Details for: ATP4A

Gene ID: 495

Symbol: ATP4A

Ensembl ID: ENSG00000105675

Description: ATPase H+/K+ transporting subunit alpha

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3176
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 1.88
    Marker Score: 730
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7686
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.01
    Marker Score: 2564
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71830
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48054
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5357
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.85
    Marker Score: 237
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.68
    Marker Score: 1074.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 469
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.5
    Marker Score: 940
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.44
    Marker Score: 256
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.43
    Marker Score: 6694
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.42
    Marker Score: 883.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.41
    Marker Score: 440
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.39
    Marker Score: 800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.35
    Marker Score: 198
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.34
    Marker Score: 181
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.34
    Marker Score: 141
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.3
    Marker Score: 613
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.27
    Marker Score: 492
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.22
    Marker Score: 131
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.22
    Marker Score: 69
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.21
    Marker Score: 120
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.18
    Marker Score: 53
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.17
    Marker Score: 92
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.17
    Marker Score: 102
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.17
    Marker Score: 70
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.16
    Marker Score: 76.5
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.14
    Marker Score: 131
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.12
    Marker Score: 194
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.12
    Marker Score: 48
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.12
    Marker Score: 52
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.11
    Marker Score: 137.5
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.11
    Marker Score: 44
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.1
    Marker Score: 221
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.09
    Marker Score: 35
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.09
    Marker Score: 79
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.09
    Marker Score: 1209
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.09
    Marker Score: 91
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.09
    Marker Score: 39
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.09
    Marker Score: 547
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.08
    Marker Score: 65
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.08
    Marker Score: 52
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.07
    Marker Score: 127
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 80
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.07
    Marker Score: 289
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.07
    Marker Score: 243
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.07
    Marker Score: 276
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.06
    Marker Score: 111
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.06
    Marker Score: 38
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.06
    Marker Score: 32.5
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.05
    Marker Score: 128
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.05
    Marker Score: 36
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.05
    Marker Score: 863
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.05
    Marker Score: 45
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.05
    Marker Score: 46
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.04
    Marker Score: 30
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.04
    Marker Score: 44
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.04
    Marker Score: 28
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.04
    Marker Score: 49
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.04
    Marker Score: 44
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.04
    Marker Score: 52
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.04
    Marker Score: 45
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.04
    Marker Score: 800
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.04
    Marker Score: 39

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Other Information

## Summary The ATP4A gene encodes for a protein called ATP4A, which is a component of the ATPase family of ion pumps. This protein is expressed in a variety of cells, including blood vessel endothelial cells, neuroendocrine cells, goblet cells, intestinal crypt stem cells of the colon, cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, transit amplifying cells, abnormal cells, and neoplastic cells. ## Key characteristics * The ATP4A gene is located on chromosome 7. * It is a large gene, encoding for a protein with a molecular weight of approximately 130 kDa. * The protein is a transmembrane protein that is expressed in the plasma membrane. * It is a member of the ATPase family of ion pumps, which are responsible for transporting ions across the plasma membrane. * ATP4A is a hexamer, meaning that it is composed of six subunits that come together to form a functional protein. * Each subunit of the ATP4A protein is responsible for transporting one molecule of ATP across the plasma membrane. ## Pathways and functions * The ATP4A protein is involved in a variety of cellular processes, including: * Maintaining the electrochemical gradient across the plasma membrane * Regulating the flow of ions across the plasma membrane * Transporting small molecules into and out of cells * The protein is important for maintaining the resting membrane potential of cells and for regulating the flow of ions in and out of cells. * Mutations in the ATP4A gene have been linked to a number of human diseases, including: * Congenital lactic acidosis * Hypokalemia * Diabetes * Hypertension ## Clinical significance The ATP4A gene is a promising target for the treatment of a variety of diseases. By understanding the role of ATP4A in human health, it may be possible to develop new treatments for these diseases.

Genular Protein ID: 3789981749

Symbol: ATP4A_HUMAN

Name: Potassium-transporting ATPase alpha chain 1

UniProtKB Accession Codes:

P20648 O00738

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 16 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EC 1 EMBL 5 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 20 Gene3D 4 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 2 SAM 1 SFLD 2 SMART 1 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 5 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2160952

Title: Human gastric (H+ + K+)-ATPase gene. Similarity to (Na+ + K+)-ATPase genes in exon/intron organization but difference in control region.

PubMed ID: 2160952

DOI: 10.1016/s0021-9258(19)38807-6

PubMed ID: 2176086

Title: Structure of the human gastric H,K-ATPase gene and comparison of the 5'-flanking sequences of the human and rat genes.

PubMed ID: 2176086

DOI: 10.1089/dna.1990.9.749

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 3036582

Title: The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit.

PubMed ID: 3036582

DOI: 10.1016/0014-5793(87)80677-4

PubMed ID: 24188822

Title: Modulation of H(+),K(+)-ATPase activity by the molecular chaperone ERp57 highly expressed in gastric parietal cells.

