Slc7a5 | ENSRNOG00000018824 | NCBI 50719

Details for: Slc7a5

Gene ID: 50719

Symbol: Slc7a5

Ensembl ID: ENSRNOG00000018824

Description: solute carrier family 7 member 5

Associated with

Amino acid transport across the plasma membrane
(R-RNO-352230)
Basigin interactions
(R-RNO-210991)
Cell surface interactions at the vascular wall
(R-RNO-202733)
Hemostasis
(R-RNO-109582)
Metabolism
(R-RNO-1430728)
Metabolism of amino acids and derivatives
(R-RNO-71291)
Slc-mediated transmembrane transport
(R-RNO-425407)
Transport of inorganic cations/anions and amino acids/oligopeptides
(R-RNO-425393)
Transport of small molecules
(R-RNO-382551)
Tryptophan catabolism
(R-RNO-71240)
Alanine transport
(GO:0032328)
Amino acid import across plasma membrane
(GO:0089718)
Amino acid transmembrane transport
(GO:0003333)
Amino acid transmembrane transporter activity
(GO:0015171)
Amino acid transport complex
(GO:1990184)
Antiporter activity
(GO:0015297)
Apical plasma membrane
(GO:0016324)
Aromatic amino acid transmembrane transporter activity
(GO:0015173)
Basal plasma membrane
(GO:0009925)
Basolateral plasma membrane
(GO:0016323)
Cellular response to amino acid stimulus
(GO:0071230)
Cellular response to glucose starvation
(GO:0042149)
Cellular response to l-arginine
(GO:1903577)
Cellular response to lipopolysaccharide
(GO:0071222)
Cytosol
(GO:0005829)
External side of apical plasma membrane
(GO:0098591)
Intracellular membrane-bounded organelle
(GO:0043231)
Isoleucine transport
(GO:0015818)
L-alpha-amino acid transmembrane transport
(GO:1902475)
L-amino acid transmembrane transporter activity
(GO:0015179)
L-amino acid transport
(GO:0015807)
L-histidine transport
(GO:1902024)
L-leucine import across plasma membrane
(GO:1903801)
L-leucine transmembrane transporter activity
(GO:0015190)
L-leucine transport
(GO:0015820)
L-tryptophan transmembrane transport
(GO:1904556)
L-tryptophan transmembrane transporter activity
(GO:0015196)
Liver regeneration
(GO:0097421)
Lysosomal membrane
(GO:0005765)
Membrane
(GO:0016020)
Methionine transport
(GO:0015821)
Microvillus membrane
(GO:0031528)
Negative regulation of autophagy
(GO:0010507)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of vascular associated smooth muscle cell apoptotic process
(GO:1905460)
Neutral amino acid transport
(GO:0015804)
Neutral l-amino acid transmembrane transporter activity
(GO:0015175)
Peptide antigen binding
(GO:0042605)
Phenylalanine transport
(GO:0015823)
Plasma membrane
(GO:0005886)
Positive regulation of glial cell proliferation
(GO:0060252)
Positive regulation of interleukin-4 production
(GO:0032753)
Positive regulation of interleukin-17 production
(GO:0032740)
Positive regulation of l-leucine import across plasma membrane
(GO:1905534)
Positive regulation of type ii interferon production
(GO:0032729)
Proline transport
(GO:0015824)
Response to hyperoxia
(GO:0055093)
Response to muscle activity
(GO:0014850)
Thyroid hormone transmembrane transporter activity
(GO:0015349)
Thyroid hormone transport
(GO:0070327)
Tryptophan transport
(GO:0015827)
Tyrosine transport
(GO:0015828)
Valine transport
(GO:0015829)
Xenobiotic transport
(GO:0042908)

Other Information

Proteins

Large neutral amino acids transporter small subunit 1

Genular Protein ID: 1569240524

Symbol: LAT1_RAT

Name: Large neutral amino acids transporter small subunit 1

UniProtKB Accession Codes:

Q63016 Q9QWL4

Database IDs:

Citations:

PubMed ID: 9726963

Title: Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98).

