ATP5F1A | ENSG00000152234 | NCBI 498

Details for: ATP5F1A

Gene ID: 498

Symbol: ATP5F1A

Ensembl ID: ENSG00000152234

Description: ATP synthase F1 subunit alpha

Associated with

Cristae formation
(R-HSA-8949613)
Formation of atp by chemiosmotic coupling
(R-HSA-163210)
Metabolism
(R-HSA-1430728)
Metabolism of proteins
(R-HSA-392499)
Mitochondrial biogenesis
(R-HSA-1592230)
Mitochondrial protein degradation
(R-HSA-9837999)
Mitochondrial protein import
(R-HSA-1268020)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Protein localization
(R-HSA-9609507)
Respiratory electron transport, atp synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
(R-HSA-163200)
The citric acid (tca) cycle and respiratory electron transport
(R-HSA-1428517)
Adp binding
(GO:0043531)
Angiostatin binding
(GO:0043532)
Atp binding
(GO:0005524)
Atp biosynthetic process
(GO:0006754)
Atp hydrolysis activity
(GO:0016887)
Cell surface
(GO:0009986)
Cellular response to dexamethasone stimulus
(GO:0071549)
Cellular response to nitric oxide
(GO:0071732)
Cop9 signalosome
(GO:0008180)
Extracellular exosome
(GO:0070062)
Lipid metabolic process
(GO:0006629)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Mhc class i protein binding
(GO:0042288)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial matrix
(GO:0005759)
Mitochondrial proton-transporting atp synthase, catalytic core
(GO:0005754)
Mitochondrial proton-transporting atp synthase complex
(GO:0005753)
Mitochondrion
(GO:0005739)
Negative regulation of endothelial cell proliferation
(GO:0001937)
Plasma membrane
(GO:0005886)
Positive regulation of blood vessel endothelial cell migration
(GO:0043536)
Protease binding
(GO:0002020)
Protein binding
(GO:0005515)
Proton-transporting atp synthase activity, rotational mechanism
(GO:0046933)
Proton-transporting atp synthase complex
(GO:0045259)
Proton-transporting atp synthase complex, catalytic core f(1)
(GO:0045261)
Proton motive force-driven atp synthesis
(GO:0015986)
Proton motive force-driven mitochondrial atp synthesis
(GO:0042776)
Proton transmembrane transport
(GO:1902600)
Response to ethanol
(GO:0045471)
Response to muscle activity
(GO:0014850)
Rna binding
(GO:0003723)

Other Information

Proteins

ATPA_HUMAN

Genular Protein ID: 998937730

Symbol: ATPA_HUMAN

Name: N/A

UniProtKB Accession Codes:

P25705 A8K092 B4DY56 K7ENP3 Q53XX6 Q8IXV2 Q96FB4 Q96HW2 Q96IR6 Q9BTV8

Database IDs:

Citations:

PubMed ID: 1830491

Title: Nucleotide sequence of a cDNA for the alpha subunit of human mitochondrial ATP synthase.

PubMed ID: 1830491

DOI: 10.1016/0167-4781(91)90183-m

PubMed ID: 8428659

Title: Amplification of the gene encoding the alpha-subunit of the mitochondrial ATP synthase complex in a human retinoblastoma cell line.

PubMed ID: 8428659

DOI: 10.1016/0378-1119(93)90124-l

PubMed ID: 8086450

Title: Gene structure and cell type-specific expression of the human ATP synthase alpha subunit.

PubMed ID: 8086450

DOI: 10.1016/0167-4781(94)90255-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19892738

Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

PubMed ID: 19892738

DOI: 10.1073/pnas.0908958106

PubMed ID: 7498159

Title: The major protein expression profile and two-dimensional protein database of human heart.

PubMed ID: 7498159

DOI: 10.1002/elps.11501601192

PubMed ID: 10077593

Title: Angiostatin binds ATP synthase on the surface of human endothelial cells.

PubMed ID: 10077593

DOI: 10.1073/pnas.96.6.2811

PubMed ID: 11410595

Title: Atp11p and Atp12p are assembly factors for the F(1)-ATPase in human mitochondria.

PubMed ID: 11410595

DOI: 10.1074/jbc.m104133200

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19285951

Title: High affinity interaction between histidine-rich glycoprotein and the cell surface type ATP synthase on T-cells.

