Details for: ATP2B4

Gene ID: 493

Symbol: ATP2B4

Ensembl ID: ENSG00000058668

Description: ATPase plasma membrane Ca2+ transporting 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 411.4559
    Cell Significance Index: -64.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 252.6382
    Cell Significance Index: -64.0800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 138.4651
    Cell Significance Index: -65.3700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 130.1146
    Cell Significance Index: -52.8600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 118.4326
    Cell Significance Index: -60.9200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 55.3657
    Cell Significance Index: -52.8600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 53.9233
    Cell Significance Index: -66.4900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.8287
    Cell Significance Index: -61.1600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 19.1905
    Cell Significance Index: -42.0000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.8087
    Cell Significance Index: -57.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.0918
    Cell Significance Index: -67.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.4769
    Cell Significance Index: 405.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.1300
    Cell Significance Index: 240.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.4306
    Cell Significance Index: 64.9000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.7943
    Cell Significance Index: 35.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.4682
    Cell Significance Index: 98.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3739
    Cell Significance Index: 275.6100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3130
    Cell Significance Index: 129.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2914
    Cell Significance Index: 463.1900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2541
    Cell Significance Index: 1132.3200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2409
    Cell Significance Index: 16.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1722
    Cell Significance Index: 31.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.1145
    Cell Significance Index: 62.5400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1070
    Cell Significance Index: 180.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0495
    Cell Significance Index: 72.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9385
    Cell Significance Index: 186.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8098
    Cell Significance Index: 22.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7702
    Cell Significance Index: 47.3400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.7061
    Cell Significance Index: 10.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5868
    Cell Significance Index: 80.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4651
    Cell Significance Index: 253.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4464
    Cell Significance Index: 54.8900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4119
    Cell Significance Index: 44.8100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4005
    Cell Significance Index: 177.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3471
    Cell Significance Index: 653.5300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2310
    Cell Significance Index: 3.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2251
    Cell Significance Index: 155.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2081
    Cell Significance Index: 94.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1957
    Cell Significance Index: 35.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1773
    Cell Significance Index: 33.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0972
    Cell Significance Index: 179.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0736
    Cell Significance Index: 2.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0598
    Cell Significance Index: 7.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0551
    Cell Significance Index: 34.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0477
    Cell Significance Index: 73.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0005
    Cell Significance Index: 0.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0186
    Cell Significance Index: -25.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0265
    Cell Significance Index: -16.5200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0273
    Cell Significance Index: -0.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0276
    Cell Significance Index: -4.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0454
    Cell Significance Index: -34.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0535
    Cell Significance Index: -39.6300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0690
    Cell Significance Index: -50.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0961
    Cell Significance Index: -54.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1019
    Cell Significance Index: -4.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1237
    Cell Significance Index: -3.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1304
    Cell Significance Index: -22.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1363
    Cell Significance Index: -8.8000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1612
    Cell Significance Index: -8.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2022
    Cell Significance Index: -58.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2162
    Cell Significance Index: -45.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2452
    Cell Significance Index: -17.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3390
    Cell Significance Index: -5.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3404
