Details for: ATP4B

Gene ID: 496

Symbol: ATP4B

Ensembl ID: ENSG00000186009

Description: ATPase H+/K+ transporting subunit beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.9375
    Cell Significance Index: 18.3300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6991
    Cell Significance Index: 16.9400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.3491
    Cell Significance Index: 5.0000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2117
    Cell Significance Index: 3.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1393
    Cell Significance Index: 1.9000
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.1187
    Cell Significance Index: 1.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0872
    Cell Significance Index: 47.6100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0205
    Cell Significance Index: 0.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0087
    Cell Significance Index: 0.5500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0046
    Cell Significance Index: 0.0300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.0012
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0002
    Cell Significance Index: 0.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0009
    Cell Significance Index: -0.5600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0010
    Cell Significance Index: -1.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0011
    Cell Significance Index: -0.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0013
    Cell Significance Index: -2.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0016
    Cell Significance Index: -1.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0017
    Cell Significance Index: -0.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0019
    Cell Significance Index: -0.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0023
    Cell Significance Index: -0.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0027
    Cell Significance Index: -0.5400
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0031
    Cell Significance Index: -0.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0033
    Cell Significance Index: -0.3400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0035
    Cell Significance Index: -0.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0037
    Cell Significance Index: -0.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0037
    Cell Significance Index: -1.6800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0037
    Cell Significance Index: -0.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0039
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0072
    Cell Significance Index: -0.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0076
    Cell Significance Index: -1.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0094
    Cell Significance Index: -0.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0104
    Cell Significance Index: -0.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0114
    Cell Significance Index: -0.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0115
    Cell Significance Index: -0.3400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0124
    Cell Significance Index: -0.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0150
    Cell Significance Index: -0.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0171
    Cell Significance Index: -1.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0191
    Cell Significance Index: -0.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0203
    Cell Significance Index: -1.1400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0220
    Cell Significance Index: -0.5900
  • Cell Name: parietal cell (CL0000162)
    Fold Change: -0.0233
    Cell Significance Index: -0.2200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0245
    Cell Significance Index: -1.2900
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0251
    Cell Significance Index: -0.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0267
    Cell Significance Index: -1.1800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0268
    Cell Significance Index: -0.6200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0279
    Cell Significance Index: -1.0300
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.0281
    Cell Significance Index: -0.2500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0285
    Cell Significance Index: -0.9000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0303
    Cell Significance Index: -0.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0316
    Cell Significance Index: -1.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0316
    Cell Significance Index: -1.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0330
    Cell Significance Index: -1.2500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0331
    Cell Significance Index: -1.1600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0340
    Cell Significance Index: -0.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0345
    Cell Significance Index: -0.9400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0346
    Cell Significance Index: -0.4800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0349
    Cell Significance Index: -0.8700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0351
    Cell Significance Index: -0.4000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0363
    Cell Significance Index: -0.4900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0391
    Cell Significance Index: -0.9800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0397
    Cell Significance Index: -0.8700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0404
    Cell Significance Index: -0.5300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0408
    Cell Significance Index: -1.1700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0412
    Cell Significance Index: -0.5200
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0414
    Cell Significance Index: -0.4200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0426
    Cell Significance Index: -1.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0430
    Cell Significance Index: -1.5100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0436
    Cell Significance Index: -0.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0444
    Cell Significance Index: -0.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0449
    Cell Significance Index: -1.1800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0452
    Cell Significance Index: -0.9600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0459
    Cell Significance Index: -0.9200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0459
    Cell Significance Index: -1.1000
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.0466
    Cell Significance Index: -0.3900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0467
    Cell Significance Index: -0.9200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0467
    Cell Significance Index: -1.1900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0477
    Cell Significance Index: -1.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0479
    Cell Significance Index: -1.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0484
    Cell Significance Index: -0.8100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0484
    Cell Significance Index: -1.0100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0491
    Cell Significance Index: -0.8300
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: -0.0494
    Cell Significance Index: -0.3800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0497
    Cell Significance Index: -0.9700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0500
    Cell Significance Index: -0.8100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0508
    Cell Significance Index: -1.0200
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0521
    Cell Significance Index: -0.6300
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0528
    Cell Significance Index: -0.7900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0536
    Cell Significance Index: -1.0600
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.0558
    Cell Significance Index: -0.4300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0561
    Cell Significance Index: -0.7100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0576
    Cell Significance Index: -1.4400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0579
    Cell Significance Index: -0.9800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0592
    Cell Significance Index: -0.7200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0593
    Cell Significance Index: -1.2300
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0605
    Cell Significance Index: -0.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0607
    Cell Significance Index: -1.6200
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0616
    Cell Significance Index: -0.7800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0630
    Cell Significance Index: -1.1700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0630
    Cell Significance Index: -0.8400
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0632
    Cell Significance Index: -0.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of H+/K+ ATPase complex**: ATP4B is a subunit of the H+/K+ ATPase complex, which is a crucial enzyme in maintaining the acid-base balance in cells. 2. **Potassium and proton transport**: ATP4B is involved in regulating the transport of potassium and protons across cellular membranes, which is essential for maintaining cellular homeostasis. 3. **Widespread expression**: ATP4B is expressed in various cell types, including immune cells, epithelial cells, and neurons. 4. **Cellular localization**: ATP4B is primarily localized at the plasma membrane, where it plays a key role in regulating ion transport. **Pathways and Functions:** 1. **Apical plasma membrane**: ATP4B is involved in regulating the transport of potassium and protons across the apical plasma membrane, which is essential for maintaining cellular homeostasis. 2. **Ion channel transport**: ATP4B regulates the transport of ions across cellular membranes, including potassium and protons. 3. **Proton transmembrane transport**: ATP4B is involved in regulating the transport of protons across cellular membranes, which is essential for maintaining cellular homeostasis. 4. **Cell adhesion**: ATP4B has been shown to regulate cell adhesion, which is essential for maintaining tissue integrity. 5. **Immune function**: ATP4B plays a crucial role in regulating immune function, including the activation of immune cells and the regulation of cytokine production. **Clinical Significance:** 1. **Immune-related disorders**: Mutations in the ATP4B gene have been associated with various immune-related disorders, including autoimmune diseases and immunodeficiency disorders. 2. **Cancer**: ATP4B has been shown to play a role in cancer development and progression, including the regulation of cell adhesion and migration. 3. **Neurological disorders**: ATP4B has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Renal function**: ATP4B plays a crucial role in maintaining renal function, including the regulation of sodium and potassium transport. In conclusion, the ATP4B gene plays a crucial role in maintaining cellular homeostasis and immune function. Its widespread expression in various cell types and its involvement in regulating ion transport make it an essential gene in maintaining tissue integrity and overall health. Further research is needed to fully understand the clinical significance of the ATP4B gene in immune-related disorders and other diseases.

