Gria1 | ENSRNOG00000045816 | NCBI 50592

Details for: Gria1

Gene ID: 50592

Symbol: Gria1

Ensembl ID: ENSRNOG00000045816

Description: glutamate ionotropic receptor AMPA type subunit 1

Associated with

Activation of ampa receptors
(R-RNO-399710)
Activation of nmda receptors and postsynaptic events
(R-RNO-442755)
Asparagine n-linked glycosylation
(R-RNO-446203)
Cargo concentration in the er
(R-RNO-5694530)
Copii-mediated vesicle transport
(R-RNO-204005)
Er to golgi anterograde transport
(R-RNO-199977)
Glutamate binding, activation of ampa receptors and synaptic plasticity
(R-RNO-399721)
Membrane trafficking
(R-RNO-199991)
Metabolism of proteins
(R-RNO-392499)
Neuronal system
(R-RNO-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-RNO-112314)
Post-translational protein modification
(R-RNO-597592)
Protein-protein interactions at synapses
(R-RNO-6794362)
Synaptic adhesion-like molecules
(R-RNO-8849932)
Trafficking of ampa receptors
(R-RNO-399719)
Trafficking of glur2-containing ampa receptors
(R-RNO-416993)
Transmission across chemical synapses
(R-RNO-112315)
Transport to the golgi and subsequent modification
(R-RNO-948021)
Unblocking of nmda receptors, glutamate binding and activation
(R-RNO-438066)
Vesicle-mediated transport
(R-RNO-5653656)
Adenylate cyclase binding
(GO:0008179)
Ampa glutamate receptor activity
(GO:0004971)
Amyloid-beta binding
(GO:0001540)
Behavioral response to pain
(GO:0048266)
Beta-2 adrenergic receptor binding
(GO:0031698)
Calcium-mediated signaling
(GO:0019722)
Cellular response to amine stimulus
(GO:0071418)
Cellular response to amino acid stimulus
(GO:0071230)
Cellular response to ammonium ion
(GO:0071242)
Cellular response to dsrna
(GO:0071359)
Cellular response to growth factor stimulus
(GO:0071363)
Cellular response to organic cyclic compound
(GO:0071407)
Cellular response to peptide hormone stimulus
(GO:0071375)
Cerebral cortex development
(GO:0021987)
Chemical synaptic transmission
(GO:0007268)
G-protein alpha-subunit binding
(GO:0001965)
G-protein beta-subunit binding
(GO:0031681)
Glutamate-gated calcium ion channel activity
(GO:0022849)
Glutamate-gated receptor activity
(GO:0004970)
Glutamate receptor binding
(GO:0035254)
Identical protein binding
(GO:0042802)
Immunoglobulin binding
(GO:0019865)
Ionotropic glutamate receptor binding
(GO:0035255)
Ionotropic glutamate receptor signaling pathway
(GO:0035235)
Ligand-gated monoatomic ion channel activity
(GO:0015276)
Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
(GO:0099507)
Long-term memory
(GO:0007616)
Long-term synaptic depression
(GO:0060292)
Long-term synaptic potentiation
(GO:0060291)
Modulation of chemical synaptic transmission
(GO:0050804)
Monoatomic ion transmembrane transport
(GO:0034220)
Myosin v binding
(GO:0031489)
Neuronal action potential
(GO:0019228)
Neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
(GO:0099583)
Pdz domain binding
(GO:0030165)
Peptide hormone receptor binding
(GO:0051428)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of locomotion involved in locomotory behavior
(GO:0090326)
Positive regulation of membrane potential
(GO:0045838)
Positive regulation of synaptic transmission
(GO:0050806)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase a binding
(GO:0051018)
Protein kinase binding
(GO:0019901)
Receptor internalization
(GO:0031623)
Regulation of monoatomic ion transmembrane transport
(GO:0034765)
Regulation of postsynaptic membrane potential
(GO:0060078)
Regulation of presynaptic membrane potential
(GO:0099505)
Regulation of receptor recycling
(GO:0001919)
Regulation of synaptic plasticity
(GO:0048167)
Response to arsenic-containing substance
(GO:0046685)
Response to cocaine
(GO:0042220)
Response to electrical stimulus
(GO:0051602)
Response to estradiol
(GO:0032355)
Response to ethanol
(GO:0045471)
Response to fungicide
(GO:0060992)
Response to lithium ion
(GO:0010226)
Response to morphine
(GO:0043278)
Response to nutrient levels
(GO:0031667)
Response to organic cyclic compound
(GO:0014070)
Response to peptide hormone
(GO:0043434)
Response to sucrose
(GO:0009744)
Response to toxic substance
(GO:0009636)
Response to xenobiotic stimulus
(GO:0009410)
Scaffold protein binding
(GO:0097110)
Signaling receptor activity
(GO:0038023)
Small gtpase binding
(GO:0031267)
Spinal cord development
(GO:0021510)
Synapse assembly
(GO:0007416)
Synaptic transmission, glutamatergic
(GO:0035249)
Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
(GO:1904315)

