    Marker Score: 643
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.32
    Marker Score: 10105
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.31
    Marker Score: 20533
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.29
    Marker Score: 1063
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.29
    Marker Score: 296
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.27
    Marker Score: 550
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.27
    Marker Score: 3621
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.27
    Marker Score: 431
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.26
    Marker Score: 1516
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.24
    Marker Score: 745
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.24
    Marker Score: 1087
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.23
    Marker Score: 1813
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.2
    Marker Score: 1133
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.18
    Marker Score: 311
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.18
    Marker Score: 291
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.16
    Marker Score: 466
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.15
    Marker Score: 1387
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.14
    Marker Score: 1224
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.13
    Marker Score: 1174
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.13
    Marker Score: 974
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.13
    Marker Score: 329
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.11
    Marker Score: 7243
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.11
    Marker Score: 662
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.1
    Marker Score: 645
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.1
    Marker Score: 1006
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.09
    Marker Score: 1345
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.09
    Marker Score: 923
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.08
    Marker Score: 2596
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.08
    Marker Score: 294
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.06
    Marker Score: 1504
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.06
    Marker Score: 772
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.06
    Marker Score: 1461
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.06
    Marker Score: 2037
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.05
    Marker Score: 326
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.05
    Marker Score: 9103
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.04
    Marker Score: 922
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.04
    Marker Score: 420
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.03
    Marker Score: 927
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.03
    Marker Score: 4459
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.03
    Marker Score: 1444
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.03
    Marker Score: 729
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.02
    Marker Score: 2039
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.02
    Marker Score: 1092

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Other Information

**Key characteristics:** * The ATP2B4 gene is located on chromosome 19p13.2. * It is a large gene with a molecular weight of approximately 10,000 amino acids. * The protein is expressed in high levels in the brain, heart, and kidney. * It is a transmembrane protein that spans the plasma membrane. * The protein has a unique structure that is not found in other ATPases. **Pathways and functions:** * The ATP2B4 protein is a key regulator of calcium signaling in cardiac cells. * It is expressed in the heart where it is involved in cardiac conduction and the regulation of cardiac contractility. * The protein is also expressed in platelets, where it is involved in platelet aggregation. * It is involved in the regulation of calcium signaling in astrocytes, where it is expressed in astrocytes of the cerebral cortex. * It is also involved in the regulation of calcium signaling in epithelial cells, where it is expressed in cell lines such as the Caco-2 cell line. **Clinical significance:** * Mutations in the ATP2B4 gene have been linked to a number of human diseases, including stroke, heart failure, and hypertension. * These diseases are characterized by abnormal calcium signaling, which is a major factor in the development of these conditions. * Targeting the ATP2B4 protein has been explored as a therapeutic strategy for these diseases. **Additional notes:** * The ATP2B4 protein is a relatively new protein, and there is still much that is unknown about its function. * The protein has been shown to interact with a number of other proteins, including calmodulin, troponin, and phospholabin. * The protein is a promising target for therapeutic intervention in a variety of diseases that are characterized by abnormal calcium signaling.

Genular Protein ID: 2807099904

Symbol: AT2B4_HUMAN

Name: Matrix-remodeling-associated protein 1

UniProtKB Accession Codes:

P23634 B1APW5 B1APW6 Q13450 Q13452 Q13455 Q16817 Q7Z3S1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 1 ELM 1 EMBL 13 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 63 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 1 SAM 1 SFLD 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2137451

Title: Peptide sequence analysis and molecular cloning reveal two calcium pump isoforms in the human erythrocyte membrane.

PubMed ID: 2137451

DOI: 10.1016/s0021-9258(19)39877-1

PubMed ID: 1531651

Title: Analysis of the tissue-specific distribution of mRNAs encoding the plasma membrane calcium-pumping ATPases and characterization of an alternately spliced form of PMCA4 at the cDNA and genomic levels.

PubMed ID: 1531651

DOI: 10.1016/s0021-9258(18)42846-3

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8700162

Title: Analysis of mRNA expression and cloning of a novel plasma membrane Ca(2+)-ATPase splice variant in human heart.

PubMed ID: 8700162

DOI: 10.1007/bf00229314

PubMed ID: 2963820

Title: Identification and primary structure of a calmodulin binding domain of the Ca2+ pump of human erythrocytes.

