Details for: ATP5F1A

Gene ID: 498

Symbol: ATP5F1A

Ensembl ID: ENSG00000152234

Description: ATP synthase F1 subunit alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 256.3311
    Cell Significance Index: -105.6000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 234.6543
    Cell Significance Index: -95.3300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 228.3093
    Cell Significance Index: -107.7900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 207.7042
    Cell Significance Index: -106.8400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 161.2912
    Cell Significance Index: -108.2300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 101.6556
    Cell Significance Index: -97.0600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 25.0565
    Cell Significance Index: -76.9600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 23.3831
    Cell Significance Index: -62.6400
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 14.6465
    Cell Significance Index: 64.8300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.1644
    Cell Significance Index: -31.0000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 6.0507
    Cell Significance Index: 48.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 5.2731
    Cell Significance Index: 276.8600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.1916
    Cell Significance Index: 56.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.9103
    Cell Significance Index: 102.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 4.3635
    Cell Significance Index: 151.6300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.0603
    Cell Significance Index: 75.0500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.7385
    Cell Significance Index: 62.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.5516
    Cell Significance Index: 93.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.1593
    Cell Significance Index: 147.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.1153
    Cell Significance Index: 220.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.8203
    Cell Significance Index: 346.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.7962
    Cell Significance Index: 504.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.7042
    Cell Significance Index: 349.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.5944
    Cell Significance Index: 356.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.5617
    Cell Significance Index: 165.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.5154
    Cell Significance Index: 1112.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.3099
    Cell Significance Index: 1261.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.1991
    Cell Significance Index: 163.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.1564
    Cell Significance Index: 254.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.1171
    Cell Significance Index: 57.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.9161
    Cell Significance Index: 120.7700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.5410
    Cell Significance Index: 19.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.5033
    Cell Significance Index: 192.7100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4059
    Cell Significance Index: 41.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2172
    Cell Significance Index: 26.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1310
    Cell Significance Index: 58.9100
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.0999
    Cell Significance Index: 8.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0640
    Cell Significance Index: 213.4300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0094
    Cell Significance Index: 9.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9121
    Cell Significance Index: 181.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8374
    Cell Significance Index: 82.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7367
    Cell Significance Index: 21.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7139
    Cell Significance Index: 37.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6778
    Cell Significance Index: 243.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6764
    Cell Significance Index: 110.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5636
    Cell Significance Index: 25.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5553
    Cell Significance Index: 501.4000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5339
    Cell Significance Index: 6.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.4872
    Cell Significance Index: 357.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3649
    Cell Significance Index: 28.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2195
    Cell Significance Index: 41.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.1543
    Cell Significance Index: 12.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1001
    Cell Significance Index: 4.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0894
    Cell Significance Index: 67.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0697
    Cell Significance Index: 2.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0556
    Cell Significance Index: 0.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0352
    Cell Significance Index: 0.9400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0276
    Cell Significance Index: 51.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0011
    Cell Significance Index: 0.0300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0376
    Cell Significance Index: -0.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0409
    Cell Significance Index: -75.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0607
    Cell Significance Index: -93.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0722
    Cell Significance Index: -45.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0738
    Cell Significance Index: -7.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0793
    Cell Significance Index: -107.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0844
    Cell Significance Index: -14.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1060
    Cell Significance Index: -78.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1081
    Cell Significance Index: -5.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1270
    Cell Significance Index: -57.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1682
    Cell Significance Index: -94.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1883
    Cell Significance Index: -117.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3147
    Cell Significance Index: -90.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3861
    Cell Significance Index: -44.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4555
    Cell Significance Index: -66.2100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4691
    Cell Significance Index: -19.2200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4928
    Cell Significance Index: -12.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5519
    Cell Significance Index: -64.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5543
    Cell Significance Index: -116.7400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6107
    Cell Significance Index: -7.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6168
    Cell Significance Index: -37.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6590
    Cell Significance Index: -36.9800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6935
    Cell Significance Index: -12.2600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7353
    Cell Significance Index: -10.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8820
    Cell Significance Index: -28.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.8944
    Cell Significance Index: -97.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.9313
    Cell Significance Index: -15.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.9399
    Cell Significance Index: -65.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9566
    Cell Significance Index: -99.6100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.1049
    Cell Significance Index: -27.6200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.2766
    Cell Significance Index: -13.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3774
    Cell Significance Index: -40.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.4279
    Cell Significance Index: -87.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.6110
    Cell Significance Index: -21.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.7799
    Cell Significance Index: -78.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -2.0345
    Cell Significance Index: -58.3200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.0957
    Cell Significance Index: -53.8700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -2.1004
    Cell Significance Index: -29.4400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.1209
    Cell Significance Index: -31.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.1322
    Cell Significance Index: -80.7400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.1736
    Cell Significance Index: -37.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The ATP5F1A gene exhibits the following key characteristics: 1. **Highly conserved**: The ATP5F1A gene is highly conserved across different species, suggesting its essential role in energy metabolism. 2. **Mitochondrial localization**: The F1 subunit alpha is localized to the mitochondrial inner membrane, where it plays a critical role in ATP production. 3. **Chemiosmosis-dependent**: The ATP synthase enzyme is dependent on the proton motive force generated by the electron transport chain to produce ATP. 4. **Rotational mechanism**: The F1 subunit alpha is responsible for the rotation of the stalk that drives the synthesis of ATP from ADP and Pi. **Pathways and Functions** The ATP5F1A gene is involved in the following pathways and functions: 1. **ATP biosynthesis**: The ATP synthase enzyme produces ATP from ADP and Pi through the process of chemiosmosis. 2. **Mitochondrial biogenesis**: The ATP5F1A gene plays a role in the regulation of mitochondrial biogenesis and maintenance. 3. **Cellular response to stress**: The ATP5F1A gene is involved in the cellular response to stress, including oxidative stress and hypoxia. 4. **Immune cell function**: The ATP5F1A gene is expressed in immune cells, including T cells and dendritic cells, suggesting its role in immune cell function and regulation. **Clinical Significance** The ATP5F1A gene has significant implications for various diseases and disorders, including: 1. **Mitochondrial disorders**: Mutations in the ATP5F1A gene can lead to mitochondrial disorders, such as MELAS syndrome and Kearns-Sayre syndrome. 2. **Cardiovascular disease**: The ATP5F1A gene is involved in the regulation of cardiac function and may play a role in the development of cardiovascular disease. 3. **Cancer**: The ATP5F1A gene is expressed in various cancer cells, suggesting its potential role in cancer development and progression. 4. **Neurodegenerative diseases**: The ATP5F1A gene may play a role in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, the ATP5F1A gene is a critical component of the mitochondrial energy metabolism pathway, and its dysregulation can lead to various diseases and disorders. Further research is needed to fully understand the role of the ATP5F1A gene in human health and disease.

