Details for: Runx1

Gene ID: 50662

Symbol: Runx1

Ensembl ID: ENSRNOG00000001704

Description: RUNX family transcription factor 1

Associated with

  • Esr-mediated signaling
    (R-RNO-8939211)
  • Estrogen-dependent gene expression
    (R-RNO-9018519)
  • Gene expression (transcription)
    (R-RNO-74160)
  • Generic transcription pathway
    (R-RNO-212436)
  • Organic cation/anion/zwitterion transport
    (R-RNO-549132)
  • Organic cation transport
    (R-RNO-549127)
  • Regulation of runx1 expression and activity
    (R-RNO-8934593)
  • Rna polymerase ii transcription
    (R-RNO-73857)
  • Runx1 and foxp3 control the development of regulatory t lymphocytes (tregs)
    (R-RNO-8877330)
  • Runx1 interacts with co-factors whose precise effect on runx1 targets is not known
    (R-RNO-8939243)
  • Runx1 regulates estrogen receptor mediated transcription
    (R-RNO-8931987)
  • Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
    (R-RNO-8936459)
  • Runx1 regulates transcription of genes involved in bcr signaling
    (R-RNO-8939245)
  • Runx1 regulates transcription of genes involved in differentiation of hscs
    (R-RNO-8939236)
  • Runx1 regulates transcription of genes involved in differentiation of myeloid cells
    (R-RNO-8939246)
  • Runx1 regulates transcription of genes involved in interleukin signaling
    (R-RNO-8939247)
  • Signaling by nuclear receptors
    (R-RNO-9006931)
  • Signal transduction
    (R-RNO-162582)
  • Slc-mediated transmembrane transport
    (R-RNO-425407)
  • Transcriptional regulation by runx1
    (R-RNO-8878171)
  • Transport of bile salts and organic acids, metal ions and amine compounds
    (R-RNO-425366)
  • Transport of small molecules
    (R-RNO-382551)
  • Atp binding
    (GO:0005524)
  • Basement membrane
    (GO:0005604)
  • Behavioral response to pain
    (GO:0048266)
  • Calcium ion binding
    (GO:0005509)
  • Cellular response to transforming growth factor beta stimulus
    (GO:0071560)
  • Central nervous system development
    (GO:0007417)
  • Chondrocyte differentiation
    (GO:0002062)
  • Chromatin
    (GO:0000785)
  • Core-binding factor complex
    (GO:0016513)
  • Definitive hemopoiesis
    (GO:0060216)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription factor binding
    (GO:0140297)
  • Dna binding
    (GO:0003677)
  • Embryonic hemopoiesis
    (GO:0035162)
  • Hair follicle morphogenesis
    (GO:0031069)
  • Hemopoiesis
    (GO:0030097)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • In utero embryonic development
    (GO:0001701)
  • Liver development
    (GO:0001889)
  • Myeloid cell differentiation
    (GO:0030099)
  • Myeloid leukocyte differentiation
    (GO:0002573)
  • Myeloid progenitor cell differentiation
    (GO:0002318)
  • Negative regulation of cd4-positive, alpha-beta t cell differentiation
    (GO:0043371)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of granulocyte differentiation
    (GO:0030853)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuron development
    (GO:0048666)
  • Neuron differentiation
    (GO:0030182)
  • Neuron fate commitment
    (GO:0048663)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Ossification
    (GO:0001503)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of cd8-positive, alpha-beta t cell differentiation
    (GO:0043378)
  • Positive regulation of cell maturation
    (GO:1903431)
  • Positive regulation of developmental process
    (GO:0051094)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of granulocyte differentiation
    (GO:0030854)
  • Positive regulation of interleukin-2 production
    (GO:0032743)
  • Positive regulation of multicellular organismal process
    (GO:0051240)
  • Positive regulation of progesterone secretion
    (GO:2000872)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Promoter-specific chromatin binding
    (GO:1990841)
  • Protein heterodimerization activity
    (GO:0046982)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of cell differentiation
    (GO:0045595)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of hair follicle cell proliferation
    (GO:0071336)
  • Regulation of signal transduction
    (GO:0009966)
  • Regulation of t cell anergy
    (GO:0002667)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to denervation involved in regulation of muscle adaptation
    (GO:0014894)
  • Response to retinoic acid
    (GO:0032526)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Skeletal system development
    (GO:0001501)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription coactivator binding
    (GO:0001223)
  • Transcription corepressor binding
    (GO:0001222)

