Details for: ATP5F1BP1

Gene ID: 507

Symbol: ATP5F1BP1

Ensembl ID: ENSG00000231635

Description: ATP synthase F1 subunit beta pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.1312
    Cell Significance Index: 1.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0556
    Cell Significance Index: -2.5900
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.1319
    Cell Significance Index: -1.2900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1525
    Cell Significance Index: -1.8200
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.2346
    Cell Significance Index: -2.9400
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.2388
    Cell Significance Index: -2.9800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2415
    Cell Significance Index: -2.9300
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2427
    Cell Significance Index: -2.6400
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.2440
    Cell Significance Index: -2.7600
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.2556
    Cell Significance Index: -2.9300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2926
    Cell Significance Index: -2.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ATP5F1BP1, or ATP synthase F1 subunit beta pseudogene 1, is a pseudogene that has been identified in the human genome. Unlike its functional counterpart, ATP5F1B, which is a crucial component of the mitochondrial ATP synthase complex, ATP5F1BP1 lacks the ability to produce functional ATP. Despite this, ATP5F1BP1 has been found to be expressed in a variety of cell types, including stromal cells, lung ciliated cells, and retinal cells. Its expression patterns are often overlapping with those of functional genes, suggesting a potential role in regulating cellular processes. **Pathways and Functions:** The exact function of ATP5F1BP1 remains unclear, but several hypotheses have been proposed based on its expression patterns and potential interactions with other genes. One possibility is that ATP5F1BP1 plays a role in regulating cellular energy metabolism, particularly in cells with high energy demands such as neurons and ciliated cells. Another hypothesis suggests that ATP5F1BP1 may be involved in the regulation of cellular signaling pathways, potentially modulating the activity of other genes involved in immune responses. Interestingly, ATP5F1BP1 has been found to be co-expressed with genes involved in immune regulation, such as cytokines and chemokines. This has led some researchers to speculate that ATP5F1BP1 may play a role in modulating immune responses, potentially influencing the development and function of immune cells. **Clinical Significance:** The discovery of ATP5F1BP1 has significant implications for our understanding of immune regulation and disease. As a pseudogene, ATP5F1BP1 may have evolved to play a role in regulating cellular processes, potentially influencing the development and function of immune cells. In the context of immunology, ATP5F1BP1 may have relevance to a range of diseases, including autoimmune disorders, where dysregulation of immune responses is a hallmark. Furthermore, the expression of ATP5F1BP1 in certain cell types may provide insights into the development and progression of diseases such as cancer, where cellular energy metabolism is often disrupted. In conclusion, the ATP5F1BP1 gene, a pseudogene with significant expression in various cell types, has sparked interest among immunologists due to its potential role in regulating cellular processes and immune responses. Further research is needed to fully elucidate the function and clinical significance of ATP5F1BP1, but its discovery highlights the complexity and diversity of gene expression in the human genome. **Recommendations:** 1. Further studies are needed to elucidate the function and clinical significance of ATP5F1BP1. 2. Researchers should investigate the potential role of ATP5F1BP1 in regulating cellular energy metabolism and immune responses. 3. The expression patterns of ATP5F1BP1 should be further characterized to determine its potential relevance to disease. 4. The discovery of ATP5F1BP1 highlights the importance of studying pseudogenes and their potential roles in regulating cellular processes. **Future Directions:** 1. Investigate the potential role of ATP5F1BP1 in regulating cellular energy metabolism and immune responses. 2. Characterize the expression patterns of ATP5F1BP1 in different cell types and tissues. 3. Explore the potential therapeutic applications of ATP5F1BP1 in regulating immune responses and cellular energy metabolism. 4. Investigate the evolutionary origins of ATP5F1BP1 and its potential role in the development of human diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.