Ptk2b | ENSRNOG00000027839 | NCBI 50646

Details for: Ptk2b

Gene ID: 50646

Symbol: Ptk2b

Ensembl ID: ENSRNOG00000027839

Description: protein tyrosine kinase 2 beta

Associated with

Cell-cell communication
(R-RNO-1500931)
Cytokine signaling in immune system
(R-RNO-1280215)
Immune system
(R-RNO-168256)
Interleukin-2 family signaling
(R-RNO-451927)
Interleukin-2 signaling
(R-RNO-9020558)
Rho gtpase cycle
(R-RNO-9012999)
Rhou gtpase cycle
(R-RNO-9013420)
Signaling by interleukins
(R-RNO-449147)
Signaling by receptor tyrosine kinases
(R-RNO-9006934)
Signaling by rho gtpases
(R-RNO-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-RNO-9716542)
Signaling by vegf
(R-RNO-194138)
Signal regulatory protein family interactions
(R-RNO-391160)
Signal transduction
(R-RNO-162582)
Vegfa-vegfr2 pathway
(R-RNO-4420097)
3-phosphoinositide-dependent protein kinase binding
(GO:0043423)
Actin filament organization
(GO:0007015)
Activation of janus kinase activity
(GO:0042976)
Adaptive immune response
(GO:0002250)
Angiogenesis
(GO:0001525)
Atp binding
(GO:0005524)
Blood vessel endothelial cell migration
(GO:0043534)
Bone resorption
(GO:0045453)
Calcium/calmodulin-dependent protein kinase activity
(GO:0004683)
Cell adhesion
(GO:0007155)
Cell differentiation
(GO:0030154)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular defense response
(GO:0006968)
Cortical cytoskeleton organization
(GO:0030865)
Enzyme binding
(GO:0019899)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Glial cell proliferation
(GO:0014009)
Glutamate receptor binding
(GO:0035254)
Integrin-mediated signaling pathway
(GO:0007229)
Ionotropic glutamate receptor signaling pathway
(GO:0035235)
Mapk cascade
(GO:0000165)
Marginal zone b cell differentiation
(GO:0002315)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of bone mineralization
(GO:0030502)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of muscle cell apoptotic process
(GO:0010656)
Negative regulation of myeloid cell differentiation
(GO:0045638)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of ossification
(GO:0030279)
Negative regulation of potassium ion transport
(GO:0043267)
Neuron projection development
(GO:0031175)
Neurotransmitter receptor regulator activity
(GO:0099602)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Oocyte maturation
(GO:0001556)
Peptidyl-tyrosine autophosphorylation
(GO:0038083)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Positive regulation of actin filament polymerization
(GO:0030838)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of cell-matrix adhesion
(GO:0001954)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of jun kinase activity
(GO:0043507)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of nitric oxide biosynthetic process
(GO:0045429)
Positive regulation of protein kinase activity
(GO:0045860)
Positive regulation of translation
(GO:0045727)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of cell adhesion
(GO:0030155)
Regulation of cell shape
(GO:0008360)
Regulation of macrophage chemotaxis
(GO:0010758)
Response to cation stress
(GO:0043157)
Response to cocaine
(GO:0042220)
Response to ethanol
(GO:0045471)
Response to glucose
(GO:0009749)
Response to hormone
(GO:0009725)
Response to hydrogen peroxide
(GO:0042542)
Response to hypoxia
(GO:0001666)
Response to immobilization stress
(GO:0035902)
Response to ischemia
(GO:0002931)
Response to mechanical stimulus
(GO:0009612)
Response to reactive oxygen species
(GO:0000302)
Response to xenobiotic stimulus
(GO:0009410)
Signal complex assembly
(GO:0007172)
Sprouting angiogenesis
(GO:0002040)
Stress fiber assembly
(GO:0043149)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)
Ubiquitin protein ligase binding
(GO:0031625)
Vascular endothelial growth factor receptor signaling pathway
(GO:0048010)

Other Information

Proteins

Protein-tyrosine kinase 2-beta

Genular Protein ID: 1715188426

Symbol: FAK2_RAT

Name: Protein-tyrosine kinase 2-beta

UniProtKB Accession Codes:

P70600 O88489 Q3T1H4 Q63201

Database IDs:

Citations:

PubMed ID: 8939945

Title: Activation of a novel calcium-dependent protein-tyrosine kinase. Correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation.

PubMed ID: 8939945

DOI: 10.1074/jbc.271.47.29993

PubMed ID: 7673154

Title: Cloning and characterization of cell adhesion kinase beta, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily.

PubMed ID: 7673154

DOI: 10.1074/jbc.270.36.21206

PubMed ID: 9645946

Title: Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein.

PubMed ID: 9645946

DOI: 10.1242/jcs.111.14.1981

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7544443

Title: Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions.

PubMed ID: 7544443

DOI: 10.1038/376737a0

PubMed ID: 8849729

Title: A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation.

PubMed ID: 8849729

DOI: 10.1038/383547a0

PubMed ID: 9422762

Title: Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions.

PubMed ID: 9422762

DOI: 10.1074/jbc.273.2.1003

PubMed ID: 11739395

Title: Pyk2/CAKbeta tyrosine kinase activity-mediated angiogenesis of pulmonary vascular endothelial cells.