PubMed ID: 19285951

DOI: 10.1016/j.bbamem.2009.03.005

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22309213

Title: Identification of a molecular component of the mitochondrial acetyl transferase program; a novel role for GCN5L1.

PubMed ID: 22309213

DOI: 10.1042/bj20120118

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30146159

Title: Microbial Siderophore Enterobactin Promotes Mitochondrial Iron Uptake and Development of the Host via Interaction with ATP Synthase.

PubMed ID: 30146159

DOI: 10.1016/j.cell.2018.07.032

PubMed ID: 23599390

Title: A complex V ATP5A1 defect causes fatal neonatal mitochondrial encephalopathy.

PubMed ID: 23599390

DOI: 10.1093/brain/awt086

PubMed ID: 23596069

Title: Targeted exome sequencing of suspected mitochondrial disorders.

PubMed ID: 23596069

DOI: 10.1212/wnl.0b013e3182918c40

PubMed ID: 34483339

Title: A recurrent de novo ATP5F1A substitution associated with neonatal complex V deficiency.

PubMed ID: 34483339

DOI: 10.1038/s41431-021-00956-0

PubMed ID: 34954817

Title: Variants in Mitochondrial ATP Synthase Cause Variable Neurologic Phenotypes.

PubMed ID: 34954817

DOI: 10.1002/ana.26293

Sequence Information:

Length: 553
Mass: 59751
Checksum: AA47BBB8EDA77EAC
Sequence:

MLSVRVAAAV VRALPRRAGL VSRNALGSSF IAARNFHASN THLQKTGTAE MSSILEERIL 
GADTSVDLEE TGRVLSIGDG IARVHGLRNV QAEEMVEFSS GLKGMSLNLE PDNVGVVVFG 
NDKLIKEGDI VKRTGAIVDV PVGEELLGRV VDALGNAIDG KGPIGSKTRR RVGLKAPGII 
PRISVREPMQ TGIKAVDSLV PIGRGQRELI IGDRQTGKTS IAIDTIINQK RFNDGSDEKK 
KLYCIYVAIG QKRSTVAQLV KRLTDADAMK YTIVVSATAS DAAPLQYLAP YSGCSMGEYF 
RDNGKHALII YDDLSKQAVA YRQMSLLLRR PPGREAYPGD VFYLHSRLLE RAAKMNDAFG 
GGSLTALPVI ETQAGDVSAY IPTNVISITD GQIFLETELF YKGIRPAINV GLSVSRVGSA 
AQTRAMKQVA GTMKLELAQY REVAAFAQFG SDLDAATQQL LSRGVRLTEL LKQGQYSPMA 
IEEQVAVIYA GVRGYLDKLE PSKITKFENA FLSHVVSQHQ ALLGTIRADG KISEQSDAKL 
KEIVTNFLAG FEA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ATP5F1A

Associated with

Other Information

Nucleotide sequence of a cDNA for the alpha subunit of human mitochondrial ATP synthase. PubMed ID: 1830491

Amplification of the gene encoding the alpha-subunit of the mitochondrial ATP synthase complex in a human retinoblastoma cell line. PubMed ID: 8428659

Gene structure and cell type-specific expression of the human ATP synthase alpha subunit. PubMed ID: 8086450

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 18. PubMed ID: 16177791

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini. PubMed ID: 19892738

The major protein expression profile and two-dimensional protein database of human heart. PubMed ID: 7498159

Angiostatin binds ATP synthase on the surface of human endothelial cells. PubMed ID: 10077593

Atp11p and Atp12p are assembly factors for the F(1)-ATPase in human mitochondria. PubMed ID: 11410595

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

High affinity interaction between histidine-rich glycoprotein and the cell surface type ATP synthase on T-cells. PubMed ID: 19285951

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Identification of a molecular component of the mitochondrial acetyl transferase program; a novel role for GCN5L1. PubMed ID: 22309213

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Microbial Siderophore Enterobactin Promotes Mitochondrial Iron Uptake and Development of the Host via Interaction with ATP Synthase. PubMed ID: 30146159

A complex V ATP5A1 defect causes fatal neonatal mitochondrial encephalopathy. PubMed ID: 23599390

Targeted exome sequencing of suspected mitochondrial disorders. PubMed ID: 23596069

A recurrent de novo ATP5F1A substitution associated with neonatal complex V deficiency. PubMed ID: 34483339

Variants in Mitochondrial ATP Synthase Cause Variable Neurologic Phenotypes. PubMed ID: 34954817