Details for: ATP5F1A
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: embryonic stem cell (CL0002322)
Fold Change: 256.3311
Cell Significance Index: -105.6000 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 234.6543
Cell Significance Index: -95.3300 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 228.3093
Cell Significance Index: -107.7900 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 207.7042
Cell Significance Index: -106.8400 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 161.2912
Cell Significance Index: -108.2300 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 101.6556
Cell Significance Index: -97.0600 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 25.0565
Cell Significance Index: -76.9600 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 23.3831
Cell Significance Index: -62.6400 - Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: 14.6465
Cell Significance Index: 64.8300 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 14.1644
Cell Significance Index: -31.0000 - Cell Name: kidney cell (CL1000497)
Fold Change: 6.0507
Cell Significance Index: 48.3100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 5.2731
Cell Significance Index: 276.8600 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 5.1916
Cell Significance Index: 56.4400 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 4.9103
Cell Significance Index: 102.7800 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 4.3635
Cell Significance Index: 151.6300 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.0603
Cell Significance Index: 75.0500 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 3.7385
Cell Significance Index: 62.9800 - Cell Name: granulosa cell (CL0000501)
Fold Change: 3.5516
Cell Significance Index: 93.3900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.1593
Cell Significance Index: 147.3000 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 3.1153
Cell Significance Index: 220.3300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.8203
Cell Significance Index: 346.7800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.7962
Cell Significance Index: 504.0700 - Cell Name: lactocyte (CL0002325)
Fold Change: 2.7042
Cell Significance Index: 349.3600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.5944
Cell Significance Index: 356.2800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.5617
Cell Significance Index: 165.2700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.5154
Cell Significance Index: 1112.1200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 2.3099
Cell Significance Index: 1261.4800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.1991
Cell Significance Index: 163.9000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.1564
Cell Significance Index: 254.3000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.1171
Cell Significance Index: 57.6300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.9161
Cell Significance Index: 120.7700 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.5410
Cell Significance Index: 19.7400 - Cell Name: odontoblast (CL0000060)
Fold Change: 1.5033
Cell Significance Index: 192.7100 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.4059
Cell Significance Index: 41.2900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.2172
Cell Significance Index: 26.3700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.1310
Cell Significance Index: 58.9100 - Cell Name: germ cell (CL0000586)
Fold Change: 1.0999
Cell Significance Index: 8.3100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0640
Cell Significance Index: 213.4300 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.0094
Cell Significance Index: 9.3000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.9121
Cell Significance Index: 181.0200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8374
Cell Significance Index: 82.8400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7367
Cell Significance Index: 21.2300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.7139
Cell Significance Index: 37.0900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.6778
Cell Significance Index: 243.1100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6764
Cell Significance Index: 110.0200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5636
Cell Significance Index: 25.5500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5553
Cell Significance Index: 501.4000 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.5339
Cell Significance Index: 6.0700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.4872
Cell Significance Index: 357.1800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3649
Cell Significance Index: 28.0100 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2195
Cell Significance Index: 41.7800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 0.1543
Cell Significance Index: 12.2200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1001
Cell Significance Index: 4.7100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0894
Cell Significance Index: 67.6500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0697
Cell Significance Index: 2.4500 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0556
Cell Significance Index: 0.9300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0352
Cell Significance Index: 0.9400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0276
Cell Significance Index: 51.8800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0011
Cell Significance Index: 0.0300 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.0376
Cell Significance Index: -0.2900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0409
Cell Significance Index: -75.4700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0607
Cell Significance Index: -93.4500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0722
Cell Significance Index: -45.8500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0738
Cell Significance Index: -7.5400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0793
Cell Significance Index: -107.7700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0844
Cell Significance Index: -14.4100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1060
Cell Significance Index: -78.5200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1081
Cell Significance Index: -5.4600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1270
Cell Significance Index: -57.6300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1682
Cell Significance Index: -94.8500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1883
Cell Significance Index: -117.5700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3147
Cell Significance Index: -90.5600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3861
Cell Significance Index: -44.2300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.4555
Cell Significance Index: -66.2100 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.4691
Cell Significance Index: -19.2200 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.4928
Cell Significance Index: -12.5900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.5519
Cell Significance Index: -64.3200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.5543
Cell Significance Index: -116.7400 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.6107
Cell Significance Index: -7.2800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.6168
Cell Significance Index: -37.9100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.6590
Cell Significance Index: -36.9800 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.6935
Cell Significance Index: -12.2600 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.7353
Cell Significance Index: -10.8600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.8820
Cell Significance Index: -28.2500 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.8944
Cell Significance Index: -97.2900 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.9313
Cell Significance Index: -15.9600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.9399
Cell Significance Index: -65.0000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.9566
Cell Significance Index: -99.6100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.1049
Cell Significance Index: -27.6200 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -1.2766
Cell Significance Index: -13.2200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.3774
Cell Significance Index: -40.5700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.4279
Cell Significance Index: -87.5400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.6110
Cell Significance Index: -21.9800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.7799
Cell Significance Index: -78.7300 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -2.0345
Cell Significance Index: -58.3200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -2.0957
Cell Significance Index: -53.8700 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -2.1004
Cell Significance Index: -29.4400 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -2.1209
Cell Significance Index: -31.7800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -2.1322
Cell Significance Index: -80.7400 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -2.1736
Cell Significance Index: -37.4700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 998937730
Symbol: ATPA_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1830491
Title: Nucleotide sequence of a cDNA for the alpha subunit of human mitochondrial ATP synthase.