PubMed ID: 11739395

DOI: 10.1074/jbc.m110673200

PubMed ID: 11739373

Title: Signal transduction of physiological concentrations of vasopressin in A7r5 vascular smooth muscle cells. A role for PYK2 and tyrosine phosphorylation of K+ channels in the stimulation of Ca2+ spiking.

PubMed ID: 11739373

DOI: 10.1074/jbc.m104726200

PubMed ID: 12097497

Title: Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: mediation through the Pyk2/Src-family kinase pathway in cortical neurons.

PubMed ID: 12097497

DOI: 10.1523/jneurosci.22-13-05452.2002

PubMed ID: 16574377

Title: Differential regulation of Pyk2 phosphorylation at Tyr-402 and Tyr-580 in intestinal epithelial cells: roles of calcium, Src, Rho kinase, and the cytoskeleton.

PubMed ID: 16574377

DOI: 10.1016/j.cellsig.2006.02.013

PubMed ID: 20071509

Title: Postsynaptic clustering and activation of Pyk2 by PSD-95.

PubMed ID: 20071509

DOI: 10.1523/jneurosci.4992-08.2010

PubMed ID: 21451101

Title: PYK2 signaling is required for PDGF-dependent vascular smooth muscle cell proliferation.

PubMed ID: 21451101

DOI: 10.1152/ajpcell.00315.2010

PubMed ID: 20849950

Title: The Pyk2 FERM regulates Pyk2 complex formation and phosphorylation.

PubMed ID: 20849950

DOI: 10.1016/j.cellsig.2010.09.015

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 1009
Mass: 115784
Checksum: D435A475BCA49E9B
Sequence:

MSGVSEPLSR VKVGTLRPPE GPPEPMVVVP VDVEKEDVRI LKVCFYSNSF NPGKNFKLVK 
CTVQTEIQEI ITSILLSGRI GPNIQLAECY GLRLKHMKSD EIHWLHPQMT VGEVQDKYEC 
LHVEAEWRYD LQIRYLPEDF MESLKEDRTT LLYFYQQLRN DYMQRYASKV SEGMALQLGC 
LELRRFFKDM PHNALDKKSN FELLEKEVGL DLFFPKQMQE NLKPKQFRKM IQQTFQQYAS 
LREEECVMKF FNTLAGFANI DQETYRCELI QGWNITVDLV IGPKGIRQLT SQDTKPTCLA 
EFKQIRSIRC LPLEETQAVL QLGIEGAPQS LSIKTSSLAE AENMADLIDG YCRLQGEHKG 
SLIIHAKKDG EKRNSLPQIP TLNLESRRSH LSESCSIESD IYAEIPDETL RRPGGPQYGV 
AREDVVLNRI LGEGFFGEVY EGVYTNHKGE KINVAVKTCK KDCTLDNKEK FMSEAVIMKN 
LDHPHIVKLI GIIEEEPTWI VMELYPYGEL GHYLERNKNS LKVPTLVLYA LQICKAMAYL 
ESINCVHRDI AVRNILVASP ECVKLGDFGL SRYIEDEDYY KASVTRLPIK WMSPESINFR 
RFTTASDVWM FAVCMWEILS FGKQPFFWLE NKDVIGVLEK GDRLPKPELC PPVLYTLMTR 
CWDYDPSDRP RFTELVCSLS DIYQMERDIA IEQERNARYR PPKILEPTAF QEPPPKPSRP 
KYKHPPQTNL LAPKLQFQVP EGLCASSPTL TSPMEYPSPV NSLHTPPLHR HNVFKRHSMR 
EEDFIRPSSR EEAQQLWEAE KIKMRQVLDR QQKQMVEDSQ WLRREERCLD PMVYMNDKSP 
LTPEKEAGYT EFTGPPQKPP RLGAQSIQPT ANLDRTDDLV YHNVMTLVEA VLELKNKLSQ 
LPPEEYVVVV KNVGLNLRKL IGSVDDLLPS LPASSRTEIE GTQKLLNKDL AELINKMRLA 
QQNAVTSLSE DCKRQMLTAS HTLAVDAKNL LDAVDQAKVV ANLAHPPAE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ptk2b

Associated with

Other Information

Activation of a novel calcium-dependent protein-tyrosine kinase. Correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation. PubMed ID: 8939945

Cloning and characterization of cell adhesion kinase beta, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily. PubMed ID: 7673154

Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein. PubMed ID: 9645946

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions. PubMed ID: 7544443

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. PubMed ID: 8849729

Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions. PubMed ID: 9422762

Pyk2/CAKbeta tyrosine kinase activity-mediated angiogenesis of pulmonary vascular endothelial cells. PubMed ID: 11739395

Signal transduction of physiological concentrations of vasopressin in A7r5 vascular smooth muscle cells. A role for PYK2 and tyrosine phosphorylation of K+ channels in the stimulation of Ca2+ spiking. PubMed ID: 11739373

Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: mediation through the Pyk2/Src-family kinase pathway in cortical neurons. PubMed ID: 12097497

Differential regulation of Pyk2 phosphorylation at Tyr-402 and Tyr-580 in intestinal epithelial cells: roles of calcium, Src, Rho kinase, and the cytoskeleton. PubMed ID: 16574377

Postsynaptic clustering and activation of Pyk2 by PSD-95. PubMed ID: 20071509

PYK2 signaling is required for PDGF-dependent vascular smooth muscle cell proliferation. PubMed ID: 21451101

The Pyk2 FERM regulates Pyk2 complex formation and phosphorylation. PubMed ID: 20849950

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903