Details for: ATP4A

Gene ID: 495

Symbol: ATP4A

Ensembl ID: ENSG00000105675

Description: ATPase H+/K+ transporting subunit alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.5745
    Cell Significance Index: 9.8500
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: 0.4625
    Cell Significance Index: 3.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.3156
    Cell Significance Index: 4.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3085
    Cell Significance Index: 8.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2895
    Cell Significance Index: 57.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0796
    Cell Significance Index: 55.0300
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 0.0760
    Cell Significance Index: 0.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0750
    Cell Significance Index: 12.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0300
    Cell Significance Index: 6.0200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0138
    Cell Significance Index: 0.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0121
    Cell Significance Index: 7.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0051
    Cell Significance Index: 0.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0021
    Cell Significance Index: 4.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0020
    Cell Significance Index: -3.6900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0028
    Cell Significance Index: -4.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0033
    Cell Significance Index: -4.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0047
    Cell Significance Index: -1.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0051
    Cell Significance Index: -3.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0053
    Cell Significance Index: -2.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0069
    Cell Significance Index: -3.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0070
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0071
    Cell Significance Index: -4.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0082
    Cell Significance Index: -3.7200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0103
    Cell Significance Index: -0.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0105
    Cell Significance Index: -0.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0118
    Cell Significance Index: -3.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0123
    Cell Significance Index: -0.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0158
    Cell Significance Index: -2.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0217
    Cell Significance Index: -4.5700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0278
    Cell Significance Index: -1.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0300
    Cell Significance Index: -4.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0311
    Cell Significance Index: -3.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0314
    Cell Significance Index: -1.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0342
    Cell Significance Index: -4.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0358
    Cell Significance Index: -2.7500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0444
    Cell Significance Index: -0.6600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0463
    Cell Significance Index: -0.5400
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0492
    Cell Significance Index: -0.5800
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0541
    Cell Significance Index: -0.7100
  • Cell Name: parietal cell (CL0000162)
    Fold Change: -0.0581
    Cell Significance Index: -0.5500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0608
    Cell Significance Index: -1.3000
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0634
    Cell Significance Index: -0.4400
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0647
    Cell Significance Index: -0.5600
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0650
    Cell Significance Index: -0.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0665
    Cell Significance Index: -3.7300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0695
    Cell Significance Index: -1.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0708
    Cell Significance Index: -2.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0708
    Cell Significance Index: -4.7600
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0710
    Cell Significance Index: -0.6800
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0715
    Cell Significance Index: -0.9100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0727
    Cell Significance Index: -3.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0750
    Cell Significance Index: -1.5700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0789
    Cell Significance Index: -1.5400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0801
    Cell Significance Index: -2.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0819
    Cell Significance Index: -3.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0837
    Cell Significance Index: -4.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0852
    Cell Significance Index: -2.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0870
    Cell Significance Index: -4.0900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0874
    Cell Significance Index: -1.2900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0881
    Cell Significance Index: -0.9600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0896
    Cell Significance Index: -2.8600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0928
    Cell Significance Index: -0.8800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0930
    Cell Significance Index: -1.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0950
    Cell Significance Index: -4.2000
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.0979
    Cell Significance Index: -0.8700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0981