PubMed ID: 1830491
PubMed ID: 8428659
Title: Amplification of the gene encoding the alpha-subunit of the mitochondrial ATP synthase complex in a human retinoblastoma cell line.
PubMed ID: 8428659
PubMed ID: 8086450
Title: Gene structure and cell type-specific expression of the human ATP synthase alpha subunit.
PubMed ID: 8086450
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16177791
Title: DNA sequence and analysis of human chromosome 18.
PubMed ID: 16177791
DOI: 10.1038/nature03983
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 19892738
Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.
PubMed ID: 19892738
PubMed ID: 7498159
Title: The major protein expression profile and two-dimensional protein database of human heart.
PubMed ID: 7498159
PubMed ID: 10077593
Title: Angiostatin binds ATP synthase on the surface of human endothelial cells.
PubMed ID: 10077593
PubMed ID: 11410595
Title: Atp11p and Atp12p are assembly factors for the F(1)-ATPase in human mitochondria.
PubMed ID: 11410595
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 19285951
Title: High affinity interaction between histidine-rich glycoprotein and the cell surface type ATP synthase on T-cells.
PubMed ID: 19285951
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22309213
Title: Identification of a molecular component of the mitochondrial acetyl transferase program; a novel role for GCN5L1.
PubMed ID: 22309213
DOI: 10.1042/bj20120118
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 30146159
Title: Microbial Siderophore Enterobactin Promotes Mitochondrial Iron Uptake and Development of the Host via Interaction with ATP Synthase.
PubMed ID: 30146159
PubMed ID: 23599390
Title: A complex V ATP5A1 defect causes fatal neonatal mitochondrial encephalopathy.
PubMed ID: 23599390
DOI: 10.1093/brain/awt086
PubMed ID: 23596069
Title: Targeted exome sequencing of suspected mitochondrial disorders.
PubMed ID: 23596069
PubMed ID: 34483339
Title: A recurrent de novo ATP5F1A substitution associated with neonatal complex V deficiency.
PubMed ID: 34483339
PubMed ID: 34954817
Title: Variants in Mitochondrial ATP Synthase Cause Variable Neurologic Phenotypes.
PubMed ID: 34954817
DOI: 10.1002/ana.26293
Sequence Information:
- Length: 553
- Mass: 59751
- Checksum: AA47BBB8EDA77EAC
- Sequence:
MLSVRVAAAV VRALPRRAGL VSRNALGSSF IAARNFHASN THLQKTGTAE MSSILEERIL GADTSVDLEE TGRVLSIGDG IARVHGLRNV QAEEMVEFSS GLKGMSLNLE PDNVGVVVFG NDKLIKEGDI VKRTGAIVDV PVGEELLGRV VDALGNAIDG KGPIGSKTRR RVGLKAPGII PRISVREPMQ TGIKAVDSLV PIGRGQRELI IGDRQTGKTS IAIDTIINQK RFNDGSDEKK KLYCIYVAIG QKRSTVAQLV KRLTDADAMK YTIVVSATAS DAAPLQYLAP YSGCSMGEYF RDNGKHALII YDDLSKQAVA YRQMSLLLRR PPGREAYPGD VFYLHSRLLE RAAKMNDAFG GGSLTALPVI ETQAGDVSAY IPTNVISITD GQIFLETELF YKGIRPAINV GLSVSRVGSA AQTRAMKQVA GTMKLELAQY REVAAFAQFG SDLDAATQQL LSRGVRLTEL LKQGQYSPMA IEEQVAVIYA GVRGYLDKLE PSKITKFENA FLSHVVSQHQ ALLGTIRADG KISEQSDAKL KEIVTNFLAG FEA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.