Other Information

Proteins

AMPA-selective glutamate receptor 1

Genular Protein ID: 18498779

Symbol: GRIA1_RAT

Name: AMPA-selective glutamate receptor 1

UniProtKB Accession Codes:

P19490

Database IDs:

Citations:

PubMed ID: 2480522

Title: Cloning by functional expression of a member of the glutamate receptor family.

PubMed ID: 2480522

DOI: 10.1038/342643a0

PubMed ID: 2166337

Title: A family of AMPA-selective glutamate receptors.

PubMed ID: 2166337

DOI: 10.1126/science.2166337

PubMed ID: 2168579

Title: Molecular cloning and functional expression of glutamate receptor subunit genes.

PubMed ID: 2168579

DOI: 10.1126/science.2168579

PubMed ID: 1699275

Title: Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS.

PubMed ID: 1699275

DOI: 10.1126/science.1699275

PubMed ID: 1709304

Title: Ca2+ permeability of KA-AMPA--gated glutamate receptor channels depends on subunit composition.

PubMed ID: 1709304

DOI: 10.1126/science.1709304

PubMed ID: 7877986

Title: Identification of a Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in non-N-methyl-D-aspartate glutamate receptors.

PubMed ID: 7877986

DOI: 10.1073/pnas.92.5.1376

PubMed ID: 8848293

Title: Antibody specific for phosphorylated AMPA-type glutamate receptors at GluR2 Ser-696.

PubMed ID: 8848293

DOI: 10.1016/0168-0102(95)00977-9

PubMed ID: 9405465

Title: Phosphorylation of the alpha-amino-3-hydroxy-5-methylisoxazole4-propionic acid receptor GluR1 subunit by calcium/calmodulin-dependent kinase II.

PubMed ID: 9405465

DOI: 10.1074/jbc.272.51.32528

PubMed ID: 9677374

Title: SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit.

PubMed ID: 9677374

DOI: 10.1074/jbc.273.31.19518

PubMed ID: 12070168

Title: Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif.

PubMed ID: 12070168

DOI: 10.1074/jbc.m204354200

PubMed ID: 11773314

Title: Voltage and concentration dependence of Ca(2+) permeability in recombinant glutamate receptor subtypes.

PubMed ID: 11773314

DOI: 10.1113/jphysiol.2001.012897

PubMed ID: 15456832

Title: Actin/alpha-actinin-dependent transport of AMPA receptors in dendritic spines: role of the PDZ-LIM protein RIL.

PubMed ID: 15456832

DOI: 10.1523/jneurosci.2100-04.2004

PubMed ID: 16793768

Title: Different domains of the AMPA receptor direct stargazin-mediated trafficking and stargazin-mediated modulation of kinetics.

PubMed ID: 16793768

DOI: 10.1074/jbc.m600679200

PubMed ID: 16630835

Title: SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses.

PubMed ID: 16630835

DOI: 10.1016/j.neuron.2006.04.005

PubMed ID: 18031684

Title: A GluR1-cGKII interaction regulates AMPA receptor trafficking.

PubMed ID: 18031684

DOI: 10.1016/j.neuron.2007.09.016

PubMed ID: 18817736

Title: AMPA receptor subunit-specific regulation by a distinct family of type II TARPs.

PubMed ID: 18817736

DOI: 10.1016/j.neuron.2008.07.034

PubMed ID: 19234459

Title: Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5.

PubMed ID: 19234459

DOI: 10.1038/nn.2266

Title:

DOI: 10.1038/nn0609-808c

PubMed ID: 19265014

Title: Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors.

PubMed ID: 19265014

DOI: 10.1126/science.1167852

PubMed ID: 20805473

Title: Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating.

PubMed ID: 20805473

DOI: 10.1073/pnas.1011706107

PubMed ID: 17069616

Title: Crystal structure of the second PDZ domain of SAP97 in complex with a GluR-A C-terminal peptide.

PubMed ID: 17069616

DOI: 10.1111/j.1742-4658.2006.05521.x

PubMed ID: 21639859

Title: Crystal structure of the glutamate receptor GluA1 N-terminal domain.