Genular Protein ID: 998937730

Symbol: ATPA_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1830491

Title: Nucleotide sequence of a cDNA for the alpha subunit of human mitochondrial ATP synthase.

PubMed ID: 1830491

DOI: 10.1016/0167-4781(91)90183-m

PubMed ID: 8428659

Title: Amplification of the gene encoding the alpha-subunit of the mitochondrial ATP synthase complex in a human retinoblastoma cell line.

PubMed ID: 8428659

DOI: 10.1016/0378-1119(93)90124-l

PubMed ID: 8086450

Title: Gene structure and cell type-specific expression of the human ATP synthase alpha subunit.

PubMed ID: 8086450

DOI: 10.1016/0167-4781(94)90255-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19892738

Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

PubMed ID: 19892738

DOI: 10.1073/pnas.0908958106

PubMed ID: 7498159

Title: The major protein expression profile and two-dimensional protein database of human heart.

PubMed ID: 7498159

DOI: 10.1002/elps.11501601192

PubMed ID: 10077593

Title: Angiostatin binds ATP synthase on the surface of human endothelial cells.

PubMed ID: 10077593

DOI: 10.1073/pnas.96.6.2811

PubMed ID: 11410595

Title: Atp11p and Atp12p are assembly factors for the F(1)-ATPase in human mitochondria.

PubMed ID: 11410595

DOI: 10.1074/jbc.m104133200

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19285951

Title: High affinity interaction between histidine-rich glycoprotein and the cell surface type ATP synthase on T-cells.

PubMed ID: 19285951

DOI: 10.1016/j.bbamem.2009.03.005

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22309213

Title: Identification of a molecular component of the mitochondrial acetyl transferase program; a novel role for GCN5L1.

PubMed ID: 22309213

DOI: 10.1042/bj20120118

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30146159

Title: Microbial Siderophore Enterobactin Promotes Mitochondrial Iron Uptake and Development of the Host via Interaction with ATP Synthase.

PubMed ID: 30146159

DOI: 10.1016/j.cell.2018.07.032

PubMed ID: 23599390

Title: A complex V ATP5A1 defect causes fatal neonatal mitochondrial encephalopathy.

PubMed ID: 23599390

DOI: 10.1093/brain/awt086

PubMed ID: 23596069

Title: Targeted exome sequencing of suspected mitochondrial disorders.

PubMed ID: 23596069

DOI: 10.1212/wnl.0b013e3182918c40

PubMed ID: 34483339

Title: A recurrent de novo ATP5F1A substitution associated with neonatal complex V deficiency.

PubMed ID: 34483339

DOI: 10.1038/s41431-021-00956-0

PubMed ID: 34954817

Title: Variants in Mitochondrial ATP Synthase Cause Variable Neurologic Phenotypes.

PubMed ID: 34954817

DOI: 10.1002/ana.26293

Sequence Information:

  • Length: 553
  • Mass: 59751
  • Checksum: AA47BBB8EDA77EAC
  • Sequence:
  • MLSVRVAAAV VRALPRRAGL VSRNALGSSF IAARNFHASN THLQKTGTAE MSSILEERIL 
    GADTSVDLEE TGRVLSIGDG IARVHGLRNV QAEEMVEFSS GLKGMSLNLE PDNVGVVVFG 
    NDKLIKEGDI VKRTGAIVDV PVGEELLGRV VDALGNAIDG KGPIGSKTRR RVGLKAPGII 
    PRISVREPMQ TGIKAVDSLV PIGRGQRELI IGDRQTGKTS IAIDTIINQK RFNDGSDEKK 
    KLYCIYVAIG QKRSTVAQLV KRLTDADAMK YTIVVSATAS DAAPLQYLAP YSGCSMGEYF 
    RDNGKHALII YDDLSKQAVA YRQMSLLLRR PPGREAYPGD VFYLHSRLLE RAAKMNDAFG 
    GGSLTALPVI ETQAGDVSAY IPTNVISITD GQIFLETELF YKGIRPAINV GLSVSRVGSA 
    AQTRAMKQVA GTMKLELAQY REVAAFAQFG SDLDAATQQL LSRGVRLTEL LKQGQYSPMA 
    IEEQVAVIYA GVRGYLDKLE PSKITKFENA FLSHVVSQHQ ALLGTIRADG KISEQSDAKL 
    KEIVTNFLAG FEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.