Details for: Gsk3a

Gene ID: 50686

Symbol: Gsk3a

Ensembl ID: ENSRNOG00000020417

Description: glycogen synthase kinase 3 alpha

Associated with

  • Atp binding
    (GO:0005524)
  • Autosome genomic imprinting
    (GO:0141068)
  • Axon
    (GO:0030424)
  • Cardiac left ventricle morphogenesis
    (GO:0003214)
  • Cell differentiation
    (GO:0030154)
  • Cell migration
    (GO:0016477)
  • Cellular response to glucocorticoid stimulus
    (GO:0071385)
  • Cellular response to insulin stimulus
    (GO:0032869)
  • Cellular response to interleukin-3
    (GO:0036016)
  • Cellular response to lithium ion
    (GO:0071285)
  • Cellular response to organic cyclic compound
    (GO:0071407)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Extrinsic apoptotic signaling pathway
    (GO:0097191)
  • Extrinsic apoptotic signaling pathway in absence of ligand
    (GO:0097192)
  • Glycogen metabolic process
    (GO:0005977)
  • Histone h2as1 kinase activity
    (GO:0044024)
  • Insulin receptor signaling pathway
    (GO:0008286)
  • Microtubule
    (GO:0005874)
  • Mitochondrion
    (GO:0005739)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of cell growth involved in cardiac muscle cell development
    (GO:0061052)
  • Negative regulation of d-glucose import
    (GO:0046325)
  • Negative regulation of dendrite development
    (GO:2000171)
  • Negative regulation of glycogen synthase activity, transferring glucose-1-phosphate
    (GO:1904227)
  • Negative regulation of insulin receptor signaling pathway
    (GO:0046627)
  • Negative regulation of tor signaling
    (GO:0032007)
  • Nervous system development
    (GO:0007399)
  • Nucleus
    (GO:0005634)
  • Peptidyl-serine phosphorylation
    (GO:0018105)
  • Peptidyl-threonine phosphorylation
    (GO:0018107)
  • Positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
    (GO:0071879)
  • Positive regulation of adenylate cyclase-activating g protein-coupled receptor signaling pathway
    (GO:0106071)
  • Positive regulation of amyloid-beta formation
    (GO:1902004)
  • Positive regulation of autophagy
    (GO:0010508)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of glycogen (starch) synthase activity
    (GO:2000467)
  • Positive regulation of heart contraction
    (GO:0045823)
  • Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
    (GO:1901030)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Positive regulation of peptidyl-serine phosphorylation
    (GO:0033138)
  • Positive regulation of peptidyl-threonine phosphorylation
    (GO:0010800)
  • Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
    (GO:0032436)
  • Positive regulation of protein targeting to mitochondrion
    (GO:1903955)
  • Positive regulation of protein ubiquitination
    (GO:0031398)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Proteasome-mediated ubiquitin-dependent protein catabolic process
    (GO:0043161)
  • Protein kinase a catalytic subunit binding
    (GO:0034236)
  • Protein kinase activity
    (GO:0004672)
  • Protein kinase binding
    (GO:0019901)
  • Protein phosphorylation
    (GO:0006468)
  • Protein serine/threonine kinase activity
    (GO:0004674)
  • Protein serine/threonine kinase binding
    (GO:0120283)
  • Protein serine kinase activity
    (GO:0106310)
  • Regulation of microtubule cytoskeleton organization
    (GO:0070507)
  • Regulation of mitophagy
    (GO:1901524)
  • Regulation of neuron projection development
    (GO:0010975)
  • Regulation of systemic arterial blood pressure
    (GO:0003073)
  • Signaling receptor binding
    (GO:0005102)
  • Tau-protein kinase activity
    (GO:0050321)
  • Wnt signaling pathway
    (GO:0016055)

Other Information

Genular Protein ID: 2381131010

Symbol: GSK3A_RAT

Name: Glycogen synthase kinase-3 alpha

UniProtKB Accession Codes:

P18265

Database IDs:

AGR 1 AlphaFoldDB 1 BRENDA 1 Bgee 1 BioGRID 1 CDD 1 CORUM 1 CTD 1 ChEBI 22 ChEMBL 1 DNASU 1 EC 6 EMBL 1 ExpressionAtlas 1 GO 56 Gene3D 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 RefSeq 1 Rhea 12 SMART 1 SMR 1 STRING 1 SUPFAM 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 2164470

Title: Molecular cloning and expression of glycogen synthase kinase-3/factor A.

PubMed ID: 2164470

DOI: 10.1002/j.1460-2075.1990.tb07419.x

PubMed ID: 8382613

Title: Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation.

PubMed ID: 8382613

DOI: 10.1002/j.1460-2075.1993.tb05715.x

PubMed ID: 17242403

Title: Inhibition of GSK3 promotes replication and survival of pancreatic beta cells.

PubMed ID: 17242403

DOI: 10.1074/jbc.m609637200

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

  • Length: 483
  • Mass: 51027
  • Checksum: A98DC1C5C7F7B716
  • Sequence:
    • MSGGGPSGGG PGGSGRARTS SFAEPGGGGG GGGGGPGGSA SGPGGTGGGK ASVGAMGGGV 
GASSSGGGPS GSGGGGSGGP GAGTSFPPPG VKLGRDSGKV TTVVATLGQG PERSQEVAYT 
DIKVIGNGSF GVVYQARLAE TRELVAIKKV LQDKRFKNRE LQIMRKLDHC NIVRLRYFFY 
SSGEKKDELY LNLVLEYVPE TVYRVARHFT KAKLIIPIIY VKVYMYQLFR SLAYIHSQGV 
CHRDIKPQNL LVDPDTAVLK LCDFGSAKQL VRGEPNVSYI CSRYYRAPEL IFGATDYTSS 
IDVWSAGCVL AELLLGQPIF PGDSGVDQLV EIIKVLGTPT REQIREMNPN YTEFKFPQIK 
AHPWTKVFKS RTPPEAIALC SSLLEYTPSS RLSPLEACAH SFFDELRSLG TQLPNNRPLP 
PLFNFSPGEL SIQPSLNAIL IPPHLRSPSG PATLTSSSQA LTETQTGQDW QAPDATPTLT 
NSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.