Details for: Grem1

Gene ID: 50566

Symbol: Grem1

Ensembl ID: ENSRNOG00000026053

Description: gremlin 1, DAN family BMP antagonist

Associated with

  • Angiogenesis
    (GO:0001525)
  • Animal organ morphogenesis
    (GO:0009887)
  • Bmp binding
    (GO:0036122)
  • Cardiac muscle cell differentiation
    (GO:0055007)
  • Cardiac muscle cell myoblast differentiation
    (GO:0060379)
  • Cell-cell signaling
    (GO:0007267)
  • Cell migration involved in sprouting angiogenesis
    (GO:0002042)
  • Cell morphogenesis
    (GO:0000902)
  • Cell surface
    (GO:0009986)
  • Collagen fibril organization
    (GO:0030199)
  • Cytokine activity
    (GO:0005125)
  • Determination of dorsal identity
    (GO:0048263)
  • Embryonic limb morphogenesis
    (GO:0030326)
  • Endothelial cell migration
    (GO:0043542)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Limb development
    (GO:0060173)
  • Mesenchymal to epithelial transition involved in metanephros morphogenesis
    (GO:0003337)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of bmp signaling pathway
    (GO:0030514)
  • Negative regulation of bone mineralization
    (GO:0030502)
  • Negative regulation of bone mineralization involved in bone maturation
    (GO:1900158)
  • Negative regulation of bone remodeling
    (GO:0046851)
  • Negative regulation of bone trabecula formation
    (GO:1900155)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of cell growth
    (GO:0030308)
  • Negative regulation of chondrocyte differentiation
    (GO:0032331)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of leukocyte chemotaxis
    (GO:0002689)
  • Negative regulation of monocyte chemotaxis
    (GO:0090027)
  • Negative regulation of osteoblast differentiation
    (GO:0045668)
  • Negative regulation of osteoblast proliferation
    (GO:0033689)
  • Negative regulation of osteoclast proliferation
    (GO:0090291)
  • Negative regulation of smad protein signal transduction
    (GO:0060392)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of branching involved in ureteric bud morphogenesis
    (GO:0090190)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of nf-kappab transcription factor activity
    (GO:0051092)
  • Positive regulation of non-canonical nf-kappab signal transduction
    (GO:1901224)
  • Positive regulation of peptidyl-tyrosine autophosphorylation
    (GO:1900086)
  • Positive regulation of protein tyrosine kinase activity
    (GO:0061098)
  • Positive regulation of receptor internalization
    (GO:0002092)
  • Positive regulation of signaling receptor activity
    (GO:2000273)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Proximal/distal pattern formation
    (GO:0009954)
  • Receptor ligand activity
    (GO:0048018)
  • Regulation of epithelial to mesenchymal transition
    (GO:0010717)
  • Regulation of focal adhesion assembly
    (GO:0051893)
  • Regulation of stress-activated mapk cascade
    (GO:0032872)
  • Sequestering of bmp from receptor via bmp binding
    (GO:0038098)
  • Signal transduction
    (GO:0007165)
  • Signal transduction by p53 class mediator
    (GO:0072331)
  • Transmembrane receptor protein tyrosine kinase activator activity
    (GO:0030297)
  • Ureteric bud formation
    (GO:0060676)
  • Vascular endothelial growth factor receptor 2 binding
    (GO:0043184)

Other Information

Genular Protein ID: 404888132

Symbol: GREM1_RAT

Name: Gremlin-1

UniProtKB Accession Codes:

O35793

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 CTD 1 EMBL 1 Ensembl 8 GO 52 Gene3D 1 GeneTree 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 RefSeq 1 SMART 1 SMR 1 STRING 1 TreeFam 1 UCSC 1 eggNOG 1

Citations:

PubMed ID: 9234736

Title: Identification of drm, a novel gene whose expression is suppressed in transformed cells and which can inhibit growth of normal but not transformed cells in culture.

PubMed ID: 9234736

DOI: 10.1128/mcb.17.8.4801

PubMed ID: 15528323

Title: Bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis.

PubMed ID: 15528323

DOI: 10.4049/jimmunol.173.10.5914

Sequence Information:

  • Length: 184
  • Mass: 20680
  • Checksum: 90AC99749B1AD8F6
  • Sequence:
    • MNRTAYTVGA LLLLLGTLLP AAEGKKKGSQ GAIPPPDKAQ HNDSEQTQSP PQPGSRTRGR 
GQGRGTAMPG EEVLESSQEA LHVTERKYLK RDWCKTQPLK QTIHEEGCNS RTIINRFCYG 
QCNSFYIPRH IRKEEGSFQS CSFCKPKKFT TMMVTLNCPE LQPPTKKKRV TRVKQCRCIS 
IDLD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.