Details for: ALDH7A1

Gene ID: 501

Symbol: ALDH7A1

Ensembl ID: ENSG00000164904

Description: aldehyde dehydrogenase 7 family member A1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 313.4780
    Cell Significance Index: -48.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 186.6400
    Cell Significance Index: -47.3400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 127.5405
    Cell Significance Index: -52.5400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 99.0260
    Cell Significance Index: -40.2300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 42.1684
    Cell Significance Index: -40.2600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 39.5554
    Cell Significance Index: -48.7700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.0991
    Cell Significance Index: -48.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.4327
    Cell Significance Index: -49.0600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.8687
    Cell Significance Index: -19.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.7560
    Cell Significance Index: 77.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.2020
    Cell Significance Index: 256.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.1975
    Cell Significance Index: 357.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.0324
    Cell Significance Index: 366.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.8309
    Cell Significance Index: 225.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6308
    Cell Significance Index: 323.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.6302
    Cell Significance Index: 43.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.5974
    Cell Significance Index: 89.6400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4615
    Cell Significance Index: 87.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.2429
    Cell Significance Index: 26.0200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.1420
    Cell Significance Index: 17.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0855
    Cell Significance Index: 56.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9548
    Cell Significance Index: 25.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9311
    Cell Significance Index: 127.8600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9286
    Cell Significance Index: 119.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9066
    Cell Significance Index: 495.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8775
    Cell Significance Index: 62.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7914
    Cell Significance Index: 36.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7708
    Cell Significance Index: 340.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7217
    Cell Significance Index: 144.7800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6080
    Cell Significance Index: 6.6100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5743
    Cell Significance Index: 397.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4953
    Cell Significance Index: 10.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4771
    Cell Significance Index: 47.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4678
    Cell Significance Index: 28.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4617
    Cell Significance Index: 416.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4487
    Cell Significance Index: 20.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4113
    Cell Significance Index: 53.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4036
    Cell Significance Index: 144.7700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3448
    Cell Significance Index: 11.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2730
    Cell Significance Index: 51.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2539
    Cell Significance Index: 18.9200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2503
    Cell Significance Index: 2.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2369
    Cell Significance Index: 16.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1794
    Cell Significance Index: 337.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1403
    Cell Significance Index: 89.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0943
    Cell Significance Index: 7.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0819
    Cell Significance Index: 13.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0675
    Cell Significance Index: 103.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0595
    Cell Significance Index: 109.7400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0471
    Cell Significance Index: 0.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0394
    Cell Significance Index: 0.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0390
    Cell Significance Index: 1.3700
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.0131
    Cell Significance Index: 0.2000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0046
    Cell Significance Index: 3.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0039
    Cell Significance Index: -1.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0140
    Cell Significance Index: -8.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0254
    Cell Significance Index: -34.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0264
    Cell Significance Index: -19.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0481
    Cell Significance Index: -36.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0527
    Cell Significance Index: -29.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0722
    Cell Significance Index: -7.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1117
    Cell Significance Index: -1.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1306
    Cell Significance Index: -6.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1440
    Cell Significance Index: -41.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1478
    Cell Significance Index: -31.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1485
    Cell Significance Index: -3.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1575
    Cell Significance Index: -22.8900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1649
    Cell Significance Index: -2.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1837
    Cell Significance Index: -21.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2061
    Cell Significance Index: -6.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2646
    Cell Significance Index: -7.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2953
    Cell Significance Index: -34.8300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3249
    Cell Significance Index: -37.0900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3451
    Cell Significance Index: -5.8100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3718
    Cell Significance Index: -9.3000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3835
    Cell Significance Index: -30.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4025
    Cell Significance Index: -25.9700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.4069
    Cell Significance Index: -5.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4086
    Cell Significance Index: -42.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4304
    Cell Significance Index: -22.4200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4516
    Cell Significance Index: -10.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4523
    Cell Significance Index: -28.5100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4627
    Cell Significance Index: -9.0300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4907
    Cell Significance Index: -8.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5109
    Cell Significance Index: -34.3500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5341
    Cell Significance Index: -12.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5413
    Cell Significance Index: -28.4200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5630
    Cell Significance Index: -12.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5998
    Cell Significance Index: -26.5300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6004
    Cell Significance Index: -6.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6741
    Cell Significance Index: -41.3300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6945
    Cell Significance Index: -26.3000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.7815
    Cell Significance Index: -6.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8806
    Cell Significance Index: -23.6000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.8812
    Cell Significance Index: -13.0100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.9150
    Cell Significance Index: -15.8200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0057
    Cell Significance Index: -25.8500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.0154
    Cell Significance Index: -27.1600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0512
    Cell Significance Index: -38.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0861
    Cell Significance Index: -35.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Metabolic Function**: ALDH7A1 is a member of the aldehyde dehydrogenase family, which catalyzes the oxidation of aldehydes to their corresponding carboxylic acids. This reaction is essential for maintaining cellular redox balance and preventing oxidative stress. 2. **Tissue Expression**: ALDH7A1 is highly expressed in various cell types, including corneal endothelial cells, syncytiotrophoblast cells, astrocytes, and cardiac neurons. Its expression pattern suggests a role in maintaining tissue-specific homeostasis. 3. **Regulation**: ALDH7A1 is regulated by various factors, including transcriptional and post-transcriptional mechanisms. The expression of ALDH7A1 can be modulated by environmental factors, such as oxidative stress and exposure to aldehydes. **Pathways and Functions** 1. **Aldehyde Metabolism**: ALDH7A1 is involved in the metabolism of aldehydes, which are toxic compounds that can cause oxidative stress and tissue damage. By oxidizing aldehydes to their corresponding carboxylic acids, ALDH7A1 helps maintain cellular redox balance and prevents oxidative stress. 2. **Glycine Betaine Biosynthesis**: ALDH7A1 is also involved in the biosynthesis of glycine betaine, a compound that plays a crucial role in protecting cells from oxidative stress. 3. **Amino Acid Metabolism**: ALDH7A1 is involved in the metabolism of amino acids, including glycine and betaine. The enzyme helps regulate the levels of these compounds in the cell. 4. **Cellular Protection**: ALDH7A1 plays a role in protecting cells from oxidative stress and damage caused by aldehydes. The enzyme's activity helps maintain cellular homeostasis and prevents the accumulation of toxic compounds. **Clinical Significance** 1. **Metabolic Disorders**: Dysregulation of ALDH7A1 has been implicated in various metabolic disorders, including liver disease, cancer, and neurodegenerative diseases. The enzyme's activity is often reduced in these conditions, leading to an accumulation of toxic compounds and oxidative stress. 2. **Cancer**: ALDH7A1 has been identified as a tumor suppressor gene in various cancers, including liver and breast cancer. The enzyme's activity is often reduced in cancer cells, leading to an accumulation of toxic compounds and oxidative stress. 3. **Neurological Conditions**: ALDH7A1 has been implicated in various neurological conditions, including Alzheimer's disease and Parkinson's disease. The enzyme's activity is often reduced in these conditions, leading to an accumulation of toxic compounds and oxidative stress. 4. **Toxicology**: ALDH7A1 has been identified as a biomarker for exposure to aldehydes, which are toxic compounds that can cause oxidative stress and tissue damage. The enzyme's activity can be used to assess the level of exposure to aldehydes and predict the risk of toxicity. In conclusion, the ALDH7A1 gene plays a crucial role in maintaining cellular homeostasis and preventing oxidative stress. Its dysregulation has been implicated in various diseases, including metabolic disorders, cancer, and neurological conditions. Further research is needed to fully understand the mechanisms of ALDH7A1 and its clinical significance.