Other Information

Genular Protein ID: 647982506

Symbol: RUNX1_RAT

Name: Runt-related transcription factor 1

UniProtKB Accession Codes:

Q63046

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 CTD 1 ChEBI 4 ELM 1 EMBL 1 Ensembl 1 ExpressionAtlas 1 GO 55 Gene3D 1 GeneTree 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 Reactome 11 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 UCSC 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 7969143

Title: AML1 is expressed in skeletal muscle and is regulated by innervation.

PubMed ID: 7969143

DOI: 10.1128/mcb.14.12.8051-8057.1994

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

  • Length: 450
  • Mass: 48556
  • Checksum: 4B53AD706D487AC3
  • Sequence:
    • MRIPVDASTS RRFTPPSTAL SPGKMSEALP LGAPDGGAAL ASKLRSGDRS MVEVLADHPG 
ELVRTDSPNF LCSVLPTHWR CNKTLPIAFK VVALGDVPDG TLVTVMAGND ENYSAELRNA 
TAAMKNQVAR FNDLRFVGRS GRGKSFTLTI TVFTNPPQVA TYHRAIKITV DGPREPRRHR 
QKLDDQTKPG SLSFSERLSE LEQLRRTAMR VSPHHPAPTP NPRASLNHST AFNPQPQSQM 
QDARQIQPSP PWSYDQSYQY LGSITSSVHP ATPISPGRAS GMTSLSAELS SRLSTAPDLT 
AFGDPRQFPT LPSISDPRMH YPGAFTYSPP VTSGIGIGMS AMSSTSRYHT YLPPPYPGSS 
QAQAGPFQTG SPSYHLYYGT SAGSYQFSMV GGERSPPRIL PPCTNASTGA ALLNPSLPSQ 
SDVVETEGSH SNSPTNMPPA RLEEAVWRPY

Genular Protein ID: 2266695927

Symbol: A0A0G2JYQ4_RAT

Name: N/A

UniProtKB Accession Codes:

A0A0G2JYQ4

Database IDs:

ARBA 5 AlphaFoldDB 1 Bgee 1 CTD 1 ChEBI 4 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneTree 1 InterPro 7 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 1 PRINTS 1 PROSITE 2 Pfam 2 Proteomes 2 RGD 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

Sequence Information:

  • Length: 464
  • Mass: 50153
  • Checksum: D9D3606A41A4F295
  • Sequence:
    • MASDSIFESF PSYPQCFVRD ASTSRRFTPP STALSPGKMS EALPLGAPDG GAALASKLRS 
GDRSMVEVLA DHPGELVRTD SPNFLCSVLP THWRCNKTLP IAFKVVALGD VPDGTLVTVM 
AGNDENYSAE LRNATAAMKN QVARFNDLRF VGRSGRGKSF TLTITVFTNP PQVATYHRAI 
KITVDGPREP RRHRQKLDDQ TKPGSLSFSE RLSELEQLRR TAMRVSPHHP APTPNPRASL 
NHSTAFNPQP QSQMQDARQI QPSPPWSYDQ SYQYLGSITS SVHPATPISP GRASGMTSLS 
AELSSRLSTA PDLTAFGDPR QFPTLPSISD PRMHYPGAFT YSPPVTSGIG IGMSAMSSTS 
RYHTYLPPPY PGSSQAQAGP FQTGSPSYHL YYGTSAGSYQ FSMVGGERSP PRILPPCTNA 
STGAALLNPS LPSQSDVVET EGSHSNSPTN MPPARLEEAV WRPY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.