PubMed ID: 24188822

DOI: 10.1016/j.febslet.2013.10.030

Sequence Information:

  • Length: 1035
  • Mass: 114119
  • Checksum: E320595E7D9E0E28
  • Sequence:
    • MGKAENYELY SVELGPGPGG DMAAKMSKKK KAGGGGGKRK EKLENMKKEM EINDHQLSVA 
ELEQKYQTSA TKGLSASLAA ELLLRDGPNA LRPPRGTPEY VKFARQLAGG LQCLMWVAAA 
ICLIAFAIQA SEGDLTTDDN LYLAIALIAV VVVTGCFGYY QEFKSTNIIA SFKNLVPQQA 
TVIRDGDKFQ INADQLVVGD LVEMKGGDRV PADIRILAAQ GCKVDNSSLT GESEPQTRSP 
ECTHESPLET RNIAFFSTMC LEGTVQGLVV NTGDRTIIGR IASLASGVEN EKTPIAIEIE 
HFVDIIAGLA ILFGATFFIV AMCIGYTFLR AMVFFMAIVV AYVPEGLLAT VTVCLSLTAK 
RLASKNCVVK NLEAVETLGS TSVICSDKTG TLTQNRMTVS HLWFDNHIHT ADTTEDQSGQ 
TFDQSSETWR ALCRVLTLCN RAAFKSGQDA VPVPKRIVIG DASETALLKF SELTLGNAMG 
YRDRFPKVCE IPFNSTNKFQ LSIHTLEDPR DPRHLLVMKG APERVLERCS SILIKGQELP 
LDEQWREAFQ TAYLSLGGLG ERVLGFCQLY LNEKDYPPGY AFDVEAMNFP SSGLCFAGLV 
SMIDPPRATV PDAVLKCRTA GIRVIMVTGD HPITAKAIAA SVGIISEGSE TVEDIAARLR 
VPVDQVNRKD ARACVINGMQ LKDMDPSELV EALRTHPEMV FARTSPQQKL VIVESCQRLG 
AIVAVTGDGV NDSPALKKAD IGVAMGIAGS DAAKNAADMI LLDDNFASIV TGVEQGRLIF 
DNLKKSIAYT LTKNIPELTP YLIYITVSVP LPLGCITILF IELCTDIFPS VSLAYEKAES 
DIMHLRPRNP KRDRLVNEPL AAYSYFQIGA IQSFAGFTDY FTAMAQEGWF PLLCVGLRAQ 
WEDHHLQDLQ DSYGQEWTFG QRLYQQYTCY TVFFISIEVC QIADVLIRKT RRLSAFQQGF 
FRNKILVIAI VFQVCIGCFL CYCPGMPNIF NFMPIRFQWW LVPLPYGILI FVYDEIRKLG 
VRCCPGSWWD QELYY

Genular Protein ID: 2906501569

Symbol: Q658V6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q658V6

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 5 Gene3D 4 Genevisible 1 GenomeRNAi 1 InterPro 11 KEGG 1 NCBI Taxonomy 1 NCBIfam 2 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 RefSeq 1 RuleBase 1 SFLD 2 SMART 2 SUPFAM 4

Sequence Information:

  • Length: 1004
  • Mass: 110793
  • Checksum: 06661456B88C595F
  • Sequence:
    • AGGGGGKRKE KLENMKKEME INDHQLSVAE LEQKYQTSAT KGLSASLAAE LLLRDGPNAL 
RPPRGTPEYV KFARQLAGGL QCLMWVAAAI CLIAFAIQAS EGDLTTDDNL YLAIALIAVV 
VVTGCFGYYQ EFKSTNIIAS FKNLVPQQAT VIRDGDKFQI NADQLVVGDL VEMKGGDRVP 
ADIRILAAQG CKVDNSSLTG ESEPQTRSPE CTHESPLETR NIAFFSTMCL EGTAQGLVVN 
TGDRTIIGRI ASLASGVENE KTPIAIEIEH FVDIIAGLAI LFGATFFIVA MCIGYTFLRA 
MVFFMAIVVA YVPEGLLATV TVCLSLTAKR LASKNCVVKN LEAVETLGST SVICSDKTGT 
LTQNRMTVSH LWFDNHIHTA DTTEDQSGQT FDQSSETWRA LCRVLTLCNR AAFKSGQDAV 
PVPKRIVIGD ASETALLKFS ELTLGNAMGY RDRFPKVCEI PFNSTNKFQL SIHTLEDPRD 
PRHLLVMKGA PERVLERCSS ILIKGQELPL DEQWREAFQT AYLSLGGLGE RVLGFCQLYL 
NEKDYPPGYA FDVEAMNFPS SGLCFAGLVS MIDPPRATVP DAVLKCRTAG IRVIMVTGDH 
PITAKAIAAS VGIISEGSET VEDIAARLRV PVDQVNRKDA RACVINGMQL KDMDPSELVE 
ALRTHPEMVF ARTSPQQKLV IVESCQRLGA IVAVTGDGVN DSPALKKADI GVAMGIAGSD 
AAKNAADMIL LDDNFASIVT GVEQGRLIFD NLKKSIAYTL TKNIPELTPY LIYITVSVPL 
PLGCITILFI ELCTDIFPSV SLAYEKAESD IMHLRPRNPK RDRLVNEPLA AYSYFQIGAI 
QSFAGFTDYF TAMAQEGWFP LLCVGLRAQW EDHHLQDLQD SYGQEWTFGQ RLYQQYTCYT 
VFFISIEVCQ IADVLIRKTR RLSAFQQGFF RNKILVIAIV FQVCIGCFLC YCPGMPNIFN 
FMPIRFQWWL VPLPYGILIF VYDEIRKLGV RCCPGSWWDQ ELYY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.