Genular Protein ID: 1113889635

Symbol: AL7A1_HUMAN

Name: Aldehyde dehydrogenase family 7 member A1

UniProtKB Accession Codes:

P49419 B2R669 B4DIC7 B4DMA0 E7EPT3 O14619 Q6IPU8 Q9BUL4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 2 CTD 1 ChEBI 57 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 3 EMBL 10 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 20 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 16 SABIO-RK 1 SASBDB 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8088832

Title: Homology between a human protein and a protein of the green garden pea.

PubMed ID: 8088832

DOI: 10.1006/geno.1994.1279

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9417906

Title: An ancient conserved gene expressed in the human inner ear: identification, expression analysis, and chromosomal mapping of human and mouse antiquitin (ATQ1).

PubMed ID: 9417906

DOI: 10.1006/geno.1997.5026

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21338592

Title: Aldehyde dehydrogenase 7A1 (ALDH7A1) attenuates reactive aldehyde and oxidative stress induced cytotoxicity.

PubMed ID: 21338592

DOI: 10.1016/j.cbi.2011.02.016

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 20207735

Title: Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress.

PubMed ID: 20207735

DOI: 10.1074/jbc.m109.077925

PubMed ID: 26260980

Title: Structural Basis of Substrate Recognition by Aldehyde Dehydrogenase 7A1.

PubMed ID: 26260980

DOI: 10.1021/acs.biochem.5b00754

PubMed ID: 16491085

Title: Mutations in antiquitin in individuals with pyridoxine-dependent seizures.

PubMed ID: 16491085

DOI: 10.1038/nm1366

PubMed ID: 17068770

Title: Biochemical and molecular characterization of 18 patients with pyridoxine-dependent epilepsy and mutations of the antiquitin (ALDH7A1) gene.

PubMed ID: 17068770

DOI: 10.1002/humu.20433

Sequence Information:

  • Length: 539
  • Mass: 58487
  • Checksum: 05385562F71312B6
  • Sequence:
    • MWRLPRALCV HAAKTSKLSG PWSRPAAFMS TLLINQPQYA WLKELGLREE NEGVYNGSWG 
GRGEVITTYC PANNEPIARV RQASVADYEE TVKKAREAWK IWADIPAPKR GEIVRQIGDA 
LREKIQVLGS LVSLEMGKIL VEGVGEVQEY VDICDYAVGL SRMIGGPILP SERSGHALIE 
QWNPVGLVGI ITAFNFPVAV YGWNNAIAMI CGNVCLWKGA PTTSLISVAV TKIIAKVLED 
NKLPGAICSL TCGGADIGTA MAKDERVNLL SFTGSTQVGK QVGLMVQERF GRSLLELGGN 
NAIIAFEDAD LSLVVPSALF AAVGTAGQRC TTARRLFIHE SIHDEVVNRL KKAYAQIRVG 
NPWDPNVLYG PLHTKQAVSM FLGAVEEAKK EGGTVVYGGK VMDRPGNYVE PTIVTGLGHD 
ASIAHTETFA PILYVFKFKN EEEVFAWNNE VKQGLSSSIF TKDLGRIFRW LGPKGSDCGI 
VNVNIPTSGA EIGGAFGGEK HTGGGRESGS DAWKQYMRRS TCTINYSKDL PLAQGIKFQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.