Smad4 | ENSRNOG00000051965 | NCBI 50554

Details for: Smad4

Gene ID: 50554

Symbol: Smad4

Ensembl ID: ENSRNOG00000051965

Description: SMAD family member 4

Associated with

Developmental biology
(R-RNO-1266738)
Downregulation of smad2/3:smad4 transcriptional activity
(R-RNO-2173795)
Foxo-mediated transcription
(R-RNO-9614085)
Foxo-mediated transcription of cell cycle genes
(R-RNO-9617828)
Gene expression (transcription)
(R-RNO-74160)
Generic transcription pathway
(R-RNO-212436)
Rna polymerase ii transcription
(R-RNO-73857)
Runx3 regulates cdkn1a transcription
(R-RNO-8941855)
Signaling by activin
(R-RNO-1502540)
Signaling by bmp
(R-RNO-201451)
Signaling by nodal
(R-RNO-1181150)
Signaling by tgf-beta receptor complex
(R-RNO-170834)
Signaling by tgfb family members
(R-RNO-9006936)
Signal transduction
(R-RNO-162582)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-RNO-2173796)
Tgf-beta receptor signaling activates smads
(R-RNO-2173789)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-RNO-2173793)
Transcriptional regulation by runx3
(R-RNO-8878159)
Adrenal gland development
(GO:0030325)
Anatomical structure morphogenesis
(GO:0009653)
Anterior/posterior pattern specification
(GO:0009952)
Atrioventricular canal development
(GO:0036302)
Atrioventricular valve formation
(GO:0003190)
Axon guidance
(GO:0007411)
Bmp signaling pathway
(GO:0030509)
Brainstem development
(GO:0003360)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Cardiac muscle hypertrophy in response to stress
(GO:0014898)
Cardiac septum development
(GO:0003279)
Cell differentiation
(GO:0030154)
Cell population proliferation
(GO:0008283)
Chromatin binding
(GO:0003682)
Collagen binding
(GO:0005518)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-templated transcription
(GO:0006351)
Dna binding
(GO:0003677)
Embryonic digit morphogenesis
(GO:0042733)
Endoderm development
(GO:0007492)
Endothelial cell activation
(GO:0042118)
Epithelial cell migration
(GO:0010631)
Epithelial to mesenchymal transition
(GO:0001837)
Epithelial to mesenchymal transition involved in endocardial cushion formation
(GO:0003198)
Female gonad development
(GO:0008585)
Filamin binding
(GO:0031005)
Gastrulation
(GO:0007369)
Gastrulation with mouth forming second
(GO:0001702)
I-smad binding
(GO:0070411)
Identical protein binding
(GO:0042802)
Intracellular iron ion homeostasis
(GO:0006879)
Intracellular signal transduction
(GO:0035556)
In utero embryonic development
(GO:0001701)
Kidney development
(GO:0001822)
Left ventricular cardiac muscle tissue morphogenesis
(GO:0003220)
Male gonad development
(GO:0008584)
Mesoderm development
(GO:0007498)
Metal ion binding
(GO:0046872)
Negative regulation of cardiac muscle hypertrophy
(GO:0010614)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of protein catabolic process
(GO:0042177)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neural crest cell differentiation
(GO:0014033)
Osteoblast differentiation
(GO:0001649)
Outflow tract septum morphogenesis
(GO:0003148)
Ovarian follicle development
(GO:0001541)
Positive regulation of cardiac muscle cell apoptotic process
(GO:0010666)
Positive regulation of cell proliferation involved in heart valve morphogenesis
(GO:0003251)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of luteinizing hormone secretion
(GO:0033686)
Positive regulation of transforming growth factor beta receptor signaling pathway
(GO:0030511)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
R-smad binding
(GO:0070412)
Regulation of cell population proliferation
(GO:0042127)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Regulation of transforming growth factor beta2 production
(GO:0032909)
Response to hypoxia
(GO:0001666)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Single fertilization
(GO:0007338)
Smad binding
(GO:0046332)
Somite rostral/caudal axis specification
(GO:0032525)
Spermatogenesis
(GO:0007283)
Sulfate binding
(GO:0043199)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coactivator binding
(GO:0001223)
Transcription corepressor binding
(GO:0001222)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)

Other Information

Proteins

Mothers against decapentaplegic homolog 4

Genular Protein ID: 1358408056

Symbol: SMAD4_RAT

Name: Mothers against decapentaplegic homolog 4

UniProtKB Accession Codes:

O70437

Database IDs:

Citations:

PubMed ID: 10670756

Title: cDNA cloning and chromosomal mapping of rat Smad2 and Smad4 and their expression in cultured rat articular chondrocytes.

PubMed ID: 10670756

DOI: 10.1507/endocrj.46.695

PubMed ID: 16619037

Title: Cited2 modulates TGF-beta-mediated upregulation of MMP9.

PubMed ID: 16619037

DOI: 10.1038/sj.onc.1209552

Sequence Information:

Length: 552
Mass: 60469
Checksum: 7AE0540AB4DF0E77
Sequence:

MDNMSITNTP TSNDACLSIV HSLMCHRQGG ESETFAKRAI ESLVKKLKEK KDELDSLITA 
ITTNGAHPSK CVTIQRTLDG RLQVAGRKGF PHVIYARLWR WPDLHKNELK HVKYCQYAFD 
LKCDSVCVNP YHYERVVSPG IDLSGLTLQS NAPPSMLVKD EYVHDFEGQP SLPTEGHSIQ 
TIQHPPSNRA STETYSAPAL LAPSESNATS TTNFPNIPVA STSQPASILA GSHSEGLLQI 
ASGPQPGQQQ NGFTAQPATY HHNSTTTWTG SRTAPYTPNL PHHQNGHLQH HPPMPPHPGH 
YWPVHNELAF QPPISNHPAP EYWCSIAYFE MDVQVGETFK VPSSCPIVTV DGYVDPSGGD 
RFCLGQLSNV HRTEAIERAR LHIGKGVQLE CKGEGDVWVR CLSDHAVFVQ SYYLDREAGR 
APGDAVHKIY PSAYIKVFDL RQCHRQMQQQ AATAQAAAAA QAAAVAGNIP GPGSVGGIAP 
AISLSAAAGI GVDDLRRLCI LRMSFVKGWG PDYPRQSIKE TPCWIEIHLH RALQLLDEVL 
HTMPIADPQP LD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.