PubMed ID: 21639859

DOI: 10.1042/bj20110801

Sequence Information:

Length: 907
Mass: 101579
Checksum: 2D4CFA7CCD532838
Sequence:

MPYIFAFFCT GFLGAVVGAN FPNNIQIGGL FPNQQSQEHA AFRFALSQLT EPPKLLPQID 
IVNISDSFEM TYRFCSQFSK GVYAIFGFYE RRTVNMLTSF CGALHVCFIT PSFPVDTSNQ 
FVLQLRPELQ EALISIIDHY KWQTFVYIYD ADRGLSVLQR VLDTAAEKNW QVTAVNILTT 
TEEGYRMLFQ DLEKKKERLV VVDCESERLN AILGQIVKLE KNGIGYHYIL ANLGFMDIDL 
NKFKESGANV TGFQLVNYTD TIPARIMQQW RTSDSRDHTR VDWKRPKYTS ALTYDGVKVM 
AEAFQSLRRQ RIDISRRGNA GDCLANPAVP WGQGIDIQRA LQQVRFEGLT GNVQFNEKGR 
RTNYTLHVIE MKHDGIRKIG YWNEDDKFVP AATDAQAGGD NSSVQNRTYI VTTILEDPYV 
MLKKNANQFE GNDRYEGYCV ELAAEIAKHV GYSYRLEIVS DGKYGARDPD TKAWNGMVGE 
LVYGRADVAV APLTITLVRE EVIDFSKPFM SLGISIMIKK PQKSKPGVFS FLDPLAYEIW 
MCIVFAYIGV SVVLFLVSRF SPYEWHSEEF EEGRDQTTSD QSNEFGIFNS LWFSLGAFMQ 
QGCDISPRSL SGRIVGGVWW FFTLIIISSY TANLAAFLTV ERMVSPIESA EDLAKQTEIA 
YGTLEAGSTK EFFRRSKIAV FEKMWTYMKS AEPSVFVRTT EEGMIRVRKS KGKYAYLLES 
TMNEYIEQRK PCDTMKVGGN LDSKGYGIAT PKGSALRNPV NLAVLKLNEQ GLLDKLKNKW 
WYDKGECGSG GGDSKDKTSA LSLSNVAGVF YILIGGLGLA MLVALIEFCY KSRSESKRMK 
GFCLIPQQSI NEAIRTSTLP RNSGAGASGG GGSGENGRVV SQDFPKSMQS IPCMSHSSGM 
PLGATGL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gria1

Associated with

Other Information

Cloning by functional expression of a member of the glutamate receptor family. PubMed ID: 2480522

A family of AMPA-selective glutamate receptors. PubMed ID: 2166337

Molecular cloning and functional expression of glutamate receptor subunit genes. PubMed ID: 2168579

Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. PubMed ID: 1699275

Ca2+ permeability of KA-AMPA--gated glutamate receptor channels depends on subunit composition. PubMed ID: 1709304

Identification of a Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in non-N-methyl-D-aspartate glutamate receptors. PubMed ID: 7877986

Antibody specific for phosphorylated AMPA-type glutamate receptors at GluR2 Ser-696. PubMed ID: 8848293

Phosphorylation of the alpha-amino-3-hydroxy-5-methylisoxazole4-propionic acid receptor GluR1 subunit by calcium/calmodulin-dependent kinase II. PubMed ID: 9405465

SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit. PubMed ID: 9677374

Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif. PubMed ID: 12070168

Voltage and concentration dependence of Ca(2+) permeability in recombinant glutamate receptor subtypes. PubMed ID: 11773314

Actin/alpha-actinin-dependent transport of AMPA receptors in dendritic spines: role of the PDZ-LIM protein RIL. PubMed ID: 15456832

Different domains of the AMPA receptor direct stargazin-mediated trafficking and stargazin-mediated modulation of kinetics. PubMed ID: 16793768

SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses. PubMed ID: 16630835

A GluR1-cGKII interaction regulates AMPA receptor trafficking. PubMed ID: 18031684

AMPA receptor subunit-specific regulation by a distinct family of type II TARPs. PubMed ID: 18817736

Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5. PubMed ID: 19234459

Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors. PubMed ID: 19265014

Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating. PubMed ID: 20805473

Crystal structure of the second PDZ domain of SAP97 in complex with a GluR-A C-terminal peptide. PubMed ID: 17069616

Crystal structure of the glutamate receptor GluA1 N-terminal domain. PubMed ID: 21639859