Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 289.0799
Cell Significance Index: -44.9700 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 186.5513
Cell Significance Index: -47.3200 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 123.6565
Cell Significance Index: -50.9400 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 109.9714
Cell Significance Index: -51.9200 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 106.9027
Cell Significance Index: -43.4300 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 97.3589
Cell Significance Index: -50.0800 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 45.7872
Cell Significance Index: -43.7200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 40.8165
Cell Significance Index: -50.3300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 15.7343
Cell Significance Index: -42.1500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 13.3108
Cell Significance Index: -52.5300 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 12.5120
Cell Significance Index: -38.4300 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 9.7277
Cell Significance Index: -21.2900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 4.9513
Cell Significance Index: 342.4100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 2.8622
Cell Significance Index: 219.6400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.5665
Cell Significance Index: 1414.4400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.5228
Cell Significance Index: 32.9900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.3482
Cell Significance Index: 270.4400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.1275
Cell Significance Index: 32.4900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.1106
Cell Significance Index: 50.3400 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 1.0777
Cell Significance Index: 15.9100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.0049
Cell Significance Index: 52.2000 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.9909
Cell Significance Index: 24.7700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9514
Cell Significance Index: 154.7400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8381
Cell Significance Index: 166.3300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.8158
Cell Significance Index: 292.6300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.8014
Cell Significance Index: 98.5400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.7941
Cell Significance Index: 143.1600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.7656
Cell Significance Index: 20.8400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.7387
Cell Significance Index: 87.1100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.7049
Cell Significance Index: 37.0100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6478
Cell Significance Index: 353.7700 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.6026
Cell Significance Index: 416.7500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.5532
Cell Significance Index: 14.7700 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.5385
Cell Significance Index: 13.1400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.5375
Cell Significance Index: 15.0200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.5229
Cell Significance Index: 13.4400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.4908
Cell Significance Index: 22.8900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.4459
Cell Significance Index: 28.1100 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.3886
Cell Significance Index: 50.2000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.3697
Cell Significance Index: 19.2600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.3061
Cell Significance Index: 19.7500 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2913
Cell Significance Index: 128.8000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.2812
Cell Significance Index: 20.9600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2627
Cell Significance Index: 36.0800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2611
Cell Significance Index: 25.8300 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.2282
Cell Significance Index: 2.7200 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.2058
Cell Significance Index: 26.3800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1949
Cell Significance Index: 37.1000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1805
Cell Significance Index: 339.8000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.1710
Cell Significance Index: 11.5000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1318
Cell Significance Index: 4.6300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.1024
Cell Significance Index: 4.5300 - Cell Name: peg cell (CL4033014)
Fold Change: 0.0873
Cell Significance Index: 2.0200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0768
Cell Significance Index: 141.7300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0694
Cell Significance Index: 31.5200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0513
Cell Significance Index: 37.6300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0495
Cell Significance Index: 31.4400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0415
Cell Significance Index: 63.8600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0132
Cell Significance Index: 2.2600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0028
Cell Significance Index: -0.2000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0038