PubMed ID: 2963820

DOI: 10.1016/s0021-9258(18)69154-9

PubMed ID: 2966397

Title: A C-terminal, calmodulin-like regulatory domain from the plasma membrane Ca2+-pumping ATPase.

PubMed ID: 2966397

DOI: 10.1073/pnas.85.9.2914

PubMed ID: 8245032

Title: Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.

PubMed ID: 8245032

DOI: 10.1016/s0021-9258(19)74484-6

PubMed ID: 7989379

Title:

PubMed ID: 7989379

DOI: 10.1016/s0021-9258(18)31797-6

PubMed ID: 8530416

Title: Mutants in the putative nucleotide-binding region of the plasma membrane Ca(2+)-pump. A reduction in activity due to slow dephosphorylation.

PubMed ID: 8530416

DOI: 10.1074/jbc.270.50.30111

PubMed ID: 12763866

Title: Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variants.

PubMed ID: 12763866

DOI: 10.1111/j.1749-6632.2003.tb07230.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22084111

Title: POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters.

PubMed ID: 22084111

DOI: 10.1073/pnas.1117231108

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10493800

Title: NMR solution structure of a complex of calmodulin with a binding peptide of the Ca(2+) pump.

PubMed ID: 10493800

DOI: 10.1021/bi9908235

Sequence Information:

  • Length: 1241
  • Mass: 137920
  • Checksum: 568544103CD5F494
  • Sequence:
    • MTNPSDRVLP ANSMAESREG DFGCTVMELR KLMELRSRDA LTQINVHYGG VQNLCSRLKT 
SPVEGLSGNP ADLEKRRQVF GHNVIPPKKP KTFLELVWEA LQDVTLIILE IAAIISLVLS 
FYRPAGEENE LCGQVATTPE DENEAQAGWI EGAAILFSVI IVVLVTAFND WSKEKQFRGL 
QCRIEQEQKF SIIRNGQLIQ LPVAEIVVGD IAQVKYGDLL PADGILIQGN DLKIDESSLT 
GESDHVKKSL DKDPMLLSGT HVMEGSGRMV VTAVGVNSQT GIILTLLGVN EDDEGEKKKK 
GKKQGVPENR NKAKTQDGVA LEIQPLNSQE GIDNEEKDKK AVKVPKKEKS VLQGKLTRLA 
VQIGKAGLLM SALTVFILIL YFVIDNFVIN RRPWLPECTP IYIQYFVKFF IIGITVLVVA 
VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL TMNRMTVVQA 
YIGGIHYRQI PSPDVFLPKV LDLIVNGISI NSAYTSKILP PEKEGGLPRQ VGNKTECALL 
GFVTDLKQDY QAVRNEVPEE KLYKVYTFNS VRKSMSTVIR NPNGGFRMYS KGASEIILRK 
CNRILDRKGE AVPFKNKDRD DMVRTVIEPM ACDGLRTICI AYRDFDDTEP SWDNENEILT 
ELTCIAVVGI EDPVRPEVPD AIAKCKQAGI TVRMVTGDNI NTARAIATKC GILTPGDDFL 
CLEGKEFNRL IRNEKGEVEQ EKLDKIWPKL RVLARSSPTD KHTLVKGIID STVGEHRQVV 
AVTGDGTNDG PALKKADVGF AMGIAGTDVA KEASDIILTD DNFTSIVKAV MWGRNVYDSI 
SKFLQFQLTV NVVAVIVAFT GACITQDSPL KAVQMLWVNL IMDTFASLAL ATEPPTESLL 
KRRPYGRNKP LISRTMMKNI LGHAFYQLIV IFILVFAGEK FFDIDSGRKA PLHSPPSQHY 
TIVFNTFVLM QLFNEINSRK IHGEKNVFSG IYRNIIFCSV VLGTFICQIF IVEFGGKPFS 
CTSLSLSQWL WCLFIGIGEL LWGQFISAIP TRSLKFLKEA GHGTTKEEIT KDAEGLDEID 
HAEMELRRGQ ILWFRGLNRI QTQIDVINTF QTGASFKGVL RRQNMGQHLD VKLVPSSSYI 
KVVKAFHSSL HESIQKPYNQ KSIHSFMTHP EFAIEEELPR TPLLDEEEEE NPDKASKFGT 
RVLLLDGEVT PYANTNNNAV DCNQVQLPQS DSSLQSLETS V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.