    Cell Significance Index: -2.4500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1020
    Cell Significance Index: -1.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1049
    Cell Significance Index: -3.6900
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1065
    Cell Significance Index: -1.6200
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.1070
    Cell Significance Index: -1.3700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1091
    Cell Significance Index: -2.2200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1106
    Cell Significance Index: -2.7600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1113
    Cell Significance Index: -1.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1125
    Cell Significance Index: -4.2600
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1132
    Cell Significance Index: -1.6100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1139
    Cell Significance Index: -2.4600
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1157
    Cell Significance Index: -1.1800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1173
    Cell Significance Index: -1.7100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1188
    Cell Significance Index: -4.3600
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.1231
    Cell Significance Index: -1.4300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1232
    Cell Significance Index: -0.8300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1271
    Cell Significance Index: -3.1700
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.1276
    Cell Significance Index: -1.3200
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.1277
    Cell Significance Index: -1.1000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1297
    Cell Significance Index: -1.7500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1324
    Cell Significance Index: -1.3700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1325
    Cell Significance Index: -1.4400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1356
    Cell Significance Index: -1.4300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.1363
    Cell Significance Index: -1.2100
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.1365
    Cell Significance Index: -0.6500
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.1382
    Cell Significance Index: -1.4300
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1388
    Cell Significance Index: -1.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1414
    Cell Significance Index: -4.0800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1415
    Cell Significance Index: -1.6200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1422
    Cell Significance Index: -1.7300
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1422
    Cell Significance Index: -1.6100
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1431
    Cell Significance Index: -1.2900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1432
    Cell Significance Index: -2.3200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1439
    Cell Significance Index: -2.8500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1453
    Cell Significance Index: -2.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Function**: The ATP4A protein is a P-type ATPase that pumps protons (H+) across membranes, generating a transmembrane electrochemical gradient. This process is crucial for maintaining proper ion balance and cellular homeostasis. 2. **Cellular localization**: The ATP4A protein is primarily localized to the apical plasma membrane of cells, where it plays a key role in regulating proton transport. 3. **Expression**: The ATP4A gene is significantly expressed in various cell types, including blood vessel endothelial cells, neuroendocrine cells, goblet cells, and stem cells in the intestinal crypts. 4. **Protein structure**: The ATP4A protein consists of two domains: the ATP-binding domain and the membrane-bound domain. The ATP-binding domain is responsible for binding ATP, while the membrane-bound domain is responsible for interacting with the proton channel. **Pathways and Functions** 1. **Apical plasma membrane**: The ATP4A protein plays a crucial role in regulating proton transport across the apical plasma membrane, which is essential for maintaining proper ion balance and cellular homeostasis. 2. **Ion channel transport**: The ATP4A protein is involved in transporting ions across membranes, including protons, potassium ions, and sodium ions. 3. **Establishment or maintenance of transmembrane electrochemical gradient**: The ATP4A protein helps to establish and maintain the transmembrane electrochemical gradient, which is essential for regulating cellular homeostasis. 4. **Intracellular potassium ion homeostasis**: The ATP4A protein helps to regulate intracellular potassium ion homeostasis by transporting potassium ions across membranes. 5. **Intracellular sodium ion homeostasis**: The ATP4A protein also helps to regulate intracellular sodium ion homeostasis by transporting sodium ions across membranes. **Clinical Significance** 1. **Gastrointestinal disorders**: Abnormal expression of the ATP4A gene has been linked to various gastrointestinal disorders, including gastroesophageal reflux disease (GERD) and inflammatory bowel disease (IBD). 2. **Neurological disorders**: The ATP4A gene has also been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Cancer**: Abnormal expression of the ATP4A gene has been linked to various types of cancer, including colorectal cancer and breast cancer. 4. **Xenobiotic response**: The ATP4A protein plays a role in regulating the response to xenobiotics, which are foreign substances that can be toxic to cells. In conclusion, the ATP4A gene encodes for a crucial protein that plays a vital role in regulating proton transport across cellular membranes. Abnormal expression of this gene has been linked to various diseases, including gastrointestinal disorders, neurological disorders, and cancer. Further research is needed to fully understand the role of the ATP4A gene in human disease and to develop therapeutic strategies to target this gene.