    Cell Significance Index: -8.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3651
    Cell Significance Index: -37.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3681
    Cell Significance Index: -38.3300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.3762
    Cell Significance Index: -5.2600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3792
    Cell Significance Index: -48.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4419
    Cell Significance Index: -50.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4816
    Cell Significance Index: -56.7900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4817
    Cell Significance Index: -54.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5153
    Cell Significance Index: -26.7700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5489
    Cell Significance Index: -16.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5749
    Cell Significance Index: -42.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6291
    Cell Significance Index: -29.3300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6726
    Cell Significance Index: -31.6100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7258
    Cell Significance Index: -57.4800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7518
    Cell Significance Index: -21.5500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.8944
    Cell Significance Index: -21.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9256
    Cell Significance Index: -29.6500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.9580
    Cell Significance Index: -14.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0140
    Cell Significance Index: -16.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0504
    Cell Significance Index: -64.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.0708
    Cell Significance Index: -67.4900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.1029
    Cell Significance Index: -15.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.1741
    Cell Significance Index: -38.4400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.2660
    Cell Significance Index: -40.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.2671
    Cell Significance Index: -66.5300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -1.3234
    Cell Significance Index: -16.9700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.3543
    Cell Significance Index: -22.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.3557
    Cell Significance Index: -59.9700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -1.4075
    Cell Significance Index: -20.0000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.4453
    Cell Significance Index: -24.9900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.4481
    Cell Significance Index: -30.8400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.4482
    Cell Significance Index: -36.2000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -1.4549
    Cell Significance Index: -18.3200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.4592
    Cell Significance Index: -31.1900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.4626
    Cell Significance Index: -20.8200
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -1.4633
    Cell Significance Index: -6.3700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.5038
    Cell Significance Index: -52.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane protein**: ATP2B4 is a transmembrane protein that spans the plasma membrane, with a large extracellular domain and a long intracellular tail. 2. **Calcium-transporting ATPase**: The gene encodes a calcium-transporting ATPase, which uses ATP hydrolysis to pump calcium ions across the plasma membrane. 3. **Regulation of calcium homeostasis**: ATP2B4 plays a crucial role in regulating intracellular calcium ion concentrations, which is essential for various cellular processes, including contraction, signaling, and development. 4. **Multiple isoforms**: The ATP2B4 gene generates multiple isoforms, which are generated through alternative splicing and differential expression in different tissues. **Pathways and Functions:** 1. **Calcium homeostasis**: ATP2B4 regulates the influx and efflux of calcium ions across the plasma membrane, maintaining intracellular calcium ion concentrations. 2. **Muscle contraction**: ATP2B4 plays a critical role in regulating muscle contraction, particularly in cardiac and smooth muscle cells. 3. **Neuronal signaling**: The gene is involved in neuronal signaling, influencing synaptic transmission and plasticity. 4. **Cellular development**: ATP2B4 is required for the development of various tissues, including the heart, brain, and smooth muscle. 5. **Regulation of cellular processes**: The gene regulates various cellular processes, including cell cycle progression, gene expression, and protein localization. **Clinical Significance:** 1. **Cardiac disorders**: Mutations in the ATP2B4 gene have been associated with cardiac disorders, such as hypertrophic cardiomyopathy and arrhythmias. 2. **Neurological disorders**: The gene is implicated in neurological disorders, including epilepsy and Alzheimer's disease. 3. **Muscle disorders**: ATP2B4 mutations have been linked to muscle disorders, such as muscular dystrophy and myotonia. 4. **Cancer**: The gene is involved in cancer development and progression, particularly in osteosarcoma and breast cancer. 5. **Therapeutic applications**: Understanding the role of ATP2B4 in various diseases has potential therapeutic implications, including the development of calcium-channel blockers and other drugs targeting calcium homeostasis. In conclusion, the ATP2B4 gene plays a critical role in maintaining calcium homeostasis and regulating various cellular processes. Its dysregulation is implicated in various diseases, highlighting the importance of this gene in human health and disease. Further research is needed to fully elucidate the functions and clinical significance of the ATP2B4 gene.

