Elane | ENSMUSG00000020125 | NCBI 50701

Details for: Elane

Gene ID: 50701

Symbol: Elane

Ensembl ID: ENSMUSG00000020125

Description: elastase, neutrophil expressed

Associated with

Activation of matrix metalloproteinases
(R-MMU-1592389)
Antimicrobial peptides
(R-MMU-6803157)
Complement cascade
(R-MMU-166658)
Degradation of the extracellular matrix
(R-MMU-1474228)
Extracellular matrix organization
(R-MMU-1474244)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Neutrophil degranulation
(R-MMU-6798695)
Programmed cell death
(R-MMU-5357801)
Pyroptosis
(R-MMU-5620971)
Regulated necrosis
(R-MMU-5218859)
Regulation of complement cascade
(R-MMU-977606)
Acute inflammatory response to antigenic stimulus
(GO:0002438)
Biosynthetic process of antibacterial peptides active against gram-negative bacteria
(GO:0002812)
Cell surface
(GO:0009986)
Collagen-containing extracellular matrix
(GO:0062023)
Cytokine binding
(GO:0019955)
Cytoplasm
(GO:0005737)
Defense response to bacterium
(GO:0042742)
Defense response to fungus
(GO:0050832)
Endopeptidase activity
(GO:0004175)
Extracellular space
(GO:0005615)
Heparin binding
(GO:0008201)
Leukocyte migration
(GO:0050900)
Leukocyte migration involved in inflammatory response
(GO:0002523)
Negative regulation of chemokine production
(GO:0032682)
Negative regulation of interleukin-8 production
(GO:0032717)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neutrophil-mediated killing of fungus
(GO:0070947)
Neutrophil-mediated killing of gram-negative bacterium
(GO:0070945)
Peptidase activity
(GO:0008233)
Phagocytosis
(GO:0006909)
Positive regulation of immune response
(GO:0050778)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of leukocyte tethering or rolling
(GO:1903238)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Protease binding
(GO:0002020)
Proteolysis
(GO:0006508)
Response to lipopolysaccharide
(GO:0032496)
Response to uv
(GO:0009411)
Response to yeast
(GO:0001878)
Secretory granule
(GO:0030141)
Serine-type endopeptidase activity
(GO:0004252)
Transcription corepressor activity
(GO:0003714)
Transcription repressor complex
(GO:0017053)

Other Information

Proteins

Neutrophil elastase

Genular Protein ID: 2845402270

Symbol: ELNE_MOUSE

Name: Neutrophil elastase

UniProtKB Accession Codes:

Q3UP87 A6H698 Q61515

Database IDs:

Citations:

PubMed ID: 8035830

Title: PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells.

PubMed ID: 8035830

DOI: 10.1128/mcb.14.8.5558-5568.1994

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10947984

Title: Degradation of outer membrane protein A in Escherichia coli killing by neutrophil elastase.

PubMed ID: 10947984

DOI: 10.1126/science.289.5482.1185

Sequence Information:

Length: 265
Mass: 28648
Checksum: 666029A299275EB6
Sequence:

MALGRLSSRT LAAMLLALFL GGPALASEIV GGRPARPHAW PFMASLQRRG GHFCGATLIA 
RNFVMSAAHC VNGLNFRSVQ VVLGAHDLRR QERTRQTFSV QRIFENGFDP SQLLNDIVII 
QLNGSATINA NVQVAQLPAQ GQGVGDRTPC LAMGWGRLGT NRPSPSVLQE LNVTVVTNMC 
RRRVNVCTLV PRRQAGICFG DSGGPLVCNN LVQGIDSFIR GGCGSGLYPD AFAPVAEFAD 
WINSIIRSHN DHLLTHPKDR EGRTN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Elane

Associated with

Other Information

PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells. PubMed ID: 8035830

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Degradation of outer membrane protein A in Escherichia coli killing by neutrophil elastase. PubMed ID: 10947984

Database document:

PubMed ID: 8035830

PubMed ID: 16141072

PubMed ID: 15489334

PubMed ID: 10947984