Nox4 | ENSMUSG00000030562 | NCBI 50490

Details for: Nox4

Gene ID: 50490

Symbol: Nox4

Ensembl ID: ENSMUSG00000030562

Description: NADPH oxidase 4

Associated with

Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to chemical stress
(R-MMU-9711123)
Detoxification of reactive oxygen species
(R-MMU-3299685)
Apical plasma membrane
(GO:0016324)
Bone resorption
(GO:0045453)
Cardiac muscle cell differentiation
(GO:0055007)
Cell morphogenesis
(GO:0000902)
Cell periphery
(GO:0071944)
Cellular response to glucose stimulus
(GO:0071333)
Defense response
(GO:0006952)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Focal adhesion
(GO:0005925)
Gene expression
(GO:0010467)
Heart process
(GO:0003015)
Heme binding
(GO:0020037)
Homocysteine metabolic process
(GO:0050667)
Mitochondrion
(GO:0005739)
Modified amino acid binding
(GO:0072341)
Nad(p)h oxidase h2o2-forming activity
(GO:0016174)
Nadph oxidase complex
(GO:0043020)
Nadph oxidase h202-forming activity
(GO:0106294)
Negative regulation of cell population proliferation
(GO:0008285)
Nucleolus
(GO:0005730)
Nucleus
(GO:0005634)
Oxidoreductase activity, acting on nad(p)h, oxygen as acceptor
(GO:0050664)
Perinuclear endoplasmic reticulum
(GO:0097038)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of dna biosynthetic process
(GO:2000573)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of hydrogen peroxide biosynthetic process
(GO:0010729)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein tyrosine kinase activity
(GO:0061098)
Positive regulation of reactive oxygen species metabolic process
(GO:2000379)
Positive regulation of smooth muscle cell migration
(GO:0014911)
Positive regulation of stress fiber assembly
(GO:0051496)
Protein tyrosine kinase binding
(GO:1990782)
Reactive oxygen species metabolic process
(GO:0072593)
Sarcoplasmic reticulum
(GO:0016529)
Stress fiber
(GO:0001725)
Superoxide-generating nad(p)h oxidase activity
(GO:0016175)
Superoxide-generating nadph oxidase activity
(GO:0106292)
Superoxide anion generation
(GO:0042554)
Superoxide metabolic process
(GO:0006801)

Other Information

Proteins

NADPH oxidase 4

Genular Protein ID: 2220331593

Symbol: NOX4_MOUSE

Name: NADPH oxidase 4

UniProtKB Accession Codes:

Q9JHI8 Q3TF39 Q8C3M1 Q8VCA3

Database IDs:

Citations:

PubMed ID: 10869423

Title: Identification of renox, an NAD(P)H oxidase in kidney.

PubMed ID: 10869423

DOI: 10.1073/pnas.130135897

PubMed ID: 11032835

Title: A novel superoxide-producing NAD(P)H oxidase in kidney.

PubMed ID: 11032835

DOI: 10.1074/jbc.m007597200

PubMed ID: 11098048

Title: A new superoxide-generating oxidase in murine osteoclasts.

PubMed ID: 11098048

DOI: 10.1074/jbc.m001004200

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15016652

Title: Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia.

PubMed ID: 15016652

DOI: 10.1182/blood-2003-07-2240

PubMed ID: 15638999

Title: Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone.

PubMed ID: 15638999

DOI: 10.1211/0022357055119

PubMed ID: 15802177

Title: Neuronal expression of the NADPH oxidase NOX4, and its regulation in mouse experimental brain ischemia.

PubMed ID: 15802177

DOI: 10.1016/j.neuroscience.2004.12.038

Sequence Information:

Length: 578
Mass: 66519
Checksum: 7887ADD40599A3D1
Sequence:

MAVSWRSWLA NEGVKHLCLL IWLSLNVLLF WKTFLLYNQG PEYYYIHQML GLGLCLSRAS 
ASVLNLNCSL ILLPMCRTVL AYLRGSQKVP SRRTRRLLDK SKTLHITCGV TICIFSGVHV 
AAHLVNALNF SVNYSEDFLE LNAARYQNED PRKLLFTTIP GLTGVCMVVV LFLMVTASTY 
AIRVSNYDIF WYTHNLFFVF YMLLLLHVSG GLLKYQTNVD THPPGCISLN QTSSQNMSIP 
DYVSEHFHGS LPRGFSKLED RYQKTLVKIC LEEPKFQAHF PQTWIWISGP LCLYCAERLY 
RCIRSNKPVT IISVINHPSD VMELRMIKEN FKARPGQYII LHCPSVSALE NHPFTLTMCP 
TETKATFGVH FKVVGDWTER FRDLLLPPSS QDSEILPFIH SRNYPKLYID GPFGSPFEES 
LNYEVSLCVA GGIGVTPFAS ILNTLLDDWK PYKLRRLYFI WVCRDIQSFQ WFADLLCVLH 
NKFWQENRPD FVNIQLYLSQ TDGIQKIIGE KYHTLNSRLF IGRPRWKLLF DEIAKCNRGK 
TVGVFCCGPS SISKTLHSLS NRNNSYGTKF EYNKESFS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nox4

Associated with

Other Information

Identification of renox, an NAD(P)H oxidase in kidney. PubMed ID: 10869423

A novel superoxide-producing NAD(P)H oxidase in kidney. PubMed ID: 11032835

A new superoxide-generating oxidase in murine osteoclasts. PubMed ID: 11098048

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia. PubMed ID: 15016652

Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone. PubMed ID: 15638999

Neuronal expression of the NADPH oxidase NOX4, and its regulation in mouse experimental brain ischemia. PubMed ID: 15802177