Cell Significance Index: -5.2100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0190
Cell Significance Index: -0.7200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0210
Cell Significance Index: -0.9800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0231
Cell Significance Index: -17.4900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0277
Cell Significance Index: -1.7000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0422
Cell Significance Index: -4.3200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0442
Cell Significance Index: -1.1900 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0525
Cell Significance Index: -0.9000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0606
Cell Significance Index: -44.9200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0784
Cell Significance Index: -2.5100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0886
Cell Significance Index: -49.9600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0965
Cell Significance Index: -60.2800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1524
Cell Significance Index: -17.7600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1551
Cell Significance Index: -44.6400 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1631
Cell Significance Index: -4.2900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1683
Cell Significance Index: -24.4600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2178
Cell Significance Index: -12.2200 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.2183
Cell Significance Index: -2.0100 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.2333
Cell Significance Index: -1.9600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2794
Cell Significance Index: -58.8400 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.3084
Cell Significance Index: -8.8000 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3186
Cell Significance Index: -8.1400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3240
Cell Significance Index: -37.1200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3731
Cell Significance Index: -38.8500 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3845
Cell Significance Index: -6.4400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4357
Cell Significance Index: -15.1400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.4427
Cell Significance Index: -6.0400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4610
Cell Significance Index: -36.5100 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.5516
Cell Significance Index: -16.2000 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.6789
Cell Significance Index: -14.2100 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.7310
Cell Significance Index: -43.8900 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.8187
Cell Significance Index: -8.4800 - Cell Name: kidney cell (CL1000497)
Fold Change: -0.8279
Cell Significance Index: -6.6100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8350
Cell Significance Index: -51.2000 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.8688
Cell Significance Index: -23.2400 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.8853
Cell Significance Index: -18.7900 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.9582
Cell Significance Index: -22.9800 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.9869
Cell Significance Index: -21.6100 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -1.0169
Cell Significance Index: -13.0400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -1.0553
Cell Significance Index: -30.2500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 715434560
Symbol: ACON_HUMAN
Name: Aconitate hydratase, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9630632
Title: Characterization of the human mitochondrial aconitase gene (ACO2).
PubMed ID: 9630632
PubMed ID: 15461802
Title: A genome annotation-driven approach to cloning the human ORFeome.
PubMed ID: 15461802
PubMed ID: 10591208
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1946331
Title: Purification and partial amino acid sequence of human aconitase.
PubMed ID: 1946331
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25351951
Title: Mutations in the tricarboxylic acid cycle enzyme, aconitase 2, cause either isolated or syndromic optic neuropathy with encephalopathy and cerebellar atrophy.
PubMed ID: 25351951
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 22405087
Title: Infantile cerebellar-retinal degeneration associated with a mutation in mitochondrial aconitase, ACO2.
PubMed ID: 22405087
Sequence Information:
- Length: 780
- Mass: 85425
- Checksum: 58C9FFBDBDC63D5E
- Sequence:
MAPYSLLVTR LQKALGVRQY HVASVLCQRA KVAMSHFEPN EYIHYDLLEK NINIVRKRLN RPLTLSEKIV YGHLDDPASQ EIERGKSYLR LRPDRVAMQD ATAQMAMLQF ISSGLSKVAV PSTIHCDHLI EAQVGGEKDL RRAKDINQEV YNFLATAGAK YGVGFWKPGS GIIHQIILEN YAYPGVLLIG TDSHTPNGGG LGGICIGVGG ADAVDVMAGI PWELKCPKVI GVKLTGSLSG WSSPKDVILK VAGILTVKGG TGAIVEYHGP GVDSISCTGM ATICNMGAEI GATTSVFPYN HRMKKYLSKT GREDIANLAD EFKDHLVPDP GCHYDQLIEI NLSELKPHIN GPFTPDLAHP VAEVGKVAEK EGWPLDIRVG LIGSCTNSSY EDMGRSAAVA KQALAHGLKC KSQFTITPGS EQIRATIERD GYAQILRDLG GIVLANACGP CIGQWDRKDI KKGEKNTIVT SYNRNFTGRN DANPETHAFV TSPEIVTALA IAGTLKFNPE TDYLTGTDGK KFRLEAPDAD ELPKGEFDPG QDTYQHPPKD SSGQHVDVSP TSQRLQLLEP FDKWDGKDLE DLQILIKVKG KCTTDHISAA GPWLKFRGHL DNISNNLLIG AINIENGKAN SVRNAVTQEF GPVPDTARYY KKHGIRWVVI GDENYGEGSS REHAALEPRH LGGRAIITKS FARIHETNLK KQGLLPLTFA DPADYNKIHP VDKLTIQGLK DFTPGKPLKC IIKHPNGTQE TILLNHTFNE TQIEWFRAGS ALNRMKELQQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.