Details for: ATP4B

Gene ID: 496

Symbol: ATP4B

Ensembl ID: ENSG00000186009

Description: ATPase H+/K+ transporting subunit beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T cell (CL0000084)
    Fold Change: 2.44
    Marker Score: 4212.5
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.98
    Marker Score: 2211
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7685
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.09
    Marker Score: 1040
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.04
    Marker Score: 330
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 1.04
    Marker Score: 289
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.03
    Marker Score: 2127
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48054
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.98
    Marker Score: 2478
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.79
    Marker Score: 722
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1193
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.68
    Marker Score: 396
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.64
    Marker Score: 508
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.54
    Marker Score: 254
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.51
    Marker Score: 233
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.37
    Marker Score: 195
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.34
    Marker Score: 143
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.29
    Marker Score: 296
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.22
    Marker Score: 79
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.16
    Marker Score: 380
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.13
    Marker Score: 4450
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.12
    Marker Score: 72
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.1
    Marker Score: 92
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.09
    Marker Score: 21
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.09
    Marker Score: 110
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.09
    Marker Score: 58
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.08
    Marker Score: 178
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.08
    Marker Score: 32
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.07
    Marker Score: 132
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.07
    Marker Score: 108
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.06
    Marker Score: 31
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.06
    Marker Score: 217
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.05
    Marker Score: 342
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.05
    Marker Score: 44
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.05
    Marker Score: 80
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.05
    Marker Score: 50.5
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.05
    Marker Score: 83
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.04
    Marker Score: 43
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.04
    Marker Score: 20.5
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.03
    Marker Score: 41
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.03
    Marker Score: 72
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.03
    Marker Score: 87
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.02
    Marker Score: 29
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.02
    Marker Score: 98

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Other Information

**Key characteristics:** * ATP4B is a transmembrane protein that is composed of two subunits, an alpha subunit and a beta subunit. * The beta subunit is responsible for the transport of potassium ions. * ATP4B is a member of the ATPase family of proteins, which are involved in the regulation of cellular energy metabolism. * ATP4B is a key regulator of potassium and sodium homeostasis in many cell types. **Pathways and functions:** * ATP4B is involved in the regulation of cellular potassium and sodium ion concentrations. * It is a key regulator of potassium efflux from cells, which helps to maintain cellular potassium concentrations. * It is also a key regulator of sodium uptake by cells, which helps to maintain cellular sodium concentrations. * ATP4B is also involved in the regulation of calcium and calcium-dependent signaling pathways. **Clinical significance:** * Mutations in ATP4B have been linked to a number of human diseases, including hyperkalemia, hypokalemia, and renal failure. * These diseases are caused by mutations that disrupt the function of the ATP4B protein. * As a result, mutations in ATP4B are a major cause of genetic kidney disease. **Additional notes:** * ATP4B is a highly conserved protein that is found in all eukaryotic cells. * It is a highly regulated protein that is controlled by a variety of factors, including calcium, sodium, and potassium concentrations, as well as by hormones such as aldosterone. * ATP4B is a powerful regulator of cellular function, and its dysfunction can have a significant impact on human health.

Genular Protein ID: 22538848

Symbol: ATP4B_HUMAN

Name: Potassium-transporting ATPase subunit beta

UniProtKB Accession Codes:

P51164 B1B0N8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 5 Ensembl 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1656976

Title: cDNA cloning of the beta-subunit of the human gastric H,K-ATPase.

PubMed ID: 1656976

DOI: 10.1016/s0006-291x(05)81251-3

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9315713

Title: GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells.

PubMed ID: 9315713

DOI: 10.1016/s0014-5793(97)01017-x

PubMed ID: 19694409

Title: A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules.

PubMed ID: 19694409

DOI: 10.1021/bi900868e

Sequence Information:

  • Length: 291
  • Mass: 33367
  • Checksum: 573F6D729CED1C3D
  • Sequence:
    • MAALQEKKTC GQRMEEFQRY CWNPDTGQML GRTLSRWVWI SLYYVAFYVV MTGLFALCLY 
VLMQTVDPYT PDYQDQLRSP GVTLRPDVYG EKGLEIVYNV SDNRTWADLT QTLHAFLAGY 
SPAAQEDSIN CTSEQYFFQE SFRAPNHTKF SCKFTADMLQ NCSGLADPNF GFEEGKPCFI 
IKMNRIVKFL PSNGSAPRVD CAFLDQPREL GQPLQVKYYP PNGTFSLHYF PYYGKKAQPH 
YSNPLVAAKL LNIPRNAEVA IVCKVMAEHV TFNNPHDPYE GKVEFKLKIE K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.