ALDH7A1 | ENSG00000164904 | NCBI 501

Details for: ALDH7A1

Gene ID: 501

Symbol: ALDH7A1

Ensembl ID: ENSG00000164904

Description: aldehyde dehydrogenase 7 family member A1

Associated with

Choline catabolism
(R-HSA-6798163)
Lysine catabolism
(R-HSA-71064)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Aldehyde dehydrogenase (nad+) activity
(GO:0004029)
Betaine-aldehyde dehydrogenase activity
(GO:0008802)
Cellular aldehyde metabolic process
(GO:0006081)
Choline catabolic process
(GO:0042426)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Glyceraldehyde-3-phosphate dehydrogenase (nad+) (non-phosphorylating) activity
(GO:0043878)
Glycine betaine biosynthetic process from choline
(GO:0019285)
Identical protein binding
(GO:0042802)
L-aminoadipate-semialdehyde dehydrogenase activity
(GO:0004043)
Mitochondrial matrix
(GO:0005759)
Mitochondrion
(GO:0005739)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Sensory perception of sound
(GO:0007605)

Other Information

Proteins

Aldehyde dehydrogenase family 7 member A1

Genular Protein ID: 1113889635

Symbol: AL7A1_HUMAN

Name: Aldehyde dehydrogenase family 7 member A1

UniProtKB Accession Codes:

P49419 B2R669 B4DIC7 B4DMA0 E7EPT3 O14619 Q6IPU8 Q9BUL4

Database IDs:

Citations:

PubMed ID: 8088832

Title: Homology between a human protein and a protein of the green garden pea.

PubMed ID: 8088832

DOI: 10.1006/geno.1994.1279

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9417906

Title: An ancient conserved gene expressed in the human inner ear: identification, expression analysis, and chromosomal mapping of human and mouse antiquitin (ATQ1).

PubMed ID: 9417906

DOI: 10.1006/geno.1997.5026

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21338592

Title: Aldehyde dehydrogenase 7A1 (ALDH7A1) attenuates reactive aldehyde and oxidative stress induced cytotoxicity.

PubMed ID: 21338592

DOI: 10.1016/j.cbi.2011.02.016

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 20207735

Title: Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress.

PubMed ID: 20207735

DOI: 10.1074/jbc.m109.077925

PubMed ID: 26260980

Title: Structural Basis of Substrate Recognition by Aldehyde Dehydrogenase 7A1.

PubMed ID: 26260980

DOI: 10.1021/acs.biochem.5b00754

PubMed ID: 16491085

Title: Mutations in antiquitin in individuals with pyridoxine-dependent seizures.

PubMed ID: 16491085

DOI: 10.1038/nm1366

PubMed ID: 17068770

Title: Biochemical and molecular characterization of 18 patients with pyridoxine-dependent epilepsy and mutations of the antiquitin (ALDH7A1) gene.

PubMed ID: 17068770

DOI: 10.1002/humu.20433

Sequence Information:

Length: 539
Mass: 58487
Checksum: 05385562F71312B6
Sequence:

MWRLPRALCV HAAKTSKLSG PWSRPAAFMS TLLINQPQYA WLKELGLREE NEGVYNGSWG 
GRGEVITTYC PANNEPIARV RQASVADYEE TVKKAREAWK IWADIPAPKR GEIVRQIGDA 
LREKIQVLGS LVSLEMGKIL VEGVGEVQEY VDICDYAVGL SRMIGGPILP SERSGHALIE 
QWNPVGLVGI ITAFNFPVAV YGWNNAIAMI CGNVCLWKGA PTTSLISVAV TKIIAKVLED 
NKLPGAICSL TCGGADIGTA MAKDERVNLL SFTGSTQVGK QVGLMVQERF GRSLLELGGN 
NAIIAFEDAD LSLVVPSALF AAVGTAGQRC TTARRLFIHE SIHDEVVNRL KKAYAQIRVG 
NPWDPNVLYG PLHTKQAVSM FLGAVEEAKK EGGTVVYGGK VMDRPGNYVE PTIVTGLGHD 
ASIAHTETFA PILYVFKFKN EEEVFAWNNE VKQGLSSSIF TKDLGRIFRW LGPKGSDCGI 
VNVNIPTSGA EIGGAFGGEK HTGGGRESGS DAWKQYMRRS TCTINYSKDL PLAQGIKFQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ALDH7A1

Associated with

Other Information

Homology between a human protein and a protein of the green garden pea. PubMed ID: 8088832

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

An ancient conserved gene expressed in the human inner ear: identification, expression analysis, and chromosomal mapping of human and mouse antiquitin (ATQ1). PubMed ID: 9417906

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Initial characterization of the human central proteome. PubMed ID: 21269460

Aldehyde dehydrogenase 7A1 (ALDH7A1) attenuates reactive aldehyde and oxidative stress induced cytotoxicity. PubMed ID: 21338592

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress. PubMed ID: 20207735

Structural Basis of Substrate Recognition by Aldehyde Dehydrogenase 7A1. PubMed ID: 26260980

Mutations in antiquitin in individuals with pyridoxine-dependent seizures. PubMed ID: 16491085

Biochemical and molecular characterization of 18 patients with pyridoxine-dependent epilepsy and mutations of the antiquitin (ALDH7A1) gene. PubMed ID: 17068770