PubMed ID: 9726963

DOI: 10.1074/jbc.273.37.23629

PubMed ID: 7532544

Title: TA1, a highly conserved oncofetal complementary DNA from rat hepatoma, encodes an integral membrane protein associated with liver development, carcinogenesis, and cell activation.

PubMed ID: 7532544

PubMed ID: 11095508

Title: Expression of a system L neutral amino acid transporter at the blood-brain barrier.

PubMed ID: 11095508

DOI: 10.1097/00001756-200011090-00021

PubMed ID: 11311135

Title: Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains.

PubMed ID: 11311135

DOI: 10.1042/bj3550725

PubMed ID: 12614332

Title: Site-directed mutagenesis of rabbit LAT1 at amino acids 219 and 234.

PubMed ID: 12614332

DOI: 10.1046/j.1471-4159.2003.01622.x

PubMed ID: 15120633

Title: Transcriptional regulation of the LAT-1/CD98 light chain.

PubMed ID: 15120633

DOI: 10.1016/j.bbrc.2004.04.062

PubMed ID: 16027961

Title: Expression of LAT1 and LAT2 amino acid transporters in human and rat intestinal epithelial cells.

PubMed ID: 16027961

DOI: 10.1007/s00726-005-0221-x

PubMed ID: 15980244

Title: L-type amino acid transporter 1-mediated L-leucine transport at the inner blood-retinal barrier.

PubMed ID: 15980244

DOI: 10.1167/iovs.04-1175

Sequence Information:

Length: 512
Mass: 55903
Checksum: B487CE0B58D73A02
Sequence:

MAVAGAKRRA VAAPATTAAE EERQAREKML EARRGDGADP EGEGVTLQRN ITLINGVAII 
VGTIIGSGIF VTPTGVLKEA GSPGLSLVVW AVCGVFSIVG ALCYAELGTT ISKSGGDYAY 
MLEVYGSLPA FLKLWIELLI IRPSSQYIVA LVFATYLLKP VFPTCPVPEE AAKLVACLCV 
LLLTAVNCYS VKAATRVQDA FAAAKLLALA LIILLGFIQM GKDIGQGDAS NLHQKLSFEG 
TNLDVGNIVL ALYSGLFAYG GWNYLNFVTE EMINPYRNLP LAIIISLPIV TLVYVLTNLA 
YFTTLSTNQM LTSEAVAVDF GNYHLGVMSW IIPVFVGLSC FGSVNGSLFT SSRLFFVGSR 
EGHLPSILSM IHPQLLTPVP SLVFTCVMTL MYAFSRDIFS IINFFSFFNW LCVALAIIGM 
MWLRFKKPEL ERPIKVNLAL PVFFILACLF LIAVSFWKTP LECGIGFAII LSGLPVYFFG 
VWWKNKPKWI LQVIFSVTVL CQKLMQVVPQ ET

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Slc7a5

Associated with

Other Information

Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98). PubMed ID: 9726963

TA1, a highly conserved oncofetal complementary DNA from rat hepatoma, encodes an integral membrane protein associated with liver development, carcinogenesis, and cell activation. PubMed ID: 7532544

Expression of a system L neutral amino acid transporter at the blood-brain barrier. PubMed ID: 11095508

Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains. PubMed ID: 11311135

Site-directed mutagenesis of rabbit LAT1 at amino acids 219 and 234. PubMed ID: 12614332

Transcriptional regulation of the LAT-1/CD98 light chain. PubMed ID: 15120633

Expression of LAT1 and LAT2 amino acid transporters in human and rat intestinal epithelial cells. PubMed ID: 16027961

L-type amino acid transporter 1-mediated L-leucine transport at the inner blood-retinal barrier. PubMed ID: 15980244