Details for: Gja5

Gene ID: 50563

Symbol: Gja5

Ensembl ID: ENSRNOG00000017484

Description: gap junction protein, alpha 5

Associated with

  • Gap junction trafficking
    (R-RNO-190828)
  • Gap junction trafficking and regulation
    (R-RNO-157858)
  • Membrane trafficking
    (R-RNO-199991)
  • Vesicle-mediated transport
    (R-RNO-5653656)
  • Angiogenesis
    (GO:0001525)
  • Artery morphogenesis
    (GO:0048844)
  • Atrial cardiac muscle cell to av node cell communication by electrical coupling
    (GO:0086044)
  • Atrial septum development
    (GO:0003283)
  • Atrial septum morphogenesis
    (GO:0060413)
  • Atrial ventricular junction remodeling
    (GO:0003294)
  • Av node cell to bundle of his cell communication
    (GO:0086067)
  • Av node cell to bundle of his cell communication by electrical coupling
    (GO:0086053)
  • Blood vessel development
    (GO:0001568)
  • Blood vessel diameter maintenance
    (GO:0097746)
  • Bundle of his cell to purkinje myocyte communication by electrical coupling
    (GO:0086054)
  • Cardiac conduction
    (GO:0061337)
  • Cardiac conduction system development
    (GO:0003161)
  • Cell-cell signaling
    (GO:0007267)
  • Cell communication by chemical coupling
    (GO:0010643)
  • Cell communication by electrical coupling
    (GO:0010644)
  • Cell communication by electrical coupling involved in cardiac conduction
    (GO:0086064)
  • Cell communication involved in cardiac conduction
    (GO:0086065)
  • Cell projection
    (GO:0042995)
  • Cellular response to platelet-derived growth factor stimulus
    (GO:0036120)
  • Connexin binding
    (GO:0071253)
  • Connexin complex
    (GO:0005922)
  • Disordered domain specific binding
    (GO:0097718)
  • Embryonic heart tube development
    (GO:0035050)
  • Embryonic limb morphogenesis
    (GO:0030326)
  • Endothelium development
    (GO:0003158)
  • Foramen ovale closure
    (GO:0035922)
  • Gap junction
    (GO:0005921)
  • Gap junction assembly
    (GO:0016264)
  • Gap junction channel activity
    (GO:0005243)
  • Gap junction channel activity involved in atrial cardiac muscle cell-av node cell electrical coupling
    (GO:0086076)
  • Gap junction channel activity involved in av node cell-bundle of his cell electrical coupling
    (GO:0086077)
  • Gap junction channel activity involved in bundle of his cell-purkinje myocyte electrical coupling
    (GO:0086078)
  • Gap junction channel activity involved in cardiac conduction electrical coupling
    (GO:0086075)
  • Gap junction hemi-channel activity
    (GO:0055077)
  • Heart development
    (GO:0007507)
  • Intercalated disc
    (GO:0014704)
  • Mitral valve development
    (GO:0003174)
  • Negative regulation of blood pressure
    (GO:0045776)
  • Negative regulation of glomerular filtration
    (GO:0003105)
  • Outflow tract morphogenesis
    (GO:0003151)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of cell communication by chemical coupling
    (GO:0010652)
  • Positive regulation of vasoconstriction
    (GO:0045907)
  • Potassium ion transport
    (GO:0006813)
  • Pulmonary valve formation
    (GO:0003193)
  • Regulation of atrial cardiac muscle cell action potential
    (GO:0098910)
  • Regulation of atrial cardiac muscle cell membrane depolarization
    (GO:0060371)
  • Regulation of av node cell action potential
    (GO:0098904)
  • Regulation of bundle of his cell action potential
    (GO:0098905)
  • Regulation of cardiac muscle contraction
    (GO:0055117)
  • Regulation of cell communication by electrical coupling
    (GO:0010649)
  • Regulation of heart rate by cardiac conduction
    (GO:0086091)
  • Regulation of membrane depolarization during cardiac muscle cell action potential
    (GO:1900825)
  • Regulation of purkinje myocyte action potential
    (GO:0098906)
  • Regulation of renin secretion into blood stream
    (GO:1900133)
  • Regulation of systemic arterial blood pressure
    (GO:0003073)
  • Regulation of ventricular cardiac muscle cell membrane depolarization
    (GO:0060373)
  • Regulation of ventricular cardiac muscle cell membrane repolarization
    (GO:0060307)
  • Renal system process involved in regulation of systemic arterial blood pressure
    (GO:0003071)
  • Sa node cell action potential
    (GO:0086015)
  • Septum primum development
    (GO:0003284)
  • Skeletal system development
    (GO:0001501)
  • Transmembrane transport
    (GO:0055085)
  • Vasodilation
    (GO:0042311)
  • Vasomotion
    (GO:1990029)
  • Ventricular cardiac muscle cell action potential
    (GO:0086005)
  • Ventricular septum development
    (GO:0003281)
  • Ventricular septum morphogenesis
    (GO:0060412)

Other Information

Genular Protein ID: 494800967

Symbol: CXA5_RAT

Name: Gap junction alpha-5 protein

UniProtKB Accession Codes:

P28234

Database IDs:

AGR 1 AlphaFoldDB 1 BMRB 1 Bgee 1 CTD 1 EMBL 5 Ensembl 12 EvolutionaryTrace 1 GO 67 Gene3D 1 GeneTree 1 HOGENOM 1 InParanoid 1 InterPro 8 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 1370487

Title: Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping.

PubMed ID: 1370487

DOI: 10.1016/s0021-9258(18)46052-8

PubMed ID: 1328644

Title: Molecular cloning and expression of rat connexin40, a gap junction protein expressed in vascular smooth muscle.

PubMed ID: 1328644

DOI: 10.1007/bf00232759

PubMed ID: 9403066

Title: Mouse connexin40: gene structure and promoter analysis.

PubMed ID: 9403066

DOI: 10.1006/geno.1997.5025

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

  • Length: 356
  • Mass: 40233
  • Checksum: 7D459FE69D9ACF0C
  • Sequence:
    • MGDWSFLGEF LEEVHKHSTV IGKVWLTVLF IFRMLVLGTA AESSWGDEQA DFRCDTIQPG 
CQNVCYDQAF PISHIRYWVL QIIFVSTPSL VYMGHAMHTV RMQEKQKLRE AEKAKEAGGT 
GTYEYLAEKA ELSCWKEVNG KIVLQGTLLN TYVCTILIRT AMEVAFMVGQ YLLYGIFLDT 
LHVCRRSPCP HPVNCYVSRP TEKNVFIVFM MAVAGLSLFL SLAELYHLGW KKIRQRLAKS 
RQGDKHQLLG PSTSLVQGLT PPPDFNQCLK NSPDEKFFSD FSNNMGSRKN PDPLATEEVP 
NQEQIPEEGF IHTQYGQKPE QPSGASAGHR FPQGYHSDKR RLSKASSKAR SDDLSV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.