Genular Protein ID: 22538848

Symbol: ATP4B_HUMAN

Name: Potassium-transporting ATPase subunit beta

UniProtKB Accession Codes:

P51164 B1B0N8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 5 Ensembl 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1656976

Title: cDNA cloning of the beta-subunit of the human gastric H,K-ATPase.

PubMed ID: 1656976

DOI: 10.1016/s0006-291x(05)81251-3

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9315713

Title: GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells.

PubMed ID: 9315713

DOI: 10.1016/s0014-5793(97)01017-x

PubMed ID: 19694409

Title: A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules.

PubMed ID: 19694409

DOI: 10.1021/bi900868e

Sequence Information:

  • Length: 291
  • Mass: 33367
  • Checksum: 573F6D729CED1C3D
  • Sequence:
    • MAALQEKKTC GQRMEEFQRY CWNPDTGQML GRTLSRWVWI SLYYVAFYVV MTGLFALCLY 
VLMQTVDPYT PDYQDQLRSP GVTLRPDVYG EKGLEIVYNV SDNRTWADLT QTLHAFLAGY 
SPAAQEDSIN CTSEQYFFQE SFRAPNHTKF SCKFTADMLQ NCSGLADPNF GFEEGKPCFI 
IKMNRIVKFL PSNGSAPRVD CAFLDQPREL GQPLQVKYYP PNGTFSLHYF PYYGKKAQPH 
YSNPLVAAKL LNIPRNAEVA IVCKVMAEHV TFNNPHDPYE GKVEFKLKIE K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.