Genular Protein ID: 2807099904

Symbol: AT2B4_HUMAN

Name: Matrix-remodeling-associated protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2137451

Title: Peptide sequence analysis and molecular cloning reveal two calcium pump isoforms in the human erythrocyte membrane.

PubMed ID: 2137451

DOI: 10.1016/s0021-9258(19)39877-1

PubMed ID: 1531651

Title: Analysis of the tissue-specific distribution of mRNAs encoding the plasma membrane calcium-pumping ATPases and characterization of an alternately spliced form of PMCA4 at the cDNA and genomic levels.

PubMed ID: 1531651

DOI: 10.1016/s0021-9258(18)42846-3

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8700162

Title: Analysis of mRNA expression and cloning of a novel plasma membrane Ca(2+)-ATPase splice variant in human heart.

PubMed ID: 8700162

DOI: 10.1007/bf00229314

PubMed ID: 2963820

Title: Identification and primary structure of a calmodulin binding domain of the Ca2+ pump of human erythrocytes.

PubMed ID: 2963820

DOI: 10.1016/s0021-9258(18)69154-9

PubMed ID: 2966397

Title: A C-terminal, calmodulin-like regulatory domain from the plasma membrane Ca2+-pumping ATPase.

PubMed ID: 2966397

DOI: 10.1073/pnas.85.9.2914

PubMed ID: 8245032

Title: Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.

PubMed ID: 8245032

DOI: 10.1016/s0021-9258(19)74484-6

PubMed ID: 7989379

Title:

PubMed ID: 7989379

DOI: 10.1016/s0021-9258(18)31797-6

PubMed ID: 8530416

Title: Mutants in the putative nucleotide-binding region of the plasma membrane Ca(2+)-pump. A reduction in activity due to slow dephosphorylation.

PubMed ID: 8530416

DOI: 10.1074/jbc.270.50.30111

PubMed ID: 12763866

Title: Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variants.

PubMed ID: 12763866

DOI: 10.1111/j.1749-6632.2003.tb07230.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22084111

Title: POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters.

PubMed ID: 22084111

DOI: 10.1073/pnas.1117231108

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10493800

Title: NMR solution structure of a complex of calmodulin with a binding peptide of the Ca(2+) pump.

PubMed ID: 10493800

DOI: 10.1021/bi9908235

Sequence Information:

  • Length: 1241
  • Mass: 137920
  • Checksum: 568544103CD5F494
  • Sequence:
  • MTNPSDRVLP ANSMAESREG DFGCTVMELR KLMELRSRDA LTQINVHYGG VQNLCSRLKT 
    SPVEGLSGNP ADLEKRRQVF GHNVIPPKKP KTFLELVWEA LQDVTLIILE IAAIISLVLS 
    FYRPAGEENE LCGQVATTPE DENEAQAGWI EGAAILFSVI IVVLVTAFND WSKEKQFRGL 
    QCRIEQEQKF SIIRNGQLIQ LPVAEIVVGD IAQVKYGDLL PADGILIQGN DLKIDESSLT 
    GESDHVKKSL DKDPMLLSGT HVMEGSGRMV VTAVGVNSQT GIILTLLGVN EDDEGEKKKK 
    GKKQGVPENR NKAKTQDGVA LEIQPLNSQE GIDNEEKDKK AVKVPKKEKS VLQGKLTRLA 
    VQIGKAGLLM SALTVFILIL YFVIDNFVIN RRPWLPECTP IYIQYFVKFF IIGITVLVVA 
    VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL TMNRMTVVQA 
    YIGGIHYRQI PSPDVFLPKV LDLIVNGISI NSAYTSKILP PEKEGGLPRQ VGNKTECALL 
    GFVTDLKQDY QAVRNEVPEE KLYKVYTFNS VRKSMSTVIR NPNGGFRMYS KGASEIILRK 
    CNRILDRKGE AVPFKNKDRD DMVRTVIEPM ACDGLRTICI AYRDFDDTEP SWDNENEILT 
    ELTCIAVVGI EDPVRPEVPD AIAKCKQAGI TVRMVTGDNI NTARAIATKC GILTPGDDFL 
    CLEGKEFNRL IRNEKGEVEQ EKLDKIWPKL RVLARSSPTD KHTLVKGIID STVGEHRQVV 
    AVTGDGTNDG PALKKADVGF AMGIAGTDVA KEASDIILTD DNFTSIVKAV MWGRNVYDSI 
    SKFLQFQLTV NVVAVIVAFT GACITQDSPL KAVQMLWVNL IMDTFASLAL ATEPPTESLL 
    KRRPYGRNKP LISRTMMKNI LGHAFYQLIV IFILVFAGEK FFDIDSGRKA PLHSPPSQHY 
    TIVFNTFVLM QLFNEINSRK IHGEKNVFSG IYRNIIFCSV VLGTFICQIF IVEFGGKPFS 
    CTSLSLSQWL WCLFIGIGEL LWGQFISAIP TRSLKFLKEA GHGTTKEEIT KDAEGLDEID 
    HAEMELRRGQ ILWFRGLNRI QTQIDVINTF QTGASFKGVL RRQNMGQHLD VKLVPSSSYI 
    KVVKAFHSSL HESIQKPYNQ KSIHSFMTHP EFAIEEELPR TPLLDEEEEE NPDKASKFGT 
    RVLLLDGEVT PYANTNNNAV DCNQVQLPQS DSSLQSLETS V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.