Genular Protein ID: 3789981749

Symbol: ATP4A_HUMAN

Name: Potassium-transporting ATPase alpha chain 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2160952

Title: Human gastric (H+ + K+)-ATPase gene. Similarity to (Na+ + K+)-ATPase genes in exon/intron organization but difference in control region.

PubMed ID: 2160952

DOI: 10.1016/s0021-9258(19)38807-6

PubMed ID: 2176086

Title: Structure of the human gastric H,K-ATPase gene and comparison of the 5'-flanking sequences of the human and rat genes.

PubMed ID: 2176086

DOI: 10.1089/dna.1990.9.749

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 3036582

Title: The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit.

PubMed ID: 3036582

DOI: 10.1016/0014-5793(87)80677-4

PubMed ID: 24188822

Title: Modulation of H(+),K(+)-ATPase activity by the molecular chaperone ERp57 highly expressed in gastric parietal cells.

PubMed ID: 24188822

DOI: 10.1016/j.febslet.2013.10.030

Sequence Information:

  • Length: 1035
  • Mass: 114119
  • Checksum: E320595E7D9E0E28
  • Sequence:
  • MGKAENYELY SVELGPGPGG DMAAKMSKKK KAGGGGGKRK EKLENMKKEM EINDHQLSVA 
    ELEQKYQTSA TKGLSASLAA ELLLRDGPNA LRPPRGTPEY VKFARQLAGG LQCLMWVAAA 
    ICLIAFAIQA SEGDLTTDDN LYLAIALIAV VVVTGCFGYY QEFKSTNIIA SFKNLVPQQA 
    TVIRDGDKFQ INADQLVVGD LVEMKGGDRV PADIRILAAQ GCKVDNSSLT GESEPQTRSP 
    ECTHESPLET RNIAFFSTMC LEGTVQGLVV NTGDRTIIGR IASLASGVEN EKTPIAIEIE 
    HFVDIIAGLA ILFGATFFIV AMCIGYTFLR AMVFFMAIVV AYVPEGLLAT VTVCLSLTAK 
    RLASKNCVVK NLEAVETLGS TSVICSDKTG TLTQNRMTVS HLWFDNHIHT ADTTEDQSGQ 
    TFDQSSETWR ALCRVLTLCN RAAFKSGQDA VPVPKRIVIG DASETALLKF SELTLGNAMG 
    YRDRFPKVCE IPFNSTNKFQ LSIHTLEDPR DPRHLLVMKG APERVLERCS SILIKGQELP 
    LDEQWREAFQ TAYLSLGGLG ERVLGFCQLY LNEKDYPPGY AFDVEAMNFP SSGLCFAGLV 
    SMIDPPRATV PDAVLKCRTA GIRVIMVTGD HPITAKAIAA SVGIISEGSE TVEDIAARLR 
    VPVDQVNRKD ARACVINGMQ LKDMDPSELV EALRTHPEMV FARTSPQQKL VIVESCQRLG 
    AIVAVTGDGV NDSPALKKAD IGVAMGIAGS DAAKNAADMI LLDDNFASIV TGVEQGRLIF 
    DNLKKSIAYT LTKNIPELTP YLIYITVSVP LPLGCITILF IELCTDIFPS VSLAYEKAES 
    DIMHLRPRNP KRDRLVNEPL AAYSYFQIGA IQSFAGFTDY FTAMAQEGWF PLLCVGLRAQ 
    WEDHHLQDLQ DSYGQEWTFG QRLYQQYTCY TVFFISIEVC QIADVLIRKT RRLSAFQQGF 
    FRNKILVIAI VFQVCIGCFL CYCPGMPNIF NFMPIRFQWW LVPLPYGILI FVYDEIRKLG 
    VRCCPGSWWD QELYY

Genular Protein ID: 2906501569

Symbol: Q658V6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 1004
  • Mass: 110793
  • Checksum: 06661456B88C595F
  • Sequence:
  • AGGGGGKRKE KLENMKKEME INDHQLSVAE LEQKYQTSAT KGLSASLAAE LLLRDGPNAL 
    RPPRGTPEYV KFARQLAGGL QCLMWVAAAI CLIAFAIQAS EGDLTTDDNL YLAIALIAVV 
    VVTGCFGYYQ EFKSTNIIAS FKNLVPQQAT VIRDGDKFQI NADQLVVGDL VEMKGGDRVP 
    ADIRILAAQG CKVDNSSLTG ESEPQTRSPE CTHESPLETR NIAFFSTMCL EGTAQGLVVN 
    TGDRTIIGRI ASLASGVENE KTPIAIEIEH FVDIIAGLAI LFGATFFIVA MCIGYTFLRA 
    MVFFMAIVVA YVPEGLLATV TVCLSLTAKR LASKNCVVKN LEAVETLGST SVICSDKTGT 
    LTQNRMTVSH LWFDNHIHTA DTTEDQSGQT FDQSSETWRA LCRVLTLCNR AAFKSGQDAV 
    PVPKRIVIGD ASETALLKFS ELTLGNAMGY RDRFPKVCEI PFNSTNKFQL SIHTLEDPRD 
    PRHLLVMKGA PERVLERCSS ILIKGQELPL DEQWREAFQT AYLSLGGLGE RVLGFCQLYL 
    NEKDYPPGYA FDVEAMNFPS SGLCFAGLVS MIDPPRATVP DAVLKCRTAG IRVIMVTGDH 
    PITAKAIAAS VGIISEGSET VEDIAARLRV PVDQVNRKDA RACVINGMQL KDMDPSELVE 
    ALRTHPEMVF ARTSPQQKLV IVESCQRLGA IVAVTGDGVN DSPALKKADI GVAMGIAGSD 
    AAKNAADMIL LDDNFASIVT GVEQGRLIFD NLKKSIAYTL TKNIPELTPY LIYITVSVPL 
    PLGCITILFI ELCTDIFPSV SLAYEKAESD IMHLRPRNPK RDRLVNEPLA AYSYFQIGAI 
    QSFAGFTDYF TAMAQEGWFP LLCVGLRAQW EDHHLQDLQD SYGQEWTFGQ RLYQQYTCYT 
    VFFISIEVCQ IADVLIRKTR RLSAFQQGFF RNKILVIAIV FQVCIGCFLC YCPGMPNIFN 
    FMPIRFQWWL VPLPYGILIF VYDEIRKLGV RCCPGSWWDQ ELYY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.